BRPI0520806A2 - derivados pirrólicos, processos para a preparação de compostos, seu uso e composição farmacêutica que os contém - Google Patents
derivados pirrólicos, processos para a preparação de compostos, seu uso e composição farmacêutica que os contémInfo
- Publication number
- BRPI0520806A2 BRPI0520806A2 BRPI0520806-8A BRPI0520806A BRPI0520806A2 BR PI0520806 A2 BRPI0520806 A2 BR PI0520806A2 BR PI0520806 A BRPI0520806 A BR PI0520806A BR PI0520806 A2 BRPI0520806 A2 BR PI0520806A2
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- processes
- preparation
- pharmaceutical composition
- composition containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/42—Nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
DERIVADOS PIRRóLICOS, PROCESSOS PARA A PREPARAçãO DE COMPOSTOS, SEU USO E COMPOSIçãO FARMACêUTICA QUE OS CONTêM. A invenção descreve novos compostos derivados de pirroles da fórmula (1), métodos para a sua obtenção e sua aplicação como drogas em composições farmacêuticas para o tratamento de câncer graças à sua atividade inibitória em determinados desacetilazos de histonas.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/ES2005/000708 WO2007074176A1 (es) | 2005-12-27 | 2005-12-27 | Nuevos derivados pirrólicos con actividad inhibidora de desacetilasas de histonas |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0520806A2 true BRPI0520806A2 (pt) | 2009-06-09 |
Family
ID=38217700
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0520806-8A BRPI0520806A2 (pt) | 2005-12-27 | 2005-12-27 | derivados pirrólicos, processos para a preparação de compostos, seu uso e composição farmacêutica que os contém |
Country Status (18)
Country | Link |
---|---|
US (1) | US7638550B2 (pt) |
EP (1) | EP1975158B9 (pt) |
JP (1) | JP4975758B2 (pt) |
CN (1) | CN101351444B (pt) |
AT (1) | ATE516268T1 (pt) |
AU (1) | AU2005339535B2 (pt) |
BR (1) | BRPI0520806A2 (pt) |
CA (1) | CA2635392C (pt) |
CY (1) | CY1111899T1 (pt) |
DK (1) | DK1975158T3 (pt) |
ES (1) | ES2369705T3 (pt) |
HK (1) | HK1125926A1 (pt) |
MX (1) | MX2008008470A (pt) |
PL (1) | PL1975158T3 (pt) |
PT (1) | PT1975158E (pt) |
RU (1) | RU2416600C2 (pt) |
SI (1) | SI1975158T1 (pt) |
WO (1) | WO2007074176A1 (pt) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1874723A2 (en) * | 2005-04-15 | 2008-01-09 | Dominion Pharmakine S.L. | New nitrogenated trans-stilbene analogs, method for the obtention and medical applications thereof |
EP2305643A1 (en) * | 2009-10-02 | 2011-04-06 | Ikerchem, S.L. | New histone deacetylase inhibitors based simultaneously on trisubstituted 1h-pyrroles and aromatic and heteroaromatic spacers |
EP2508510A1 (en) * | 2011-04-06 | 2012-10-10 | Ikerchem, S.L. | Hydroxyphenyl pyrrole compounds containing an hydroxamic acid as hdac inhibitors and medicinal applications thereof |
CN103373969B (zh) * | 2012-04-27 | 2015-09-16 | 中国科学院上海有机化学研究所 | 苯基唑环取代酰胺类化合物及其制备方法和用途 |
DK3297992T3 (da) | 2015-05-22 | 2020-04-20 | Chong Kun Dang Pharmaceutical Corp | Heterocykliske alkylderivatforbindelser som selektive histondeacetylase-inhibitorer og farmaceutiske sammensætninger omfattende samme |
CN106565583A (zh) * | 2016-11-15 | 2017-04-19 | 淮阴师范学院 | 多取代吡咯衍生物的制备方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998025896A1 (en) * | 1996-12-10 | 1998-06-18 | G.D. Searle & Co. | Substituted pyrrolyl compounds for the treatment of inflammation |
JP4191825B2 (ja) * | 1998-09-10 | 2008-12-03 | あすか製薬株式会社 | 5−アミノイソキサゾール誘導体 |
CN1378450A (zh) * | 1999-09-08 | 2002-11-06 | 斯隆-凯特林癌症研究院 | 新型细胞分化剂和组蛋白脱乙酰基酶抑制剂及其使用方法 |
ATE430567T1 (de) * | 2000-09-29 | 2009-05-15 | Topotarget Uk Ltd | Carbaminsäurederivate enthaltend eine amidgruppe zur behandlung von malaria |
US6576612B1 (en) * | 2000-10-02 | 2003-06-10 | Pharmacia Italia S.P.A. | Antitumor therapy comprising distamycin derivatives |
ATE482933T1 (de) | 2003-05-26 | 2010-10-15 | Takeda Pharmaceutical | Sulfopyrrolderivate |
EP1691803A1 (en) * | 2003-12-05 | 2006-08-23 | Warner-Lambert Company LLC | N-alkyl pyrroles as hmg-coa reductase inhibitors |
BRPI0508464B8 (pt) * | 2004-03-11 | 2021-05-25 | Altana Pharma Ag | sulfonilpirróis, composição farmacêutica compreendendo os mesmos e uso dos mesmos |
-
2005
- 2005-12-27 CN CN2005800524523A patent/CN101351444B/zh not_active Expired - Fee Related
- 2005-12-27 EP EP05850516A patent/EP1975158B9/en not_active Not-in-force
- 2005-12-27 ES ES05850516T patent/ES2369705T3/es active Active
- 2005-12-27 AT AT05850516T patent/ATE516268T1/de active
- 2005-12-27 JP JP2008547990A patent/JP4975758B2/ja not_active Expired - Fee Related
- 2005-12-27 WO PCT/ES2005/000708 patent/WO2007074176A1/es active Application Filing
- 2005-12-27 AU AU2005339535A patent/AU2005339535B2/en not_active Ceased
- 2005-12-27 PL PL05850516T patent/PL1975158T3/pl unknown
- 2005-12-27 RU RU2008130876/04A patent/RU2416600C2/ru not_active IP Right Cessation
- 2005-12-27 SI SI200531342T patent/SI1975158T1/sl unknown
- 2005-12-27 US US10/571,497 patent/US7638550B2/en not_active Expired - Fee Related
- 2005-12-27 MX MX2008008470A patent/MX2008008470A/es active IP Right Grant
- 2005-12-27 DK DK05850516.5T patent/DK1975158T3/da active
- 2005-12-27 PT PT05850516T patent/PT1975158E/pt unknown
- 2005-12-27 BR BRPI0520806-8A patent/BRPI0520806A2/pt not_active IP Right Cessation
- 2005-12-27 CA CA2635392A patent/CA2635392C/en not_active Expired - Fee Related
-
2009
- 2009-05-04 HK HK09104096.6A patent/HK1125926A1/xx not_active IP Right Cessation
-
2011
- 2011-10-05 CY CY20111100951T patent/CY1111899T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
ATE516268T1 (de) | 2011-07-15 |
CN101351444A (zh) | 2009-01-21 |
DK1975158T3 (da) | 2011-10-24 |
PL1975158T3 (pl) | 2011-12-30 |
RU2008130876A (ru) | 2010-02-10 |
AU2005339535A1 (en) | 2007-07-05 |
EP1975158A1 (en) | 2008-10-01 |
MX2008008470A (es) | 2008-09-26 |
CA2635392A1 (en) | 2007-07-05 |
HK1125926A1 (en) | 2009-08-21 |
ES2369705T3 (es) | 2011-12-05 |
EP1975158B1 (en) | 2011-07-13 |
PT1975158E (pt) | 2011-09-23 |
EP1975158B9 (en) | 2012-02-29 |
AU2005339535B2 (en) | 2012-02-23 |
EP1975158A4 (en) | 2009-11-11 |
WO2007074176A1 (es) | 2007-07-05 |
US20080262073A1 (en) | 2008-10-23 |
SI1975158T1 (sl) | 2011-10-28 |
CY1111899T1 (el) | 2015-11-04 |
US7638550B2 (en) | 2009-12-29 |
JP2009521519A (ja) | 2009-06-04 |
CN101351444B (zh) | 2011-07-13 |
CA2635392C (en) | 2013-07-23 |
RU2416600C2 (ru) | 2011-04-20 |
JP4975758B2 (ja) | 2012-07-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 10A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |