HK1125926A1 - Pyrrole derivatives with histone deacetylase inhibitor activity - Google Patents

Pyrrole derivatives with histone deacetylase inhibitor activity

Info

Publication number
HK1125926A1
HK1125926A1 HK09104096.6A HK09104096A HK1125926A1 HK 1125926 A1 HK1125926 A1 HK 1125926A1 HK 09104096 A HK09104096 A HK 09104096A HK 1125926 A1 HK1125926 A1 HK 1125926A1
Authority
HK
Hong Kong
Prior art keywords
histone deacetylase
deacetylase inhibitor
inhibitor activity
pyrrole derivatives
pyrroles
Prior art date
Application number
HK09104096.6A
Other languages
English (en)
Inventor
Mora Fernando Pedro Cossio
Badosa Manel Esteller
Olascoaga Aizpea Zubia
Ansa Dorleta Otaegui
Original Assignee
Univ Pais Vasco
Ct Nac Investigaciones Oncologicas Cnio
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pais Vasco, Ct Nac Investigaciones Oncologicas Cnio filed Critical Univ Pais Vasco
Publication of HK1125926A1 publication Critical patent/HK1125926A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/42—Nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK09104096.6A 2005-12-27 2009-05-04 Pyrrole derivatives with histone deacetylase inhibitor activity HK1125926A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/ES2005/000708 WO2007074176A1 (es) 2005-12-27 2005-12-27 Nuevos derivados pirrólicos con actividad inhibidora de desacetilasas de histonas

Publications (1)

Publication Number Publication Date
HK1125926A1 true HK1125926A1 (en) 2009-08-21

Family

ID=38217700

Family Applications (1)

Application Number Title Priority Date Filing Date
HK09104096.6A HK1125926A1 (en) 2005-12-27 2009-05-04 Pyrrole derivatives with histone deacetylase inhibitor activity

Country Status (18)

Country Link
US (1) US7638550B2 (pt)
EP (1) EP1975158B9 (pt)
JP (1) JP4975758B2 (pt)
CN (1) CN101351444B (pt)
AT (1) ATE516268T1 (pt)
AU (1) AU2005339535B2 (pt)
BR (1) BRPI0520806A2 (pt)
CA (1) CA2635392C (pt)
CY (1) CY1111899T1 (pt)
DK (1) DK1975158T3 (pt)
ES (1) ES2369705T3 (pt)
HK (1) HK1125926A1 (pt)
MX (1) MX2008008470A (pt)
PL (1) PL1975158T3 (pt)
PT (1) PT1975158E (pt)
RU (1) RU2416600C2 (pt)
SI (1) SI1975158T1 (pt)
WO (1) WO2007074176A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090298905A1 (en) * 2005-04-15 2009-12-03 Fernando Pedro Cossio Nitrogenatd trans-stilbene analogs, method for the obtention and medical applications thereof
EP2305643A1 (en) 2009-10-02 2011-04-06 Ikerchem, S.L. New histone deacetylase inhibitors based simultaneously on trisubstituted 1h-pyrroles and aromatic and heteroaromatic spacers
EP2508510A1 (en) * 2011-04-06 2012-10-10 Ikerchem, S.L. Hydroxyphenyl pyrrole compounds containing an hydroxamic acid as hdac inhibitors and medicinal applications thereof
CN103373969B (zh) * 2012-04-27 2015-09-16 中国科学院上海有机化学研究所 苯基唑环取代酰胺类化合物及其制备方法和用途
PL3297992T3 (pl) * 2015-05-22 2020-07-27 Chong Kun Dang Pharmaceutical Corp. Heterocykloalkilowe związki pochodne jako selektywne inhibitory deacetylazy histonowej oraz zawierające je kompozycje farmaceutyczne
CN106565583A (zh) * 2016-11-15 2017-04-19 淮阴师范学院 多取代吡咯衍生物的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2208964T3 (es) * 1996-12-10 2004-06-16 G.D. SEARLE & CO. Compuestos de pirrolilo substituidos para el tratamiento de la inflamacion.
JP4191825B2 (ja) * 1998-09-10 2008-12-03 あすか製薬株式会社 ５−アミノイソキサゾール誘導体
EP1231919B1 (en) * 1999-09-08 2015-09-30 Sloan-Kettering Institute For Cancer Research Derivatives of 1-amino-1-(hetero)arylaminocarbonyl-6-hydroxyaminocarbonylhexane useful in the treatment of tumors
JP2004509941A (ja) * 2000-09-29 2004-04-02 プロリフィクス　リミテッド Ｈｄａｃインヒビターとしてのアミド結合を含むカルバミン酸化合物
US6576612B1 (en) * 2000-10-02 2003-06-10 Pharmacia Italia S.P.A. Antitumor therapy comprising distamycin derivatives
EP1628957B1 (en) 2003-05-26 2010-09-29 Takeda Pharmaceutical Company Limited Sulfopyrroles
EP1691803A1 (en) * 2003-12-05 2006-08-23 Warner-Lambert Company LLC N-alkyl pyrroles as hmg-coa reductase inhibitors
EA012451B1 (ru) * 2004-03-11 2009-10-30 4Сц Аг Новые амидозамещённые гидрокси-6-фенилфенантридины

Also Published As

Publication number Publication date
US7638550B2 (en) 2009-12-29
EP1975158B1 (en) 2011-07-13
CA2635392C (en) 2013-07-23
JP2009521519A (ja) 2009-06-04
EP1975158A1 (en) 2008-10-01
JP4975758B2 (ja) 2012-07-11
ES2369705T3 (es) 2011-12-05
CN101351444B (zh) 2011-07-13
CN101351444A (zh) 2009-01-21
US20080262073A1 (en) 2008-10-23
PL1975158T3 (pl) 2011-12-30
EP1975158B9 (en) 2012-02-29
MX2008008470A (es) 2008-09-26
AU2005339535A1 (en) 2007-07-05
WO2007074176A1 (es) 2007-07-05
RU2008130876A (ru) 2010-02-10
BRPI0520806A2 (pt) 2009-06-09
DK1975158T3 (da) 2011-10-24
ATE516268T1 (de) 2011-07-15
CY1111899T1 (el) 2015-11-04
PT1975158E (pt) 2011-09-23
CA2635392A1 (en) 2007-07-05
SI1975158T1 (sl) 2011-10-28
AU2005339535B2 (en) 2012-02-23
RU2416600C2 (ru) 2011-04-20
EP1975158A4 (en) 2009-11-11

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20151227