HK1144284A1 - 6h-dibenz0 [b, e] oxepine derived nonsteroidal mineralocorticoid receptor antagonists - Google Patents

6h-dibenz0 [b, e] oxepine derived nonsteroidal mineralocorticoid receptor antagonists

Info

Publication number
HK1144284A1
HK1144284A1 HK10110689.3A HK10110689A HK1144284A1 HK 1144284 A1 HK1144284 A1 HK 1144284A1 HK 10110689 A HK10110689 A HK 10110689A HK 1144284 A1 HK1144284 A1 HK 1144284A1
Authority
HK
Hong Kong
Prior art keywords
dibenz0
oxepine
receptor antagonists
mineralocorticoid receptor
derived
Prior art date
Application number
HK10110689.3A
Other languages
English (en)
Inventor
Konstantinos Gavardinas
Prabhakar Kondaji Jadhav
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40430143&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1144284(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of HK1144284A1 publication Critical patent/HK1144284A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/40—Mineralocorticosteroids, e.g. aldosterone; Drugs increasing or potentiating the activity of mineralocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
HK10110689.3A 2007-12-19 2010-11-17 6h-dibenz0 [b, e] oxepine derived nonsteroidal mineralocorticoid receptor antagonists HK1144284A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1477607P 2007-12-19 2007-12-19
PCT/US2008/085997 WO2009085584A1 (en) 2007-12-19 2008-12-09 6h-dibenz0 [b, e] oxepine derived nonsteroidal mineralocorticoid receptor antagonists

Publications (1)

Publication Number Publication Date
HK1144284A1 true HK1144284A1 (en) 2011-02-11

Family

ID=40430143

Family Applications (1)

Application Number Title Priority Date Filing Date
HK10110689.3A HK1144284A1 (en) 2007-12-19 2010-11-17 6h-dibenz0 [b, e] oxepine derived nonsteroidal mineralocorticoid receptor antagonists

Country Status (34)

Country Link
US (1) US7994164B2 (uk)
EP (2) EP2537845B1 (uk)
JP (1) JP5562866B2 (uk)
KR (1) KR101254382B1 (uk)
CN (1) CN101903377B (uk)
AR (1) AR069554A1 (uk)
AU (1) AU2008343524B2 (uk)
BR (1) BRPI0820805A2 (uk)
CA (1) CA2710409C (uk)
CL (1) CL2008003600A1 (uk)
CO (1) CO6300953A2 (uk)
DK (1) DK2235007T3 (uk)
DO (1) DOP2010000185A (uk)
EA (1) EA017668B1 (uk)
EC (2) ECSP10010266A (uk)
ES (2) ES2396605T3 (uk)
GT (1) GT201000179A (uk)
HK (1) HK1144284A1 (uk)
HR (1) HRP20120916T1 (uk)
IL (1) IL206353A (uk)
MA (1) MA31910B1 (uk)
MX (1) MX2010006911A (uk)
MY (1) MY150474A (uk)
NZ (1) NZ586300A (uk)
PE (1) PE20091057A1 (uk)
PL (1) PL2235007T3 (uk)
PT (1) PT2235007E (uk)
RS (1) RS52594B (uk)
SI (1) SI2235007T1 (uk)
TN (1) TN2010000292A1 (uk)
TW (1) TWI431010B (uk)
UA (1) UA100131C2 (uk)
WO (1) WO2009085584A1 (uk)
ZA (1) ZA201004257B (uk)

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Publication number Priority date Publication date Assignee Title
US8242140B2 (en) 2007-08-03 2012-08-14 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
JP5623289B2 (ja) 2007-12-19 2014-11-12 ベーリンガーインゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ウイルスポリメラーゼインヒビター
EP2406252B1 (en) * 2009-03-12 2015-05-20 Eli Lilly and Company Mineralocorticoid receptor antagonist and methods of use
EP3238781B1 (en) 2010-05-10 2019-07-31 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for the treatment of fluid accumulation in and/ or under the retina
JP6180930B2 (ja) 2010-06-16 2017-08-16 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 創傷治癒過程における再上皮化を刺激するための方法及び組成物
CN102060670A (zh) * 2011-01-04 2011-05-18 常州大学 一种2-溴-6-氟苯甲醇的制备方法
MX2015015163A (es) 2013-05-02 2016-02-22 Pfizer Derivados de imidazo-triazina como inhibidores de pde10.
AR099416A1 (es) 2014-02-28 2016-07-20 Lilly Co Eli Terapia combinada para la hipertensión resistente
EA029518B1 (ru) 2014-06-30 2018-04-30 Астразенека Аб Бензоксазиноновые амиды в качестве модуляторов минералокортикоидного рецептора
US20170246166A1 (en) * 2014-11-21 2017-08-31 Eli Lilly And Company 1,2-benzothiazole compounds for the treatment of kidney disorders
US20180280414A1 (en) 2015-10-13 2018-10-04 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of choroidal neovascularisation
ES2973248T3 (es) 2016-07-26 2024-06-19 Inst Nat Sante Rech Med Antagonista del receptor mineralocorticoide para el tratamiento de la osteoartritis
CN109069502B (zh) * 2016-09-24 2021-08-06 山东亨利医药科技有限责任公司 含盐皮质激素受体拮抗剂的药物组合物及其用途
JP2023518168A (ja) 2020-03-11 2023-04-28 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 対象が中心性漿液性脈絡網膜症を有するか、または有する危険性があるかどうかを決定する方法。
WO2023031277A1 (en) 2021-08-31 2023-03-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the treatment of ocular rosacea

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US4072756A (en) 1973-05-17 1978-02-07 Sandoz Ltd. Tricyclo piperidino ketones and soporific compositions thereof
SE426341C (sv) * 1980-02-14 1985-09-23 Fagersta Ab Sett att forhindra korrosion i en forbrenningsanleggnings kylare och skorsten vid kylning av rokgaser
FR2603713B1 (fr) 1986-09-10 1992-07-24 Canon Kk Derive nouveau de 5h-dibenzo(a,d)cycloheptane-(ene)ylidene, son procede de production et support electrophotographique photosensible le contenant
US4999363A (en) * 1988-06-09 1991-03-12 Kyowa Hakko Kogyo Co., Ltd. Tricyclic compounds
GB8914061D0 (en) 1989-06-19 1989-08-09 Wellcome Found Agents for potentiating the effects of antitumour agents and combating multiple drug resistance
US5378701A (en) 1991-12-27 1995-01-03 Kyowa Hakko Kogyo Tricyclic compounds
CO4980885A1 (es) 1997-12-29 2000-11-27 Ortho Mcneil Pharm Inc Compuestos de trifenilpropanamida utiles en el tratamiento de inflamaciones y metodos para preparar dicho compuesto
EP1154997A4 (en) 1999-01-26 2002-11-04 Dana Farber Cancer Inst Inc PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE
AU2002352772B2 (en) * 2001-11-21 2006-10-26 Kyowa Hakko Kogyo Co., Ltd. Chemokine receptor antagonists and methods of use thereof
TW200400816A (en) * 2002-06-26 2004-01-16 Lilly Co Eli Tricyclic steroid hormone nuclear receptor modulators
SI1697350T1 (sl) 2003-12-19 2008-12-31 Lilly Co Eli Modulatorji jedrnega receptorja tricikličnih steroidnih hormonov
US7482344B2 (en) 2003-12-19 2009-01-27 Eli Lilly And Company Tricyclic steroid hormone nuclear receptor modulators
TWI350168B (en) 2004-05-07 2011-10-11 Incyte Corp Amido compounds and their use as pharmaceuticals
MX2007001129A (es) * 2004-07-28 2007-04-19 Irm Llc Compuestos y composiciones como moduladores de receptores nucleares de hormonas esteroidales.
GEP20125565B (en) 2004-11-10 2012-07-10 Incyte Corp Lactam compounds and their pharmaceutical use
RS20090208A (en) 2006-10-31 2010-06-30 Pfizer Products Inc. Pyrazoline compounds as mineralocorticoid receptor antagonists
EP2142194A1 (en) 2007-03-29 2010-01-13 N.V. Organon Mineralocorticoid receptor antagonists
PE20091339A1 (es) 2007-12-21 2009-09-26 Glaxo Group Ltd Derivados de oxadiazol con actividad sobre receptores s1p1
GB0725102D0 (en) 2007-12-21 2008-01-30 Glaxo Group Ltd Compounds
WO2009094157A1 (en) 2008-01-25 2009-07-30 Arena Pharmaceuticals, Inc. Dihydro- 1h- pyrrolo [1,2-a] indol-1-yl carboxylic derivatives which act as s1p1 agonists
EP2406252B1 (en) 2009-03-12 2015-05-20 Eli Lilly and Company Mineralocorticoid receptor antagonist and methods of use

Also Published As

Publication number Publication date
BRPI0820805A2 (pt) 2015-06-16
EP2537845A1 (en) 2012-12-26
JP2011507868A (ja) 2011-03-10
RS52594B (en) 2013-04-30
PL2235007T3 (pl) 2013-03-29
KR20100082866A (ko) 2010-07-20
NZ586300A (en) 2012-06-29
CN101903377B (zh) 2014-07-09
PE20091057A1 (es) 2009-07-20
EA017668B1 (ru) 2013-02-28
WO2009085584A1 (en) 2009-07-09
EP2537845B1 (en) 2014-03-19
CO6300953A2 (es) 2011-07-21
EP2235007B1 (en) 2012-10-31
EP2235007A1 (en) 2010-10-06
CA2710409A1 (en) 2009-07-09
HRP20120916T1 (hr) 2012-12-31
IL206353A (en) 2014-06-30
ES2396605T3 (es) 2013-02-22
UA100131C2 (uk) 2012-11-26
CN101903377A (zh) 2010-12-01
KR101254382B1 (ko) 2013-04-15
AR069554A1 (es) 2010-02-03
AU2008343524A1 (en) 2009-07-09
CA2710409C (en) 2012-11-06
DK2235007T3 (da) 2012-12-17
CL2008003600A1 (es) 2010-02-19
ZA201004257B (en) 2011-11-30
MX2010006911A (es) 2010-10-05
MA31910B1 (fr) 2010-12-01
IL206353A0 (en) 2010-12-30
DOP2010000185A (es) 2010-09-15
US7994164B2 (en) 2011-08-09
TW200930721A (en) 2009-07-16
PT2235007E (pt) 2013-01-22
MY150474A (en) 2014-01-30
ECSP10010266A (es) 2010-07-30
US20090163472A1 (en) 2009-06-25
JP5562866B2 (ja) 2014-07-30
SI2235007T1 (sl) 2013-01-31
TWI431010B (zh) 2014-03-21
TN2010000292A1 (en) 2011-11-11
EA201070762A1 (ru) 2010-12-30
ES2459318T3 (es) 2014-05-09
AU2008343524B2 (en) 2012-03-08
GT201000179A (es) 2012-04-16
ECSP12012048A (es) 2012-08-31

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20161209