HK1121084A1 - Thioninium compounds and their use - Google Patents

Thioninium compounds and their use

Info

Publication number
HK1121084A1
HK1121084A1 HK09100375.6A HK09100375A HK1121084A1 HK 1121084 A1 HK1121084 A1 HK 1121084A1 HK 09100375 A HK09100375 A HK 09100375A HK 1121084 A1 HK1121084 A1 HK 1121084A1
Authority
HK
Hong Kong
Prior art keywords
thioninium
compounds
thioninium compounds
Prior art date
Application number
HK09100375.6A
Other languages
English (en)
Chinese (zh)
Inventor
Claude Michel Wischik
Janet Elizabeth Rickard
Charles Robert Harrington
David Horsley
John Mervyn David Storey
Colin Marshall
James Peter Sinclair
Original Assignee
Wista Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wista Lab Ltd filed Critical Wista Lab Ltd
Publication of HK1121084A1 publication Critical patent/HK1121084A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HK09100375.6A 2006-03-29 2009-01-14 Thioninium compounds and their use HK1121084A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78669906P 2006-03-29 2006-03-29
PCT/GB2007/001107 WO2007110630A1 (en) 2006-03-29 2007-03-28 Thioninium compounds and their use

Publications (1)

Publication Number Publication Date
HK1121084A1 true HK1121084A1 (en) 2009-04-17

Family

ID=38163667

Family Applications (2)

Application Number Title Priority Date Filing Date
HK09100375.6A HK1121084A1 (en) 2006-03-29 2009-01-14 Thioninium compounds and their use
HK15108741.8A HK1208000A1 (en) 2006-03-29 2015-09-08 Thioninium compounds and their use

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK15108741.8A HK1208000A1 (en) 2006-03-29 2015-09-08 Thioninium compounds and their use

Country Status (14)

Country Link
EP (2) EP2853293B1 (hr)
JP (1) JP5184507B2 (hr)
CN (2) CN101460222B (hr)
AU (1) AU2007231127B2 (hr)
CA (1) CA2645919C (hr)
DK (2) DK2853293T3 (hr)
ES (2) ES2525001T3 (hr)
HK (2) HK1121084A1 (hr)
HR (2) HRP20141261T1 (hr)
MY (2) MY172157A (hr)
PL (2) PL2853293T3 (hr)
PT (2) PT2853293T (hr)
SI (2) SI2853293T1 (hr)
WO (1) WO2007110630A1 (hr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5725605B2 (ja) * 2007-06-19 2015-05-27 ウイスタ・ラボラトリーズ・リミテッドＷｉｓｔａ Ｌａｂｏｒａｔｏｒｉｅｓ Ｌｔｄ． 軽度認知障害を処置するためのフェノチアジン化合物
WO2010067078A2 (en) * 2008-12-10 2010-06-17 Wista Laboratories Ltd. 3,6-disubstituted xanthylium salts as medicaments
CN102958525B (zh) 2010-04-30 2017-05-24 普罗瑟塔抗病毒股份有限公司 抗病毒化合物
HUE031633T2 (en) 2011-02-11 2017-07-28 Wista Lab Ltd Phenothiazine diaminium salts and their use
CN102690244A (zh) * 2011-03-22 2012-09-26 中国科学院上海生命科学研究院 调节α-突触核蛋白积聚的物质及其制药用途
WO2012145567A1 (en) 2011-04-20 2012-10-26 Prosetta Antiviral Inc. Antiviral compounds
GB201317702D0 (en) * 2013-10-07 2013-11-20 Wista Lab Ltd Methods of chemical synthesis of diaminophenothiazinium compounds including methylthioninium chloride (MTC)
GB201512678D0 (en) 2015-07-20 2015-08-26 Wista Lab Ltd Methods of chemical synthesis
SG11201900228YA (en) 2016-07-25 2019-02-27 Wista Lab Ltd Administration and dosage of diaminophenothiazines
GB201614834D0 (en) * 2016-09-01 2016-10-19 Wista Lab Ltd Treatment of dementia
GB201621817D0 (en) 2016-12-21 2017-02-01 Wista Lab Ltd Methods of chemical synthesis
EP3826639A1 (en) 2018-07-26 2021-06-02 WisTa Laboratories Ltd. Optimised dosage of diaminophenothiazines in populations
US20220049102A1 (en) * 2019-09-21 2022-02-17 RK Pharma Solutions LLC Process for the Purification of Methylene Blue
GB202010652D0 (en) 2020-07-10 2020-08-26 Wista Lab Ltd Anti-tau antibodies
WO2023232764A1 (en) 2022-05-31 2023-12-07 Wista Laboratories Ltd. Treatment of neurodegenerative disorders utilising methylthioninium (mt)-containing compounds
WO2024061971A1 (en) 2022-09-21 2024-03-28 Wista Laboratories Ltd. Novel formulations and vehicles

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996004915A1 (en) * 1994-08-08 1996-02-22 Albert Einstein College Of Medicine Of Yeshiva University Methods for treating and/or preventing alzheimer's disease using phenothiazines and/or thioxanthenes
GB9506197D0 (en) 1995-03-27 1995-05-17 Hoffmann La Roche Inhibition of tau-tau association.
JP2000344685A (ja) * 1999-03-26 2000-12-12 Bf Kenkyusho:Kk アズールａ類似化合物によるアミロイドが蓄積する疾患の画像診断プローブおよびそれを含む画像診断用組成物
GB0101049D0 (en) * 2001-01-15 2001-02-28 Univ Aberdeen Materials and methods relating to protein aggregation in neurodegenerative disease
GB0106953D0 (en) * 2001-03-20 2001-05-09 Univ Aberdeen Neufofibrillary labels
GB0322756D0 (en) 2003-09-29 2003-10-29 Univ Aberdeen Methods of chemical synthesis
JP2007512297A (ja) * 2003-11-28 2007-05-17 フォトファーマイカ リミテッド 生物活性メチレンブルー誘導体（２）における開発
PT1799662E (pt) 2004-09-23 2013-07-09 Wista Lab Ltd Métodos de síntese química e purificação de compostos de diaminofenotiazínio incluindo cloreto de metiltionínio (mtc)
CN101084204B (zh) 2004-09-23 2012-12-05 卫思道制药有限公司 包括亚甲蓝(mtc)在内的二氨基吩噻嗪鎓化合物的化学合成和纯化方法

Also Published As

Publication number Publication date
DK2001556T3 (da) 2014-11-10
ES2659030T3 (es) 2018-03-13
HRP20180204T1 (hr) 2018-03-09
EP2853293A1 (en) 2015-04-01
EP2853293B1 (en) 2017-11-22
PT2853293T (pt) 2018-02-13
CN103641794A (zh) 2014-03-19
SI2853293T1 (en) 2018-03-30
DK2853293T3 (en) 2018-01-22
MY162640A (en) 2017-06-30
AU2007231127A1 (en) 2007-10-04
AU2007231127B2 (en) 2013-03-14
MY172157A (en) 2019-11-15
CN103641794B (zh) 2016-09-21
JP2009531405A (ja) 2009-09-03
CA2645919A1 (en) 2007-10-04
HRP20141261T1 (en) 2015-03-13
PT2001556E (pt) 2014-12-09
PL2001556T3 (pl) 2015-03-31
PL2853293T3 (pl) 2018-05-30
EP2001556B1 (en) 2014-10-01
SI2001556T1 (sl) 2014-12-31
ES2525001T3 (es) 2014-12-16
WO2007110630A1 (en) 2007-10-04
CN101460222A (zh) 2009-06-17
CA2645919C (en) 2016-05-31
JP5184507B2 (ja) 2013-04-17
CN101460222B (zh) 2013-12-04
EP2001556A1 (en) 2008-12-17
HK1208000A1 (en) 2016-02-19

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