ATE423108T1 - Nitrile verwendbar als reversible cystein- protease inhibitoren - Google Patents

Nitrile verwendbar als reversible cystein- protease inhibitoren

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Publication number
ATE423108T1
ATE423108T1 AT02741825T AT02741825T ATE423108T1 AT E423108 T1 ATE423108 T1 AT E423108T1 AT 02741825 T AT02741825 T AT 02741825T AT 02741825 T AT02741825 T AT 02741825T AT E423108 T1 ATE423108 T1 AT E423108T1
Authority
AT
Austria
Prior art keywords
compounds
reversible
nitriles
protease inhibitors
cystein protease
Prior art date
Application number
AT02741825T
Other languages
English (en)
Inventor
Eugene R Hickey
Younes Bekkali
Usha R Patel
Denice M Spero
David S Thomson
Erick R R Young
Original Assignee
Boehringer Ingelheim Pharma
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Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Application granted granted Critical
Publication of ATE423108T1 publication Critical patent/ATE423108T1/de

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    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84Nitriles
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    • C07C255/24Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/29Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton containing cyano groups and acylated amino groups bound to the carbon skeleton
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AT02741825T 2001-06-08 2002-06-05 Nitrile verwendbar als reversible cystein- protease inhibitoren ATE423108T1 (de)

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US29686301P 2001-06-08 2001-06-08

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ATE423108T1 true ATE423108T1 (de) 2009-03-15

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US (1) US6982263B2 (de)
EP (1) EP1399431B1 (de)
JP (1) JP4309251B2 (de)
AT (1) ATE423108T1 (de)
CA (1) CA2449192C (de)
DE (1) DE60231207D1 (de)
ES (1) ES2319396T3 (de)
MX (1) MXPA03011113A (de)
WO (1) WO2002100849A2 (de)

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MXPA03005601A (es) 2000-12-22 2004-12-02 Axys Pharm Inc Nuevos compuestos y composiciones como inhibidores de catepsina.
DE10141650C1 (de) 2001-08-24 2002-11-28 Lohmann Therapie Syst Lts Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen
CN1324008C (zh) 2001-09-14 2007-07-04 安万特药物公司 作为组织蛋白酶抑制剂的新化合物和组合物
WO2003042197A1 (en) 2001-11-14 2003-05-22 Aventis Pharmaceuticals Inc. Oligopeptides and compositions containing them as cathepsin s inhibitors
US7326719B2 (en) * 2003-03-13 2008-02-05 Boehringer Ingelheim Pharmaceuticals, Inc. Cathepsin S inhibitors
US7297714B2 (en) * 2003-10-21 2007-11-20 Irm Llc Inhibitors of cathepsin S
RU2346943C2 (ru) 2003-10-24 2009-02-20 Авентис Фармасьютикалз Инк. Новые соединения и композиции в качестве ингибиторов катепсина
FR2866884B1 (fr) * 2004-02-26 2007-08-31 Sanofi Synthelabo Derives d'aryl-et d'heteroaryl-piperidinecarboxylates, leur preparation et leur application en therapeutique
TW200533398A (en) * 2004-03-29 2005-10-16 Bristol Myers Squibb Co Novel therapeutic agents for the treatment of migraine
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US20030119827A1 (en) 2003-06-26
CA2449192A1 (en) 2002-12-19
EP1399431B1 (de) 2009-02-18
WO2002100849A3 (en) 2003-10-16
EP1399431A2 (de) 2004-03-24
MXPA03011113A (es) 2004-03-19
ES2319396T3 (es) 2009-05-07
CA2449192C (en) 2010-10-26
US6982263B2 (en) 2006-01-03

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