HK1148749A1 - Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid - Google Patents
Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acidInfo
- Publication number
- HK1148749A1 HK1148749A1 HK11103104.4A HK11103104A HK1148749A1 HK 1148749 A1 HK1148749 A1 HK 1148749A1 HK 11103104 A HK11103104 A HK 11103104A HK 1148749 A1 HK1148749 A1 HK 1148749A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- dimethoxy
- octa
- bicyclo
- tetrahydro
- azepin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0901556A FR2943668B1 (fr) | 2009-03-31 | 2009-03-31 | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable. |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1148749A1 true HK1148749A1 (en) | 2011-09-16 |
Family
ID=40983371
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK11103104.4A HK1148749A1 (en) | 2009-03-31 | 2011-03-28 | Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid |
Country Status (35)
Country | Link |
---|---|
US (1) | US8119794B2 (xx) |
EP (1) | EP2241553B1 (xx) |
JP (1) | JP5107381B2 (xx) |
KR (1) | KR101166632B1 (xx) |
CN (1) | CN101851204B (xx) |
AR (1) | AR075978A1 (xx) |
AT (1) | ATE517093T1 (xx) |
AU (1) | AU2010201035B2 (xx) |
BR (1) | BRPI1000865A2 (xx) |
CA (1) | CA2697563C (xx) |
CL (1) | CL2010000253A1 (xx) |
CY (1) | CY1111914T1 (xx) |
DK (1) | DK2241553T3 (xx) |
EA (1) | EA016353B1 (xx) |
ES (1) | ES2370150T3 (xx) |
FR (1) | FR2943668B1 (xx) |
GE (1) | GEP20125446B (xx) |
HK (1) | HK1148749A1 (xx) |
HR (1) | HRP20110683T1 (xx) |
JO (1) | JO2781B1 (xx) |
MA (1) | MA31746B1 (xx) |
ME (1) | ME00986B (xx) |
MX (1) | MX2010003213A (xx) |
MY (1) | MY150014A (xx) |
NZ (1) | NZ584310A (xx) |
PE (1) | PE20110098A1 (xx) |
PL (1) | PL2241553T3 (xx) |
RS (1) | RS51920B (xx) |
SA (1) | SA110310239B1 (xx) |
SI (1) | SI2241553T1 (xx) |
TW (1) | TWI376371B (xx) |
UA (1) | UA105894C2 (xx) |
UY (1) | UY32499A (xx) |
WO (1) | WO2010112705A1 (xx) |
ZA (1) | ZA201002120B (xx) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5632279B2 (ja) * | 2007-05-30 | 2014-11-26 | アイエヌディー−スイフト ラボラトリーズ リミテッド | 塩酸イバブラジンの調製方法及びポリモルフ |
FR2971507B1 (fr) | 2011-02-14 | 2013-01-18 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
FR2984320B1 (fr) * | 2011-12-20 | 2013-11-29 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
FR2988720B1 (fr) * | 2012-03-27 | 2014-03-14 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
CN103848789B (zh) * | 2012-11-29 | 2016-05-18 | 江苏恒瑞医药股份有限公司 | 一种伊伐布雷定的制备方法 |
EP3101010A1 (en) | 2015-06-03 | 2016-12-07 | Urquima S.A. | New method for the preparation of highly pure ivabradine base and salts thereof |
CN113372274B (zh) * | 2020-03-10 | 2023-03-24 | 鲁南制药集团股份有限公司 | 一种伊伐布雷定的制备方法 |
CN113372273B (zh) * | 2020-03-10 | 2023-05-09 | 鲁南制药集团股份有限公司 | 一种伊伐布雷定中间体化合物iv |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3119874A1 (de) * | 1981-05-19 | 1982-12-09 | Dr. Karl Thomae Gmbh, 7950 Biberach | "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel" |
FR2681862B1 (fr) * | 1991-09-27 | 1993-11-12 | Adir Cie | Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent. |
FR2868777B1 (fr) * | 2004-04-13 | 2006-05-26 | Servier Lab | Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
FR2870537A1 (fr) * | 2004-05-19 | 2005-11-25 | Servier Lab | Nouveau procede de synthese du (1s)-4,5-dimethoxy-1-(methyl aminomethyl-)-benzocyclobutane et de ses sels d'addition, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable |
JP5632279B2 (ja) | 2007-05-30 | 2014-11-26 | アイエヌディー−スイフト ラボラトリーズ リミテッド | 塩酸イバブラジンの調製方法及びポリモルフ |
-
2009
- 2009-03-31 ME MEP-2010-54A patent/ME00986B/me unknown
- 2009-03-31 FR FR0901556A patent/FR2943668B1/fr not_active Expired - Fee Related
-
2010
- 2010-03-16 PE PE2010000155A patent/PE20110098A1/es not_active Application Discontinuation
- 2010-03-17 MY MYPI2010001175A patent/MY150014A/en unknown
- 2010-03-17 UY UY0001032499A patent/UY32499A/es not_active Application Discontinuation
- 2010-03-17 AU AU2010201035A patent/AU2010201035B2/en not_active Ceased
- 2010-03-18 MA MA32705A patent/MA31746B1/fr unknown
- 2010-03-22 CL CL2010000253A patent/CL2010000253A1/es unknown
- 2010-03-24 CA CA2697563A patent/CA2697563C/fr not_active Expired - Fee Related
- 2010-03-24 MX MX2010003213A patent/MX2010003213A/es active IP Right Grant
- 2010-03-25 ZA ZA2010/02120A patent/ZA201002120B/en unknown
- 2010-03-29 US US12/798,048 patent/US8119794B2/en not_active Expired - Fee Related
- 2010-03-29 UA UAA201003585A patent/UA105894C2/uk unknown
- 2010-03-29 SA SA110310239A patent/SA110310239B1/ar unknown
- 2010-03-29 NZ NZ584310A patent/NZ584310A/en not_active IP Right Cessation
- 2010-03-29 AR ARP100101003A patent/AR075978A1/es not_active Application Discontinuation
- 2010-03-29 TW TW099109448A patent/TWI376371B/zh not_active IP Right Cessation
- 2010-03-29 GE GEAP201011742A patent/GEP20125446B/en unknown
- 2010-03-30 PL PL10290165T patent/PL2241553T3/pl unknown
- 2010-03-30 EA EA201000398A patent/EA016353B1/ru not_active IP Right Cessation
- 2010-03-30 AT AT10290165T patent/ATE517093T1/de active
- 2010-03-30 EP EP10290165A patent/EP2241553B1/fr active Active
- 2010-03-30 WO PCT/FR2010/000269 patent/WO2010112705A1/fr active Application Filing
- 2010-03-30 RS RS20110377A patent/RS51920B/en unknown
- 2010-03-30 SI SI201030007T patent/SI2241553T1/sl unknown
- 2010-03-30 JP JP2010076767A patent/JP5107381B2/ja active Active
- 2010-03-30 ES ES10290165T patent/ES2370150T3/es active Active
- 2010-03-30 BR BRPI1000865-9A patent/BRPI1000865A2/pt not_active Application Discontinuation
- 2010-03-30 DK DK10290165.9T patent/DK2241553T3/da active
- 2010-03-31 JO JO2010103A patent/JO2781B1/en active
- 2010-03-31 CN CN2010101546876A patent/CN101851204B/zh not_active Expired - Fee Related
- 2010-03-31 KR KR1020100029269A patent/KR101166632B1/ko active IP Right Grant
-
2011
- 2011-03-28 HK HK11103104.4A patent/HK1148749A1/xx not_active IP Right Cessation
- 2011-09-22 HR HR20110683T patent/HRP20110683T1/hr unknown
- 2011-10-06 CY CY20111100957T patent/CY1111914T1/el unknown
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20200327 |