HK1117548A1 - Ob-fold used as scaffold for engineering new specific binders - Google Patents

Ob-fold used as scaffold for engineering new specific binders

Info

Publication number
HK1117548A1
HK1117548A1 HK08111475.3A HK08111475A HK1117548A1 HK 1117548 A1 HK1117548 A1 HK 1117548A1 HK 08111475 A HK08111475 A HK 08111475A HK 1117548 A1 HK1117548 A1 HK 1117548A1
Authority
HK
Hong Kong
Prior art keywords
scaffold
new specific
specific binders
engineering new
fold used
Prior art date
Application number
HK08111475.3A
Other languages
English (en)
Inventor
Frederic Pecorari
Pedro Alzari
Original Assignee
Pasteur Institut
Centre Nat Rech Scient
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pasteur Institut, Centre Nat Rech Scient filed Critical Pasteur Institut
Publication of HK1117548A1 publication Critical patent/HK1117548A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1041—Ribosome/Polysome display, e.g. SPERT, ARM
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1228—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1228—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K16/1232—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia from Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polyurethanes Or Polyureas (AREA)
HK08111475.3A 2006-12-04 2008-10-16 Ob-fold used as scaffold for engineering new specific binders HK1117548A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06291869A EP1930342B1 (en) 2006-12-04 2006-12-04 OB-fold used as scaffold for engineering new specific binders

Publications (1)

Publication Number Publication Date
HK1117548A1 true HK1117548A1 (en) 2009-01-16

Family

ID=37964126

Family Applications (2)

Application Number Title Priority Date Filing Date
HK08111475.3A HK1117548A1 (en) 2006-12-04 2008-10-16 Ob-fold used as scaffold for engineering new specific binders
HK10107761.0A HK1141304A1 (en) 2006-12-04 2010-08-13 Ob-fold used as scaffold for engineering new specific binders ob-fold

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK10107761.0A HK1141304A1 (en) 2006-12-04 2010-08-13 Ob-fold used as scaffold for engineering new specific binders ob-fold

Country Status (13)

Country Link
US (4) US20100145008A1 (xx)
EP (3) EP1930342B1 (xx)
JP (3) JP2010511691A (xx)
CN (2) CN103145812A (xx)
AT (1) ATE542830T1 (xx)
AU (1) AU2007330409B2 (xx)
CA (1) CA2671553C (xx)
DK (1) DK2099817T3 (xx)
ES (2) ES2536509T3 (xx)
HK (2) HK1117548A1 (xx)
IL (1) IL199057A (xx)
MX (1) MX2009005949A (xx)
WO (1) WO2008068637A2 (xx)

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JP5851842B2 (ja) 2009-01-12 2016-02-03 サイトムエックス セラピューティクス, インク.CytomX Therapeutics, Inc. 改変した抗体組成物、それを作製および使用する方法
AU2010215761B2 (en) * 2009-02-23 2017-04-06 Cytomx Therapeutics, Inc Proproteins and methods of use thereof
SG179200A1 (en) * 2009-09-16 2012-04-27 Univ Massey Fusion polypeptides and uses thereof
EP2341079A1 (en) 2009-12-23 2011-07-06 Institut Pasteur Immunoglobulin-binding proteins derived from Sac7d and uses thereof
EP2469278A1 (en) 2010-12-21 2012-06-27 Institut Pasteur Reagentless fluorescent biosensors from nanofitins, rational design methods to create reagentless fluorescent biosensors and methods of their use
FR2974816A1 (fr) 2011-05-04 2012-11-09 Centre Nat Rech Scient Methode de generation de proteines
EP3489396B1 (en) 2012-12-27 2021-03-03 National Institute of Advanced Industrial Science and Technology Molecule library constructed on the basis of backbone structure of microprotein
FR3004650B1 (fr) * 2013-04-22 2015-05-29 Affilogic Composition topique comprenant un variant d'une protéine sauvage à pli-OB, ainsi que son procédé de préparation
EP2955196A1 (en) 2014-06-10 2015-12-16 Effimune Antibodies directed against CD127
CN114057857A (zh) 2014-06-20 2022-02-18 豪夫迈·罗氏有限公司 基于chagasin的支架组合物、方法和应用
FR3027521B1 (fr) * 2014-10-24 2016-12-16 Affilogic Compositions pour administration par voie orale
CA2980189A1 (en) 2015-04-24 2016-10-27 Genentech, Inc. Multispecific antigen-binding proteins
JP7053479B2 (ja) 2016-02-29 2022-04-12 オセ イムノセラピューティクス ＩＬ７受容体細胞外ドメインα鎖に対する非拮抗性抗体及び癌治療におけるそれらの使用
EP3509616A1 (en) 2016-09-09 2019-07-17 H. Hoffnabb-La Roche Ag Selective peptide inhibitors of frizzled
CA3051318A1 (en) 2017-02-17 2018-08-23 Ose Immunotherapeutics New uses of anti-sirpg antibodies
EP3434692A1 (en) 2017-07-24 2019-01-30 Encefa Compounds which specifically binds to cd38 for use in the treatment of neurodegenerative diseases
WO2019073080A1 (en) 2017-10-13 2019-04-18 Ose Immunotherapeutics ANTI-SIRPA MODIFIED ANTIBODIES AND USES THEREOF
EP3483180A1 (en) 2017-11-14 2019-05-15 Affilogic Multi specific molecules
BR112020011768A2 (pt) 2017-12-15 2020-11-17 Syngenta Participations Ag ligantes diferentes de anticorpos para detecção de proteínas alvo
AU2019233577A1 (en) 2018-03-13 2020-09-03 Ose Immunotherapeutics Use of anti-human SIRPa v1 antibodies and method for producing anti-SIRPa v1 antibodies
WO2019193029A1 (en) 2018-04-03 2019-10-10 Ose Immunotherapeutics Anti-chemokin like receptor 1 antibodies and their therapeutic applications
US20230242640A1 (en) 2018-08-22 2023-08-03 Ose Immunotherapeutics ANTI-SIRPg Compounds
EP3632924A1 (en) * 2018-10-07 2020-04-08 Affilogic Binders for inhibiting formation of multimeric proteins
BR112021012027A2 (pt) 2018-12-21 2021-11-03 Ose Immunotherapeutics Molécula bifuncional direcionada contra pd-1 humano
WO2020152290A1 (en) 2019-01-23 2020-07-30 Encefa Cd31 competitors and uses thereof
CN113795514A (zh) 2019-05-09 2021-12-14 豪夫迈·罗氏有限公司 制备抗体的方法
WO2020231504A1 (en) 2019-05-16 2020-11-19 Massachusetts Institute Of Technology Glycan-binding proteins and related compositions and methods
EP4077367A1 (en) * 2019-12-18 2022-10-26 Bracco Imaging SPA Anti-her2 polypeptides derivatives as new diagnostic molecular probes
EP3878858A1 (en) * 2020-03-11 2021-09-15 Affilogic Variants of sac7d and their use in cancer therapy
GB202019817D0 (en) * 2020-12-15 2021-01-27 Univ Oxford Innovation Ltd Ligand-binding polypeptides and uses thereof
EP4043481A1 (en) * 2021-02-15 2022-08-17 Affilogic Compounds and methods for extending half life of biomolecules
JP2024513711A (ja) 2021-03-18 2024-03-27 アフィロジック 抗ｃ３因子ｓａｃ７ｄバリアントおよびその補体介在性障害を治療するための医学的使用
EP4059949A1 (en) 2021-03-18 2022-09-21 Affilogic Anti-factor c3 sac7d variants and their medical use for treating complement-mediated disorders
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WO2023140360A1 (ja) * 2022-01-20 2023-07-27 京都府公立大学法人 抗体模倣分子

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Also Published As

Publication number Publication date
JP6684761B2 (ja) 2020-04-22
WO2008068637A2 (en) 2008-06-12
EP1930342B1 (en) 2012-01-25
ES2536509T3 (es) 2015-05-26
WO2008068637A3 (en) 2008-10-30
JP2014169304A (ja) 2014-09-18
EP2099817B1 (en) 2015-02-11
CN101652386B (zh) 2013-03-20
EP2570424B1 (en) 2016-09-28
EP2570424A1 (en) 2013-03-20
US20160010083A1 (en) 2016-01-14
JP2018035139A (ja) 2018-03-08
AU2007330409A1 (en) 2008-06-12
ATE542830T1 (de) 2012-02-15
EP1930342A1 (en) 2008-06-11
US20170166887A1 (en) 2017-06-15
EP2099817A2 (en) 2009-09-16
US20100145008A1 (en) 2010-06-10
HK1141304A1 (en) 2010-11-05
IL199057A (en) 2016-02-29
DK2099817T3 (en) 2015-05-18
CN103145812A (zh) 2013-06-12
AU2007330409B2 (en) 2013-04-18
US10584330B2 (en) 2020-03-10
CA2671553C (en) 2017-09-05
US11434585B2 (en) 2022-09-06
CA2671553A1 (en) 2008-06-12
US20200181601A1 (en) 2020-06-11
US9422548B2 (en) 2016-08-23
JP6253496B2 (ja) 2017-12-27
MX2009005949A (es) 2009-06-30
CN101652386A (zh) 2010-02-17
JP2010511691A (ja) 2010-04-15
ES2602782T3 (es) 2017-02-22

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