HK1152474A1 - 用於預防和治療膿毒症的方法和組合物 - Google Patents
用於預防和治療膿毒症的方法和組合物Info
- Publication number
- HK1152474A1 HK1152474A1 HK11106525.8A HK11106525A HK1152474A1 HK 1152474 A1 HK1152474 A1 HK 1152474A1 HK 11106525 A HK11106525 A HK 11106525A HK 1152474 A1 HK1152474 A1 HK 1152474A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- sepsis
- prevention
- compositions
- treatment
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47068103P | 2003-05-15 | 2003-05-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1152474A1 true HK1152474A1 (zh) | 2012-03-02 |
Family
ID=33476736
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK11106525.8A HK1152474A1 (zh) | 2003-05-15 | 2011-06-23 | 用於預防和治療膿毒症的方法和組合物 |
Country Status (11)
Country | Link |
---|---|
US (1) | US8329169B2 (zh) |
EP (2) | EP2266606B1 (zh) |
JP (2) | JP4768620B2 (zh) |
CN (2) | CN102258784A (zh) |
AU (2) | AU2004241069B2 (zh) |
CA (1) | CA2524534C (zh) |
DK (1) | DK1628530T3 (zh) |
ES (2) | ES2387275T3 (zh) |
HK (1) | HK1152474A1 (zh) |
MX (1) | MXPA05011886A (zh) |
WO (1) | WO2004103294A2 (zh) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2007001332A2 (en) * | 2004-08-04 | 2007-01-04 | University Of Massachusetts | Anti-pathogen immunoadhesins |
US8420783B2 (en) | 2004-12-08 | 2013-04-16 | Immunomedics, Inc. | Method and compositions for immunotherapy of inflammatory and immune-dysregulatory diseases |
CN101932337A (zh) * | 2007-06-11 | 2010-12-29 | 宾夕法尼亚大学董事会 | 替代途径的血清灭菌蛋白调节及其应用 |
WO2009121065A2 (en) * | 2008-03-28 | 2009-10-01 | Apellis Ag | Modulation and repletion/enhancement of the complement system for treatment of trauma |
WO2010135717A2 (en) | 2009-05-21 | 2010-11-25 | Potentia Pharmaceuticals, Inc. | Complement assays and uses thereof |
AU2010264520A1 (en) | 2009-06-23 | 2012-01-19 | Alexion Pharmaceuticals, Inc. | Bispecific antibodies that bind to complement proteins |
EP2309001A1 (de) * | 2009-09-23 | 2011-04-13 | SIRS-Lab GmbH | Verfahren zur in vitro Erfassung und Unterscheidung von pathophysiologischen Zuständen |
WO2011106635A1 (en) * | 2010-02-25 | 2011-09-01 | The Trustees Of The University Of Pennsylvania | Treatment of sepsis using complement inhibitors |
EP2545075B1 (en) * | 2010-03-10 | 2020-07-01 | NovelMed Therapeutics, Inc. | Humanized and chimeric anti-properdin antibodies |
SG185383A1 (en) * | 2010-04-30 | 2012-12-28 | Alexion Pharma Inc | Anti-c5a antibodies and methods for using the antibodies |
WO2012145392A2 (en) * | 2011-04-18 | 2012-10-26 | Curators Of The University Of Missouri | Saccharide conjugates |
JP5793188B2 (ja) | 2011-05-13 | 2015-10-14 | 国立大学法人 東京大学 | 自己免疫疾患治療及び予防薬としてのctrp6 |
CN103649756B (zh) * | 2011-05-19 | 2016-07-06 | 持田制药株式会社 | 使用血液样本的呼吸道传染病的诊断 |
AU2012279288B2 (en) | 2011-07-01 | 2017-07-20 | The Trustees Of The University Of Pennsylvania | Anti-properdin antibodies and uses thereof |
CN102363781A (zh) * | 2011-10-19 | 2012-02-29 | 海南大学 | 一种有效抑制小鼠mCD14基因表达的小干扰核糖核酸分子 |
CN102533758B (zh) * | 2011-10-19 | 2014-04-02 | 海南大学 | 一种抑制水牛膜分化抗原14 基因表达的小核糖核酸分子 |
CN106831985A (zh) | 2011-12-21 | 2017-06-13 | 诺华股份有限公司 | 用于抗体靶定p因子的组合物和方法 |
CN110818798A (zh) | 2012-10-25 | 2020-02-21 | 美国比奥维拉迪维股份有限公司 | 抗补体C1s抗体和其用途 |
EP2914291B1 (en) | 2012-11-02 | 2022-02-23 | Bioverativ USA Inc. | Anti-complement c1s antibodies and uses thereof |
WO2014186599A2 (en) * | 2013-05-15 | 2014-11-20 | Annexon, Inc. | Anti-complement factor c1s antibodies and uses thereof |
AU2014287221C1 (en) | 2013-07-09 | 2020-03-05 | Annexon, Inc. | Anti-complement factor C1q antibodies and uses thereof |
EA034870B1 (ru) * | 2013-08-07 | 2020-03-31 | Алексион Фармасьютикалз, Инк. | Белковые биомаркеры атипичного гемолитического уремического синдрома |
US20150104445A1 (en) * | 2013-10-10 | 2015-04-16 | Viropharma Holdings Limited | Methods of inhibiting the alternative pathway of complement immune system activation and compositions used therein |
EP3071217A2 (en) * | 2013-11-18 | 2016-09-28 | Westfälische Wilhelms-Universität Münster | Methods, peptides and antibodies for preventing, treating and diagnosing an inflammatory condition |
US20170107294A1 (en) * | 2014-03-21 | 2017-04-20 | Nordlandssykehuset Hf | Anti-cd14 antibodies and uses thereof |
NZ727420A (en) | 2014-06-12 | 2018-06-29 | Ra Pharmaceuticals Inc | Modulation of complement activity |
AU2015343029B2 (en) | 2014-11-05 | 2021-07-29 | Annexon, Inc. | Humanized anti-complement factor C1q antibodies and uses thereof |
US20160168237A1 (en) * | 2014-12-12 | 2016-06-16 | Alexion Pharmaceuticals, Inc. | Method for treating a complement mediated disorder caused by an infectious agent in a patient |
PT3250230T (pt) | 2015-01-28 | 2021-12-07 | Ra Pharmaceuticals Inc | Moduladores da atividade do complemento |
HRP20230093T1 (hr) | 2015-04-06 | 2023-03-31 | Bioverativ Usa Inc. | Humanizirana anti-c1s protutijela i postupci njihove primjene |
WO2017075189A1 (en) | 2015-10-27 | 2017-05-04 | University Of Massachusetts | Factor h-fc immunotherapy |
JP6976943B2 (ja) | 2015-11-24 | 2021-12-08 | アネクソン,インコーポレーテッド | 抗補体因子C1q Fab断片及びその使用 |
EP3389692B1 (en) | 2015-12-16 | 2020-03-04 | RA Pharmaceuticals, Inc. | Modulators of complement activity |
WO2017134043A1 (en) * | 2016-02-01 | 2017-08-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical composition for neutralising the cytotoxic activity of extracellular histone proteins in subjects suffering from sepsis |
US11123399B2 (en) | 2016-12-07 | 2021-09-21 | Ra Pharmaceuticals, Inc. | Modulators of complement activity |
WO2019112984A1 (en) | 2017-12-04 | 2019-06-13 | Ra Pharmaceuticals, Inc. | Modulators of complement activity |
GB201800620D0 (en) | 2018-01-15 | 2018-02-28 | Univ Manchester | C3b Binding Polypeptide |
WO2020011869A2 (en) | 2018-07-11 | 2020-01-16 | Roche Innovation Center Copenhagen A/S | Antisense oligonucleotides targeting tlr2 |
CN113543796A (zh) | 2019-03-08 | 2021-10-22 | Ra制药公司 | 齐鲁考普作为深层组织穿透性c5抑制剂 |
EP3947352A1 (en) | 2019-03-29 | 2022-02-09 | RA Pharmaceuticals, Inc. | Complement modulators and related methods |
MX2021013010A (es) | 2019-04-24 | 2022-01-18 | Ra Pharmaceuticals Inc | Composiciones y metodos para modular la actividad del complemento. |
Family Cites Families (43)
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US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
DE3785967T2 (de) * | 1986-04-28 | 1993-12-02 | Cetus Corp | Monoklonale Antikörper gegen C5A und DES-ARG74-C5A, ihre Herstellung und ihre Verwendung. |
US5093117A (en) | 1989-01-24 | 1992-03-03 | Baxter International Inc. | Compositions and method for the treatment or prophylaxis of sepsis or septic shock |
JP2744130B2 (ja) * | 1989-08-01 | 1998-04-28 | スクリップス クリニック アンド リサーチ ファウンデーション | 敗血症治療用組成物 |
US6315999B1 (en) | 1989-08-10 | 2001-11-13 | Solvay, S.A. | Pharmaceutical product for the treatment of sepsis |
DE4029227A1 (de) | 1990-09-14 | 1992-03-19 | Imtox Gmbh | Arzneimittel enthaltend cd14 |
AU2694592A (en) | 1991-09-30 | 1993-05-03 | Walser, Mackenzie | Methods for treatment of free-radical-mediated tissue injury |
CA2133758A1 (en) * | 1992-04-06 | 1993-10-14 | Sanna M. Goyert | A novel therapy for treating sepsis using a soluble form of recombinant cd14 myelomonocytic antigen |
US6063764A (en) | 1992-06-01 | 2000-05-16 | Washington University & Chiron Corp. | Method for using lipoprotein associated coagulation inhibitor to treat sepsis |
US5330754A (en) * | 1992-06-29 | 1994-07-19 | Archana Kapoor | Membrane-associated immunogens of mycobacteria |
AU685433B2 (en) | 1993-02-12 | 1998-01-22 | Regents Of The University Of Minnesota | Pulmonary administration of sCR1 and other complement inhibitory proteins |
ATE335072T1 (de) | 1993-05-28 | 2006-08-15 | Scripps Research Inst | Methoden für inhibition der cd14-abhängigen zellaktivierung |
SK283096B6 (sk) * | 1994-07-05 | 2003-02-04 | Steeno Research Group A/S | Imunomodulátory |
WO1996008272A1 (en) * | 1994-09-16 | 1996-03-21 | The Scripps Research Institute | Use of antibodies to block the effects of gram-positive bacteria and mycobacteria |
EP0800534A2 (en) * | 1994-12-23 | 1997-10-15 | Laboratoires Om S.A. | Use of mhc-ii binding and/or mhc-ii mimicking molecules for the prevention and/or treatment of inflammatory diseases |
US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
US6042821A (en) | 1995-11-21 | 2000-03-28 | Smithkline Beecham Corporation | Method of treating sepsis with chemokines |
US6290948B1 (en) | 1996-05-14 | 2001-09-18 | Smithkline Beecham Corporation | Method of treating sepsis and ARDS using chamohine beta-10 |
EP0901379B1 (en) * | 1996-05-22 | 2000-09-06 | University Of Alberta | Type-2 chemokine binding proteins and methods of use therefor |
WO1998017312A1 (fr) | 1996-10-22 | 1998-04-30 | Chugai Seiyaku Kabushiki Kaisha | Remede contre les troubles septiques et comprenant un anticorps anti-il-8 en qualite d'ingredient actif |
US6172220B1 (en) | 1997-01-21 | 2001-01-09 | Board Of Regents Of University Of Nebraska | Isolated algal lipopolysaccharides and use of same to inhibit endotoxin-initiated sepsis |
EP0911400A1 (en) | 1997-03-07 | 1999-04-28 | Mochida Pharmaceutical Co., Ltd. | Antisense compounds to cd14 |
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EP1115875A1 (en) * | 1998-09-24 | 2001-07-18 | Regents Of The University Of Minnesota | Human complement c3-degrading polypeptide from streptococcus pneumoniae |
CN1324244A (zh) * | 1998-10-22 | 2001-11-28 | 伊莱利利公司 | 治疗脓毒症的方法 |
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JP4489976B2 (ja) * | 1999-04-09 | 2010-06-23 | ビーエーエスエフ ソシエタス・ヨーロピア | 補体プロテアーゼの低分子インヒビター |
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US6673346B1 (en) * | 1999-08-31 | 2004-01-06 | The Regents Of The University Of Michigan | Compositions and methods for the treatment of sepsis |
AU2001234925A1 (en) * | 2000-02-08 | 2001-08-20 | The University Of Virginia Patent Foundation | Methods for the prevention and treatment of infections using anti-C3b(i) antibodies |
US20020006915A1 (en) | 2000-02-15 | 2002-01-17 | Mack Strong Vivian E. | Use of COX-2 inhibitors to treat sepsis, complications thereof, and EP receptor modulation |
US20040092712A1 (en) * | 2000-03-31 | 2004-05-13 | Shoji Furusako | Tlr/cd14 binding inhibitor |
EP1275713A4 (en) * | 2000-03-31 | 2004-06-30 | Mochida Pharm Co Ltd | BINDING INHIBITOR BETWEEN THE TOLL-TYPE RECEPTOR AND CD14 |
DE60039921D1 (de) | 2000-09-29 | 2008-09-25 | Neurogen Corp | Hochaffine kleinmolekülige c5a-rezeptor-modulatoren |
JPWO2002042333A1 (ja) * | 2000-11-22 | 2004-03-25 | 持田製薬株式会社 | Cd14/tlr結合阻害作用を有する抗cd14モノクローナル抗体 |
AU2002256971B2 (en) | 2000-12-28 | 2008-04-03 | Altus Pharmaceuticals Inc. | Crystals of whole antibodies and fragments thereof and methods for making and using them |
US20030077576A1 (en) * | 2001-03-20 | 2003-04-24 | Joann Trial | Use of monoclonal antibodies and functional assays for prediction of risk of opportunistic infection |
DK1425028T3 (da) | 2001-05-16 | 2010-03-01 | Yeda Res & Dev | Anvendelse af IL-18 inhibitorer til behandling eller forebyggelse af sepsis |
ES2283594T5 (es) * | 2001-08-17 | 2016-03-15 | Genentech, Inc. | Inhibidores de la ruta del complemento que se unen a C5 y C5a sin impedir la formación de C5b |
US20060140939A1 (en) * | 2003-02-21 | 2006-06-29 | Fung Sek C M | Methods for preventing and treating tissue damage associated with ischemia-reperfusion injury |
-
2004
- 2004-05-14 ES ES04752211T patent/ES2387275T3/es not_active Expired - Lifetime
- 2004-05-14 CN CN201110169068A patent/CN102258784A/zh active Pending
- 2004-05-14 CA CA2524534A patent/CA2524534C/en not_active Expired - Fee Related
- 2004-05-14 US US10/556,998 patent/US8329169B2/en not_active Expired - Fee Related
- 2004-05-14 EP EP10179747.0A patent/EP2266606B1/en not_active Expired - Lifetime
- 2004-05-14 WO PCT/US2004/015135 patent/WO2004103294A2/en active Application Filing
- 2004-05-14 EP EP04752211A patent/EP1628530B8/en not_active Expired - Fee Related
- 2004-05-14 DK DK04752211.5T patent/DK1628530T3/da active
- 2004-05-14 JP JP2006533066A patent/JP4768620B2/ja not_active Expired - Fee Related
- 2004-05-14 MX MXPA05011886A patent/MXPA05011886A/es active IP Right Grant
- 2004-05-14 ES ES10179747.0T patent/ES2522525T3/es not_active Expired - Lifetime
- 2004-05-14 AU AU2004241069A patent/AU2004241069B2/en not_active Ceased
- 2004-05-14 CN CN2004800126841A patent/CN1787741B/zh not_active Expired - Fee Related
-
2010
- 2010-12-06 AU AU2010249190A patent/AU2010249190B2/en not_active Ceased
-
2011
- 2011-01-27 JP JP2011014797A patent/JP2011105747A/ja active Pending
- 2011-06-23 HK HK11106525.8A patent/HK1152474A1/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU2004241069B2 (en) | 2010-09-09 |
MXPA05011886A (es) | 2006-02-17 |
CA2524534A1 (en) | 2004-12-02 |
ES2387275T3 (es) | 2012-09-19 |
CA2524534C (en) | 2012-12-11 |
ES2522525T3 (es) | 2014-11-14 |
EP1628530B1 (en) | 2012-06-06 |
AU2004241069A1 (en) | 2004-12-02 |
CN102258784A (zh) | 2011-11-30 |
JP2006528981A (ja) | 2006-12-28 |
US8329169B2 (en) | 2012-12-11 |
AU2010249190A1 (en) | 2011-01-06 |
CN1787741B (zh) | 2011-08-17 |
CN1787741A (zh) | 2006-06-14 |
EP2266606A1 (en) | 2010-12-29 |
AU2010249190B2 (en) | 2013-02-28 |
EP1628530A2 (en) | 2006-03-01 |
WO2004103294A2 (en) | 2004-12-02 |
EP2266606B1 (en) | 2014-09-10 |
EP1628530A4 (en) | 2007-08-29 |
US20070274989A1 (en) | 2007-11-29 |
WO2004103294A3 (en) | 2005-05-26 |
JP2011105747A (ja) | 2011-06-02 |
EP1628530B8 (en) | 2012-08-01 |
JP4768620B2 (ja) | 2011-09-07 |
DK1628530T3 (da) | 2012-07-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20200518 |