HK1131167A1 - 淚液脂質運載蛋白的突變蛋白及其獲得方法 - Google Patents

淚液脂質運載蛋白的突變蛋白及其獲得方法

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Publication number
HK1131167A1
HK1131167A1 HK09110805.5A HK09110805A HK1131167A1 HK 1131167 A1 HK1131167 A1 HK 1131167A1 HK 09110805 A HK09110805 A HK 09110805A HK 1131167 A1 HK1131167 A1 HK 1131167A1
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HK
Hong Kong
Prior art keywords
mutein
muteins
obtaining
methods
same
Prior art date
Application number
HK09110805.5A
Other languages
English (en)
Inventor
‧詹森
‧許爾斯邁爾
‧施勒胡伯爾
‧霍爾鮑姆
‧斯克拉
‧布德羅
‧琼斯
‧金伯
‧迪爾曼
Original Assignee
皮里斯股份公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 皮里斯股份公司 filed Critical 皮里斯股份公司
Publication of HK1131167A1 publication Critical patent/HK1131167A1/zh

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    • C—CHEMISTRY; METALLURGY
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
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    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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HK09110805.5A 2006-08-01 2009-11-19 淚液脂質運載蛋白的突變蛋白及其獲得方法 HK1131167A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US82107306P 2006-08-01 2006-08-01
US91201307P 2007-04-16 2007-04-16
PCT/EP2007/057971 WO2008015239A2 (en) 2006-08-01 2007-08-01 Muteins of tear lipocalin and methods for obtaining the same

Publications (1)

Publication Number Publication Date
HK1131167A1 true HK1131167A1 (zh) 2010-01-15

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HK09110805.5A HK1131167A1 (zh) 2006-08-01 2009-11-19 淚液脂質運載蛋白的突變蛋白及其獲得方法

Country Status (14)

Country Link
US (4) US8313924B2 (zh)
EP (1) EP2046820B1 (zh)
JP (1) JP5608368B2 (zh)
KR (1) KR101516023B1 (zh)
CN (2) CN105112477A (zh)
AT (1) ATE485304T1 (zh)
AU (1) AU2007280398B2 (zh)
CA (1) CA2659413C (zh)
DE (1) DE602007009995D1 (zh)
DK (1) DK2046820T3 (zh)
HK (1) HK1131167A1 (zh)
MX (1) MX2009001203A (zh)
SG (1) SG173332A1 (zh)
WO (1) WO2008015239A2 (zh)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG173332A1 (en) * 2006-08-01 2011-08-29 Pieris Ag Muteins of tear lipocalin and methods for obtaining the same
AU2009209591B2 (en) * 2008-01-30 2012-08-02 Pieris Ag Muteins of tear lipocalin having affinity to human c-Met receptor tyrosine kinase and methods for obtaining the same
US20090274623A1 (en) * 2008-01-30 2009-11-05 General Electric Company In vivo imaging agents for met receptor tyrosine kinase
CN106139123A (zh) 2009-08-05 2016-11-23 爱力根公司 脂质运载蛋白突变蛋白的控制释放制剂
WO2011069992A2 (en) * 2009-12-07 2011-06-16 Pieris Ag Muteins of human lipocalin 2 (lcn2, hngal) with affinity for a given target
PT2580236T (pt) * 2010-06-08 2019-05-30 Astrazeneca Ab Muteínas da lipocalina de lágrima, que se ligam ao recetor-alfa da il-4
MX349622B (es) * 2010-09-08 2017-08-07 Halozyme Inc Metodos para evaluar e identificar o evolucionar proteinas terapeuticas condicionalmente activas.
WO2012050923A2 (en) * 2010-09-28 2012-04-19 Amylin Pharmaceuticals, Inc. Engineered polypeptides having enhanced duration of action
WO2012136685A1 (en) 2011-04-04 2012-10-11 Pieris Ag Methods and compositions for anti-vegf and anti-c-met therapy
WO2012172054A1 (en) 2011-06-16 2012-12-20 Scil Proteins Gmbh Modified multimeric ubiquitin proteins binding vegf-a
WO2013068590A1 (en) * 2011-11-11 2013-05-16 Pieris Ag Lipocalin muteins as vegf antagonists for use in treating diseases caused or promoted by increased vascularization
EP3453400B1 (en) * 2011-12-13 2021-01-20 Pieris Pharmaceuticals GmbH Methods for preventing or treating certain disorders by inhibiting binding of il-4 and/or il-13 to their respective receptors
MX361727B (es) 2011-12-30 2018-12-14 Halozyme Inc Variantes de polipeptido ph20, formulaciones y usos de las mismas.
US9522940B2 (en) 2012-05-23 2016-12-20 Pieris Pharmaceuticals Gmbh Lipocalin muteins with binding-affinity for glypican-3 (GPC-3) and use of lipocalin muteins for target-specific delivery to cells expressing GPC-3
US10526384B2 (en) * 2012-11-19 2020-01-07 Pieris Pharmaceuticals Gmbh Interleukin-17A-specific and interleukin-23-specific binding polypeptides and uses thereof
US20140149578A1 (en) * 2012-11-26 2014-05-29 Go Daddy Operating Company, LLC Method For Testing Methods of Accelerating Content Delivery
USRE48805E1 (en) 2013-03-06 2021-11-02 Vision Global Holdings Ltd. Method for cancer targeting treatment and detection of arginine using albumin-binding arginine deiminase fusion protein
US9255262B2 (en) * 2013-03-06 2016-02-09 Vision Global Holdings Ltd. Albumin-binding arginine deminase and the use thereof
RU2015142437A (ru) 2013-03-14 2017-04-27 Дайити Санкио Ко., Лтд Новые связывающие белки для pcsk9
TW201534726A (zh) 2013-07-03 2015-09-16 Halozyme Inc 熱穩定ｐｈ２０玻尿酸酶變異體及其用途
US9388239B2 (en) * 2014-05-01 2016-07-12 Consejo Nacional De Investigation Cientifica Anti-human VEGF antibodies with unusually strong binding affinity to human VEGF-A and cross reactivity to human VEGF-B
CN113621050A (zh) * 2014-05-22 2021-11-09 皮里斯制药有限公司 新型特异性结合多肽及其用途
US11382963B2 (en) 2015-01-12 2022-07-12 Pieris Pharmaceuticals Gmbh Engineered T cells and uses therefor
EP3064507A1 (en) 2015-03-06 2016-09-07 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Fusion proteins comprising a binding protein and an interleukin-15 polypeptide having a reduced affinity for IL15ra and therapeutic uses thereof
CA2980839A1 (en) 2015-05-04 2016-11-10 Pieris Pharmaceuticals Gmbh Proteins specific for cd137
CN114316067A (zh) * 2015-05-04 2022-04-12 皮里斯制药有限公司 抗癌融合多肽
CN114456252A (zh) 2015-05-18 2022-05-10 皮里斯制药有限公司 对磷脂酰肌醇聚糖-3（gpc3）具有亲和力的人脂质运载蛋白2的突变蛋白
CA2980838A1 (en) 2015-05-18 2016-11-24 Pieris Pharmaceuticals Gmbh Anti-cancer fusion polypeptide
WO2018015380A1 (en) 2016-07-18 2018-01-25 Philippe Ulsemer Natural microorganisms which are naturally capable of binding toxins and/or toxin receptors
PT3583120T (pt) 2017-02-17 2022-12-15 Denali Therapeutics Inc Polipeptídeos de ligação ao recetor de transferrina manipulados
US20210269499A1 (en) 2018-06-21 2021-09-02 Technische Universitaet Muenchen Hepatitis b and/or hepatitis d-permissive cells and animals
KR20210133254A (ko) 2019-02-26 2021-11-05 피어이스 파마슈티컬즈 게엠베하 Cd137 및 gpc3에 특이적인 신규한 융합 단백질
EP3946417A1 (en) 2019-03-29 2022-02-09 Pieris Pharmaceuticals GmbH Inhaled administration of lipocalin muteins
EP3946415A1 (en) 2019-03-29 2022-02-09 Astrazeneca AB Lipocalin mutein for treatment of asthma
AU2021399151A1 (en) 2020-12-18 2023-07-27 Astrazeneca Ab Lipocalin mutein dry powder formulation for treatment of asthma

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6446467B1 (en) 1997-07-29 2002-09-10 Physical Optics Corporation Monolithic glass light shaping diffuser and method for its production
DE19742706B4 (de) 1997-09-26 2013-07-25 Pieris Proteolab Ag Lipocalinmuteine
DE19926068C1 (de) 1999-06-08 2001-01-11 Arne Skerra Muteine des Bilin-Bindungsproteins
DE60129432T2 (de) * 2000-05-16 2008-04-17 Bolder Biotechnology, Inc., Louisville Verfahren zur rückfaltung von proteinen mit freien cysteinresten
WO2003029471A1 (en) 2001-09-27 2003-04-10 Pieris Proteolab Ag Muteins of apolipoprotein d
WO2003029462A1 (en) 2001-09-27 2003-04-10 Pieris Proteolab Ag Muteins of human neutrophil gelatinase-associated lipocalin and related proteins
EP1658308A1 (en) 2003-08-25 2006-05-24 Pieris ProteoLab AG Muteins of a bilin-binding protein with affinity for a given target
AU2003275958A1 (en) * 2003-08-25 2005-03-10 Pieris Proteolab Ag Muteins of tear lipocalin
EP2899277A1 (en) * 2004-11-26 2015-07-29 Pieris AG Compound with affinity for the cytotoxic T lymphocyte-associated antigen (CTLA-4)
EP1996613B1 (en) * 2006-03-20 2014-04-30 Technische Universität München Muteins of tear lipocalin with affinity for the t-cell coreceptor cd4
SG173332A1 (en) * 2006-08-01 2011-08-29 Pieris Ag Muteins of tear lipocalin and methods for obtaining the same

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US20190015477A1 (en) 2019-01-17
US20160256525A1 (en) 2016-09-08
DE602007009995D1 (de) 2010-12-02
MX2009001203A (es) 2009-06-01
CN105112477A (zh) 2015-12-02
EP2046820A2 (en) 2009-04-15
CA2659413A1 (en) 2008-02-07
ATE485304T1 (de) 2010-11-15
WO2008015239A3 (en) 2008-08-21
JP2009545301A (ja) 2009-12-24
WO2008015239A2 (en) 2008-02-07
EP2046820B1 (en) 2010-10-20
AU2007280398B2 (en) 2012-05-10
US10046027B2 (en) 2018-08-14
US8313924B2 (en) 2012-11-20
AU2007280398A1 (en) 2008-02-07
JP5608368B2 (ja) 2014-10-15
DK2046820T3 (da) 2011-02-07
US9221887B2 (en) 2015-12-29
US20130017996A1 (en) 2013-01-17
US20090305982A1 (en) 2009-12-10
CN104650213A (zh) 2015-05-27
KR101516023B1 (ko) 2015-04-30
SG173332A1 (en) 2011-08-29
CA2659413C (en) 2016-06-14
KR20090090295A (ko) 2009-08-25

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