HK1078610A1 - Method of differentiating/inducing bone marrow interstitial cells into nerve cells and skeleton muscle cells by transferrin notch gene - Google Patents

Method of differentiating/inducing bone marrow interstitial cells into nerve cells and skeleton muscle cells by transferrin notch gene

Info

Publication number
HK1078610A1
HK1078610A1 HK05110355.3A HK05110355A HK1078610A1 HK 1078610 A1 HK1078610 A1 HK 1078610A1 HK 05110355 A HK05110355 A HK 05110355A HK 1078610 A1 HK1078610 A1 HK 1078610A1
Authority
HK
Hong Kong
Prior art keywords
cells
transferrin
differentiating
bone marrow
inducing bone
Prior art date
Application number
HK05110355.3A
Other languages
English (en)
Inventor
Marl Dezawa
Hajime Sawada
Hiroshi Kanno
Masahiko Takano
Original Assignee
Sanbio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2002030003A external-priority patent/JP3948971B2/ja
Application filed by Sanbio Inc filed Critical Sanbio Inc
Publication of HK1078610A1 publication Critical patent/HK1078610A1/xx

Links

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0658—Skeletal muscle cells, e.g. myocytes, myotubes, myoblasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/42—Notch; Delta; Jagged; Serrate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1352—Mesenchymal stem cells
    • C12N2502/1358—Bone marrow mesenchymal stem cells (BM-MSC)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
    • C12N2506/1353—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from bone marrow mesenchymal stem cells (BM-MSC)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
HK05110355.3A 2002-02-06 2005-11-18 Method of differentiating/inducing bone marrow interstitial cells into nerve cells and skeleton muscle cells by transferrin notch gene HK1078610A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002030003A JP3948971B2 (ja) 2001-08-30 2002-02-06 Ｎｏｔｃｈ遺伝子の導入を用いて骨髄間質細胞を神経細胞及び骨格筋細胞に分化・誘導する方法
PCT/JP2003/001260 WO2003066856A1 (en) 2002-02-06 2003-02-06 METHOD OF DIFFERENTIATING/INDUCING BONE MARROW INTERSTITIAL CELLS INTO NERVE CELLS AND SKELETON MUSCLE CELLS BY TRANSFERRING Notch GENE

Publications (1)

Publication Number Publication Date
HK1078610A1 true HK1078610A1 (en) 2006-03-17

Family

ID=27677898

Family Applications (2)

Application Number Title Priority Date Filing Date
HK05110355.3A HK1078610A1 (en) 2002-02-06 2005-11-18 Method of differentiating/inducing bone marrow interstitial cells into nerve cells and skeleton muscle cells by transferrin notch gene
HK10104703.8A HK1139039A1 (en) 2002-02-06 2010-05-14 Method of differentiating/inducing bone marrow interstitial cells into nerve cells and skeleton muscle cells by transferrin notch gene

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK10104703.8A HK1139039A1 (en) 2002-02-06 2010-05-14 Method of differentiating/inducing bone marrow interstitial cells into nerve cells and skeleton muscle cells by transferrin notch gene

Country Status (10)

Country Link
US (7) US7682825B2 (xx)
EP (2) EP1479767B1 (xx)
CN (2) CN101584869B (xx)
AU (1) AU2003207064B2 (xx)
CA (1) CA2475288C (xx)
DK (1) DK1479767T3 (xx)
ES (1) ES2431518T3 (xx)
HK (2) HK1078610A1 (xx)
PT (1) PT1479767E (xx)
WO (1) WO2003066856A1 (xx)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1479767T3 (da) 2002-02-06 2013-11-25 Sanbio Inc Fremgangsmåde til differentiering/inducering af stromaceller fra knoglemarv til nerveceller ved overføring af Notch-gen
US20050265983A1 (en) * 2002-11-17 2005-12-01 Eldad Melamed Methods, nucleic acid constructs and cells for treating neurodegenerative disorders
WO2004085632A1 (ja) * 2003-03-25 2004-10-07 Japan Science And Technology Agency 幹細胞の分化誘導および分化能の制御
PL1737950T3 (pl) * 2004-04-12 2012-02-29 Sanbio Inc Komórki wykazujące cechy neuronalnych komórek progenitorowych
JP4581085B2 (ja) 2004-12-24 2010-11-17 国立大学法人京都大学 骨格筋細胞の分化誘導方法
DK1855700T3 (da) 2005-03-07 2014-01-13 Sanbio Inc Anvendelse af neuronale præcursorceller til behandling af læsioner i centralnervesystemet
GB0504881D0 (en) * 2005-03-09 2005-04-13 Univ Edinburgh Directed neural differentiation
KR101309778B1 (ko) * 2005-03-23 2013-09-23 에포스 디벨롭먼트 리미티드 디지털 펜 조립체
ES2524996T3 (es) 2005-06-16 2014-12-16 Ramot At Tel Aviv University Ltd. Células aisladas y poblaciones que comprenden a las mismas para el tratamiento de enfermedades del SNC
WO2008102460A1 (en) * 2007-02-23 2008-08-28 Sanbio Inc. Transplantation of bone marrow stromal cell-induced neural stem cells for promoting fuctional recovery after spinal cord injury
CN101801396B (zh) * 2007-08-15 2013-10-30 桑比欧公司 治疗神经变性的方法和组合物
DK2222839T3 (en) 2007-12-03 2015-12-21 Sanbio Inc Methods and compositions for modulating differentiation of pluripotent cells
WO2009073178A1 (en) * 2007-12-03 2009-06-11 Sanbio, Inc. Extracellular matrix from pluripotent cells
PL2274430T3 (pl) * 2008-04-30 2017-09-29 Sanbio Inc Komórki regenerujące nerwy ze zmianami w metylacji DNA
US8663987B2 (en) 2008-05-28 2014-03-04 Ramot At Tel-Aviv University Ltd. Mesenchymal stem cells for the treatment of CNS diseases
US10421961B2 (en) * 2009-06-10 2019-09-24 Exostem Biotec Ltd Methods, systems, and compositions for neuronal differentiation of multipotent stromal cells
CN103547275B (zh) 2011-04-06 2016-12-28 桑比欧公司 用于调节外周免疫功能的方法和组合物
US20120263681A1 (en) * 2011-04-12 2012-10-18 Fujifilm Corporation Composition comprising cell and biocompatible polymer
EP2806881A1 (en) 2012-01-27 2014-12-03 SanBio, Inc. Methods and compositions for modulating angiogenesis and vasculogenesis
EP2844745A2 (en) 2012-02-22 2015-03-11 Brainstem Biotec Ltd. Generation of neural stem cells and motor neurons
US9828593B2 (en) * 2012-05-16 2017-11-28 Sanbio, Inc. Methods and compositions for treatment of traumatic brain injury and for modulation of migration of neurogenic cells
JP6362596B2 (ja) 2012-08-06 2018-07-25 ブレインストーム セル セラペウティクス リミテッド 神経栄養因子を分泌する間葉系幹細胞の作製方法
JP5856029B2 (ja) * 2012-08-31 2016-02-09 阿部　博幸 間葉系幹細胞を未分化増殖させる方法、および間葉系幹細胞を濃縮する方法
KR101906756B1 (ko) 2012-10-09 2018-12-05 산바이오 인코포레이티드 망막 변성의 치료 방법 및 치료용 조성물
US10564149B2 (en) 2014-02-11 2020-02-18 Brainstorm Cell Therapeutics Ltd. Populations of mesenchymal stem cells that secrete neurotrophic factors
WO2015175631A1 (en) 2014-05-13 2015-11-19 Celgard, Llc Functionalized porous membranes and methods of manufacture and use
CN107427536B (zh) 2015-04-01 2022-02-08 桑比欧公司 用于刺激细胞增殖和提供fgf2同种型的生物活性混合物的方法和组合物
CN106399381B (zh) * 2015-07-30 2019-11-26 中国农业大学 miR-34c在体外诱导骨骼肌细胞分化中的应用
WO2018017538A1 (en) 2016-07-21 2018-01-25 Sanbio, Inc. Msc growth predictor assays
EP3548114A4 (en) 2016-12-28 2020-07-15 SanBio, Inc. CELL RELEASE SYSTEM AND METHOD FOR THE OPERATION THEREOF
CN111793608B (zh) * 2017-07-28 2022-05-17 杨涛 定向诱导hiPSC分化为神经细胞体系的HS5条件培养基
JP2020537522A (ja) 2017-10-13 2020-12-24 イーエムベーアー−インスティテュート フュール モレクラレ バイオテクノロジー ゲゼルシャフト ミット ベシュレンクテル ハフツング 体細胞の増強された再プログラミング
US20220387506A1 (en) * 2021-05-27 2022-12-08 Sanbio, Inc. Cell therapies and methods of treatment for small-volume stroke

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5226914A (en) * 1990-11-16 1993-07-13 Caplan Arnold I Method for treating connective tissue disorders
DE4138621A1 (de) * 1991-11-25 1993-06-17 Boehringer Ingelheim Int Verfahren zum screenen von substanzen mit modulierender wirkung auf einen rezeptorabhaengigen zellulaeren signaluebertragungsweg
US5591625A (en) * 1993-11-24 1997-01-07 Case Western Reserve University Transduced mesenchymal stem cells
US5780300A (en) * 1995-09-29 1998-07-14 Yale University Manipulation of non-terminally differentiated cells using the notch pathway
RO120850B1 (ro) * 1996-11-07 2006-08-30 Imperial College Of Science Technology & Medic "notch"
ES2246085T3 (es) * 1998-05-07 2006-02-01 University Of South Florida Celulas de medula osea como fuente de neuronas util para reparar la medula espinal y el cerebro.
AU6056299A (en) * 1998-09-21 2000-04-10 Musc Foundation For Research Development Non-hematopoietic cells, including cardiomyocytes and skeletal muscle cells, derived from hematopoietic stem cells and methods of making and using them
US7105150B2 (en) * 1999-02-12 2006-09-12 Stemcells California, Inc. In vivo screening methods using enriched neural stem cells
US7015037B1 (en) * 1999-08-05 2006-03-21 Regents Of The University Of Minnesota Multiponent adult stem cells and methods for isolation
US6555374B1 (en) * 1999-08-19 2003-04-29 Artecel Sciences, Inc. Multiple mesodermal lineage differentiation potentials for adipose tissue-derived stromal cells and uses thereof
WO2001022978A2 (en) * 1999-09-30 2001-04-05 Mcgill University Autologous marrow stem cell (msc) transplantation for myocardial regeneration
ATE370225T1 (de) 2000-02-11 2007-09-15 Philadelphia Health & Educatio Differenzierung von knochenmarkzellen in neuronale zellen und deren verwendungen
KR100449141B1 (ko) * 2001-04-19 2004-09-21 (주)라이프코드 간엽 간세포를 신경세포로 분화시키는 방법
DK1479767T3 (da) 2002-02-06 2013-11-25 Sanbio Inc Fremgangsmåde til differentiering/inducering af stromaceller fra knoglemarv til nerveceller ved overføring af Notch-gen
DK1855700T3 (da) * 2005-03-07 2014-01-13 Sanbio Inc Anvendelse af neuronale præcursorceller til behandling af læsioner i centralnervesystemet
CN101801396B (zh) * 2007-08-15 2013-10-30 桑比欧公司 治疗神经变性的方法和组合物
DK2222839T3 (en) 2007-12-03 2015-12-21 Sanbio Inc Methods and compositions for modulating differentiation of pluripotent cells
PL2274430T3 (pl) * 2008-04-30 2017-09-29 Sanbio Inc Komórki regenerujące nerwy ze zmianami w metylacji DNA

Also Published As

Publication number Publication date
US20160304835A1 (en) 2016-10-20
CA2475288A1 (en) 2003-08-14
US7682825B2 (en) 2010-03-23
US9399046B2 (en) 2016-07-26
US11512284B2 (en) 2022-11-29
EP1479767A4 (en) 2005-02-16
US8361456B2 (en) 2013-01-29
EP1479767B1 (en) 2013-08-21
AU2003207064B2 (en) 2006-07-13
AU2003207064A1 (en) 2003-09-02
CA2475288C (en) 2014-09-02
CN1639335A (zh) 2005-07-13
US20160151418A9 (en) 2016-06-02
US10196605B2 (en) 2019-02-05
US20120009160A1 (en) 2012-01-12
US20100310523A1 (en) 2010-12-09
CN100497621C (zh) 2009-06-10
EP1479767A1 (en) 2004-11-24
ES2431518T3 (es) 2013-11-26
US20130209428A1 (en) 2013-08-15
HK1139039A1 (en) 2010-09-10
DK1479767T3 (da) 2013-11-25
PT1479767E (pt) 2013-11-07
US8133725B2 (en) 2012-03-13
WO2003066856A1 (en) 2003-08-14
US20100144034A1 (en) 2010-06-10
CN101584869B (zh) 2013-03-27
US20190136183A1 (en) 2019-05-09
CN101584869A (zh) 2009-11-25
EP2270146A1 (en) 2011-01-05
US20060166362A1 (en) 2006-07-27
US8969078B2 (en) 2015-03-03

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