HK1157399A1 - Mutant dna polymerases and related methods - Google Patents

Mutant dna polymerases and related methods

Info

Publication number
HK1157399A1
HK1157399A1 HK11111827.3A HK11111827A HK1157399A1 HK 1157399 A1 HK1157399 A1 HK 1157399A1 HK 11111827 A HK11111827 A HK 11111827A HK 1157399 A1 HK1157399 A1 HK 1157399A1
Authority
HK
Hong Kong
Prior art keywords
related methods
dna polymerases
mutant dna
mutant
polymerases
Prior art date
Application number
HK11111827.3A
Other languages
English (en)
Inventor
Keith A Bauer
David Harrow Gelfand
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HK1157399A1 publication Critical patent/HK1157399A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1276—RNA-directed DNA polymerase (2.7.7.49), i.e. reverse transcriptase or telomerase

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
HK11111827.3A 2007-07-13 2011-11-02 Mutant dna polymerases and related methods HK1157399A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94973207P 2007-07-13 2007-07-13
PCT/EP2008/005714 WO2009010251A2 (fr) 2007-07-13 2008-07-12 Adn polymérases mutantes et procédés associés

Publications (1)

Publication Number Publication Date
HK1157399A1 true HK1157399A1 (en) 2012-06-29

Family

ID=39800730

Family Applications (1)

Application Number Title Priority Date Filing Date
HK11111827.3A HK1157399A1 (en) 2007-07-13 2011-11-02 Mutant dna polymerases and related methods

Country Status (8)

Country Link
US (1) US8026091B2 (fr)
EP (1) EP2164955B1 (fr)
JP (1) JP5612469B2 (fr)
CN (1) CN102099464B (fr)
CA (1) CA2693657C (fr)
ES (1) ES2403591T3 (fr)
HK (1) HK1157399A1 (fr)
WO (1) WO2009010251A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2706999C (fr) * 2007-11-28 2013-01-22 F. Hoffmann-La Roche Ag Adn polymerases mutantes dotees d'une capacite amelioree de polymerisation activee par la pyrophosphorolyse (pap)
US10150990B2 (en) 2008-04-21 2018-12-11 Roche Molecular Systems, Inc. Ribonucleotide tag nucleic acid detection
US8715991B2 (en) 2010-06-18 2014-05-06 Roche Molecular Systems, Inc. DNA polymerases with increased 3'-mismatch discrimination
CN103003418B (zh) * 2010-06-18 2015-08-26 霍夫曼-拉罗奇有限公司 具有增强的3’-错配辨别力的dna聚合酶
AU2011267421B2 (en) 2010-06-18 2014-04-24 F. Hoffmann-La Roche Ag DNA polymerases with increased 3'-mismatch discrimination
US10597643B2 (en) 2016-04-29 2020-03-24 Omniome, Inc. Polymerases engineered to reduce nucleotide-independent DNA binding
CA3022431C (fr) 2016-04-29 2023-03-21 Omniome, Inc. Procede de determination d'une sequence d'acides nucleiques
CN109486788B (zh) * 2018-10-26 2021-10-22 南京市胸科医院 一种突变体dna聚合酶及其制备方法和应用
US20220325259A1 (en) * 2020-04-30 2022-10-13 Daan Gene Co., Ltd. A heat-resistant dna polymerase mutant with high amplification activity

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5374553A (en) * 1986-08-22 1994-12-20 Hoffmann-La Roche Inc. DNA encoding a thermostable nucleic acid polymerase enzyme from thermotoga maritima
JP3112148B2 (ja) 1995-05-31 2000-11-27 東洋紡績株式会社 核酸の増幅方法およびその試薬
AU717156B2 (en) * 1995-12-27 2000-03-16 Takara Bio Inc. Novel DNA polymerase
US6329178B1 (en) 2000-01-14 2001-12-11 University Of Washington DNA polymerase mutant having one or more mutations in the active site
US7179590B2 (en) 2000-04-18 2007-02-20 Roche Molecular Systems, Inc High temperature reverse transcription using mutant DNA polymerases
US7148049B2 (en) * 2002-04-02 2006-12-12 Roche Molecular Systems, Inc. Thermostable or thermoactive DNA polymerase molecules with attenuated 3′-5′ exonuclease activity
ES2546945T3 (es) 2003-11-03 2015-09-30 Medical Research Council Polimerasa
JP2006197947A (ja) * 2006-04-26 2006-08-03 Toyobo Co Ltd エキソヌクレアーゼ活性が低減された耐熱性ｄｎａポリメラーゼおよびその用途

Also Published As

Publication number Publication date
ES2403591T3 (es) 2013-05-20
CA2693657A1 (fr) 2009-01-22
CN102099464A (zh) 2011-06-15
EP2164955A2 (fr) 2010-03-24
JP5612469B2 (ja) 2014-10-22
JP2010532979A (ja) 2010-10-21
WO2009010251A8 (fr) 2010-04-08
US8026091B2 (en) 2011-09-27
WO2009010251A3 (fr) 2009-03-05
EP2164955B1 (fr) 2013-03-06
CA2693657C (fr) 2013-09-10
CN102099464B (zh) 2013-10-30
WO2009010251A2 (fr) 2009-01-22
US20090137000A1 (en) 2009-05-28

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20210711