TW200700386A - Process for the preparation of racemic and optically active 4-chloro-3-[5-chloro-1-(2,4-dimethoxybenzyl)-3-alkyl-2-oxo-2,3-dihydro-1h-indol-3-yl]benzoic acid derivatives - Google Patents

Process for the preparation of racemic and optically active 4-chloro-3-[5-chloro-1-(2,4-dimethoxybenzyl)-3-alkyl-2-oxo-2,3-dihydro-1h-indol-3-yl]benzoic acid derivatives

Info

Publication number
TW200700386A
TW200700386A TW095103671A TW95103671A TW200700386A TW 200700386 A TW200700386 A TW 200700386A TW 095103671 A TW095103671 A TW 095103671A TW 95103671 A TW95103671 A TW 95103671A TW 200700386 A TW200700386 A TW 200700386A
Authority
TW
Taiwan
Prior art keywords
chloro
dimethoxybenzyl
indol
racemic
dihydro
Prior art date
Application number
TW095103671A
Other languages
Chinese (zh)
Inventor
Csaba Gonczi
Lajos Nagy
Gyorgyne Szvoboda
Valeria Kazinczy
Zoltan Finta
Istvan Hermecz
Csilla Majlath
Csutor Andrea Santane
Karoly Kanai
Loic Foulon
Gerard Valette
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of TW200700386A publication Critical patent/TW200700386A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention relates to a process for preparation of racemic and optically active 4-chloro-3-[5-chloro-1-(2,4-dimethoxybenzyl)-3-alkyl-2-oxo-2,3-dihydro-1H-indol-3-yl] benzoic acid derivatives of the general formula (I), , wherein R represents a hydrogen atom or a straight or branched alkyl group containing 1-4 carbon atoms and R1 represents a straight or branched alkyl group containing 1-4 carbon atoms.
TW095103671A 2005-02-04 2006-02-03 Process for the preparation of racemic and optically active 4-chloro-3-[5-chloro-1-(2,4-dimethoxybenzyl)-3-alkyl-2-oxo-2,3-dihydro-1h-indol-3-yl]benzoic acid derivatives TW200700386A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0500178A HUP0500178A2 (en) 2005-02-04 2005-02-04 Process for the preparation of racemic and optically active 4-chloro-3-[5-chloro-1-(2,4-dimethoxybenzyl)-3-alkyl-2-oxo-2,3-dihydro-1h-indol-3-yl]benzoic acid derivatives using a phase transfer catalyst

Publications (1)

Publication Number Publication Date
TW200700386A true TW200700386A (en) 2007-01-01

Family

ID=89985797

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095103671A TW200700386A (en) 2005-02-04 2006-02-03 Process for the preparation of racemic and optically active 4-chloro-3-[5-chloro-1-(2,4-dimethoxybenzyl)-3-alkyl-2-oxo-2,3-dihydro-1h-indol-3-yl]benzoic acid derivatives

Country Status (5)

Country Link
AR (1) AR052473A1 (en)
HU (1) HUP0500178A2 (en)
TW (1) TW200700386A (en)
UY (1) UY29362A1 (en)
WO (1) WO2006082454A1 (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6673790B1 (en) * 2000-04-03 2004-01-06 Sanofi-Synthelabo Indolin-2-one derivatives, preparation and their use as ocytocin receptor ligands

Also Published As

Publication number Publication date
HU0500178D0 (en) 2005-04-28
HUP0500178A2 (en) 2007-03-28
UY29362A1 (en) 2006-08-31
WO2006082454A1 (en) 2006-08-10
AR052473A1 (en) 2007-03-21

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