HK1099751A1 - Triazolone derivatives as mmp inhibitors for the treatment of asthma and copd - Google Patents
Triazolone derivatives as mmp inhibitors for the treatment of asthma and copdInfo
- Publication number
- HK1099751A1 HK1099751A1 HK07105624.6A HK07105624A HK1099751A1 HK 1099751 A1 HK1099751 A1 HK 1099751A1 HK 07105624 A HK07105624 A HK 07105624A HK 1099751 A1 HK1099751 A1 HK 1099751A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- copd
- asthma
- treatment
- mmp inhibitors
- triazolone derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0400850A SE0400850D0 (sv) | 2004-03-30 | 2004-03-30 | Novel Compounds |
PCT/SE2005/000448 WO2005095362A1 (en) | 2004-03-30 | 2005-03-29 | Triazolone derivatives as mmp inhibitors for the treatment of asthma and copd |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1099751A1 true HK1099751A1 (en) | 2007-08-24 |
Family
ID=32105805
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK07105624.6A HK1099751A1 (en) | 2004-03-30 | 2007-05-29 | Triazolone derivatives as mmp inhibitors for the treatment of asthma and copd |
Country Status (10)
Country | Link |
---|---|
US (2) | US20070219217A1 (es) |
EP (1) | EP1732903B1 (es) |
JP (1) | JP2007530672A (es) |
CN (1) | CN1960979A (es) |
AT (1) | ATE423105T1 (es) |
DE (1) | DE602005012811D1 (es) |
ES (1) | ES2320679T3 (es) |
HK (1) | HK1099751A1 (es) |
SE (1) | SE0400850D0 (es) |
WO (1) | WO2005095362A1 (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007000240A1 (en) | 2005-06-28 | 2007-01-04 | Sanofi-Aventis | Isoquinoline derivatives as inhibitors of rho-kinase |
DK1910333T3 (da) | 2005-07-26 | 2013-08-19 | Sanofi Sa | Piperidinylsubstituerede isoquinolonderivater som RHO-kinaseinhibitorer |
CN101228132B (zh) | 2005-07-26 | 2012-10-10 | 塞诺菲-安万特股份有限公司 | 作为Rho-激酶抑制剂的环己基胺异喹啉酮衍生物 |
DK2132194T3 (da) | 2006-12-27 | 2011-06-27 | Sanofi Aventis | Substituerede isoquinoliner og deres anvendelse som Rho-kinase inhibitorer |
NZ577980A (en) | 2006-12-27 | 2012-01-12 | Sanofi Aventis | Cycloalkylamine substituted isoquinolone derivatives |
WO2008077552A1 (en) | 2006-12-27 | 2008-07-03 | Sanofi-Aventis | Substituted isoquinoline and isoquinolinone derivatives |
JP5405316B2 (ja) | 2006-12-27 | 2014-02-05 | サノフイ | シクロアルキルアミン置換イソキノリン誘導体 |
MX2009005967A (es) | 2006-12-27 | 2009-06-15 | Sanofi Aventis | Derivados de isoquinolina e isoquinolinona sustituidos con cicloalquilamina. |
EP2102187B1 (en) | 2006-12-27 | 2015-04-01 | Sanofi | Substituted isoquinoline and isoquinolinone derivatives as inhibitors of rho-kinase |
AU2009241365B2 (en) | 2008-04-28 | 2015-01-22 | Revalesio Corporation | Compositions and methods for treating multiple sclerosis |
DK2313374T3 (da) | 2008-06-24 | 2013-12-16 | Sanofi Sa | 6-substituerede isoquinoliner og isoquinolinoner |
AU2009262509B2 (en) | 2008-06-24 | 2014-01-30 | Sanofi | Bi-and polycyclic substituted isoquinoline and isoquinoline derivatives as Rho kinase inhibitors |
KR101638326B1 (ko) | 2008-06-24 | 2016-07-12 | 사노피 | Rho 키나제 억제제로서의 치환된 이소퀴놀린 및 이소퀴놀리논 |
GB0813142D0 (en) | 2008-07-17 | 2008-08-27 | Glaxo Group Ltd | Novel compounds |
GB0813144D0 (en) | 2008-07-17 | 2008-08-27 | Glaxo Group Ltd | Novel compounds |
CN102858175A (zh) * | 2010-02-22 | 2013-01-02 | 葛兰素史密斯克莱有限责任公司 | 作为脂肪酸合成酶抑制剂的三唑酮 |
NZ604035A (en) | 2010-06-04 | 2015-02-27 | Albany Molecular Res Inc | Glycine transporter-1 inhibitors, methods of making them, and uses thereof |
EP2822931B1 (en) | 2012-03-09 | 2017-05-03 | Inception 2, Inc. | Triazolone compounds and uses thereof |
EP2935228B9 (en) | 2012-12-20 | 2017-12-06 | Inception 2, Inc. | Triazolone compounds and uses thereof |
CA2921420A1 (en) | 2013-09-06 | 2015-03-12 | Inception 2, Inc. | Triazolone compounds and uses thereof |
CN104876917B (zh) * | 2015-06-16 | 2017-09-19 | 上海皓元医药股份有限公司 | 用作脂肪酸合成酶抑制剂的三唑酮的合成方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19504627A1 (de) * | 1995-02-13 | 1996-08-14 | Bayer Ag | Verfahren und neue Zwischenprodukte zur Herstellung von Triazolinonen |
AU766191B2 (en) * | 1999-06-04 | 2003-10-09 | Merck & Co., Inc. | Substituted piperidines as melanocortin-4 receptor agonists |
WO2001026575A1 (en) * | 1999-10-12 | 2001-04-19 | The Board Of Trustees Of The Leland Stanford Jr. University | Methods of diagnosing and treating urinary incontinence |
EP1110958A1 (en) * | 1999-12-20 | 2001-06-27 | Ucb, S.A. | Alpha-arylethylpiperazine derivatives as neurokinin antagonists |
AU2001250850A1 (en) * | 2000-03-17 | 2001-10-03 | Dupont Pharmaceuticals Company | Beta-amino acid derivatives as inhibitors of matrix metalloproteases and tnf-alpha |
GB0203412D0 (en) * | 2002-02-13 | 2002-04-03 | Pharmagene Lab Ltd | 5-HT 2B receptor antagonists |
MXPA04008803A (es) * | 2002-03-13 | 2004-11-26 | Schering Corp | Antagonistas de neuroquinina-1. |
AR039625A1 (es) * | 2002-04-18 | 2005-03-02 | Merck & Co Inc | Proceso para la preparacion de 5-((2(r)--(1(r)- (3,5-bis (trifluormetil) fenil)etoxi-3 (s) - (4-fluorfenil) -4-morfolinil) metil) -1,2-dihidro-3h-1,2,4-triazol-3-ona |
US20040010010A1 (en) * | 2002-04-30 | 2004-01-15 | Ebetino Frank Hallock | Melanocortin receptor ligands |
MXPA04011730A (es) * | 2002-05-31 | 2005-07-14 | Takeda Pharmaceutical | Derivados de piperidina, proceso para producir el mismo, y uso. |
SE0202539D0 (sv) * | 2002-08-27 | 2002-08-27 | Astrazeneca Ab | Compounds |
KR20060106106A (ko) * | 2005-04-06 | 2006-10-12 | 삼성전자주식회사 | 고속 레벨 쉬프터 |
-
2004
- 2004-03-30 SE SE0400850A patent/SE0400850D0/xx unknown
-
2005
- 2005-03-29 DE DE602005012811T patent/DE602005012811D1/de active Active
- 2005-03-29 WO PCT/SE2005/000448 patent/WO2005095362A1/en active Application Filing
- 2005-03-29 EP EP05722275A patent/EP1732903B1/en not_active Not-in-force
- 2005-03-29 ES ES05722275T patent/ES2320679T3/es active Active
- 2005-03-29 US US10/593,543 patent/US20070219217A1/en not_active Abandoned
- 2005-03-29 JP JP2007506108A patent/JP2007530672A/ja active Pending
- 2005-03-29 AT AT05722275T patent/ATE423105T1/de not_active IP Right Cessation
- 2005-03-29 CN CNA2005800176722A patent/CN1960979A/zh active Pending
-
2007
- 2007-05-29 HK HK07105624.6A patent/HK1099751A1/xx not_active IP Right Cessation
-
2009
- 2009-08-10 US US12/538,522 patent/US20090299066A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2007530672A (ja) | 2007-11-01 |
EP1732903A1 (en) | 2006-12-20 |
WO2005095362A1 (en) | 2005-10-13 |
US20070219217A1 (en) | 2007-09-20 |
ATE423105T1 (de) | 2009-03-15 |
DE602005012811D1 (de) | 2009-04-02 |
ES2320679T3 (es) | 2009-05-27 |
US20090299066A1 (en) | 2009-12-03 |
CN1960979A (zh) | 2007-05-09 |
SE0400850D0 (sv) | 2004-03-31 |
EP1732903B1 (en) | 2009-02-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20130329 |