HK1099751A1 - Triazolone derivatives as mmp inhibitors for the treatment of asthma and copd - Google Patents

Triazolone derivatives as mmp inhibitors for the treatment of asthma and copd

Info

Publication number
HK1099751A1
HK1099751A1 HK07105624.6A HK07105624A HK1099751A1 HK 1099751 A1 HK1099751 A1 HK 1099751A1 HK 07105624 A HK07105624 A HK 07105624A HK 1099751 A1 HK1099751 A1 HK 1099751A1
Authority
HK
Hong Kong
Prior art keywords
copd
asthma
treatment
mmp inhibitors
triazolone derivatives
Prior art date
Application number
HK07105624.6A
Other languages
English (en)
Inventor
Anders Eriksson
Matti Lepistoe
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of HK1099751A1 publication Critical patent/HK1099751A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK07105624.6A 2004-03-30 2007-05-29 Triazolone derivatives as mmp inhibitors for the treatment of asthma and copd HK1099751A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0400850A SE0400850D0 (sv) 2004-03-30 2004-03-30 Novel Compounds
PCT/SE2005/000448 WO2005095362A1 (en) 2004-03-30 2005-03-29 Triazolone derivatives as mmp inhibitors for the treatment of asthma and copd

Publications (1)

Publication Number Publication Date
HK1099751A1 true HK1099751A1 (en) 2007-08-24

Family

ID=32105805

Family Applications (1)

Application Number Title Priority Date Filing Date
HK07105624.6A HK1099751A1 (en) 2004-03-30 2007-05-29 Triazolone derivatives as mmp inhibitors for the treatment of asthma and copd

Country Status (10)

Country Link
US (2) US20070219217A1 (es)
EP (1) EP1732903B1 (es)
JP (1) JP2007530672A (es)
CN (1) CN1960979A (es)
AT (1) ATE423105T1 (es)
DE (1) DE602005012811D1 (es)
ES (1) ES2320679T3 (es)
HK (1) HK1099751A1 (es)
SE (1) SE0400850D0 (es)
WO (1) WO2005095362A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007000240A1 (en) 2005-06-28 2007-01-04 Sanofi-Aventis Isoquinoline derivatives as inhibitors of rho-kinase
DK1910333T3 (da) 2005-07-26 2013-08-19 Sanofi Sa Piperidinylsubstituerede isoquinolonderivater som RHO-kinaseinhibitorer
CN101228132B (zh) 2005-07-26 2012-10-10 塞诺菲-安万特股份有限公司 作为Rho-激酶抑制剂的环己基胺异喹啉酮衍生物
DK2132194T3 (da) 2006-12-27 2011-06-27 Sanofi Aventis Substituerede isoquinoliner og deres anvendelse som Rho-kinase inhibitorer
NZ577980A (en) 2006-12-27 2012-01-12 Sanofi Aventis Cycloalkylamine substituted isoquinolone derivatives
WO2008077552A1 (en) 2006-12-27 2008-07-03 Sanofi-Aventis Substituted isoquinoline and isoquinolinone derivatives
JP5405316B2 (ja) 2006-12-27 2014-02-05 サノフイ シクロアルキルアミン置換イソキノリン誘導体
MX2009005967A (es) 2006-12-27 2009-06-15 Sanofi Aventis Derivados de isoquinolina e isoquinolinona sustituidos con cicloalquilamina.
EP2102187B1 (en) 2006-12-27 2015-04-01 Sanofi Substituted isoquinoline and isoquinolinone derivatives as inhibitors of rho-kinase
AU2009241365B2 (en) 2008-04-28 2015-01-22 Revalesio Corporation Compositions and methods for treating multiple sclerosis
DK2313374T3 (da) 2008-06-24 2013-12-16 Sanofi Sa 6-substituerede isoquinoliner og isoquinolinoner
AU2009262509B2 (en) 2008-06-24 2014-01-30 Sanofi Bi-and polycyclic substituted isoquinoline and isoquinoline derivatives as Rho kinase inhibitors
KR101638326B1 (ko) 2008-06-24 2016-07-12 사노피 Ｒｈｏ 키나제 억제제로서의 치환된 이소퀴놀린 및 이소퀴놀리논
GB0813142D0 (en) 2008-07-17 2008-08-27 Glaxo Group Ltd Novel compounds
GB0813144D0 (en) 2008-07-17 2008-08-27 Glaxo Group Ltd Novel compounds
CN102858175A (zh) * 2010-02-22 2013-01-02 葛兰素史密斯克莱有限责任公司 作为脂肪酸合成酶抑制剂的三唑酮
NZ604035A (en) 2010-06-04 2015-02-27 Albany Molecular Res Inc Glycine transporter-1 inhibitors, methods of making them, and uses thereof
EP2822931B1 (en) 2012-03-09 2017-05-03 Inception 2, Inc. Triazolone compounds and uses thereof
EP2935228B9 (en) 2012-12-20 2017-12-06 Inception 2, Inc. Triazolone compounds and uses thereof
CA2921420A1 (en) 2013-09-06 2015-03-12 Inception 2, Inc. Triazolone compounds and uses thereof
CN104876917B (zh) * 2015-06-16 2017-09-19 上海皓元医药股份有限公司 用作脂肪酸合成酶抑制剂的三唑酮的合成方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19504627A1 (de) * 1995-02-13 1996-08-14 Bayer Ag Verfahren und neue Zwischenprodukte zur Herstellung von Triazolinonen
AU766191B2 (en) * 1999-06-04 2003-10-09 Merck & Co., Inc. Substituted piperidines as melanocortin-4 receptor agonists
WO2001026575A1 (en) * 1999-10-12 2001-04-19 The Board Of Trustees Of The Leland Stanford Jr. University Methods of diagnosing and treating urinary incontinence
EP1110958A1 (en) * 1999-12-20 2001-06-27 Ucb, S.A. Alpha-arylethylpiperazine derivatives as neurokinin antagonists
AU2001250850A1 (en) * 2000-03-17 2001-10-03 Dupont Pharmaceuticals Company Beta-amino acid derivatives as inhibitors of matrix metalloproteases and tnf-alpha
GB0203412D0 (en) * 2002-02-13 2002-04-03 Pharmagene Lab Ltd 5-HT 2B receptor antagonists
MXPA04008803A (es) * 2002-03-13 2004-11-26 Schering Corp Antagonistas de neuroquinina-1.
AR039625A1 (es) * 2002-04-18 2005-03-02 Merck & Co Inc Proceso para la preparacion de 5-((2(r)--(1(r)- (3,5-bis (trifluormetil) fenil)etoxi-3 (s) - (4-fluorfenil) -4-morfolinil) metil) -1,2-dihidro-3h-1,2,4-triazol-3-ona
US20040010010A1 (en) * 2002-04-30 2004-01-15 Ebetino Frank Hallock Melanocortin receptor ligands
MXPA04011730A (es) * 2002-05-31 2005-07-14 Takeda Pharmaceutical Derivados de piperidina, proceso para producir el mismo, y uso.
SE0202539D0 (sv) * 2002-08-27 2002-08-27 Astrazeneca Ab Compounds
KR20060106106A (ko) * 2005-04-06 2006-10-12 삼성전자주식회사 고속 레벨 쉬프터

Also Published As

Publication number Publication date
JP2007530672A (ja) 2007-11-01
EP1732903A1 (en) 2006-12-20
WO2005095362A1 (en) 2005-10-13
US20070219217A1 (en) 2007-09-20
ATE423105T1 (de) 2009-03-15
DE602005012811D1 (de) 2009-04-02
ES2320679T3 (es) 2009-05-27
US20090299066A1 (en) 2009-12-03
CN1960979A (zh) 2007-05-09
SE0400850D0 (sv) 2004-03-31
EP1732903B1 (en) 2009-02-18

Similar Documents

Publication Publication Date Title
HK1099751A1 (en) Triazolone derivatives as mmp inhibitors for the treatment of asthma and copd
TW200635917A (en) Novel compounds
UA93425C2 (ru) Производные гидантоина, которые применяются kak mmp ингибиторы
TW200616995A (en) Novel compounds
TW200635916A (en) Compounds
SE0202539D0 (sv) Compounds
SE0200920D0 (sv) Novel compounds
TW200801003A (en) Novel compounds
SE0104140D0 (sv) Novel Compounds
TW200605888A (en) Novel compounds
TW200639156A (en) New compounds
TW200800999A (en) Novel compounds
TNSN05278A1 (en) Inhibitors of phosphatidylinositol 3-kinase
NO20054329L (no) Adamantanderivater, fremgangsmater for deres fremstilling og farmasoytiske sammensetninger som innbefatter slike
TW200726747A (en) Chemical compounds
TW200738659A (en) Novel compounds
MX2009010059A (es) Derivados de quinolina para el tratamiento de enfermedades inflamatorias.
TW200728302A (en) Chemical compounds VI
TW200730493A (en) Chemical compounds
TW200833670A (en) Novel compounds 569
MX2010009022A (es) Derivados 16 alfa, 17 alfa-acetal glucocorticoesteroideos y su uso.
TW200714598A (en) Urea derivatives, methods for their manufacture, and uses therefor
IL183373A0 (en) 3-[2-(3-acylamino-2-oxo-2h-pyridin-1-yl)-acetylamino]-4-oxo-pentanoic acid derivatives, pharmaceutical compositions containing the same and methods for the preparation thereof
TW200740781A (en) Novel compounds
MX2009006010A (es) Derivados de amina y su uso en enfermedades mediadas por el adrenoreceptor beta 2.

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20130329