HK1094974A1 - Identification of a jak2 mutation in polycythemia vera - Google Patents

Identification of a jak2 mutation in polycythemia vera

Info

Publication number
HK1094974A1
HK1094974A1 HK07101976A HK07101976A HK1094974A1 HK 1094974 A1 HK1094974 A1 HK 1094974A1 HK 07101976 A HK07101976 A HK 07101976A HK 07101976 A HK07101976 A HK 07101976A HK 1094974 A1 HK1094974 A1 HK 1094974A1
Authority
HK
Hong Kong
Prior art keywords
mutation
identification
polycythemia vera
jak2
jak2 mutation
Prior art date
Application number
HK07101976A
Other languages
English (en)
Inventor
William Vainchenker
Valerie Ugo
Chloe James
Jean-Pierre Le Couedic
Nicole Casadevall
Original Assignee
Assist Publ Hopitaux De Paris
Inst Nat Sante Rech Med
Roussy Inst Gustave
Univ Versailles Saint Quentin En Yvelines
Univ Paris Sud
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34953071&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1094974(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Assist Publ Hopitaux De Paris, Inst Nat Sante Rech Med, Roussy Inst Gustave, Univ Versailles Saint Quentin En Yvelines, Univ Paris Sud filed Critical Assist Publ Hopitaux De Paris
Publication of HK1094974A1 publication Critical patent/HK1094974A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57426—Specifically defined cancers leukemia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57496—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving intracellular compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205—Phosphotransferases in general
    • G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases
    • G01N2333/91215—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases with a definite EC number (2.7.1.-)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
HK07101976A 2004-10-27 2007-02-21 Identification of a jak2 mutation in polycythemia vera HK1094974A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0411480A FR2877013A1 (fr) 2004-10-27 2004-10-27 Indentification d'une mutation de jak2 impliquee dans la polyglobulie de vaquez
PCT/EP2005/055586 WO2006045827A1 (fr) 2004-10-27 2005-10-26 Identification d'une mutation de jak2 impliquée dans la polyglobulie de vaquez

Publications (1)

Publication Number Publication Date
HK1094974A1 true HK1094974A1 (en) 2007-04-20

Family

ID=34953071

Family Applications (1)

Application Number Title Priority Date Filing Date
HK07101976A HK1094974A1 (en) 2004-10-27 2007-02-21 Identification of a jak2 mutation in polycythemia vera

Country Status (21)

Country Link
US (9) US7781199B2 (xx)
EP (2) EP1692281B8 (xx)
JP (3) JP5090171B2 (xx)
KR (1) KR101203003B1 (xx)
CN (1) CN101072870B (xx)
AT (1) ATE382082T1 (xx)
AU (1) AU2005298636B2 (xx)
BR (1) BRPI0517398B8 (xx)
CA (3) CA2585062C (xx)
DE (1) DE602005004008T2 (xx)
DK (1) DK1692281T3 (xx)
ES (1) ES2296229T3 (xx)
FR (1) FR2877013A1 (xx)
HK (1) HK1094974A1 (xx)
IL (1) IL182761A0 (xx)
MX (1) MX2007005174A (xx)
PL (1) PL1692281T3 (xx)
PT (1) PT1692281E (xx)
SI (1) SI1692281T1 (xx)
WO (1) WO2006045827A1 (xx)
ZA (1) ZA200703433B (xx)

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WO2011067373A1 (fr) * 2009-12-04 2011-06-09 Assistance Publique - Hopitaux De Paris Methode de detection d'une polyglobulie chez un chien
AU2011214254B2 (en) * 2010-02-10 2016-06-09 Genon Biotechnologies Oy Dual activity kinase domains and uses thereof
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CN103243153B (zh) * 2012-02-10 2014-11-05 复旦大学附属华山医院 Jak2 v617f突变的检测应用
WO2014068072A1 (en) 2012-10-31 2014-05-08 Institut Gustave-Roussy Identification, assessment and therapy of essential thrombocythemia with resistance to jak2 inhibitors
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CA2890658A1 (en) 2012-11-09 2014-05-15 The Johns Hopkins University A genetic assay to determine prognosis in polycythemia vera patients
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CN108138234A (zh) * 2015-04-15 2018-06-08 普罗麦迪奥股份有限公司 治疗骨髓增生性障碍的方法
CA2983820A1 (en) 2015-04-23 2016-10-27 Quest Diagnostics Investments Incorporated Methods and compositions for the detection of calr mutations in myeloproliferative diseases
JP7320350B2 (ja) 2015-08-04 2023-08-03 アクセルロン ファーマ インコーポレイテッド 骨髄増殖性障害を処置するための方法
CN105441573A (zh) * 2016-01-11 2016-03-30 武汉海吉力生物科技有限公司 用于检测人类jak2基因v617f突变的引物、探针及试剂盒
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WO2021257857A1 (en) 2020-06-19 2021-12-23 Incyte Corporation Naphthyridinone compounds as jak2 v617f inhibitors
WO2021257863A1 (en) 2020-06-19 2021-12-23 Incyte Corporation Pyrrolotriazine compounds as jak2 v617f inhibitors
WO2022006456A1 (en) 2020-07-02 2022-01-06 Incyte Corporation Tricyclic pyridone compounds as jak2 v617f inhibitors
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Also Published As

Publication number Publication date
BRPI0517398A (pt) 2008-10-14
DE602005004008D1 (de) 2008-02-07
ATE382082T1 (de) 2008-01-15
EP1692281B8 (fr) 2008-02-13
ZA200703433B (en) 2008-08-27
US11162100B2 (en) 2021-11-02
IL182761A0 (en) 2007-07-24
CA2585062C (fr) 2012-11-20
US20060288432A1 (en) 2006-12-21
CA2647086C (fr) 2012-09-18
DE602005004008T2 (de) 2009-02-12
US8466338B2 (en) 2013-06-18
US20140249204A1 (en) 2014-09-04
US10563200B2 (en) 2020-02-18
EP1692281A1 (fr) 2006-08-23
JP5090171B2 (ja) 2012-12-05
WO2006045827A1 (fr) 2006-05-04
US8852931B2 (en) 2014-10-07
FR2877013A1 (fr) 2006-04-28
CA2585062A1 (fr) 2006-05-04
US20190323007A1 (en) 2019-10-24
DK1692281T3 (da) 2008-05-13
US7781199B2 (en) 2010-08-24
MX2007005174A (es) 2007-10-10
EP1895000A1 (fr) 2008-03-05
KR20070104338A (ko) 2007-10-25
CN101072870A (zh) 2007-11-14
AU2005298636A1 (en) 2006-05-04
BRPI0517398B1 (pt) 2021-03-02
US8637235B2 (en) 2014-01-28
US10364430B2 (en) 2019-07-30
JP5290884B2 (ja) 2013-09-18
US7429456B2 (en) 2008-09-30
JP2013135673A (ja) 2013-07-11
JP6103691B2 (ja) 2017-03-29
US20090162849A1 (en) 2009-06-25
US20130189683A1 (en) 2013-07-25
JP2008517613A (ja) 2008-05-29
US20150051263A2 (en) 2015-02-19
JP2009278982A (ja) 2009-12-03
AU2005298636B2 (en) 2009-11-26
CN101072870B (zh) 2013-01-30
CA2647086A1 (fr) 2006-05-04
CA2754028A1 (fr) 2006-05-04
BRPI0517398B8 (pt) 2021-05-25
SI1692281T1 (sl) 2008-04-30
KR101203003B1 (ko) 2012-11-21
EP1692281B1 (fr) 2007-12-26
US20080076135A1 (en) 2008-03-27
US20220042016A1 (en) 2022-02-10
PL1692281T3 (pl) 2008-06-30
US20120066776A1 (en) 2012-03-15
US20200140863A1 (en) 2020-05-07
PT1692281E (pt) 2008-02-06
ES2296229T3 (es) 2008-04-16

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