HK1139039A1 - Method of differentiating/inducing bone marrow interstitial cells into nerve cells and skeleton muscle cells by transferrin notch gene - Google Patents

Method of differentiating/inducing bone marrow interstitial cells into nerve cells and skeleton muscle cells by transferrin notch gene

Info

Publication number
HK1139039A1
HK1139039A1 HK10104703.8A HK10104703A HK1139039A1 HK 1139039 A1 HK1139039 A1 HK 1139039A1 HK 10104703 A HK10104703 A HK 10104703A HK 1139039 A1 HK1139039 A1 HK 1139039A1
Authority
HK
Hong Kong
Prior art keywords
cells
bone marrow
notch
gene
skeletal muscle
Prior art date
Application number
HK10104703.8A
Other languages
English (en)
Inventor
Mari Dezawa
Hajime Sawada
Hiroshi Kanno
Masahiko Takano
Original Assignee
Sanbio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2002030003A external-priority patent/JP3948971B2/ja
Application filed by Sanbio Inc filed Critical Sanbio Inc
Publication of HK1139039A1 publication Critical patent/HK1139039A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0658—Skeletal muscle cells, e.g. myocytes, myotubes, myoblasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/42—Notch; Delta; Jagged; Serrate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1352—Mesenchymal stem cells
    • C12N2502/1358—Bone marrow mesenchymal stem cells (BM-MSC)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
    • C12N2506/1353—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from bone marrow mesenchymal stem cells (BM-MSC)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
HK10104703.8A 2002-02-06 2010-05-14 Method of differentiating/inducing bone marrow interstitial cells into nerve cells and skeleton muscle cells by transferrin notch gene HK1139039A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2002030003A JP3948971B2 (ja) 2001-08-30 2002-02-06 Ｎｏｔｃｈ遺伝子の導入を用いて骨髄間質細胞を神経細胞及び骨格筋細胞に分化・誘導する方法

Publications (1)

Publication Number Publication Date
HK1139039A1 true HK1139039A1 (en) 2010-09-10

Family

ID=27677898

Family Applications (2)

Application Number Title Priority Date Filing Date
HK05110355.3A HK1078610A1 (en) 2002-02-06 2005-11-18 Method of differentiating/inducing bone marrow interstitial cells into nerve cells and skeleton muscle cells by transferrin notch gene
HK10104703.8A HK1139039A1 (en) 2002-02-06 2010-05-14 Method of differentiating/inducing bone marrow interstitial cells into nerve cells and skeleton muscle cells by transferrin notch gene

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK05110355.3A HK1078610A1 (en) 2002-02-06 2005-11-18 Method of differentiating/inducing bone marrow interstitial cells into nerve cells and skeleton muscle cells by transferrin notch gene

Country Status (10)

Country Link
US (7) US7682825B2 (xx)
EP (2) EP1479767B1 (xx)
CN (2) CN100497621C (xx)
AU (1) AU2003207064B2 (xx)
CA (1) CA2475288C (xx)
DK (1) DK1479767T3 (xx)
ES (1) ES2431518T3 (xx)
HK (2) HK1078610A1 (xx)
PT (1) PT1479767E (xx)
WO (1) WO2003066856A1 (xx)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7682825B2 (en) * 2002-02-06 2010-03-23 Sanbio, Inc. Differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells by introduction of notch gene
US20050265983A1 (en) * 2002-11-17 2005-12-01 Eldad Melamed Methods, nucleic acid constructs and cells for treating neurodegenerative disorders
EP1619242A4 (en) * 2003-03-25 2006-09-06 Japan Science & Tech Agency CONTROL OF INDUCTION OF DIFFERENTIATION OF STEM CELLS AND DIFFERENTIATION CAPACITY
AU2005233582B2 (en) 2004-04-12 2009-01-29 Sanbio, Inc. Cells exhibiting neuronal progenitor cell characteristics
JP4581085B2 (ja) 2004-12-24 2010-11-17 国立大学法人京都大学 骨格筋細胞の分化誘導方法
PT1855700E (pt) * 2005-03-07 2013-12-10 Sanbio Inc Utilização de materiais para tratamento de lesões do sistema nervoso central
GB0504881D0 (en) * 2005-03-09 2005-04-13 Univ Edinburgh Directed neural differentiation
AU2006225986B2 (en) * 2005-03-23 2011-09-01 Qualcomm Incorporated Method and system for digital pen assembly
ES2524996T3 (es) 2005-06-16 2014-12-16 Ramot At Tel Aviv University Ltd. Células aisladas y poblaciones que comprenden a las mismas para el tratamiento de enfermedades del SNC
WO2008102460A1 (en) * 2007-02-23 2008-08-28 Sanbio Inc. Transplantation of bone marrow stromal cell-induced neural stem cells for promoting fuctional recovery after spinal cord injury
JP5662147B2 (ja) * 2007-08-15 2015-01-28 サンバイオ，インコーポレイティド 神経変性を治療するための方法及び組成物
WO2009073178A1 (en) * 2007-12-03 2009-06-11 Sanbio, Inc. Extracellular matrix from pluripotent cells
PL2222839T3 (pl) 2007-12-03 2016-02-29 Sanbio Inc Sposoby i kompozycje do modulowania i różnicowania pluripotencjalnych komórek
ES2594229T3 (es) * 2008-04-30 2016-12-16 Sanbio, Inc. Células de regeneración nerviosa con alteraciones en la metilación del ADN
DK2620493T3 (da) 2008-05-28 2019-07-01 Univ Ramot Mesenkymale stamceller til behandling af CNS-sygdomme
EP2440660A4 (en) * 2009-06-10 2013-08-28 Brainstem Biotec Ltd METHODS, SYSTEMS, AND COMPOSITIONS FOR NEURONAL DIFFERENTIATION OF PLURIPOTENT STROMAL CELLS
JP5932970B2 (ja) 2011-04-06 2016-06-08 サンバイオ，インコーポレイティド 末梢免疫機能を調節するための方法及び組成物
US20120263681A1 (en) 2011-04-12 2012-10-18 Fujifilm Corporation Composition comprising cell and biocompatible polymer
EP2806881A1 (en) 2012-01-27 2014-12-03 SanBio, Inc. Methods and compositions for modulating angiogenesis and vasculogenesis
JP2015509366A (ja) 2012-02-22 2015-03-30 ブレインステム バイオテック リミテッド 神経幹細胞および運動ニューロンの生成
CN104519891B (zh) * 2012-05-16 2019-03-22 桑比欧公司 用于治疗创伤性脑损伤和用于调节神经原性细胞迁移的方法和组合物
ES2813407T3 (es) 2012-08-06 2021-03-23 Brainstorm Cell Therapeutics Ltd Métodos para generar células madre mesenquimales que secretan factores neurotróficos
JP5856029B2 (ja) * 2012-08-31 2016-02-09 阿部　博幸 間葉系幹細胞を未分化増殖させる方法、および間葉系幹細胞を濃縮する方法
US9326999B2 (en) 2012-10-09 2016-05-03 Sanbio, Inc. Methods and compositions for treatment of retinal degeneration
JP6628253B2 (ja) 2014-02-11 2020-01-08 ブレインストーム セル セラペウティクス リミテッド 細胞の適性を判定する方法
WO2015175631A1 (en) 2014-05-13 2015-11-19 Celgard, Llc Functionalized porous membranes and methods of manufacture and use
EP3277297B1 (en) 2015-04-01 2021-07-28 SanBio, Inc. Methods and compositions for stimulation of cell proliferation and provision of biologically active mixtures of fgf2 isoforms
CN106399381B (zh) * 2015-07-30 2019-11-26 中国农业大学 miR-34c在体外诱导骨骼肌细胞分化中的应用
CA3030866A1 (en) 2016-07-21 2018-01-25 Sanbio, Inc. Msc growth predictor assays
CA3047329A1 (en) 2016-12-28 2018-07-05 Sanbio, Inc. Cell delivery system and methods of operation thereof
CN111793608B (zh) * 2017-07-28 2022-05-17 杨涛 定向诱导hiPSC分化为神经细胞体系的HS5条件培养基
EP3694985A1 (en) 2017-10-13 2020-08-19 IMBA-Institut für Molekulare Biotechnologie GmbH Enhanced reprogramming of somatic cells
WO2022251829A1 (en) * 2021-05-27 2022-12-01 Sanbio, Inc. Cell therapies and methods of treatment for small-volume stroke

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5226914A (en) * 1990-11-16 1993-07-13 Caplan Arnold I Method for treating connective tissue disorders
DE4138621A1 (de) * 1991-11-25 1993-06-17 Boehringer Ingelheim Int Verfahren zum screenen von substanzen mit modulierender wirkung auf einen rezeptorabhaengigen zellulaeren signaluebertragungsweg
US5591625A (en) 1993-11-24 1997-01-07 Case Western Reserve University Transduced mesenchymal stem cells
US5780300A (en) * 1995-09-29 1998-07-14 Yale University Manipulation of non-terminally differentiated cells using the notch pathway
AU736361B2 (en) * 1996-11-07 2001-07-26 Lorantis Limited Notch
ES2246085T3 (es) * 1998-05-07 2006-02-01 University Of South Florida Celulas de medula osea como fuente de neuronas util para reparar la medula espinal y el cerebro.
AU6056299A (en) * 1998-09-21 2000-04-10 Musc Foundation For Research Development Non-hematopoietic cells, including cardiomyocytes and skeletal muscle cells, derived from hematopoietic stem cells and methods of making and using them
US7105150B2 (en) 1999-02-12 2006-09-12 Stemcells California, Inc. In vivo screening methods using enriched neural stem cells
US7015037B1 (en) 1999-08-05 2006-03-21 Regents Of The University Of Minnesota Multiponent adult stem cells and methods for isolation
US6555374B1 (en) * 1999-08-19 2003-04-29 Artecel Sciences, Inc. Multiple mesodermal lineage differentiation potentials for adipose tissue-derived stromal cells and uses thereof
EP1221956A2 (en) * 1999-09-30 2002-07-17 McGILL UNIVERSITY Autologous marrow stem cell (msc) transplantation for myocardial regeneration
AU3685401A (en) 2000-02-11 2001-08-20 Philadelphia Health Differentiation of bone marrow cells into neuronal cells and uses therefor
KR100449141B1 (ko) 2001-04-19 2004-09-21 (주)라이프코드 간엽 간세포를 신경세포로 분화시키는 방법
US7682825B2 (en) * 2002-02-06 2010-03-23 Sanbio, Inc. Differentiation of bone marrow stromal cells to neural cells or skeletal muscle cells by introduction of notch gene
PT1855700E (pt) 2005-03-07 2013-12-10 Sanbio Inc Utilização de materiais para tratamento de lesões do sistema nervoso central
JP5662147B2 (ja) * 2007-08-15 2015-01-28 サンバイオ，インコーポレイティド 神経変性を治療するための方法及び組成物
PL2222839T3 (pl) 2007-12-03 2016-02-29 Sanbio Inc Sposoby i kompozycje do modulowania i różnicowania pluripotencjalnych komórek
ES2594229T3 (es) 2008-04-30 2016-12-16 Sanbio, Inc. Células de regeneración nerviosa con alteraciones en la metilación del ADN

Also Published As

Publication number Publication date
US20160151418A9 (en) 2016-06-02
CN100497621C (zh) 2009-06-10
US8969078B2 (en) 2015-03-03
US20130209428A1 (en) 2013-08-15
US10196605B2 (en) 2019-02-05
ES2431518T3 (es) 2013-11-26
US8361456B2 (en) 2013-01-29
EP1479767A4 (en) 2005-02-16
HK1078610A1 (en) 2006-03-17
US8133725B2 (en) 2012-03-13
AU2003207064A1 (en) 2003-09-02
US20060166362A1 (en) 2006-07-27
CA2475288C (en) 2014-09-02
DK1479767T3 (da) 2013-11-25
CN1639335A (zh) 2005-07-13
US20190136183A1 (en) 2019-05-09
EP1479767B1 (en) 2013-08-21
CN101584869B (zh) 2013-03-27
WO2003066856A1 (en) 2003-08-14
EP2270146A1 (en) 2011-01-05
US7682825B2 (en) 2010-03-23
CN101584869A (zh) 2009-11-25
EP1479767A1 (en) 2004-11-24
US20100144034A1 (en) 2010-06-10
US20120009160A1 (en) 2012-01-12
US11512284B2 (en) 2022-11-29
US9399046B2 (en) 2016-07-26
CA2475288A1 (en) 2003-08-14
AU2003207064B2 (en) 2006-07-13
PT1479767E (pt) 2013-11-07
US20100310523A1 (en) 2010-12-09
US20160304835A1 (en) 2016-10-20

Similar Documents

Publication Publication Date Title
HK1139039A1 (en) Method of differentiating/inducing bone marrow interstitial cells into nerve cells and skeleton muscle cells by transferrin notch gene
CA2444724A1 (en) Method for differentiating mesenchymal stem cells into neural cells
DE69938653D1 (de) Isolierte stromalzellen zur verwendung in der behandlung von erkrankungen des zentralnervensystems
BRPI0408733A (pt) derivação de neurÈnios dopaminérgicos terminalmente diferenciados de células tronco embriÈnicas humanas
MY159562A (en) Adipose tissue derived stromal cells for the treatment of neurological disorders
GB2434801B (en) Method of producing multipotent stem cells derived from human adipose tissue
WO2003066072A3 (en) Cell therapy using immunoregulatory t-cells
HK1102598A1 (en) Therapeutic use of a growth factor, nsg33
WO2005013897A3 (en) Magnetic nanoparticle compositions, and methods related thereto
EP1302536A3 (en) Embryonic stem cells and neural progenitor cells derived therefrom
WO2008157791A3 (en) Methods and compositions for stimulating neurogenesis and inhibiting neuronal degeneration using isothiazolopyrimidinones
NZ215195A (en) Neovascularisation inhibitor and processes for its production
EP1561814A4 (en) SPECIFICALLY EXPRESSED IN POSTMITOTIC DOPAMIN-PRODUCING NEURONAL PRECURSOR CELLS
Lee et al. Extremely low frequency electromagnetic fields enhance neuronal differentiation of human mesenchymal stem cells on graphene-based substrates
WO2005021704A3 (en) In vitro generation of gabaergic neurons from embryonic stem cells and their use in the treatment of neurological disorders
WO2007035722A8 (en) Methods and compositions for stimulating neurogenesis and inhibiting neuronal degeneration
IL172499A0 (en) Method for producing retinal nerve cells from stem/progenitor cells derived from iris tissue and retinal nerve cells obtained by same method
PL325646A1 (en) Transplantation of nerve cells using pluripotential nuroepithelial cells
WO2003024471A3 (en) Effect of growth hormone and igf-1 on neural stem cells and therapeutic application
IL129178A0 (en) Induction of nerve generation
EP1685832A4 (en) NERVE REGENERATION PROMOTERS
WO2006110806A3 (en) Multipotent adult stem cells
WO2006119965A3 (en) Growth factor mutants with altered biological attributes
WO2002063938A3 (en) Production and use of dopaminergic cells to treat dopaminergic deficiencies
IL184132A0 (en) Method for inducing differentiation to skeletal muscle cells

Legal Events

Date Code Title Description
PE Patent expired

Effective date: 20230205