HK1128679A1 - 1,2-diphenylethene derivatives for treatment of immune diseases 12- - Google Patents
1,2-diphenylethene derivatives for treatment of immune diseases 12-Info
- Publication number
- HK1128679A1 HK1128679A1 HK09106335.2A HK09106335A HK1128679A1 HK 1128679 A1 HK1128679 A1 HK 1128679A1 HK 09106335 A HK09106335 A HK 09106335A HK 1128679 A1 HK1128679 A1 HK 1128679A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- treatment
- immune diseases
- diphenylethene
- derivatives
- diphenylethene derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/37—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by etherified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/205—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic parts with unsaturation outside the rings
- C07C39/21—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic parts with unsaturation outside the rings with at least one hydroxy group on a non-condensed ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/24—Halogenated derivatives
- C07C39/373—Halogenated derivatives with all hydroxy groups on non-condensed rings and with unsaturation outside the aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/215—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring having unsaturation outside the six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/52—Unsaturated compounds containing hydroxy or O-metal groups a hydroxy or O-metal group being bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/017—Esters of hydroxy compounds having the esterified hydroxy group bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/40—Radicals substituted by oxygen atoms
- C07D307/42—Singly bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26207401P | 2001-01-18 | 2001-01-18 | |
| US32273501P | 2001-09-18 | 2001-09-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1128679A1 true HK1128679A1 (en) | 2009-11-06 |
Family
ID=26949001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK09106335.2A HK1128679A1 (en) | 2001-01-18 | 2009-07-14 | 1,2-diphenylethene derivatives for treatment of immune diseases 12- |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20040102517A1 (es) |
| EP (1) | EP1368306B1 (es) |
| JP (1) | JP4230770B2 (es) |
| KR (1) | KR100836207B1 (es) |
| CN (2) | CN101434517B (es) |
| AU (1) | AU2002226225B2 (es) |
| CA (1) | CA2433417C (es) |
| ES (1) | ES2401077T3 (es) |
| HK (1) | HK1128679A1 (es) |
| WO (1) | WO2002057219A1 (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7321050B2 (en) | 1999-12-06 | 2008-01-22 | Welichem Biotech Inc. | Anti-inflammatory and psoriasis treatment and protein kinase inhibition by hydroxy stilbenes and novel stilbene derivatives and analogues |
| EP1368306B1 (en) | 2001-01-18 | 2013-01-16 | Welichem Biotech Inc. | Novel 1,2-diphenylethene derivatives for treatment of immune diseases |
| WO2003009807A2 (en) | 2001-07-23 | 2003-02-06 | Galileo Laboratories, Inc. | Cytoprotective compounds, pharmaceutical and cosmetic formulations, and methods |
| WO2006078941A2 (en) * | 2005-01-20 | 2006-07-27 | Sirtris Pharmaceuticals, Inc. | Novel sirtuin activating compounds and methods of use thereof |
| CN1301246C (zh) * | 2005-04-20 | 2007-02-21 | 江苏省原子医学研究所 | 1－氰基－1－(3,5－二甲氧基苯基)－2－(4－r基苯基)乙烯及其制备方法 |
| CN1300077C (zh) * | 2005-12-07 | 2007-02-14 | 中国科学院广州化学研究所 | 一种白藜芦醇的制备方法 |
| CA2705463C (en) * | 2007-08-10 | 2014-10-07 | Basil Rigas | Anti-inflammatory compounds and uses thereof |
| US9040507B2 (en) | 2008-06-02 | 2015-05-26 | Novelmed Therapeutics, Inc. | Method for treating inflammatory conditions |
| KR101151861B1 (ko) | 2012-01-10 | 2012-06-08 | ㈜엠알이노베이션 | 여드름 피부개선용 조성물 |
| JP2014133732A (ja) * | 2013-07-09 | 2014-07-24 | Meisterbio Co Ltd | ヒスタミン遊離抑制剤 |
| CN114042041B (zh) | 2015-05-21 | 2023-08-22 | 德玛万科学有限责任公司 | 局部药物组合物 |
| US11617724B2 (en) | 2015-05-21 | 2023-04-04 | Dermavant Sciences GmbH | Topical pharmaceutical compositions |
| CA3082115A1 (en) | 2017-11-10 | 2019-05-16 | Dermavant Sciences GmbH | Process for preparing tapinarof |
| US11497718B2 (en) | 2018-11-13 | 2022-11-15 | Dermavant Sciences GmbH | Use of tapinarof for the treatment of atopic dermatitis |
| AU2022243973A1 (en) | 2021-03-25 | 2023-09-14 | Walter Jäger | Compounds for use in the treatment and prevention of covid- 19 |
| CN113072488A (zh) * | 2021-03-30 | 2021-07-06 | 广东工业大学 | 一种苯乙烯衍生物及其合成方法与应用 |
| CN114957171A (zh) * | 2022-06-21 | 2022-08-30 | 广东工业大学 | 一种新颖五元杂环取代的苯乙烯衍生物及其制备方法和应用 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2289506A (en) * | 1940-07-16 | 1942-07-14 | Carl F Kuebler | Brake |
| FR1442295A (fr) | 1964-10-08 | 1966-06-17 | Smith Kline French Lab | Nouveaux dérivés de l'acide beta, beta-diphényl acrylique et leur procédé de préparation |
| FR2429219A1 (fr) * | 1978-06-22 | 1980-01-18 | Parcor | Medicament a base de derives de la thienopyridone ou de la furopyridone |
| DE3210570A1 (de) | 1982-03-23 | 1983-10-06 | Hoechst Ag | 3-azolyl-1,2-diaryl-1-halogen-1-propene, ihre herstellung, ihre verwendung als pflanzenschutzmittel und diese verbindungen enthaltende praeparate |
| US4515883A (en) | 1983-04-14 | 1985-05-07 | Ricoh Company, Ltd. | Stilbene derivatives, distyryl derivatives and electrophotographic photoconductor comprising at least one of the derivatives |
| JPS6122047A (ja) * | 1984-07-07 | 1986-01-30 | Koichi Shiyudo | 安息香酸誘導体 |
| IE59813B1 (en) * | 1986-05-09 | 1994-04-06 | Warner Lambert Co | Styryl pyrazoles, isoxazoles and analogs thereof having activity as 5-lipoxy-genase inhibitors and pharmaceutical compositions containing them |
| DE3722886A1 (de) | 1987-07-10 | 1989-01-19 | Basf Ag | Verfahren zur herstellung von (alpha),ss-substituierten acroleinen und neue substituierte acroleine |
| ES2056983T3 (es) * | 1988-03-21 | 1994-10-16 | Boehringer Ingelheim Pharma | Compuestos para inhibir la biosintesis de metabolitos de acido araquidonico derivados de lipoxigenasa. |
| US5268517A (en) | 1989-07-14 | 1993-12-07 | Basf Aktiengesellschaft | Stereoselective preparation of Z-1,2-diarylallyl chlorides and the conversion thereof into azolylmethyloxiranes, and novel intermediates |
| FI102273B (fi) | 1989-09-11 | 1998-11-13 | Eisai Co Ltd | Kinonijohdannaiset, niiden valmistaminen ja niiden farmakologinen käyt tö |
| FR2676052B1 (fr) * | 1991-05-02 | 1994-04-29 | Cird Galderma | Nouveaux composes polycycliques aromatiques et leur utilisation en medecine humaine ou veterinaire et en cosmetique. |
| JPH0561192A (ja) | 1991-08-30 | 1993-03-12 | Fuji Photo Film Co Ltd | ポジ型フオトレジスト組成物 |
| EP0626955A1 (en) * | 1992-02-11 | 1994-12-07 | Allergan, Inc. | Heteroaryl substituted phenylethenyl compounds having retinoid-like biological activity |
| GB9204945D0 (en) * | 1992-03-06 | 1992-04-22 | Erba Carlo Spa | 3-aryl-glycidic ester derivatives and process for their preparation |
| JPH06135948A (ja) * | 1992-10-30 | 1994-05-17 | Taiho Yakuhin Kogyo Kk | スチレン誘導体又はその塩 |
| CA2135488A1 (en) | 1993-03-10 | 1994-09-15 | Koichi Hashimoto | Stilbene derivative and stilbene analog derivative, and use thereof |
| JPH0816059B2 (ja) * | 1993-05-21 | 1996-02-21 | 三井東圧化学株式会社 | 免疫調節剤 |
| JPH0753359A (ja) * | 1993-06-11 | 1995-02-28 | Kao Corp | リポキシゲナーゼ阻害剤 |
| WO1995003695A1 (en) | 1993-07-27 | 1995-02-09 | Agro-Biotech Corporation | Novel fungicidal properties of metabolites, culture broth, stilbene derivatives and indole derivatives produced by the bacteria xenorhabdus and photorhabdus spp. |
| US5770620A (en) | 1995-06-19 | 1998-06-23 | Ontogen Corporation | Aryl acrylic acid derivatives useful as protein tyrosine phosphatase inhibitors |
| US5830441A (en) | 1998-01-20 | 1998-11-03 | Isp Investments Inc. | Photostable UV absorbent containing A-cyano cinnamyl moiety |
| PT1068870E (pt) | 1998-04-03 | 2006-10-31 | Ajinomoto Kk | Agentes antitumorais |
| FR2778337B1 (fr) * | 1998-05-05 | 2001-08-31 | Inst Nat Sante Rech Med | Antagonistes des ligands du recepteur des arylhydrocarbures |
| US7105552B2 (en) * | 1998-05-08 | 2006-09-12 | Theracos, Inc. | Heterocyclic analogs of diphenylethylene compounds |
| US6624197B1 (en) | 1998-05-08 | 2003-09-23 | Calyx Therapeutics, Inc. | Diphenylethylene compounds |
| CA2331468C (en) | 1998-05-19 | 2005-06-28 | Otsuka Pharmaceutical Factory, Inc. | Pyrazolo[1,5-a]pyrimidine derivatives |
| FR2785284B1 (fr) | 1998-11-02 | 2000-12-01 | Galderma Res & Dev | Analogues de la vitamine d |
| US20020002200A1 (en) | 2000-02-04 | 2002-01-03 | Bishwagit Nag | Novel diphenylethylene compounds |
| CA2393297C (en) | 1999-12-06 | 2010-10-05 | Welichem Biotech Inc. | Polyhydroxystilbenes as antipsoriatic agents and protein kinase inhibitors |
| JP2001261585A (ja) | 2000-03-15 | 2001-09-26 | Chemiprokasei Kaisha Ltd | ハロゲン化ビニル化合物の合成法 |
| US6413504B1 (en) | 2000-06-30 | 2002-07-02 | Calyx Therapeutics, Inc. | Alpha-arylated cinnamic esters and 1,4-bis(alpha-carboxyl-beta-styryl)benzene esters an UV-blocking agents |
| FI117617B (fi) * | 2000-12-08 | 2006-12-29 | Outokumpu Oy | Menetelmä elohopean poistamiseksi kaasusta |
| EP1368306B1 (en) | 2001-01-18 | 2013-01-16 | Welichem Biotech Inc. | Novel 1,2-diphenylethene derivatives for treatment of immune diseases |
| FR2829760B1 (fr) | 2001-09-17 | 2004-03-26 | Oreal | Procede de preparation d'acides alpha-(phenyl)cinnamique et/ou de leurs derives, et leur utilisation dans une composition cosmetique |
| KR100839214B1 (ko) | 2002-03-26 | 2008-06-17 | 웰리켐 바이오 테크 인크. | 치료 활성을 갖는 신규의 디티올로피롤론 |
| JP2006508930A (ja) | 2002-10-01 | 2006-03-16 | ウェリケム バイオテック インコーポレーテッド | 新規生物活性ジフェニルエテン化合物およびその治療への適用 |
| US7371773B2 (en) | 2003-02-04 | 2008-05-13 | Kabushiki Kaisha Yakult Honsha | Breast cancer resistance protein (BCRP) inhibitor |
| CN101486666B (zh) | 2007-12-14 | 2014-06-04 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | 具有调节血脂作用的α，β-苯基取代的丙烯酰胺衍生物 |
| US7902247B2 (en) | 2008-01-09 | 2011-03-08 | Allergan, Inc. | Substituted-aryl-2-phenylethyl-1H-imidazole compounds as subtype selective modulators of alpha 2B and/or alpha 2C adrenergic receptors |
| US7884228B1 (en) | 2008-05-06 | 2011-02-08 | Alcon, Inc. | UV-absorbers for ophthalmic lens materials |
-
2002
- 2002-01-17 EP EP02716007A patent/EP1368306B1/en not_active Expired - Lifetime
- 2002-01-17 CN CN200910001412.6A patent/CN101434517B/zh not_active Expired - Lifetime
- 2002-01-17 AU AU2002226225A patent/AU2002226225B2/en not_active Expired
- 2002-01-17 ES ES02716007T patent/ES2401077T3/es not_active Expired - Lifetime
- 2002-01-17 WO PCT/CA2002/000059 patent/WO2002057219A1/en active Application Filing
- 2002-01-17 KR KR1020027012338A patent/KR100836207B1/ko active IP Right Grant
- 2002-01-17 CN CNB028001214A patent/CN100462354C/zh not_active Expired - Lifetime
- 2002-01-17 US US10/466,879 patent/US20040102517A1/en not_active Abandoned
- 2002-01-17 CA CA2433417A patent/CA2433417C/en not_active Expired - Lifetime
- 2002-01-17 JP JP2002557901A patent/JP4230770B2/ja not_active Expired - Lifetime
-
2009
- 2009-02-11 US US12/369,595 patent/US8487009B2/en not_active Expired - Lifetime
- 2009-07-14 HK HK09106335.2A patent/HK1128679A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US20090149548A1 (en) | 2009-06-11 |
| CN101434517B (zh) | 2014-08-27 |
| AU2002226225B2 (en) | 2008-03-20 |
| CA2433417C (en) | 2010-10-19 |
| CN1455766A (zh) | 2003-11-12 |
| CN101434517A (zh) | 2009-05-20 |
| KR20020091141A (ko) | 2002-12-05 |
| US8487009B2 (en) | 2013-07-16 |
| WO2002057219A1 (en) | 2002-07-25 |
| US20040102517A1 (en) | 2004-05-27 |
| ES2401077T3 (es) | 2013-04-16 |
| CN100462354C (zh) | 2009-02-18 |
| EP1368306A1 (en) | 2003-12-10 |
| EP1368306B1 (en) | 2013-01-16 |
| JP2004529085A (ja) | 2004-09-24 |
| CA2433417A1 (en) | 2002-07-25 |
| KR100836207B1 (ko) | 2008-06-09 |
| JP4230770B2 (ja) | 2009-02-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PE | Patent expired |
Effective date: 20220113 |