HK1111360A1 - Toll like receptor 3 antagonists, methods and uses toll 3 - Google Patents

Toll like receptor 3 antagonists, methods and uses toll 3

Info

Publication number
HK1111360A1
HK1111360A1 HK08102121.0A HK08102121A HK1111360A1 HK 1111360 A1 HK1111360 A1 HK 1111360A1 HK 08102121 A HK08102121 A HK 08102121A HK 1111360 A1 HK1111360 A1 HK 1111360A1
Authority
HK
Hong Kong
Prior art keywords
toll
antagonists
receptor
methods
uses toll
Prior art date
Application number
HK08102121.0A
Other languages
English (en)
Chinese (zh)
Inventor
Jill Carton
Mark Cunningham
Anuk Das
Karen Duffy
David M Knight
Roberta Lamb
Mouhamadou L Mbow
Gopalan Raghunathan
Mateo Lani San
Robert T Sarisky
Nicole Stowell
Raymond Sweet
Shanrong Zhao
Shizhong Chen
Jill Giles-Komar
Kristen Picha
Vedrana Stojanovic-Susulic
Theresa J Goletz
Original Assignee
Janssen Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc
Publication of HK1111360A1 publication Critical patent/HK1111360A1/xx

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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C07K2317/565—Complementarity determining region [CDR]
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HK08102121.0A 2004-11-30 2008-02-26 Toll like receptor 3 antagonists, methods and uses toll 3 HK1111360A1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US63181504P 2004-11-30 2004-11-30
US63639904P 2004-12-15 2004-12-15
US64187705P 2005-01-06 2005-01-06
US71319505P 2005-08-31 2005-08-31
US72761005P 2005-10-18 2005-10-18
PCT/US2005/043373 WO2006060513A2 (fr) 2004-11-30 2005-11-30 Antagonistes du recepteur toll-3, methodes et applications

Publications (1)

Publication Number Publication Date
HK1111360A1 true HK1111360A1 (en) 2008-08-08

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ID=36565702

Family Applications (2)

Application Number Title Priority Date Filing Date
HK08102121.0A HK1111360A1 (en) 2004-11-30 2008-02-26 Toll like receptor 3 antagonists, methods and uses toll 3
HK09109752.0A HK1131744A1 (en) 2004-11-30 2009-10-21 Toll like receptor 3 antagonists, methods and uses toll

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK09109752.0A HK1131744A1 (en) 2004-11-30 2009-10-21 Toll like receptor 3 antagonists, methods and uses toll

Country Status (16)

Country Link
US (1) US8153583B2 (fr)
EP (2) EP1824514B1 (fr)
JP (2) JP5039560B2 (fr)
KR (1) KR101317264B1 (fr)
AR (1) AR051836A1 (fr)
AU (1) AU2005311894A1 (fr)
BR (1) BRPI0518664A2 (fr)
CA (1) CA2589636C (fr)
EA (1) EA200701192A1 (fr)
HK (2) HK1111360A1 (fr)
IL (1) IL183541A (fr)
MX (1) MX2007006442A (fr)
NO (1) NO20073293L (fr)
NZ (1) NZ555475A (fr)
TW (1) TWI487535B (fr)
WO (1) WO2006060513A2 (fr)

Families Citing this family (39)

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Publication number Priority date Publication date Assignee Title
GB0121591D0 (en) 2001-09-06 2001-10-24 Chiron Spa Hybrid and tandem expression of neisserial proteins
JP5199878B2 (ja) * 2005-10-27 2013-05-15 セントカー・インコーポレーテツド Ｔｏｌｌ様受容体３モジュレーター、方法および用途
US8066981B2 (en) * 2006-11-14 2011-11-29 The Texas A & M University System Compositions and methods related to toll-like receptor-3
WO2008147956A2 (fr) * 2007-05-25 2008-12-04 Centocor, Inc. Modulateurs du récepteur 3 de type toll et utilisations de ceux-ci
KR101603109B1 (ko) 2007-12-07 2016-03-25 지모제넥틱스, 인코포레이티드 Ｉｌ-31에 특이적인 인간화된 항체 분자
US7982007B2 (en) * 2007-12-26 2011-07-19 Centocor, Inc. Cynomolgus toll-like receptor 3
US20100105875A1 (en) * 2008-06-09 2010-04-29 Maria Scarselli Antibodies against neisserial factor H binding protein
EP2138513B1 (fr) * 2008-06-27 2011-02-09 Theranor SPRL Compositions pharmaceutiques d'anticorps pour les maladies causées par les virus
EP2344175B1 (fr) * 2008-10-02 2015-07-22 Janssen Biotech, Inc. Procédés de suppression de l'activité des récepteurs de type toll
UA109397C2 (uk) 2008-10-31 2015-08-25 Антагоністи тол-подібного рецептора 3
US8460659B2 (en) 2008-10-31 2013-06-11 Janssen Biotech, Inc. Toll-like receptor 3 antagonists for the treatment of metabolic and cardiovascular diseases
US20100136096A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems for modulating inflammation
US20100136095A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems for modulating inflammation
US20100137246A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Anti-inflammatory compositions and methods
US20100137844A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Delivery devices for modulating inflammation
US20100136097A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems for modulating inflammation
US20100135983A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Anti-inflammatory compositions and methods
US20100136094A1 (en) * 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Systems for modulating inflammation
PT2425008E (pt) * 2009-04-29 2015-12-04 Janssen Biotech Inc Antagonistas do recetor tipo toll 3, métodos e usos
ES2543095T3 (es) 2009-07-10 2015-08-14 Innate Pharma Agentes de unión a TLR3
WO2011041582A2 (fr) 2009-09-30 2011-04-07 President And Fellows Of Harvard College Procédés de modulation de l'autophagie par la modulation de produits géniques inhibant l'autophagie
AU2012206614A1 (en) 2011-01-12 2013-08-01 Innate Pharma TLR3 binding agents
US20130078250A1 (en) * 2011-08-23 2013-03-28 Oliver Ast Bispecific t cell activating antigen binding molecules
HUE038225T2 (hu) * 2011-08-23 2018-10-29 Roche Glycart Ag Bispecifikus, T-sejtaktiváló antigénkötõ, molekulák
EA201490623A1 (ru) 2011-09-12 2016-01-29 Янссен Байотек Инк. Антагонисты толл-подобного рецептора 3 для лечения метаболических и сердечно-сосудистых заболеваний
DK2855527T3 (en) 2012-05-31 2018-11-26 Innate Pharma TLR3 BINDERS
TWI682941B (zh) 2013-02-01 2020-01-21 美商再生元醫藥公司 含嵌合恆定區之抗體
SG11201504497TA (en) 2013-02-26 2015-09-29 Roche Glycart Ag Bispecific t cell activating antigen binding molecules
US9198898B2 (en) 2013-06-24 2015-12-01 Tigercat Pharma, Inc. Use of NK-1 receptor antagonists in pruritus
US8906951B1 (en) 2013-06-24 2014-12-09 Tigercat Pharma, Inc. Use of NK-1 receptor antagonists in pruritus
TWI701042B (zh) 2014-03-19 2020-08-11 美商再生元醫藥公司 用於腫瘤治療之方法及抗體組成物
EP3221359B1 (fr) 2014-11-17 2020-05-27 Regeneron Pharmaceuticals, Inc. Procédés pour le traitement de tumeurs à l'aide de cd3xcd20 anticorps bispécifiques
JP6773679B2 (ja) 2015-03-30 2020-10-21 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Ｆｃガンマ受容体に対する結合が低下した重鎖定常領域
MA43025A (fr) 2015-10-02 2021-05-26 Hoffmann La Roche Molécules bispécifiques de liaison à l'antigène activant les lymphocytes t anti-ceaxcd3
WO2017097723A2 (fr) 2015-12-09 2017-06-15 F. Hoffmann-La Roche Ag Méthode de traitement
AU2017205089B2 (en) 2016-01-08 2023-10-05 F. Hoffmann-La Roche Ag Methods of treating CEA-positive cancers using PD-1 axis binding antagonists and anti-CEA/anti-CD3 bispecific antibodies
WO2019246312A1 (fr) 2018-06-20 2019-12-26 Progenity, Inc. Traitement d'une maladie du tractus gastro-intestinal avec un immunomodulateur
WO2019246317A1 (fr) 2018-06-20 2019-12-26 Progenity, Inc. Traitement d'une maladie ou d'un état dans un tissu provenant de l'endoderme
CA3110513A1 (fr) 2018-08-31 2020-03-05 Regeneron Pharmaceuticals, Inc. Strategie de dosage permettant d'attenuer le syndrome de liberation de cytokines pour des anticorps bispecifiques cd3/c20

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5225539A (en) * 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US20030032090A1 (en) * 1997-05-07 2003-02-13 Schering Corporation, A New Jersey Corporation Human receptor proteins; related reagents and methods
CN1935840A (zh) 1997-05-07 2007-03-28 先灵公司 人Toll样受体蛋白、相关试剂和方法
EP1158989B1 (fr) 1999-03-09 2007-06-20 Anker, Stefan Utilisation d'inhibiteurs des endotoxines pour le traitement de la cachexie
GB9930616D0 (en) 1999-12-24 2000-02-16 Mathilda & Terence Kennedy Ins Activation and inhibition of the immune system
US7709451B2 (en) * 2001-09-07 2010-05-04 Trustees Of Boston University Method and composition for treating immune complex associated disorders
CN1633598A (zh) 2001-10-05 2005-06-29 科勒制药股份公司 Toll样受体3信号传导的激动剂和拮抗剂
EP1495756A4 (fr) 2002-04-08 2009-10-28 Takeda Pharmaceutical Agent therapeutique pour la prevention d'etat septique grave
JP2004016021A (ja) * 2002-06-12 2004-01-22 Japan Science & Technology Corp 抗体および阻害剤並びにそれを用いた形質転換方法および形質転換キット
KR20060016817A (ko) * 2003-06-20 2006-02-22 콜리 파마슈티칼 게엠베하 소분자 톨-유사 수용체 (ｔｌｒ) 길항제

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