HK1121768A1 - A method for the mass production of immunoglobulin fc region deleted initial methionine residues - Google Patents
A method for the mass production of immunoglobulin fc region deleted initial methionine residuesInfo
- Publication number
- HK1121768A1 HK1121768A1 HK09101855.3A HK09101855A HK1121768A1 HK 1121768 A1 HK1121768 A1 HK 1121768A1 HK 09101855 A HK09101855 A HK 09101855A HK 1121768 A1 HK1121768 A1 HK 1121768A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- immunoglobulin
- mass production
- region
- methionine residues
- initial methionine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20050074989 | 2005-08-16 | ||
| PCT/KR2006/003207 WO2007021129A1 (en) | 2005-08-16 | 2006-08-16 | A method for the mass production of immunoglobulin fc region deleted initial methionine residues |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1121768A1 true HK1121768A1 (en) | 2009-04-30 |
Family
ID=37757762
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK09101855.3A HK1121768A1 (en) | 2005-08-16 | 2009-02-26 | A method for the mass production of immunoglobulin fc region deleted initial methionine residues |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7968316B2 (xx) |
| EP (1) | EP1928910B1 (xx) |
| JP (2) | JP5846712B2 (xx) |
| CN (1) | CN101258164B (xx) |
| AU (1) | AU2006280587B2 (xx) |
| CA (1) | CA2619771C (xx) |
| DK (1) | DK1928910T3 (xx) |
| ES (1) | ES2456672T3 (xx) |
| HK (1) | HK1121768A1 (xx) |
| MY (1) | MY149128A (xx) |
| PT (1) | PT1928910E (xx) |
| RU (1) | RU2428430C2 (xx) |
| UA (1) | UA97628C2 (xx) |
| WO (1) | WO2007021129A1 (xx) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101835802B (zh) * | 2007-06-01 | 2014-04-09 | 马里兰大学巴尔的摩分校 | 免疫球蛋白恒定区Fc受体结合剂 |
| US9636420B2 (en) * | 2008-07-23 | 2017-05-02 | Hanmi Science Co., Ltd. | Polypeptide complex comprising non-peptidyl polymer having three functional ends |
| AR081066A1 (es) * | 2010-04-02 | 2012-06-06 | Hanmi Holdings Co Ltd | Conjugado de insulina donde se usa un fragmento de inmunoglobulina |
| AU2011282579B2 (en) | 2010-07-28 | 2014-10-23 | Gliknik Inc. | Fusion proteins of natural human protein fragments to create orderly multimerized immunoglobulin Fc compositions |
| KR20130049671A (ko) | 2011-11-04 | 2013-05-14 | 한미사이언스 주식회사 | 생리활성 폴리펩타이드 결합체 제조 방법 |
| AR090281A1 (es) | 2012-03-08 | 2014-10-29 | Hanmi Science Co Ltd | Proceso mejorado para la preparacion de un complejo polipeptidico fisiologicamente activo |
| DK2825633T3 (da) * | 2012-03-12 | 2019-05-20 | Hanmi Science Co Ltd | Fremgangsmåde til dyrkning af E. coli-celler til høj densitet |
| KR102073748B1 (ko) * | 2013-01-31 | 2020-02-05 | 한미약품 주식회사 | 재조합 효모 형질전환체 및 이를 이용하여 면역글로불린 단편을 생산하는 방법 |
| KR101895634B1 (ko) | 2013-05-31 | 2018-09-05 | 한미약품 주식회사 | 변이된 힌지 영역을 포함하는 IgG4 Fc 단편 |
| KR102231217B1 (ko) * | 2015-09-24 | 2021-03-24 | 한미약품 주식회사 | 면역글로불린 단편의 특정 위치를 연결 부위로 이용한 단백질 결합체 |
| KR20170037247A (ko) * | 2015-09-25 | 2017-04-04 | 한미약품 주식회사 | 개시 메티오닌 잔기를 포함하는 면역글로불린 Fc 영역의 생산방법 |
| CA3026420A1 (en) | 2016-06-07 | 2017-12-14 | Gliknik Inc. | Cysteine-optimized stradomers |
| US20200078470A1 (en) | 2016-12-05 | 2020-03-12 | Hanmi Pharm. Co., Ltd. | Conjugate with attenuated immune response |
| AU2017371179B2 (en) | 2016-12-09 | 2022-07-14 | Gliknik Inc. | Manufacturing optimization of GL-2045, a multimerizing stradomer |
| BR112019009495A2 (pt) | 2016-12-09 | 2019-08-06 | Gliknik Inc | métodos de tratamento de distúrbios inflamatórios com compostos de fc multivalentes |
| CN110305874A (zh) * | 2019-06-19 | 2019-10-08 | 浙江省肿瘤医院 | 长爪沙鼠免疫球蛋白IgG1、IgG2重组蛋白、基因及其应用 |
| KR102478588B1 (ko) * | 2019-07-18 | 2022-12-16 | 한미약품 주식회사 | 신규 중간체 제조를 통한 지속형 약물 결합체의 제조 방법 |
| KR20210144606A (ko) | 2020-05-22 | 2021-11-30 | 한미약품 주식회사 | 글루카곤 유도체의 지속형 결합체의 액상 제제 |
| IL298415A (en) | 2020-05-22 | 2023-01-01 | Hanmi Pharm Ind Co Ltd | Liquid formulations of long-acting conjugate of glucagon, glp-1, and gip trigonal agonist |
| CN116096397A (zh) | 2020-07-15 | 2023-05-09 | 韩美药品株式会社 | 胰高血糖素衍生物或其缀合物对于肝脏疾病的治疗用途 |
| WO2022015115A1 (ko) | 2020-07-17 | 2022-01-20 | 한미약품 주식회사 | 3중 작용성 지속형 결합체 또는 3중 작용제를 포함하는 조합물의 치료학적 용도 |
| BR112023019917A2 (pt) | 2021-04-09 | 2023-11-14 | Hanmi Pharm Ind Co Ltd | Uso de uma composição farmacêutica |
| KR20230095666A (ko) | 2021-12-22 | 2023-06-29 | 한미약품 주식회사 | 간 표적 물질 및 이의 용도 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62153300A (ja) * | 1985-12-26 | 1987-07-08 | Teijin Ltd | ヒト免疫グロブリンＧＦｃ領域蛋白質およびその製造方法 |
| JPS63290899A (ja) * | 1987-05-22 | 1988-11-28 | Takeda Chem Ind Ltd | ヒトＩｇＥＦｃ蛋白質のフラグメントおよびその製造法 |
| JP2844870B2 (ja) * | 1989-07-21 | 1999-01-13 | 味の素株式会社 | 組み替えｄｎａ法によるポリペプチドの製造法 |
| US5605690A (en) * | 1989-09-05 | 1997-02-25 | Immunex Corporation | Methods of lowering active TNF-α levels in mammals using tumor necrosis factor receptor |
| JP2845558B2 (ja) * | 1990-03-30 | 1999-01-13 | ダイセル化学工業株式会社 | メチオニンアミノペプチダーゼのｄｎａ配列 |
| US5349053A (en) | 1990-06-01 | 1994-09-20 | Protein Design Labs, Inc. | Chimeric ligand/immunoglobulin molecules and their uses |
| ES2120949T4 (es) | 1990-06-28 | 2011-12-29 | Sanofi-Aventis Deutschland Gmbh 50% | Proteinas de fusión con porciones de inmunoglobulinas, su preparación y empleo. |
| US7253264B1 (en) * | 1990-06-28 | 2007-08-07 | Sanofi-Arentideutschland GmbH | Immunoglobulin fusion proteins, their production and use |
| GB9206422D0 (en) * | 1992-03-24 | 1992-05-06 | Bolt Sarah L | Antibody preparation |
| JP3512237B2 (ja) * | 1994-07-05 | 2004-03-29 | タカラバイオ株式会社 | 耐熱性メチオニンアミノペプチダーゼ及びその遺伝子 |
| US6030613A (en) * | 1995-01-17 | 2000-02-29 | The Brigham And Women's Hospital, Inc. | Receptor specific transepithelial transport of therapeutics |
| US5723125A (en) | 1995-12-28 | 1998-03-03 | Tanox Biosystems, Inc. | Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide |
| US6315824B1 (en) * | 1996-02-02 | 2001-11-13 | Rodrigue V. Lauzon | Coacervate stabilizer system |
| AU8182298A (en) | 1997-07-10 | 1999-02-08 | Beth Israel Deaconess Medical Center | Recombinant erythropoietin / immunoglobulin fusion proteins |
| US6165476A (en) * | 1997-07-10 | 2000-12-26 | Beth Israel Deaconess Medical Center | Fusion proteins with an immunoglobulin hinge region linker |
| US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| CA2372400C (en) | 1999-05-19 | 2010-04-27 | Lexigen Pharmaceuticals Corp. | Expression and export of interferon-alpha proteins as fc fusion proteins |
| EP1200124B1 (en) | 1999-07-13 | 2008-09-10 | Bolder Biotechnology, Inc. | Erythropoietin-immunoglobulin fusion proteins |
| US20030144187A1 (en) * | 1999-09-03 | 2003-07-31 | Colin R. Dunstan | Opg fusion protein compositions and methods |
| US6979556B2 (en) * | 2000-12-14 | 2005-12-27 | Genentech, Inc. | Separate-cistron contructs for secretion of aglycosylated antibodies from prokaryotes |
| US6900292B2 (en) * | 2001-08-17 | 2005-05-31 | Lee-Hwei K. Sun | Fc fusion proteins of human erythropoietin with increased biological activities |
| US6797493B2 (en) | 2001-10-01 | 2004-09-28 | Lee-Hwei K. Sun | Fc fusion proteins of human granulocyte colony-stimulating factor with increased biological activities |
| KR20040092783A (ko) | 2003-04-29 | 2004-11-04 | 매그나칩 반도체 유한회사 | 비터비 알고리즘을 이용한 트렐리스 디코더와 그의스테이트 그룹핑방법 |
| WO2005047334A1 (en) | 2003-11-13 | 2005-05-26 | Hanmi Pharmaceutical. Co., Ltd. | Igg fc fragment for a drug carrier and method for the preparation thereof |
| ATE506433T1 (de) * | 2003-12-19 | 2011-05-15 | Novo Nordisk As | Prozessierung von peptiden und proteinen |
-
2006
- 2006-08-16 EP EP06783620.5A patent/EP1928910B1/en active Active
- 2006-08-16 US US12/063,379 patent/US7968316B2/en active Active
- 2006-08-16 CN CN2006800297115A patent/CN101258164B/zh active Active
- 2006-08-16 MY MYPI20080247A patent/MY149128A/en unknown
- 2006-08-16 PT PT67836205T patent/PT1928910E/pt unknown
- 2006-08-16 CA CA2619771A patent/CA2619771C/en active Active
- 2006-08-16 JP JP2008526876A patent/JP5846712B2/ja active Active
- 2006-08-16 WO PCT/KR2006/003207 patent/WO2007021129A1/en active Application Filing
- 2006-08-16 UA UAA200803277A patent/UA97628C2/ru unknown
- 2006-08-16 AU AU2006280587A patent/AU2006280587B2/en active Active
- 2006-08-16 DK DK06783620.5T patent/DK1928910T3/en active
- 2006-08-16 RU RU2008110050/10A patent/RU2428430C2/ru active
- 2006-08-16 ES ES06783620.5T patent/ES2456672T3/es active Active
-
2009
- 2009-02-26 HK HK09101855.3A patent/HK1121768A1/xx unknown
-
2014
- 2014-03-26 JP JP2014063351A patent/JP2014110816A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1928910B1 (en) | 2014-01-15 |
| JP2009513110A (ja) | 2009-04-02 |
| CN101258164B (zh) | 2013-05-01 |
| US20080293106A1 (en) | 2008-11-27 |
| US7968316B2 (en) | 2011-06-28 |
| BRPI0614516A2 (pt) | 2011-03-29 |
| EP1928910A4 (en) | 2010-03-24 |
| UA97628C2 (ru) | 2012-03-12 |
| WO2007021129A1 (en) | 2007-02-22 |
| CA2619771A1 (en) | 2007-02-22 |
| PT1928910E (pt) | 2014-03-06 |
| MY149128A (en) | 2013-07-15 |
| CN101258164A (zh) | 2008-09-03 |
| CA2619771C (en) | 2012-05-22 |
| DK1928910T3 (en) | 2014-03-10 |
| AU2006280587A1 (en) | 2007-02-22 |
| JP5846712B2 (ja) | 2016-01-20 |
| RU2428430C2 (ru) | 2011-09-10 |
| EP1928910A1 (en) | 2008-06-11 |
| AU2006280587B2 (en) | 2011-02-24 |
| JP2014110816A (ja) | 2014-06-19 |
| RU2008110050A (ru) | 2009-09-27 |
| ES2456672T3 (es) | 2014-04-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CHRG | Changes in the register |
Free format text: CORRECTION OF THE CHINESE NAME OF INVENTOR |