BR0117190A - Composto, composição farmacêutica, uso do composto, e, processo para fabricá-lo - Google Patents

Composto, composição farmacêutica, uso do composto, e, processo para fabricá-lo

Info

Publication number
BR0117190A
BR0117190A BR0117190-9A BR0117190A BR0117190A BR 0117190 A BR0117190 A BR 0117190A BR 0117190 A BR0117190 A BR 0117190A BR 0117190 A BR0117190 A BR 0117190A
Authority
BR
Brazil
Prior art keywords
compound
template
amino acid
beta
manufacturing
Prior art date
Application number
BR0117190-9A
Other languages
English (en)
Inventor
Daniel Obrecht
John Anthony Robinson
Anne Descours
Original Assignee
Polyphor Ltd
Universitot Z Rich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polyphor Ltd, Universitot Z Rich filed Critical Polyphor Ltd
Publication of BR0117190A publication Critical patent/BR0117190A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Detergent Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

"COMPOSTO, COMPOSIçãO FARMACêUTICA, USO DO COMPOSTO, E, PROCESSO PARA FABRICá-LO". Peptideomiméticos de grampo-de-cabelo <225> fixados-a-gabarito da fórmula geral em que Z é uma cadeia fixa-ao-gabarito de 7 ou 11 radicais de aminoácidos <244> que, dependendo de suas posições na cadeia (contadas partindo do aminoácido N-terminal) são Gly, ou Pro, ou de determinados tipos que, como os símbolos remanescentes nas fórmulas acima, são definidos na descrição e nas reivindicações, e seus sais, apresentam a propriedade de inbir proteases, em particular serina proteases. Estes peptideomiméticos de grampo-de-cabelo em <225> podem ser fabricados por meio de um processo que se baseia em uma estratégia sintética mista de fase sólida e de fase solução.
BR0117190-9A 2001-12-11 2001-12-11 Composto, composição farmacêutica, uso do composto, e, processo para fabricá-lo BR0117190A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2001/014528 WO2003054000A1 (en) 2001-12-11 2001-12-11 Template-fixed peptidomimeticsas inhibitors of serine proteases

Publications (1)

Publication Number Publication Date
BR0117190A true BR0117190A (pt) 2004-10-13

Family

ID=8164720

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0117190A BRPI0117190B1 (pt) 2001-12-11 2001-12-11 composto, composição farmacêutica, processo para a fabricação de um composto e uso do mesmo
BR0117190-9A BR0117190A (pt) 2001-12-11 2001-12-11 Composto, composição farmacêutica, uso do composto, e, processo para fabricá-lo

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BRPI0117190A BRPI0117190B1 (pt) 2001-12-11 2001-12-11 composto, composição farmacêutica, processo para a fabricação de um composto e uso do mesmo

Country Status (11)

Country Link
US (1) US7417024B2 (pt)
EP (1) EP1458747B1 (pt)
JP (1) JP4098244B2 (pt)
CN (3) CN101157924A (pt)
AT (1) ATE422501T1 (pt)
AU (1) AU2002234564C1 (pt)
BR (2) BRPI0117190B1 (pt)
CA (1) CA2466591C (pt)
DE (1) DE60137654D1 (pt)
HK (1) HK1117541A1 (pt)
WO (1) WO2003054000A1 (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60321053D1 (de) * 2003-05-02 2008-06-26 Polyphor Ag Matrizenfixierte peptidmimetika als medikamente gegen hiv und krebs
AU2003232253A1 (en) 2003-05-02 2004-11-23 Polyphor Ag Template-fixed beta-hairpin peptidomimetics with cxcr4 antagonizing activity
EP1633774B1 (en) 2003-06-18 2010-02-17 Tranzyme Pharma Inc. Macrocyclic antagonists of the motilin receptor
US7994118B2 (en) 2003-11-15 2011-08-09 Polyphor Ltd. Template fixed beta-hairpin loop mimetics and their use in phage display
KR101272633B1 (ko) * 2005-02-17 2013-06-10 유니베르시태트 취리히 프로테아제 저해 활성을 가지는 주형-고정된 β-헤어핀구조의 펩티드모방체
CN105111280B (zh) * 2005-02-17 2020-01-24 波利弗尔有限公司 具有蛋白酶抑制活性的模板固定的β-发夹肽模拟物
WO2007079597A1 (en) 2006-01-16 2007-07-19 Polyphor Ltd. Template - fixed peptidomimetics with antimicrobial activity
WO2008092281A1 (en) 2007-01-29 2008-08-07 Polyphor Ltd. Template-fixed peptidomimetics
EP2118123B1 (en) 2007-01-31 2015-10-14 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
CN101641372B (zh) 2007-02-28 2012-11-28 波利弗尔有限公司 模板固定的肽模拟物
WO2008121767A2 (en) 2007-03-28 2008-10-09 President And Fellows Of Harvard College Stitched polypeptides
WO2012021876A2 (en) 2010-08-13 2012-02-16 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
AU2012326026B2 (en) 2011-10-18 2017-04-13 Aileron Therapeutics, Inc. Peptidomimetic macrocyles
KR102112373B1 (ko) 2012-02-15 2020-05-18 에일러론 테라퓨틱스 인코포레이티드 펩티드모방체 마크로사이클
US8987414B2 (en) 2012-02-15 2015-03-24 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
SG11201503052RA (en) 2012-11-01 2015-05-28 Aileron Therapeutics Inc Disubstituted amino acids and methods of preparation and use thereof
CA2933656C (en) * 2013-12-27 2021-04-20 Polyphor Ag Beta-hairpin peptidomimetics as selective elastase inhibitors
HUE059846T2 (hu) * 2013-12-27 2023-01-28 Spexis Ag Béta-hajtû peptidomimimetikumok, mint szelektív elasztáz inhibitorok
WO2016049359A1 (en) 2014-09-24 2016-03-31 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
CN107106642B (zh) 2014-09-24 2021-02-26 艾瑞朗医疗公司 拟肽大环化合物及其制剂
AU2016235424A1 (en) 2015-03-20 2017-10-05 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
CN108368161A (zh) 2015-09-10 2018-08-03 艾瑞朗医疗公司 作为mcl-1调节剂的拟肽大环化合物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2382931C (en) 1999-08-30 2011-01-25 Polyphor Ag Synthesis of template-fixed .beta.-hairpin loop mimetics

Also Published As

Publication number Publication date
CN101157720B (zh) 2012-04-04
ATE422501T1 (de) 2009-02-15
EP1458747B1 (en) 2009-02-11
WO2003054000A1 (en) 2003-07-03
US7417024B2 (en) 2008-08-26
HK1117541A1 (en) 2009-01-16
DE60137654D1 (de) 2009-03-26
CN101157924A (zh) 2008-04-09
BRPI0117190B1 (pt) 2018-10-23
AU2002234564C1 (en) 2009-07-02
CN101157720A (zh) 2008-04-09
AU2002234564B2 (en) 2008-11-06
JP4098244B2 (ja) 2008-06-11
US20050187145A1 (en) 2005-08-25
EP1458747A1 (en) 2004-09-22
AU2002234564A1 (en) 2003-07-09
CN1582296A (zh) 2005-02-16
CA2466591C (en) 2012-09-25
JP2005524613A (ja) 2005-08-18
CA2466591A1 (en) 2003-07-03

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 23/10/2018, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 18A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2544 DE 08-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.