HK1096972A1 - Inhibition of syk kinase expression - Google Patents
Inhibition of syk kinase expressionInfo
- Publication number
- HK1096972A1 HK1096972A1 HK07103911.3A HK07103911A HK1096972A1 HK 1096972 A1 HK1096972 A1 HK 1096972A1 HK 07103911 A HK07103911 A HK 07103911A HK 1096972 A1 HK1096972 A1 HK 1096972A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- inhibition
- syk kinase
- kinase expression
- expression
- syk
- Prior art date
Links
- 102000000551 Syk Kinase Human genes 0.000 title 1
- 108010016672 Syk Kinase Proteins 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/10—Protein-tyrosine kinases (2.7.10)
- C12Y207/10001—Receptor protein-tyrosine kinase (2.7.10.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48429903P | 2003-07-03 | 2003-07-03 | |
PCT/US2004/020990 WO2005007623A2 (en) | 2003-07-03 | 2004-07-01 | Inhibition of syk kinase expression |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1096972A1 true HK1096972A1 (en) | 2007-06-15 |
Family
ID=34079054
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK07103911.3A HK1096972A1 (en) | 2003-07-03 | 2007-04-16 | Inhibition of syk kinase expression |
Country Status (8)
Country | Link |
---|---|
US (3) | US7173015B2 (de) |
EP (2) | EP2371835A1 (de) |
JP (2) | JP2007524397A (de) |
CN (2) | CN101961497A (de) |
AU (1) | AU2004257167B2 (de) |
CA (1) | CA2531069A1 (de) |
HK (1) | HK1096972A1 (de) |
WO (1) | WO2005007623A2 (de) |
Families Citing this family (134)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2406192A1 (en) * | 2000-04-13 | 2001-10-25 | Thomas N. Wight | Therapeutic compounds and methods for formulating v3, a versican isoform |
US20060160759A1 (en) * | 2002-09-28 | 2006-07-20 | Jianzhu Chen | Influenza therapeutic |
WO2005049838A2 (en) * | 2003-11-14 | 2005-06-02 | Yale University | Syk-targeted nucleic acid interference |
EP1789447B1 (de) | 2004-08-16 | 2012-04-25 | Immune Disease Institute, Inc. | Verfahren zur lieferung von rna-interferenz und verwendungen damit |
US7507809B2 (en) | 2005-01-07 | 2009-03-24 | Alnylam Pharmaceuticals, Inc. | RNAi modulation of RSV and therapeutic uses thereof |
US20090203055A1 (en) * | 2005-04-18 | 2009-08-13 | Massachusetts Institute Of Technology | Compositions and methods for RNA interference with sialidase expression and uses thereof |
TW201336514A (zh) * | 2006-04-13 | 2013-09-16 | Alcon Res Ltd | RNA干擾(RNAi)所媒介之與脾酪胺酸激酶相關之發炎症狀的抑制作用(二) |
US20080139531A1 (en) * | 2006-12-04 | 2008-06-12 | Alcon Manufacturing Ltd. | Use of connective tissue mast cell stabilizers to facilitate ocular surface re-epithelization and wound repair |
AR066016A1 (es) * | 2007-04-11 | 2009-07-15 | Alcon Res Ltd | Uso de un inhibidor del tnf alfa junto con una antihistamina para tratar la rinitis alergica y la conjuntivitis alergica |
US20100215588A1 (en) * | 2007-04-26 | 2010-08-26 | Rami Skaliter | Therapeutic delivery of inhibitory nucleic acid molecules to the respiratory system |
US8183221B2 (en) * | 2007-09-05 | 2012-05-22 | Medtronic, Inc. | Suppression of SCN9A gene expression and/or function for the treatment of pain |
US8410067B2 (en) * | 2007-11-06 | 2013-04-02 | Benaroya Research Institute | Inhibition of versican with siRNA and other molecules |
JP2011506484A (ja) * | 2007-12-13 | 2011-03-03 | アルニラム ファーマシューティカルズ, インコーポレイテッド | Rsv感染の予防または治療のための方法および組成物 |
EP3067359A1 (de) | 2008-09-23 | 2016-09-14 | Scott G. Petersen | Selbstfreisetzende biolabile phosphatgeschützte pro-oligos für therapeutika auf oligonukleotidbasis und vermittlung von rna-interferenz |
EP2350277A1 (de) * | 2008-10-23 | 2011-08-03 | Alnylam Pharmaceuticals, Inc. | Verfahren und zusammensetzungen zur vorbeugung oder behandlung einer rsv-infektion unter verwendung modifizierter duplex-rna-moleküle |
CA2773483A1 (en) * | 2009-10-01 | 2011-04-07 | Alcon Research, Ltd. | Olopatadine compositions and uses thereof |
US9551710B2 (en) | 2010-02-09 | 2017-01-24 | Drexel University | Signaling molecule involved in ultraviolet damage to skin |
KR101223483B1 (ko) * | 2010-09-10 | 2013-01-17 | 한국과학기술연구원 | 전하결합 및 생분해성 공유결합으로 동시에 연결된 고분자―siRNA 나노입자 전달체 |
US20120310140A1 (en) | 2010-12-01 | 2012-12-06 | Spinal Modulation, Inc. | Directed delivery of agents to neural anatomy |
DK2914296T4 (da) | 2012-11-01 | 2022-01-03 | Infinity Pharmaceuticals Inc | Behandling af cancere under anvendelse af PI3-kinase-isoform-modulatorer |
NZ629037A (en) | 2013-03-15 | 2017-04-28 | Infinity Pharmaceuticals Inc | Salts and solid forms of isoquinolinones and composition comprising and methods of using the same |
AU2014273946B2 (en) | 2013-05-30 | 2020-03-12 | Infinity Pharmaceuticals, Inc. | Treatment of cancers using PI3 kinase isoform modulators |
TW201536329A (zh) * | 2013-08-09 | 2015-10-01 | Isis Pharmaceuticals Inc | 用於調節失養性肌強直蛋白質激酶(dmpk)表現之化合物及方法 |
PL3052485T3 (pl) | 2013-10-04 | 2022-02-28 | Infinity Pharmaceuticals, Inc. | Związki heterocykliczne i ich zastosowania |
US9751888B2 (en) | 2013-10-04 | 2017-09-05 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
WO2015061204A1 (en) | 2013-10-21 | 2015-04-30 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
WO2015131080A1 (en) | 2014-02-28 | 2015-09-03 | Nimbus Lakshmi, Inc. | Tyk2 inhibitors and uses thereof |
SG11201607705XA (en) | 2014-03-19 | 2016-10-28 | Infinity Pharmaceuticals Inc | Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders |
US20150320754A1 (en) | 2014-04-16 | 2015-11-12 | Infinity Pharmaceuticals, Inc. | Combination therapies |
AU2015249666A1 (en) * | 2014-04-25 | 2016-11-17 | The Brigham And Women's Hospital, Inc. | Compositions and methods for treating subjects with immune-mediated diseases |
CN117164657A (zh) | 2014-08-12 | 2023-12-05 | 莫纳什大学 | 定向淋巴的前药 |
US9708348B2 (en) | 2014-10-03 | 2017-07-18 | Infinity Pharmaceuticals, Inc. | Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof |
TWI788655B (zh) | 2015-02-27 | 2023-01-01 | 美商林伯士拉克許米公司 | 酪胺酸蛋白質激酶2(tyk2)抑制劑及其用途 |
WO2017004134A1 (en) | 2015-06-29 | 2017-01-05 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
JP6802263B2 (ja) | 2015-09-02 | 2020-12-16 | ニンバス ラクシュミ, インコーポレイテッド | Tyk2阻害剤およびその使用 |
WO2017041139A1 (en) | 2015-09-08 | 2017-03-16 | Monash University | Lymph directing prodrugs |
WO2017044720A1 (en) | 2015-09-11 | 2017-03-16 | Navitor Pharmaceuticals, Inc. | Rapamycin analogs and uses thereof |
CA3234750A1 (en) | 2015-10-23 | 2017-04-27 | Navitor Pharmaceuticals, Inc. | Modulators of sestrin-gator2 interaction and uses thereof |
US11370792B2 (en) | 2015-12-14 | 2022-06-28 | Raze Therapeutics, Inc. | Caffeine inhibitors of MTHFD2 and uses thereof |
EP4234552A3 (de) | 2016-03-09 | 2023-10-18 | Raze Therapeutics, Inc. | 3-phosphoglycerat-dehydrogenase-inhibitoren und verwendungen davon |
ES2965264T3 (es) | 2016-03-09 | 2024-04-11 | Raze Therapeutics Inc | Inhibidores de la 3-fosfoglicerato deshidrogenasa y sus usos |
WO2017177230A1 (en) | 2016-04-08 | 2017-10-12 | X4 Pharmaceuticals, Inc. | Methods for treating cancer |
US10919914B2 (en) | 2016-06-08 | 2021-02-16 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
ES2870920T3 (es) | 2016-06-21 | 2021-10-28 | X4 Pharmaceuticals Inc | Inhibidores de CXCR4 y usos de los mismos |
JP6994767B2 (ja) | 2016-06-21 | 2022-01-14 | エックス4 ファーマシューティカルズ, インコーポレイテッド | Cxcr4阻害剤およびその使用 |
WO2017223229A1 (en) | 2016-06-21 | 2017-12-28 | X4 Pharmaceuticals, Inc. | Cxcr4 inhibitors and uses thereof |
SG10201912456RA (en) | 2016-06-24 | 2020-02-27 | Infinity Pharmaceuticals Inc | Combination therapies |
CN109952303B (zh) | 2016-10-14 | 2022-10-21 | 林伯士拉克许米公司 | Tyk2抑制剂及其用途 |
WO2018075937A1 (en) | 2016-10-21 | 2018-04-26 | Nimbus Lakshmi, Inc. | Tyk2 inhibitors and uses thereof |
EP3538091A4 (de) | 2016-11-08 | 2020-06-10 | Navitor Pharmaceuticals, Inc. | Phenyl-amino-piperidin-mtorc-inhibitoren und verwendungen davon |
AU2017368050A1 (en) | 2016-11-29 | 2019-06-20 | Puretech Lyt, Inc. | Exosomes for delivery of therapeutic agents |
US11091451B2 (en) | 2016-12-05 | 2021-08-17 | Raze Therapeutics, Inc. | SHMT inhibitors and uses thereof |
JP2020502238A (ja) | 2016-12-23 | 2020-01-23 | バイスクルアールディー・リミテッド | 新規連結構造を有するペプチド誘導体 |
EP3565638B8 (de) | 2017-01-06 | 2024-04-10 | BicycleRD Limited | Bizyklische konjugat zur behandlung von krebs |
TWI783978B (zh) | 2017-03-08 | 2022-11-21 | 美商林伯士拉克許米公司 | Tyk2抑制劑、其用途及生產方法 |
EP3375778A1 (de) | 2017-03-14 | 2018-09-19 | Artax Biopharma Inc. | Aryl-piperidinderivate |
EP3375784A1 (de) | 2017-03-14 | 2018-09-19 | Artax Biopharma Inc. | Aza-dihydro-acridonderivate |
US11339144B2 (en) | 2017-04-10 | 2022-05-24 | Navitor Pharmaceuticals, Inc. | Heteroaryl Rheb inhibitors and uses thereof |
CN116370448A (zh) | 2017-04-26 | 2023-07-04 | 纳维托制药有限公司 | Sestrin-gator2相互作用的调节剂及其用途 |
US10857196B2 (en) | 2017-04-27 | 2020-12-08 | Bicycletx Limited | Bicyclic peptide ligands and uses thereof |
JP7301757B2 (ja) | 2017-06-26 | 2023-07-03 | バイスクルアールディー・リミテッド | 検出可能部分を持つ二環式ペプチドリガンドおよびその使用 |
PT3658557T (pt) | 2017-07-28 | 2024-09-11 | Nimbus Lakshmi Inc | Inibidores de tyk2 e usos dos mesmos |
JP2020529427A (ja) | 2017-08-04 | 2020-10-08 | バイスクルテクス・リミテッド | Cd137に対して特異的な二環式ペプチドリガンド |
US20200283482A1 (en) | 2017-08-14 | 2020-09-10 | Bicyclerd Limited | Bicyclic peptide ligand prr-a conjugates and uses thereof |
EP3668887A1 (de) | 2017-08-14 | 2020-06-24 | Bicyclerd Limited | Bicyclische peptid-ligand-sting-konjugate und verwendungen davon |
US11883497B2 (en) | 2017-08-29 | 2024-01-30 | Puretech Lyt, Inc. | Lymphatic system-directing lipid prodrugs |
AU2018324037A1 (en) | 2017-08-29 | 2020-04-16 | Monash University | Lymphatic system-directing lipid prodrugs |
WO2019060693A1 (en) | 2017-09-22 | 2019-03-28 | Kymera Therapeutics, Inc. | CRBN LIGANDS AND USES THEREOF |
JP7366031B2 (ja) | 2017-09-22 | 2023-10-20 | カイメラ セラピューティクス, インコーポレイテッド | タンパク質分解剤およびそれらの使用 |
US11608345B1 (en) | 2017-12-19 | 2023-03-21 | Puretech Lyt, Inc. | Lipid prodrugs of rapamycin and its analogs and uses thereof |
EP3727362A4 (de) | 2017-12-19 | 2021-10-06 | PureTech LYT, Inc. | Lipidprodrugs von mycophenolsäure und ihre verwendungen |
US11304954B2 (en) | 2017-12-19 | 2022-04-19 | Puretech Lyt, Inc. | Lipid prodrugs of mycophenolic acid and uses thereof |
TWI825046B (zh) | 2017-12-19 | 2023-12-11 | 英商拜西可泰克斯有限公司 | Epha2特用之雙環胜肽配位基 |
GB201721265D0 (en) | 2017-12-19 | 2018-01-31 | Bicyclerd Ltd | Bicyclic peptide ligands specific for EphA2 |
IL315310A (en) | 2017-12-26 | 2024-10-01 | Kymera Therapeutics Inc | IRAK joints and used in them |
WO2019140380A1 (en) | 2018-01-12 | 2019-07-18 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
US11512080B2 (en) | 2018-01-12 | 2022-11-29 | Kymera Therapeutics, Inc. | CRBN ligands and uses thereof |
CN111918651B (zh) | 2018-01-29 | 2024-01-30 | 默克专利股份有限公司 | Gcn2抑制剂及其用途 |
AU2019212969A1 (en) | 2018-01-29 | 2020-08-13 | Merck Patent Gmbh | GCN2 inhibitors and uses thereof |
AU2019229258B2 (en) | 2018-02-27 | 2023-09-14 | Artax Biopharma Inc. | Chromene derivatives as inhibitors of TCR-Nck interaction |
CN112218865B (zh) | 2018-04-24 | 2024-03-12 | 沃泰克斯药物股份有限公司 | 喋啶酮化合物及其用途 |
CN112236428A (zh) | 2018-04-24 | 2021-01-15 | 默克专利股份有限公司 | 抗增殖化合物及其用途 |
IL279329B1 (en) | 2018-06-15 | 2024-09-01 | Navitor Pharm Inc | Rapamycin analogs and their uses |
US11180531B2 (en) | 2018-06-22 | 2021-11-23 | Bicycletx Limited | Bicyclic peptide ligands specific for Nectin-4 |
GB201810316D0 (en) | 2018-06-22 | 2018-08-08 | Bicyclerd Ltd | Peptide ligands for binding to EphA2 |
EP3817748A4 (de) | 2018-07-06 | 2022-08-24 | Kymera Therapeutics, Inc. | Tricyclische crbn-liganden und verwendungen davon |
US10548889B1 (en) | 2018-08-31 | 2020-02-04 | X4 Pharmaceuticals, Inc. | Compositions of CXCR4 inhibitors and methods of preparation and use |
EP3846793B1 (de) | 2018-09-07 | 2024-01-24 | PIC Therapeutics, Inc. | Eif4e-inhibitoren und verwendungen davon |
EP3866789A4 (de) | 2018-10-15 | 2022-07-06 | Nimbus Lakshmi, Inc. | Tyk2-inhibitoren und verwendungen davon |
CN112955459A (zh) | 2018-10-23 | 2021-06-11 | 拜斯科技术开发有限公司 | 双环肽配体和其用途 |
US11345654B2 (en) | 2018-10-24 | 2022-05-31 | Navitor Pharmaceuticals, Inc. | Polymorphic compounds and uses thereof |
US11053241B2 (en) | 2018-11-30 | 2021-07-06 | Nimbus Lakshmi, Inc. | TYK2 inhibitors and uses thereof |
MX2021006154A (es) | 2018-11-30 | 2021-08-24 | Kymera Therapeutics Inc | Degradadores de cinasas asociadas al receptor de interleucina 1 (irak) y usos de los mismos. |
EP3670659A1 (de) | 2018-12-20 | 2020-06-24 | Abivax | Biomarker und verwendungen bei der behandlung von viralen infektionen, entzündlichen oder krebserkrankungen |
JP2022518505A (ja) | 2019-01-23 | 2022-03-15 | ニンバス ラクシュミ, インコーポレイテッド | Tyk2阻害剤およびその使用 |
WO2020165600A1 (en) | 2019-02-14 | 2020-08-20 | Bicycletx Limited | Bicyclic peptide ligand sting conjugates and uses thereof |
AU2020253990A1 (en) | 2019-04-02 | 2021-10-28 | Bicycletx Limited | Bicycle toxin conjugates and uses thereof |
US11485750B1 (en) | 2019-04-05 | 2022-11-01 | Kymera Therapeutics, Inc. | STAT degraders and uses thereof |
JP2022534425A (ja) | 2019-05-31 | 2022-07-29 | イケナ オンコロジー, インコーポレイテッド | Tead阻害剤およびその使用 |
TW202110485A (zh) | 2019-07-30 | 2021-03-16 | 英商拜西可泰克斯有限公司 | 異質雙環肽複合物 |
AU2020345962A1 (en) | 2019-09-11 | 2022-03-31 | Vincere Biosciences, Inc. | USP30 inhibitors and uses thereof |
BR112022004451A2 (pt) | 2019-09-13 | 2022-06-21 | Nimbus Saturn Inc | Antagonistas de hpk1 e usos dos mesmos |
WO2021087432A1 (en) | 2019-11-01 | 2021-05-06 | Navitor Pharmaceuticals, Inc. | Methods of treatment using an mtorc1 modulator |
US11819476B2 (en) | 2019-12-05 | 2023-11-21 | Janssen Pharmaceutica Nv | Rapamycin analogs and uses thereof |
KR20220145325A (ko) | 2019-12-17 | 2022-10-28 | 카이메라 쎄라퓨틱스 인코포레이티드 | Irak 분해제 및 이의 용도 |
US11591332B2 (en) | 2019-12-17 | 2023-02-28 | Kymera Therapeutics, Inc. | IRAK degraders and uses thereof |
CN115297931A (zh) | 2019-12-23 | 2022-11-04 | 凯麦拉医疗公司 | Smarca降解剂和其用途 |
KR20220149534A (ko) | 2020-02-05 | 2022-11-08 | 퓨어테크 엘와이티, 아이엔씨. | 신경스테로이드의 지질 전구약물 |
WO2021178488A1 (en) | 2020-03-03 | 2021-09-10 | PIC Therapeutics, Inc. | Eif4e inhibitors and uses thereof |
JP2023518423A (ja) | 2020-03-19 | 2023-05-01 | カイメラ セラピューティクス, インコーポレイテッド | Mdm2分解剤およびそれらの使用 |
TW202210483A (zh) | 2020-06-03 | 2022-03-16 | 美商凱麥拉醫療公司 | Irak降解劑之結晶型 |
WO2022038158A1 (en) | 2020-08-17 | 2022-02-24 | Bicycletx Limited | Bicycle conjugates specific for nectin-4 and uses thereof |
CA3200814A1 (en) | 2020-12-02 | 2022-06-09 | Alfredo C. Castro | Tead inhibitors and uses thereof |
WO2022120353A1 (en) | 2020-12-02 | 2022-06-09 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
EP4288427A1 (de) | 2021-02-02 | 2023-12-13 | Liminal Biosciences Limited | Gpr84-antagonisten und verwendungen davon |
US20230091528A1 (en) | 2021-02-02 | 2023-03-23 | Liminal Biosciences Limited | Gpr84 antagonists and uses thereof |
CN116867494A (zh) | 2021-02-15 | 2023-10-10 | 凯麦拉医疗公司 | Irak4降解剂和其用途 |
WO2022187856A1 (en) | 2021-03-05 | 2022-09-09 | Nimbus Saturn, Inc. | Hpk1 antagonists and uses thereof |
JP2024513011A (ja) | 2021-03-29 | 2024-03-21 | ニンバス サターン, インコーポレイテッド | Hpk1アンタゴニスト及びその使用 |
AU2022258968A1 (en) | 2021-04-16 | 2023-10-19 | Ikena Oncology, Inc. | Mek inhibitors and uses thereof |
TW202309030A (zh) | 2021-05-07 | 2023-03-01 | 美商凱麥拉醫療公司 | Cdk2降解劑及其用途 |
JP2024532276A (ja) | 2021-08-25 | 2024-09-05 | ピク セラピューティクス, インコーポレイテッド | eIF4E阻害剤及びその使用 |
TW202315621A (zh) | 2021-08-25 | 2023-04-16 | 美商皮克醫療公司 | Eif4e抑制劑及其用途 |
EP4396352A2 (de) | 2021-09-01 | 2024-07-10 | Ionis Pharmaceuticals, Inc. | Verbindungen und verfahren zur reduzierung der dmpk-expression |
WO2023114984A1 (en) | 2021-12-17 | 2023-06-22 | Ikena Oncology, Inc. | Tead inhibitors and uses thereof |
AU2023214044A1 (en) | 2022-01-31 | 2024-08-08 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
WO2023173057A1 (en) | 2022-03-10 | 2023-09-14 | Ikena Oncology, Inc. | Mek inhibitors and uses thereof |
WO2023173053A1 (en) | 2022-03-10 | 2023-09-14 | Ikena Oncology, Inc. | Mek inhibitors and uses thereof |
WO2023211889A1 (en) | 2022-04-25 | 2023-11-02 | Ikena Oncology, Inc. | Polymorphic compounds and uses thereof |
WO2023230205A1 (en) | 2022-05-25 | 2023-11-30 | Ikena Oncology, Inc. | Mek inhibitors and uses thereof |
WO2024028365A1 (en) | 2022-08-02 | 2024-02-08 | Liminal Biosciences Limited | Substituted pyridone gpr84 antagonists and uses thereof |
TW202416950A (zh) | 2022-08-02 | 2024-05-01 | 英商利米那生物科技有限公司 | 雜芳基甲醯胺及相關gpr84拮抗劑及其用途 |
TW202415650A (zh) | 2022-08-02 | 2024-04-16 | 英商利米那生物科技有限公司 | 芳基-三唑基及相關gpr84拮抗劑及其用途 |
US20240208961A1 (en) | 2022-11-22 | 2024-06-27 | PIC Therapeutics, Inc. | Eif4e inhibitors and uses thereof |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989005358A1 (en) | 1987-11-30 | 1989-06-15 | University Of Iowa Research Foundation | Dna and rna molecules stabilized by modifications of the 3'-terminal phosphodiester linkage and their use as nucleic acid probes and as therapeutic agents to block the expression of specifically targeted genes |
US5256555A (en) | 1991-12-20 | 1993-10-26 | Ambion, Inc. | Compositions and methods for increasing the yields of in vitro RNA transcription and other polynucleotide synthetic reactions |
US5858981A (en) * | 1993-09-30 | 1999-01-12 | University Of Pennsylvania | Method of inhibiting phagocytosis |
US5939262A (en) | 1996-07-03 | 1999-08-17 | Ambion, Inc. | Ribonuclease resistant RNA preparation and utilization |
US6057134A (en) | 1996-10-07 | 2000-05-02 | Ambion, Inc. | Modulating the efficiency of nucleic acid amplification reactions with 3' modified oligonucleotides |
US6111086A (en) | 1998-02-27 | 2000-08-29 | Scaringe; Stephen A. | Orthoester protecting groups |
US20030084471A1 (en) | 2000-03-16 | 2003-05-01 | David Beach | Methods and compositions for RNA interference |
AU2001245793A1 (en) * | 2000-03-16 | 2001-09-24 | Cold Spring Harbor Laboratory | Methods and compositions for rna interference |
DK1309726T4 (en) | 2000-03-30 | 2019-01-28 | Whitehead Inst Biomedical Res | RNA Sequence-Specific Mediators of RNA Interference |
CZ308053B6 (cs) * | 2000-12-01 | 2019-11-27 | Max Planck Gesellschaft | Izolovaná molekula dvouřetězcové RNA, způsob její výroby a její použití |
CA2447360A1 (en) * | 2001-05-09 | 2002-11-14 | Alk-Abello A/S | Pharmaceutical compositions for preventing or treating th1 and th2 cell related diseases by modulating the th1/th2 ratio. |
DE60233574D1 (de) * | 2001-07-10 | 2009-10-15 | Univ R | Verfahren und zusammensetzungen zum nachweis des aktivierungszustands multipler proteine in einzelzellen |
US7381535B2 (en) * | 2002-07-10 | 2008-06-03 | The Board Of Trustees Of The Leland Stanford Junior | Methods and compositions for detecting receptor-ligand interactions in single cells |
US20050130117A1 (en) * | 2001-10-03 | 2005-06-16 | Davis Cong L. | Modulators of lymphocyte activation and migration |
US7308364B2 (en) * | 2001-11-07 | 2007-12-11 | The University Of Arkansas For Medical Sciences | Diagnosis of multiple myeloma on gene expression profiling |
US7894992B2 (en) * | 2001-11-07 | 2011-02-22 | Board Of Trustees Of The University Of Arkansas | Diagnosis and classification of multiple myeloma |
US7371736B2 (en) * | 2001-11-07 | 2008-05-13 | The Board Of Trustees Of The University Of Arkansas | Gene expression profiling based identification of DKK1 as a potential therapeutic targets for controlling bone loss |
US20060141493A1 (en) * | 2001-11-09 | 2006-06-29 | Duke University Office Of Science And Technology | Atherosclerotic phenotype determinative genes and methods for using the same |
US20040018522A1 (en) * | 2002-05-09 | 2004-01-29 | Brigham And Women's Hospital, Inc. | Identification of dysregulated genes in patients with multiple sclerosis |
JP4557714B2 (ja) * | 2002-05-10 | 2010-10-06 | メディミューン,エルエルシー | EphA2モノクローナル抗体およびその使用法 |
DK2284266T3 (da) * | 2002-11-14 | 2014-01-13 | Thermo Fisher Scient Biosciences Inc | sIRNA-MOLEKYLE MOD TP53 |
US7250496B2 (en) * | 2002-11-14 | 2007-07-31 | Rosetta Genomics Ltd. | Bioinformatically detectable group of novel regulatory genes and uses thereof |
WO2004052364A1 (en) * | 2002-12-06 | 2004-06-24 | The Trustees Of Boston University | METHODS FOR SUSTAINING eNOS ACTIVITY |
US20040219575A1 (en) * | 2002-12-26 | 2004-11-04 | Toomas Neuman | Methods and compositions for the diagnosis, prognosis, and treatment of cancer |
CA2514986A1 (en) * | 2003-02-05 | 2004-08-19 | Applied Research Systems Ars Holding N.V. | Mucin-like polypeptides |
US20050147593A1 (en) * | 2003-05-22 | 2005-07-07 | Medimmune, Inc. | EphA2, EphA4 and LMW-PTP and methods of treatment of hyperproliferative cell disorders |
CA2550274A1 (en) * | 2003-11-12 | 2005-05-26 | Acea Biosciences, Inc. | Real time electronic cell sensing systems and applications for cell-based assays |
WO2005049838A2 (en) * | 2003-11-14 | 2005-06-02 | Yale University | Syk-targeted nucleic acid interference |
US20050153923A1 (en) * | 2003-12-04 | 2005-07-14 | Kinch Michael S. | Targeted drug delivery using EphA2 or EphA4 binding moieties |
JP2007527240A (ja) * | 2004-03-01 | 2007-09-27 | マサチューセッツ インスティテュート オブ テクノロジー | アレルギー性鼻炎および喘息のためのRNAiベースの治療 |
-
2004
- 2004-07-01 EP EP10013162A patent/EP2371835A1/de not_active Withdrawn
- 2004-07-01 WO PCT/US2004/020990 patent/WO2005007623A2/en active Application Filing
- 2004-07-01 CA CA002531069A patent/CA2531069A1/en not_active Abandoned
- 2004-07-01 JP JP2006517793A patent/JP2007524397A/ja not_active Withdrawn
- 2004-07-01 CN CN2009102218611A patent/CN101961497A/zh active Pending
- 2004-07-01 AU AU2004257167A patent/AU2004257167B2/en not_active Ceased
- 2004-07-01 US US10/880,612 patent/US7173015B2/en not_active Expired - Fee Related
- 2004-07-01 EP EP04756414A patent/EP1692153A4/de not_active Withdrawn
- 2004-07-01 CN CN200480019112A patent/CN100577680C/zh not_active Expired - Fee Related
-
2006
- 2006-12-15 US US11/639,243 patent/US20070219152A1/en not_active Abandoned
-
2007
- 2007-04-16 HK HK07103911.3A patent/HK1096972A1/xx unknown
-
2011
- 2011-05-03 US US13/067,035 patent/US20120093913A1/en not_active Abandoned
- 2011-05-11 JP JP2011106343A patent/JP2011200238A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU2004257167A2 (en) | 2005-01-27 |
WO2005007623A2 (en) | 2005-01-27 |
EP1692153A4 (de) | 2007-03-21 |
AU2004257167B2 (en) | 2012-03-29 |
WO2005007623A3 (en) | 2006-05-18 |
US20050075306A1 (en) | 2005-04-07 |
EP1692153A2 (de) | 2006-08-23 |
JP2007524397A (ja) | 2007-08-30 |
CA2531069A1 (en) | 2005-01-27 |
US20070219152A1 (en) | 2007-09-20 |
CN1860127A (zh) | 2006-11-08 |
US7173015B2 (en) | 2007-02-06 |
AU2004257167A1 (en) | 2005-01-27 |
EP2371835A1 (de) | 2011-10-05 |
WO2005007623A8 (en) | 2006-03-23 |
JP2011200238A (ja) | 2011-10-13 |
US20120093913A1 (en) | 2012-04-19 |
CN100577680C (zh) | 2010-01-06 |
CN101961497A (zh) | 2011-02-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1096972A1 (en) | Inhibition of syk kinase expression | |
AP2048A (en) | Diazepinoindole derivatives as kinase inhibitors | |
IL172132A0 (en) | Thienopyridone derivatives as kinase inhibitors | |
IL173381A0 (en) | 2-aminophenyl-4-phenylpyrimidines as kinase inhibitors | |
HK1199254A1 (en) | Process for the preparation of aurora kinase inhibitors | |
PL373371A1 (en) | Aryl ketone pyrrolo-triazine compounds useful as kinase inhibitors | |
HK1173394A1 (zh) | 二酮哌嗪的合成 | |
IL165515A0 (en) | Bisindolyl-maleimid derivatives as kinase inhibitors | |
SI1476162T1 (sl) | Nadzirana sinteza ziprasidona | |
AU2003271566A8 (en) | Pyrrolopyrazines as kinase inhibitors | |
IL172375A0 (en) | Chinazoline derivatives as aurora kinase inhibitors | |
IL209082A0 (en) | Fushed heterocyclic compounds | |
IL167088A (en) | Pyrazolopyrimidine derivatives as cyclin dependent kinase inhibitors | |
PL373649A1 (en) | Kinase inhibitors | |
SI1569907T1 (sl) | Na nikotinamidu osnovani kinazni inhibitorji | |
EP1624844A4 (de) | Formulierung auf basis von morinda citrifolia zur hemmung von metastasen von karzinogenen zellen | |
EP1558609A4 (de) | Kinase-hemmer | |
PL378116A1 (pl) | Heterocykliczne inhibitory kinazy | |
ME00716B (me) | Jedinjenja i postupci za inhibiciju mitotičke progresije inhibiranjem aurora kinaze | |
ZA200407609B (en) | Use of vitamin d compounds | |
EP1390052A4 (de) | Hemmung von jun kinase | |
IL174867A0 (en) | Processes for preparation of ziprasidone | |
EP1569907A4 (de) | Nicotinamid-basierte kinasehemmer | |
EP1605893A4 (de) | Trans-membran-antikörper-induzierte apoptose-hemmung | |
EP1670422A4 (de) | Identifizierung von kinase-inhibitoren |