HK1105971A1 - Pyrrazolo-pyrimidine derivatives - Google Patents

Pyrrazolo-pyrimidine derivatives

Info

Publication number
HK1105971A1
HK1105971A1 HK07111355.9A HK07111355A HK1105971A1 HK 1105971 A1 HK1105971 A1 HK 1105971A1 HK 07111355 A HK07111355 A HK 07111355A HK 1105971 A1 HK1105971 A1 HK 1105971A1
Authority
HK
Hong Kong
Prior art keywords
pyrrazolo
pyrimidine derivatives
pyrimidine
derivatives
Prior art date
Application number
HK07111355.9A
Other languages
English (en)
Inventor
Erwin Goetschi
Juergen Wichmann
Thomas Johannes Woltering
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HK1105971A1 publication Critical patent/HK1105971A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK07111355.9A 2004-06-21 2007-10-22 Pyrrazolo-pyrimidine derivatives HK1105971A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04102837 2004-06-21
PCT/EP2005/006302 WO2005123738A1 (en) 2004-06-21 2005-06-13 Pyrrazolo-pyrimidine derivatives

Publications (1)

Publication Number Publication Date
HK1105971A1 true HK1105971A1 (en) 2008-02-29

Family

ID=34971089

Family Applications (1)

Application Number Title Priority Date Filing Date
HK07111355.9A HK1105971A1 (en) 2004-06-21 2007-10-22 Pyrrazolo-pyrimidine derivatives

Country Status (26)

Country Link
US (1) US7378417B2 (zh)
EP (1) EP1761541B1 (zh)
JP (1) JP4608542B2 (zh)
CN (1) CN100528876C (zh)
AR (1) AR049521A1 (zh)
AT (1) ATE383361T1 (zh)
AU (1) AU2005254657B2 (zh)
BR (1) BRPI0512330A (zh)
CA (1) CA2571487C (zh)
DE (1) DE602005004287T2 (zh)
DK (1) DK1761541T3 (zh)
ES (1) ES2299044T3 (zh)
HK (1) HK1105971A1 (zh)
HR (1) HRP20080070T3 (zh)
IL (1) IL179736A (zh)
MX (1) MXPA06014809A (zh)
MY (1) MY143368A (zh)
NO (1) NO20070249L (zh)
NZ (1) NZ551660A (zh)
PL (1) PL1761541T3 (zh)
PT (1) PT1761541E (zh)
RU (1) RU2378277C2 (zh)
SI (1) SI1761541T1 (zh)
TW (1) TWI301835B (zh)
WO (1) WO2005123738A1 (zh)
ZA (1) ZA200610102B (zh)

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CN101115755B (zh) * 2005-02-11 2013-01-16 弗·哈夫曼-拉罗切有限公司 作为mglur2拮抗剂的吡唑并-嘧啶衍生物
KR100973609B1 (ko) 2005-03-23 2010-08-03 에프. 호프만-라 로슈 아게 ｍＧｌｕＲ2 길항제로서 아세틸렌일-피라졸로-피리미딘유도체
DE602006013493D1 (de) 2005-09-27 2010-05-20 Hoffmann La Roche Oxadiazolylpyrazolopyrimidine als mglur2-antagonisten
WO2007048064A2 (en) * 2005-10-21 2007-04-26 Exelixis, Inc. Amino-pyrimidines as casein kinase ii (ck2) modulators
EP2178375B1 (en) * 2007-07-20 2014-09-24 Merck Sharp & Dohme Corp. Pyrazoloý1,5-a¨pyrimidine derivatives
KR101686685B1 (ko) * 2008-10-31 2016-12-14 제넨테크, 인크. 피라졸로피리미딘 ｊａｋ 억제제 화합물 및 방법
AR078171A1 (es) 2009-09-15 2011-10-19 Sanofi Aventis Dihidrobenzocicloalquiloximetil-oxazolopirimidinonas sustituidas, preparacion y uso de las mismas
WO2012075393A2 (en) * 2010-12-02 2012-06-07 President And Fellows Of Harvard College Activators of proteasomal degradation and uses thereof
JP6154746B2 (ja) 2010-12-08 2017-06-28 ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ グルコセレブロシダーゼ活性剤としての置換ピラゾロピリミジン類
WO2012149157A2 (en) 2011-04-26 2012-11-01 Bioenergenix Heterocyclic compounds for the inhibition of pask
US9464035B2 (en) 2012-03-28 2016-10-11 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Salicylic acid derivatives useful as glucocerebrosidase activators
CA2885808A1 (en) 2012-10-23 2014-05-01 F. Hoffmann-La Roche Ag Mglu2/3 antagonists for the treatment of autistic disorders
WO2014066743A1 (en) 2012-10-25 2014-05-01 Bioenergenix Heterocyclic compounds for the inhibition of pask
WO2014066795A1 (en) 2012-10-25 2014-05-01 Bioenergenix Heterocyclic compounds for the inhibition of pask
KR20160143853A (ko) 2014-04-23 2016-12-14 에프. 호프만-라 로슈 아게 지적 장애의 치료를 위한 mglu2/3 길항제
JOP20150179B1 (ar) * 2014-08-01 2021-08-17 Janssen Pharmaceutica Nv مركبات 6 ، 7 ثاني هيدرو بيرازولو [ 1، 5 الفا ] بيرازين – 4 (5 يد) – اون واستخدامها كمنظمات الوسترية سلبية لمستقبلات ملجور 2
EP3000814A1 (en) 2014-09-26 2016-03-30 Domain Therapeutics Substituted pyrazoloquinazolinones and pyrroloquinazolinones as allosteric modulators of group II metabotropic glutamate receptors
EP3215510B1 (en) 2014-11-06 2023-06-07 Bial-R&D Investments, S.A. Substituted imidazo[1,5-a]pyrimidines and their use in the treatment of medical disorders
WO2016073895A1 (en) 2014-11-06 2016-05-12 Lysosomal Therapeutics Inc. Substituted pyrazolo(1,5-a)pyrimidines and their use in the treatment of medical disorders
CA2966581A1 (en) 2014-11-06 2016-05-12 Lysosomal Therapeutics Inc. Substituted pyrrolo[1,2-a]pyrimidines and their use in the treatment of medical disorders
ES2727158T3 (es) 2014-12-03 2019-10-14 Janssen Pharmaceutica Nv Ligandos para PET de mGluR2 radiomarcados
WO2017066428A1 (en) 2015-10-13 2017-04-20 H. Lee Moffitt Cancer Center & Research Institute, Inc. Brd4-kinase inhibitors as cancer therapeutics
LT3389727T (lt) 2015-12-18 2020-10-12 Janssen Pharmaceutica Nv Radioaktyviai pažymėti mglur2/3 pet ligandai
WO2017103179A1 (en) 2015-12-18 2017-06-22 Janssen Pharmaceutica Nv Radiolabelled mglur2/3 pet ligands
CA3020310A1 (en) 2016-04-06 2017-10-12 Lysosomal Therapeutics Inc. Pyrrolo[1,2-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
CA3020305A1 (en) 2016-04-06 2017-10-12 Lysosomal Therapeutics Inc. Imidazo [1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
EP3440080A4 (en) * 2016-04-06 2020-01-22 Lysosomal Therapeutics Inc. PYRAZOLO [1,5-A] PYRIMIDINYL CARBOXAMIDE COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS
WO2017192931A1 (en) 2016-05-05 2017-11-09 Lysosomal Therapeutics Inc. SUBSTITUTED IMDAZO[1,2-α]PYRIDINES, SUBSTITUTED IMIDAZO[1,2-α]PYRAZINES, RELATED COMPOUNDS, AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS
CN109311902B (zh) 2016-05-05 2022-07-15 Bial研发投资股份有限公司 取代的咪唑并[1,2-b]哒嗪、咪唑并[1,5-b]哒嗪、相关化合物及其用途
JP2022502515A (ja) * 2018-10-15 2022-01-11 ニンバス ラクシュミ， インコーポレイテッド Ｔｙｋ２阻害剤およびその使用

Family Cites Families (5)

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Publication number Priority date Publication date Assignee Title
US5017212A (en) * 1986-03-20 1991-05-21 Takeda Chemical Industries, Ltd. Sulfonylurea compounds and herbicidal use
ATE214704T1 (de) * 1997-07-18 2002-04-15 Hoffmann La Roche 5h-thiazolo(3,2-a)pyrimidinderivate
IL148905A0 (en) * 1999-09-30 2002-09-12 Neurogen Corp Pfizer Inc Certain alkylene diamine-substituted pyrazolo{1,5,-a}-1,5-pyrimidines and pyrazolo{1,5,-a}-1,3,5-triazines
US7534800B2 (en) * 2002-03-28 2009-05-19 Eisai R & D Development Co., Ltd. 7-azaindoles as inhibitors of c-Jun N-terminal kinases for the treatment of neurodegenerative disorders
US7329662B2 (en) * 2003-10-03 2008-02-12 Hoffmann-La Roche Inc. Pyrazolo-pyridine

Also Published As

Publication number Publication date
JP2008503510A (ja) 2008-02-07
AR049521A1 (es) 2006-08-09
EP1761541B1 (en) 2008-01-09
ES2299044T3 (es) 2008-05-16
NO20070249L (no) 2007-02-15
SI1761541T1 (sl) 2008-06-30
RU2378277C2 (ru) 2010-01-10
JP4608542B2 (ja) 2011-01-12
MXPA06014809A (es) 2007-02-12
CN1964973A (zh) 2007-05-16
CN100528876C (zh) 2009-08-19
IL179736A0 (en) 2007-05-15
HRP20080070T3 (en) 2008-05-31
DE602005004287T2 (de) 2008-12-24
EP1761541A1 (en) 2007-03-14
ATE383361T1 (de) 2008-01-15
WO2005123738A1 (en) 2005-12-29
ZA200610102B (en) 2008-08-27
PT1761541E (pt) 2008-03-13
PL1761541T3 (pl) 2008-06-30
US20050282827A1 (en) 2005-12-22
US7378417B2 (en) 2008-05-27
TWI301835B (en) 2008-10-11
BRPI0512330A (pt) 2008-02-26
DE602005004287D1 (de) 2008-02-21
CA2571487C (en) 2013-04-30
AU2005254657A1 (en) 2005-12-29
NZ551660A (en) 2009-08-28
TW200626598A (en) 2006-08-01
IL179736A (en) 2010-12-30
AU2005254657B2 (en) 2011-03-17
MY143368A (en) 2011-04-29
RU2006143571A (ru) 2008-07-27
CA2571487A1 (en) 2005-12-29
DK1761541T3 (da) 2008-04-28

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20130613