HK1142639A1 - Stable recombinant adenosine deaminase - Google Patents

Stable recombinant adenosine deaminase

Info

Publication number
HK1142639A1
HK1142639A1 HK10109192.5A HK10109192A HK1142639A1 HK 1142639 A1 HK1142639 A1 HK 1142639A1 HK 10109192 A HK10109192 A HK 10109192A HK 1142639 A1 HK1142639 A1 HK 1142639A1
Authority
HK
Hong Kong
Prior art keywords
adenosine deaminase
stable recombinant
recombinant adenosine
stable
deaminase
Prior art date
Application number
HK10109192.5A
Other languages
English (en)
Inventor
David R Filpula
Stephen K Youngster
Original Assignee
Sigma Tau Rare Diseases S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Rare Diseases S A filed Critical Sigma Tau Rare Diseases S A
Publication of HK1142639A1 publication Critical patent/HK1142639A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/04—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
    • C12Y305/04014—Deoxycytidine deaminase (3.5.4.14)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
HK10109192.5A 2007-04-20 2010-09-27 Stable recombinant adenosine deaminase HK1142639A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91300907P 2007-04-20 2007-04-20
PCT/US2008/060805 WO2008131208A1 (en) 2007-04-20 2008-04-18 Stable recombinant adenosine deaminase

Publications (1)

Publication Number Publication Date
HK1142639A1 true HK1142639A1 (en) 2010-12-10

Family

ID=39875917

Family Applications (1)

Application Number Title Priority Date Filing Date
HK10109192.5A HK1142639A1 (en) 2007-04-20 2010-09-27 Stable recombinant adenosine deaminase

Country Status (20)

Country Link
US (1) US8071741B2 (zh)
EP (1) EP2147116B1 (zh)
JP (1) JP5511653B2 (zh)
KR (1) KR101499095B1 (zh)
CN (1) CN101688244B (zh)
AU (1) AU2008242748B2 (zh)
BR (1) BRPI0810383B1 (zh)
CA (1) CA2684750C (zh)
DK (1) DK2147116T3 (zh)
ES (1) ES2569940T3 (zh)
HK (1) HK1142639A1 (zh)
HR (1) HRP20160482T1 (zh)
HU (1) HUE027603T2 (zh)
IL (1) IL201592A (zh)
MX (1) MX2009011319A (zh)
NZ (1) NZ580981A (zh)
PL (1) PL2147116T3 (zh)
SI (1) SI2147116T1 (zh)
TW (1) TWI412591B (zh)
WO (1) WO2008131208A1 (zh)

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MX2009011320A (es) 2007-04-20 2009-12-15 Enzon Pharmaceuticals Inc Terapia anticancer enzimatica.
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RU2573933C1 (ru) * 2014-08-21 2016-01-27 Дафот Энтерпрайсис Лимитед Пептид для лечения сахарного диабета 2-го типа и его осложнений
KR102122463B1 (ko) * 2014-10-14 2020-06-15 할로자임, 아이엔씨 아데노신 디아미네이즈-2(ada2)의 조성물, 이의 변이체 및 이를 사용하는 방법
CN104531793B (zh) * 2014-12-20 2018-04-27 郁庆明 全细胞生物转化制备l-2-氨基丁酸的方法
WO2018191619A1 (en) 2017-04-13 2018-10-18 Senti Biosciences, Inc. Combinatorial cancer immunotherapy
EP3655021B1 (en) 2017-07-19 2023-03-22 Unikeris Limited Adenosine deaminase for treating or ameliorating scleroderma-associated vasculopathy
WO2019155969A1 (ja) * 2018-02-09 2019-08-15 天野エンザイム株式会社 夾雑活性が低減したヌクレオシダーゼ剤
CN113164518A (zh) 2018-10-17 2021-07-23 森迪生物科学公司 组合癌症免疫疗法
US11419898B2 (en) 2018-10-17 2022-08-23 Senti Biosciences, Inc. Combinatorial cancer immunotherapy
CN116814595B (zh) * 2023-08-30 2023-11-28 江苏申基生物科技有限公司 一种腺苷脱氨酶突变体及其固定化

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Also Published As

Publication number Publication date
CA2684750A1 (en) 2008-10-30
CN101688244B (zh) 2013-05-08
HRP20160482T1 (hr) 2016-06-03
CA2684750C (en) 2014-08-05
SI2147116T1 (sl) 2016-06-30
AU2008242748A1 (en) 2008-10-30
ES2569940T3 (es) 2016-05-13
RU2009142844A (ru) 2011-05-27
BRPI0810383A2 (pt) 2019-08-27
WO2008131208A1 (en) 2008-10-30
AU2008242748B2 (en) 2013-12-05
HUE027603T2 (en) 2016-10-28
CN101688244A (zh) 2010-03-31
KR101499095B1 (ko) 2015-03-05
PL2147116T3 (pl) 2016-08-31
DK2147116T3 (en) 2016-05-30
IL201592A (en) 2016-05-31
EP2147116A4 (en) 2010-07-28
IL201592A0 (en) 2010-05-31
BRPI0810383B1 (pt) 2022-12-20
MX2009011319A (es) 2009-12-11
US20090047271A1 (en) 2009-02-19
US8071741B2 (en) 2011-12-06
KR20100016302A (ko) 2010-02-12
JP2010524472A (ja) 2010-07-22
JP5511653B2 (ja) 2014-06-04
NZ580981A (en) 2012-02-24
EP2147116A1 (en) 2010-01-27
TW200902719A (en) 2009-01-16
TWI412591B (zh) 2013-10-21
EP2147116B1 (en) 2016-03-02

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