HK1117521A1 - Process for preparation of aseptic 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3- yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4h- pyrido[1,2-a]pyrimidin-4-one palmitate ester - Google Patents

Process for preparation of aseptic 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3- yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4h- pyrido[1,2-a]pyrimidin-4-one palmitate ester

Info

Publication number
HK1117521A1
HK1117521A1 HK08108269.9A HK08108269A HK1117521A1 HK 1117521 A1 HK1117521 A1 HK 1117521A1 HK 08108269 A HK08108269 A HK 08108269A HK 1117521 A1 HK1117521 A1 HK 1117521A1
Authority
HK
Hong Kong
Prior art keywords
benzisoxazol
pyrido
pyrimidin
piperidinyl
aseptic
Prior art date
Application number
HK08108269.9A
Other languages
English (en)
Inventor
Thomas Frederik Ernestine Spittaels
Joannes Petrus Van Dun
Jurgen Alois Verbraeken
Benny Wouters
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of HK1117521A1 publication Critical patent/HK1117521A1/xx

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK08108269.9A 2005-04-25 2008-07-25 Process for preparation of aseptic 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3- yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4h- pyrido[1,2-a]pyrimidin-4-one palmitate ester HK1117521A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05103343 2005-04-25
EP05103391 2005-04-26
PCT/EP2006/061694 WO2006114384A1 (en) 2005-04-25 2006-04-20 Preparation of aseptic 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4h-pyridio[1,2-a]pyrimidin-4-one palmitate ester

Publications (1)

Publication Number Publication Date
HK1117521A1 true HK1117521A1 (en) 2009-01-16

Family

ID=36847642

Family Applications (1)

Application Number Title Priority Date Filing Date
HK08108269.9A HK1117521A1 (en) 2005-04-25 2008-07-25 Process for preparation of aseptic 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3- yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4h- pyrido[1,2-a]pyrimidin-4-one palmitate ester

Country Status (6)

Country Link
US (1) US20080214808A1 (xx)
EP (1) EP1879890A1 (xx)
JP (1) JP5249748B2 (xx)
CN (1) CN101163702B (xx)
HK (1) HK1117521A1 (xx)
WO (1) WO2006114384A1 (xx)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA72189C2 (uk) 1997-11-17 2005-02-15 Янссен Фармацевтика Н.В. Фармацевтична композиція, що містить водну суспензію субмікронних ефірів 9-гідроксирисперидон жирних кислот
TW200825077A (en) * 2006-08-14 2008-06-16 Teva Pharma Crystal forms of 9-hydroxy-risperidone (paliperidone)
US7820816B2 (en) 2006-08-23 2010-10-26 Teva Pharmaceutical Industries Ltd. Process for the synthesis of CMHTP and intermediates thereof
US20080171876A1 (en) * 2007-05-10 2008-07-17 Santiago Ini Pure paliperidone and processes for preparing thereof
WO2009026621A1 (en) * 2007-08-29 2009-03-05 Alphapharm Pty Ltd Pharmaceutical compound & composition
WO2009070306A1 (en) * 2007-11-27 2009-06-04 Teva Pharmaceutical Industries Ltd. Processes for preparing crystal forms of 9-hydroxy-risperidone (paliperidone)
DK2234617T3 (da) 2007-12-19 2021-05-25 Janssen Pharmaceutica Nv Doseringsskema forbundet med langtidsvirkende injicerbare paliperidonestere
US20090209757A1 (en) * 2008-01-10 2009-08-20 Santiago Ini Processes for the preparation and purification of paliperidone palmitate
US20130053405A1 (en) * 2009-10-06 2013-02-28 Ulrich Hersel Carrier linked paliperidone prodrugs
JP2013509435A (ja) 2009-10-30 2013-03-14 ヤンセン ファーマシューティカ エヌ．ベー． 長時間作用型注入可能パリペリドンエステルに関連した投与レジメン
WO2011114213A1 (en) 2010-03-15 2011-09-22 Inventia Healthcare Private Limited Stabilized prolonged release pharmaceutical composition comprising atypical antipsychotic
US8088594B2 (en) * 2010-03-16 2012-01-03 Saladax Biomedical Inc. Risperidone immunoassay
TWI577377B (zh) 2010-09-16 2017-04-11 Ｖｉｉｖ醫療保健公司 醫藥組合物
EP2683717B1 (en) 2011-05-31 2016-05-25 Ramamohan Rao, Davuluri Preparation of 3-[2-[4-((6-fluoro-1, 2-benzisoxazol-3-yl)-l-piperidinyl)-6, 7, 8, 9-tetrahydro-9-hydroxy-2-methyl-4h-pyrido[ 1, 2-a]-pyrimidin-4-one (paliperidone) and paliperidone palmitate.
WO2013046225A2 (en) * 2011-08-10 2013-04-04 Glenmark Generics Limited Process for the preparation of paliperidone palmitate
US20210145836A1 (en) * 2012-05-09 2021-05-20 Icrom Spa Production of sterile active pharmaceutical ingredients
WO2014031630A2 (en) 2012-08-21 2014-02-27 Ortho-Clinical Diagnostics, Inc Antibodies to paliperidone and use thereof
JP2015529199A (ja) 2012-08-21 2015-10-05 オルソ−クリニカル ダイアグノスティクス，インコーポレイティド パリペリドンハプテンに対する抗体及びその使用
CA2882563C (en) 2012-08-21 2022-11-29 Eric Hryhorenko Antibodies to risperidone haptens and use thereof
JP6131500B2 (ja) * 2012-08-21 2017-05-24 ヤンセン ファーマシューティカ エヌ．ベー． リスペリドン及びパリペリドンのハプテン
EP3933406A3 (en) 2012-08-21 2022-04-20 Janssen Pharmaceutica NV Antibodies to risperidone and use thereof
US9963449B2 (en) * 2015-01-19 2018-05-08 Aurobindo Pharma Ltd Process for the preparation of Paliperidone palmitate
WO2016157061A1 (en) 2015-03-31 2016-10-06 Wockhardt Limited Aseptic wet milling process for paliperidone palmitate
EP3744326B1 (en) 2015-04-07 2023-12-06 Janssen Pharmaceutica NV Dosing regimen for missed doses for long-acting injectable paliperidone esters
WO2016199170A2 (en) * 2015-06-10 2016-12-15 Cipla Limited Paliperidone palmitate particles and compositions thereof
JP6851318B2 (ja) * 2015-11-26 2021-03-31 持田製薬株式会社 ピラゾール誘導体の結晶
US10444250B2 (en) 2015-12-17 2019-10-15 Janssen Pharmaceutica Nv Antibodies to risperidone and use thereof
CN113024546B (zh) * 2019-12-25 2022-06-10 江苏晶立信医药科技有限公司 一种小粒径棕榈酸帕利哌酮的制备方法
CN111533737A (zh) * 2020-05-22 2020-08-14 烟台大学 4-氟帕利哌酮棕榈酸酯及其制备方法和应用
TW202222317A (zh) 2020-11-30 2022-06-16 比利時商健生藥品公司 與延釋帕利哌酮可注射配製物相關之投藥方案（一）
HUE065573T2 (hu) 2020-11-30 2024-06-28 Janssen Pharmaceutica Nv Elnyújtott felszabadulású paliperidon injektálható készítményeihez kapcsolódó adagolási rendek
PT4025187T (pt) 2020-11-30 2024-02-28 Janssen Pharmaceutica Nv Regimes de administração associados a formulações injetáveis de paliperidona de libertação prolongada
MX2024002215A (es) 2021-08-20 2024-05-10 Janssen Pharmaceutica Nv Regímenes de dosificación asociados con formulaciones inyectables de paliperidona de liberación prolongada.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5158952A (en) * 1988-11-07 1992-10-27 Janssen Pharmaceutica N.V. 3-[2-[4-(6-fluoro-1,2-benzisoxozol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9 tetrahydro-9-hydroxy-2-methyl-4H-pyrido [1,2-a]pyrimidin-4-one, compositions and method of use
TW487572B (en) 1996-05-20 2002-05-21 Janssen Pharmaceutica Nv Aqueous suspensions of 9-hydroxyrisperidone fatty acid esters
UA72189C2 (uk) * 1997-11-17 2005-02-15 Янссен Фармацевтика Н.В. Фармацевтична композиція, що містить водну суспензію субмікронних ефірів 9-гідроксирисперидон жирних кислот

Also Published As

Publication number Publication date
CN101163702A (zh) 2008-04-16
WO2006114384A1 (en) 2006-11-02
JP5249748B2 (ja) 2013-07-31
JP2008538780A (ja) 2008-11-06
US20080214808A1 (en) 2008-09-04
EP1879890A1 (en) 2008-01-23
CN101163702B (zh) 2011-09-07

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PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20230420