WO2006110185A3 - Antiinfective lipopeptides - Google Patents

Antiinfective lipopeptides Download PDF

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Publication number
WO2006110185A3
WO2006110185A3 PCT/US2005/040919 US2005040919W WO2006110185A3 WO 2006110185 A3 WO2006110185 A3 WO 2006110185A3 US 2005040919 W US2005040919 W US 2005040919W WO 2006110185 A3 WO2006110185 A3 WO 2006110185A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
antiinfective
lipopeptides
relates
producing
Prior art date
Application number
PCT/US2005/040919
Other languages
French (fr)
Other versions
WO2006110185A2 (en
Inventor
Dylan Christopher Alexander
Richard H Baltz
Paul Brian
Gal Marie-Francoise Coeffet-Le
Sascha Doekel
Xiaowei He
Vidya Kulkarni
Christopher Leitheiser
Vivian Pak Woon Miao
Kien Trung Nguyen
Ian Barrie Parr
Daniel Ritz
Yanzhi Zhang
Original Assignee
Cubist Pharm Inc
Dylan Christopher Alexander
Richard H Baltz
Paul Brian
Gal Marie-Francoise Coeffet-Le
Sascha Doekel
Xiaowei He
Vidya Kulkarni
Christopher Leitheiser
Vivian Pak Woon Miao
Kien Trung Nguyen
Ian Barrie Parr
Daniel Ritz
Yanzhi Zhang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cubist Pharm Inc, Dylan Christopher Alexander, Richard H Baltz, Paul Brian, Gal Marie-Francoise Coeffet-Le, Sascha Doekel, Xiaowei He, Vidya Kulkarni, Christopher Leitheiser, Vivian Pak Woon Miao, Kien Trung Nguyen, Ian Barrie Parr, Daniel Ritz, Yanzhi Zhang filed Critical Cubist Pharm Inc
Priority to US11/667,645 priority Critical patent/US20080051326A1/en
Priority to CA002587848A priority patent/CA2587848A1/en
Priority to JP2007541346A priority patent/JP2008519848A/en
Priority to AU2005330517A priority patent/AU2005330517A1/en
Priority to BRPI0517830-4A priority patent/BRPI0517830A/en
Priority to EP05857738A priority patent/EP1814588A2/en
Priority to RU2007121705/04A priority patent/RU2007121705A/en
Publication of WO2006110185A2 publication Critical patent/WO2006110185A2/en
Priority to IL183109A priority patent/IL183109A0/en
Priority to NO20072634A priority patent/NO20072634L/en
Publication of WO2006110185A3 publication Critical patent/WO2006110185A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention relates to novel depsipeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel depsipeptide compounds and intermediates used in producing these compounds.
PCT/US2005/040919 2004-11-12 2005-11-11 Antiinfective lipopeptides WO2006110185A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
US11/667,645 US20080051326A1 (en) 2004-11-12 2005-11-11 Antiinfective Lipopeptides
CA002587848A CA2587848A1 (en) 2004-11-12 2005-11-11 Antiinfective lipopeptides
JP2007541346A JP2008519848A (en) 2004-11-12 2005-11-11 Anti-infective lipopeptide
AU2005330517A AU2005330517A1 (en) 2004-11-12 2005-11-11 Antiinfective lipopeptides
BRPI0517830-4A BRPI0517830A (en) 2004-11-12 2005-11-11 anti-infectious lipopeptides
EP05857738A EP1814588A2 (en) 2004-11-12 2005-11-11 Antiinfective lipopeptides
RU2007121705/04A RU2007121705A (en) 2004-11-12 2005-11-11 ANTI-INFECTIOUS LIPOPEPTIDES
IL183109A IL183109A0 (en) 2004-11-12 2007-05-10 Antiinfective lipopeptides
NO20072634A NO20072634L (en) 2004-11-12 2007-05-24 Anti-infective lipopeptides

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US62705604P 2004-11-12 2004-11-12
US60/627,056 2004-11-12
US71070505P 2005-08-23 2005-08-23
US60/710,705 2005-08-23

Publications (2)

Publication Number Publication Date
WO2006110185A2 WO2006110185A2 (en) 2006-10-19
WO2006110185A3 true WO2006110185A3 (en) 2007-10-25

Family

ID=37087468

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/040919 WO2006110185A2 (en) 2004-11-12 2005-11-11 Antiinfective lipopeptides

Country Status (10)

Country Link
EP (1) EP1814588A2 (en)
JP (1) JP2008519848A (en)
KR (1) KR20070086038A (en)
AU (1) AU2005330517A1 (en)
BR (1) BRPI0517830A (en)
CA (1) CA2587848A1 (en)
IL (1) IL183109A0 (en)
NO (1) NO20072634L (en)
RU (1) RU2007121705A (en)
WO (1) WO2006110185A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS53152B (en) 2008-12-22 2014-06-30 Cubist Pharmaceuticals Inc. Novel antibacterial agents for the treatment of gram positive infections
MX2013013760A (en) * 2011-05-26 2014-01-08 Cubist Pharm Inc Cb-183,315 compositions and related methods.
KR101723649B1 (en) 2014-10-23 2017-04-06 서울대학교산학협력단 Novel peptide compound, a preparing method thereof, and a use thereof
CN113061164B (en) * 2021-03-29 2023-01-10 四川大学 Cyclic lipopeptide compound and application thereof in anti-rheumatoid arthritis drugs
WO2023152229A1 (en) * 2022-02-09 2023-08-17 Teitur Trophics Aps Novel peptides

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001044271A2 (en) * 1999-12-15 2001-06-21 Cubist Pharmaceuticals, Inc. Daptomycin analogs and their use as antibacterial agents
WO2001044272A2 (en) * 1999-12-15 2001-06-21 Cubist Pharmaceuticals, Inc. Daptomycin analogs as antibacterial agents
WO2001044274A1 (en) * 1999-12-15 2001-06-21 Cubist Pharmaceuticals, Inc. Lipopeptides as antibacterial agents
WO2003014147A1 (en) * 2001-08-06 2003-02-20 Cubist Pharmaceuticals, Inc. Novel depsipeptides and process for preparing same
WO2003014297A2 (en) * 2001-08-06 2003-02-20 Cubist Pharmaceuticals, Inc. Compositions and methods relating to the daptomycin biosynthetic gene cluster

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001044271A2 (en) * 1999-12-15 2001-06-21 Cubist Pharmaceuticals, Inc. Daptomycin analogs and their use as antibacterial agents
WO2001044272A2 (en) * 1999-12-15 2001-06-21 Cubist Pharmaceuticals, Inc. Daptomycin analogs as antibacterial agents
WO2001044274A1 (en) * 1999-12-15 2001-06-21 Cubist Pharmaceuticals, Inc. Lipopeptides as antibacterial agents
WO2003014147A1 (en) * 2001-08-06 2003-02-20 Cubist Pharmaceuticals, Inc. Novel depsipeptides and process for preparing same
WO2003014297A2 (en) * 2001-08-06 2003-02-20 Cubist Pharmaceuticals, Inc. Compositions and methods relating to the daptomycin biosynthetic gene cluster

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BALTZ RH: "NATURAL PRODUCTS TO DRUGS: DAPTOMYCIN AND RELATED LIPOPEPTIDE ANTIBIOTICS", NATURAL PRODUCT REPORTS, XX, XX, vol. 22, no. 6, 2005, pages 717 - 741, XP008074232 *
FINKING R ET AL: "Biosynthesis of nonribosomal peptides", ANNUAL REVIEW OF MICROBIOLOGY, ANNUAL REVIEWS INC., PALO ALTO, CA, US, vol. 58, 10 June 2004 (2004-06-10), pages 453 - 488, XP002431366, ISSN: 0066-4227 *
GRÜNEWALD JAN ET AL: "Synthesis and derivatization of daptomycin: a chemoenzymatic route to acidic lipopeptide antibiotics.", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 29 DEC 2004, vol. 126, no. 51, 29 December 2004 (2004-12-29), pages 17025 - 17031, XP002444217, ISSN: 0002-7863 *
NGUYEN KIEN T ET AL: "Combinatorial biosynthesis of novel antibiotics related to daptomycin.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 14 NOV 2006, vol. 103, no. 46, 14 November 2006 (2006-11-14), pages 17462 - 17467, XP002444219, ISSN: 0027-8424 *
RICHARD H BALTZ ET AL: "Combinatorial biosynthesis of lipopeptide antibiotics in Streptomyces roseosporus", JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY ; OFFICIAL JOURNAL OF THE SOCIETY FOR INDUSTRIAL MICROBIOLOGY, SPRINGER-VERLAG, BE, vol. 33, no. 2, 1 February 2006 (2006-02-01), pages 66 - 74, XP019357774, ISSN: 1476-5535 *

Also Published As

Publication number Publication date
RU2007121705A (en) 2008-12-20
BRPI0517830A (en) 2008-10-21
CA2587848A1 (en) 2006-10-19
IL183109A0 (en) 2008-04-13
AU2005330517A2 (en) 2006-10-19
NO20072634L (en) 2007-08-09
AU2005330517A1 (en) 2006-10-19
WO2006110185A2 (en) 2006-10-19
JP2008519848A (en) 2008-06-12
KR20070086038A (en) 2007-08-27
EP1814588A2 (en) 2007-08-08

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