HK1117541A1 - Template-fixed peptidomimeticsas inhibitors of serine proteases - Google Patents

Template-fixed peptidomimeticsas inhibitors of serine proteases

Info

Publication number
HK1117541A1
HK1117541A1 HK08107766.9A HK08107766A HK1117541A1 HK 1117541 A1 HK1117541 A1 HK 1117541A1 HK 08107766 A HK08107766 A HK 08107766A HK 1117541 A1 HK1117541 A1 HK 1117541A1
Authority
HK
Hong Kong
Prior art keywords
template
fixed
serine proteases
peptidomimeticsas
inhibitors
Prior art date
Application number
HK08107766.9A
Other languages
English (en)
Inventor
D Obrecht
J A Robinson
A Descours
Original Assignee
Polyphor Ltd
Univ Zuerich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polyphor Ltd, Univ Zuerich filed Critical Polyphor Ltd
Publication of HK1117541A1 publication Critical patent/HK1117541A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
HK08107766.9A 2001-12-11 2008-07-15 Template-fixed peptidomimeticsas inhibitors of serine proteases HK1117541A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2001/014528 WO2003054000A1 (en) 2001-12-11 2001-12-11 Template-fixed peptidomimeticsas inhibitors of serine proteases

Publications (1)

Publication Number Publication Date
HK1117541A1 true HK1117541A1 (en) 2009-01-16

Family

ID=8164720

Family Applications (1)

Application Number Title Priority Date Filing Date
HK08107766.9A HK1117541A1 (en) 2001-12-11 2008-07-15 Template-fixed peptidomimeticsas inhibitors of serine proteases

Country Status (11)

Country Link
US (1) US7417024B2 (xx)
EP (1) EP1458747B1 (xx)
JP (1) JP4098244B2 (xx)
CN (3) CN101157924A (xx)
AT (1) ATE422501T1 (xx)
AU (1) AU2002234564C1 (xx)
BR (2) BR0117190A (xx)
CA (1) CA2466591C (xx)
DE (1) DE60137654D1 (xx)
HK (1) HK1117541A1 (xx)
WO (1) WO2003054000A1 (xx)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7838496B2 (en) 2003-05-02 2010-11-23 Polyphor Ag/Ltd. Template-fixed peptidomimetics as medicaments against HIV and cancer
AU2003232253A1 (en) 2003-05-02 2004-11-23 Polyphor Ag Template-fixed beta-hairpin peptidomimetics with cxcr4 antagonizing activity
DE602004025569D1 (de) 2003-06-18 2010-04-01 Tranzyme Pharma Inc Makrozyklische motilin rezeptorantagonisten
EP1689863B1 (en) * 2003-11-15 2014-05-28 Polyphor Ltd. Template fixed beta-hairpin loop mimetics and their use in phage display
CA2598360C (en) * 2005-02-17 2016-12-20 Polyphor Ltd. Template-fixed beta-hairpin peptidomimetics with protease inhibitory activity
CN105111280B (zh) * 2005-02-17 2020-01-24 波利弗尔有限公司 具有蛋白酶抑制活性的模板固定的β-发夹肽模拟物
WO2007079597A1 (en) * 2006-01-16 2007-07-19 Polyphor Ltd. Template - fixed peptidomimetics with antimicrobial activity
ES2425575T3 (es) 2007-01-29 2013-10-16 Polyphor Ltd. Peptidomiméticos fijados a una matriz
PT2118123E (pt) 2007-01-31 2016-02-10 Harvard College Péptidos de p53 estabilizados e suas utilizações
EA017583B1 (ru) 2007-02-28 2013-01-30 Полифор Лтд. Закрепленные на матрице пептидомиметики
EP2508531B1 (en) 2007-03-28 2016-10-19 President and Fellows of Harvard College Stitched polypeptides
PT2603600T (pt) 2010-08-13 2019-02-27 Aileron Therapeutics Inc Macrociclos peptidomiméticos
CA2852468A1 (en) 2011-10-18 2013-04-25 Aileron Therapeutics, Inc. Peptidomimetic macrocyles
CA2864120A1 (en) 2012-02-15 2013-08-22 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
RU2017145921A (ru) 2012-02-15 2019-02-21 Эйлерон Терапьютикс, Инк. Пептидомиметические макроциклы
BR112015009470A2 (pt) 2012-11-01 2019-12-17 Aileron Therapeutics Inc aminoácidos dissubstituídos e seus métodos de preparação e uso
WO2015096872A1 (en) * 2013-12-27 2015-07-02 Polyphor Ag Beta-hairpin peptidomimetics as selective elastase inhibitors
NZ722025A (en) * 2013-12-27 2019-06-28 Polyphor Ag Beta-hairpin peptidomimetics as selective elastase inhibitors
CN112972378A (zh) 2014-09-24 2021-06-18 艾瑞朗医疗公司 拟肽大环化合物及其制剂
SG11201702223UA (en) 2014-09-24 2017-04-27 Aileron Therapeutics Inc Peptidomimetic macrocycles and uses thereof
BR112017019738A2 (pt) 2015-03-20 2018-05-29 Aileron Therapeutics Inc macrociclos peptidomiméticos e usos dos mesmos
WO2017044633A1 (en) 2015-09-10 2017-03-16 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of mcl-1

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1367789B (zh) 1999-08-30 2012-06-06 波利弗尔股份公司 模板固定的β-发夹环模拟物的合成

Also Published As

Publication number Publication date
ATE422501T1 (de) 2009-02-15
JP2005524613A (ja) 2005-08-18
CN101157720B (zh) 2012-04-04
CN1582296A (zh) 2005-02-16
CA2466591A1 (en) 2003-07-03
AU2002234564B2 (en) 2008-11-06
DE60137654D1 (de) 2009-03-26
JP4098244B2 (ja) 2008-06-11
CN101157924A (zh) 2008-04-09
EP1458747B1 (en) 2009-02-11
CA2466591C (en) 2012-09-25
BRPI0117190B1 (pt) 2018-10-23
AU2002234564A1 (en) 2003-07-09
US7417024B2 (en) 2008-08-26
CN101157720A (zh) 2008-04-09
AU2002234564C1 (en) 2009-07-02
WO2003054000A1 (en) 2003-07-03
EP1458747A1 (en) 2004-09-22
US20050187145A1 (en) 2005-08-25
BR0117190A (pt) 2004-10-13

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20181207