HK1090924A1 - Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof - Google Patents

Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof

Info

Publication number
HK1090924A1
HK1090924A1 HK06112592.1A HK06112592A HK1090924A1 HK 1090924 A1 HK1090924 A1 HK 1090924A1 HK 06112592 A HK06112592 A HK 06112592A HK 1090924 A1 HK1090924 A1 HK 1090924A1
Authority
HK
Hong Kong
Prior art keywords
synthesis
intermediates
carbamate prodrugs
acyloxy
alkyl
Prior art date
Application number
HK06112592.1A
Other languages
English (en)
Inventor
Mark A Gallop
Xuedong Dai
Randall A Scheuerman
Stephen P Raillard
Suresh K Manthati
Fenmei Yao
Thu Phan
Maria Ludwikow
Ge Peng
Seema Bhat
Original Assignee
Xenoport Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenoport Inc filed Critical Xenoport Inc
Publication of HK1090924A1 publication Critical patent/HK1090924A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
HK06112592.1A 2003-12-30 2006-11-16 Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof HK1090924A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US53364903P 2003-12-30 2003-12-30
US60663704P 2004-08-13 2004-08-13
PCT/US2004/043823 WO2005066122A2 (en) 2003-12-30 2004-12-30 Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof

Publications (1)

Publication Number Publication Date
HK1090924A1 true HK1090924A1 (en) 2007-01-05

Family

ID=34753006

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06112592.1A HK1090924A1 (en) 2003-12-30 2006-11-16 Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof

Country Status (10)

Country Link
US (5) US7227028B2 (ja)
EP (2) EP1716115B1 (ja)
JP (2) JP4927563B2 (ja)
CN (1) CN102702065A (ja)
CA (1) CA2551859C (ja)
DK (1) DK1716115T3 (ja)
ES (1) ES2405329T3 (ja)
HK (1) HK1090924A1 (ja)
IL (2) IL176341A (ja)
WO (1) WO2005066122A2 (ja)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7186855B2 (en) * 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7025745B2 (en) * 2002-10-07 2006-04-11 Advanced Cardiovascular Systems, Inc. Method of making a catheter balloon using a tapered mandrel
WO2005010011A2 (en) * 2003-07-15 2005-02-03 Xenoport, Inc. Methods of synthesis of acyloxyalkyl compounds
AU2004267100B2 (en) 2003-08-20 2010-10-07 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
AU2004272111A1 (en) * 2003-09-11 2005-03-24 Xenoport, Inc. Treating and/or preventing urinary incontinence using prodrugs of GABA analogs
SI1677767T1 (sl) * 2003-10-14 2011-11-30 Xenoport Inc Kristalinična oblika analoga gama-aminomaslene kisline
ES2405329T3 (es) 2003-12-30 2013-05-30 Xenoport, Inc. Síntesis de profármacos de carbarnato de aciloxialquilo y productos intermedios de los mismos
CA2580690A1 (en) * 2004-10-21 2006-05-04 Transtech Pharma, Inc. Bissulfonamide compounds as agonists of galr1, compositions, and methods of use
WO2006050472A2 (en) 2004-11-03 2006-05-11 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphonous and -phosphinic acids
US8795725B2 (en) 2004-11-04 2014-08-05 Xenoport, Inc. GABA analog prodrug sustained release oral dosage forms
JP4938771B2 (ja) 2005-06-20 2012-05-23 ゼノポート，インコーポレーテッド トラネキサム酸のカルバミン酸アシルオキシアルキルプロドラッグ、合成法、および使用
WO2007085933A2 (en) * 2006-01-25 2007-08-02 Glenmark Pharmaceuticals Limited Process for the preparation of n-[1-(s)-ethoxycarbonyl-1-butyl]-(s)-alanine-dmt complex and its use in the preparation of perindopril
TW200820963A (en) * 2006-07-28 2008-05-16 Xenoport Inc Acyloxyalkyl carbamate prodrugs of α-amino acids, methods of synthesis and use
WO2008033572A1 (en) 2006-09-15 2008-03-20 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
EP2117517B1 (en) * 2007-01-11 2011-06-01 XenoPort, Inc. Sustained release oral dosage forms of a prodrug of r-baclofen and methods of treatment
US20090118365A1 (en) * 2007-11-06 2009-05-07 Xenoport, Inc Use of Prodrugs of GABA B Agonists for Treating Neuropathic and Musculoskeletal Pain
WO2009094577A2 (en) * 2008-01-25 2009-07-30 Xenoport, Inc. Mesophasic forms of (3s)-aminomethyl-5-methyl-hexanoic acid prodrugs and methods of use
ES2601852T3 (es) * 2008-01-25 2017-02-16 Xenoport, Inc. Forma cristalina de sales de calcio de ácidos (3S)-aminometil-5-metil-hexanoicos y métodos de uso
WO2009094563A2 (en) 2008-01-25 2009-07-30 Xenoport, Inc. Crystalline form of calcium-salts of (3s)-aminomethyl-b-methyl-hexanoic acids and methods of use
WO2009096985A1 (en) * 2008-02-01 2009-08-06 Xenoport, Inc. Sustained release particulate oral dosage forms of (r)-baclofen prodrugs and methods of treatment
US20100137442A2 (en) * 2008-02-01 2010-06-03 Xenoport, Inc. Sustained Release Particulate Oral Dosage Forms of (R)-Baclofen and Methods of Treatment
SG176464A1 (en) 2008-05-09 2011-12-29 Agency Science Tech & Res Diagnosis and treatment of kawasaki disease
WO2010008886A2 (en) * 2008-06-24 2010-01-21 Teva Pharmaceutical Industries Ltd. Processes for preparing prodrugs of gabapentin and intermediates thereof
WO2010003046A2 (en) * 2008-07-02 2010-01-07 Teva Pharmaceutical Industries Ltd. Gabapentin enacarbil salts and processes for their preparation
WO2010017498A1 (en) * 2008-08-07 2010-02-11 Xenoport, Inc. Methods of synthesizing n-hydroxysuccinimidyl carbonates
WO2010017504A1 (en) * 2008-08-07 2010-02-11 Xenoport, Inc. Methods of synthesizing 1-(acyloxy)-alkyl carbamate prodrugs
WO2010063002A2 (en) * 2008-11-26 2010-06-03 Teva Pharmaceutical Industries Ltd. Processes for the preparation and purification of gabapentin enacarbil
WO2010075520A1 (en) 2008-12-23 2010-07-01 Teva Pharmaceutical Industries Ltd. Preparation of gabapentin enacarbil intermediate
NZ594648A (en) 2009-03-03 2013-12-20 Xenoport Inc Sustained release oral dosage forms of an r-baclofen prodrug
US20100226981A1 (en) * 2009-03-06 2010-09-09 Xenoport, Inc. Oral dosage forms having a high loading of a gabapentin prodrug
EP2419401A2 (en) * 2009-04-17 2012-02-22 XenoPort, Inc. GAMMA-AMINO-BUTYRIC ACID DERIVATIVES AS GABAb RECEPTOR LIGANDS
WO2011012721A1 (en) 2009-07-31 2011-02-03 Ascendis Pharma As Carrier linked pramipexole prodrugs
WO2011012723A1 (en) 2009-07-31 2011-02-03 Ascendis Pharma As Injectable sustained release compositions comprising a pramipexole prodrug
US20110060040A1 (en) * 2009-09-04 2011-03-10 Xenoport, Inc. Uses of acyloxyalkyl carbamate prodrugs of tranexamic acid
US20110124705A1 (en) * 2009-11-24 2011-05-26 Xenoport, Inc. Prodrugs of alpha-2-delta ligands, pharmaceutical compositions and uses thereof
US20110130454A1 (en) * 2009-11-24 2011-06-02 Xenoport, Inc. Prodrugs of gamma-amino acid, alpha-2-delta ligands, pharmaceutical compositions and uses thereof
WO2011091164A1 (en) 2010-01-22 2011-07-28 Xenoport, Inc. Oral dosage forms having a high loading of a tranexamic acid prodrug
US8377956B2 (en) * 2010-03-01 2013-02-19 Xenoport, Inc. Use of (3R)-4-{[(1S)-2-methyl-1-(2-methylpropanoyloxy)propoxy]carbonylamino}-3-(4-chlorophenyl) butanoic acid for treating urinary incontinence
WO2011112535A2 (en) * 2010-03-10 2011-09-15 Promentis Pharmaceuticals, Inc. Propionic acids, propionic acid esters, and related compounds
CN102803226B (zh) 2010-03-18 2016-05-04 第一三共株式会社 环烷基取代的咪唑衍生物
US9248111B2 (en) 2011-03-01 2016-02-02 Pharnext Therapeutic approaches for treating parkinson's disease
EP2705842A1 (en) 2012-09-05 2014-03-12 Pharnext Therapeutic approaches for treating parkinson's disease
UA113165C2 (xx) 2011-03-01 2016-12-26 Застосування комбінації баклофену і акампросату для лікування неврологічних захворювань та композиція, яка містить баклофен і акампросат
CN103596562B (zh) 2011-03-01 2016-06-01 法耐斯特公司 基于巴氯芬和阿坎酸的神经性障碍疗法
WO2013023155A1 (en) 2011-08-11 2013-02-14 Xenoport, Inc. Anhydrous and hemihydrate crystalline forms of an (r)-baclofen prodrug, methods of synthesis and methods of use
WO2013026777A1 (en) * 2011-08-24 2013-02-28 Solvay Sa Fluoroalkyl s-(fluoro)alkyl thiocarbonates, a method for the preparation of fluoroalkyl s-(fluoro)alkyl thiocarbonates, and their use
CA2879114A1 (en) 2012-07-18 2014-01-23 Pharnext Baclofen and acamprosate based therapy of macular degeneration disorders
EP2705843A1 (en) 2012-09-05 2014-03-12 Pharnext Therapeutic approaches for treating epilepsy and related disorders through reduction of epileptogenesis
EP2705841A1 (en) 2012-09-05 2014-03-12 Pharnext Combinations of nootropic agents for treating cognitive dysfunctions
EP2961730A2 (en) 2013-02-26 2016-01-06 XenoPort, Inc. Method of making 1-(acyloxy)-alkyl carbamate compounds
US9822075B2 (en) 2013-11-05 2017-11-21 Astrazeneca Ab NMDA antagonist prodrugs
JP6271766B2 (ja) 2014-02-03 2018-01-31 クワドリガ バイオサイエンシーズ， インコーポレイテッド 化学療法剤としてのβ置換γアミノ酸および類似体
MX2016010095A (es) 2014-02-03 2017-02-15 Quadriga Biosciences Inc Beta-aminoacidos beta-sustituidos y sus analogos como agentes quimioterapeuticos.
KR20160111013A (ko) 2014-02-11 2016-09-23 파넥스트 신경질환의 치료를 위한 바클로펜, 아캄프로세이트 및 중쇄 트리-글리세리드의 조합
EP3206695A4 (en) 2014-10-17 2018-06-20 The Board of Trustees of the University of Illionis Scalable synthesis of reduced toxicity derivative of amphotericin b
US10308612B2 (en) 2015-06-26 2019-06-04 Daiichi Sankyo Company, Limited Method for producing 1-(acyloxy)alkyl carbamate derivative
CN108026026B (zh) 2015-08-03 2021-02-09 夸德里加生物科学公司 作为化疗剂的β-取代的β-氨基酸和类似物及其应用
EP3339291A1 (en) 2016-12-22 2018-06-27 Vita Api Proteasome inhibiting ss-lactam prodrugs useful for the treatment of cancer and neurodegenerative disorders
WO2018197383A1 (en) 2017-04-24 2018-11-01 Pharnext Idalopirdine-based combinatorial therapies of alzheimer's disease
CN108976147B (zh) * 2017-05-31 2021-02-12 首都医科大学 氨基正己酰氨基甲环酰氨基正己酰碱性氨基酸，其合成，活性和应用
EP3746062A1 (en) 2018-01-29 2020-12-09 Pharnext Baclofen and acamprosate based therapy of alzheimer's disease in patients having lost responsiveness to acetylcholinesterase inhibitor therapy

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0079872B1 (en) 1981-11-17 1985-03-20 KabiVitrum AB Antifibrinolytically active compounds
US4426391A (en) * 1982-09-15 1984-01-17 Merck & Co., Inc. [(Alkoxycarbonyl)oxy]alkyl esters of methyldopa
US4760057A (en) * 1983-06-23 1988-07-26 Merck & Co., Inc. (Acyloxyalkoxy)carbonyl derivatives as bioreversible prodrug moieties for primary and secondary amine functions in drugs
US4916230A (en) * 1984-07-02 1990-04-10 Merck & Co., Inc. Process for preparing novel N-(acyloxy-alkoxy)carbonyl derivatives useful as bioreversible prodrug moieties for primary and secondary amine functions in drugs
US5098999A (en) 1989-08-23 1992-03-24 Hitachi Chemical Company Amino-protected dopa derivative and production thereof
JP2629375B2 (ja) * 1989-09-14 1997-07-09 日立化成工業株式会社 アミノ基が保護されたドーパ又はドーパ誘導体の製造法
EP0416689B1 (en) 1989-09-06 1995-11-29 Merck & Co. Inc. Acyloxymethyl esters of bisphosphonic acids as bone resorption inhibitors
GB9001405D0 (en) 1990-01-22 1990-03-21 Leo Pharm Prod Ltd New intermediates,their production and use
SE9200858L (sv) * 1992-03-20 1993-09-21 Kabi Pharmacia Ab Metod för framställning av pellets med fördröjd frisättning
SE9300013L (sv) 1992-12-30 1994-07-01 Kabi Pharmacia Ab Nytt förfarande och mellanprodukter för framställning av pro- läkemedel
IL111584A0 (en) 1993-11-18 1995-01-24 Merck & Co Inc Prodrugs of an inhibitor of hiv protease and pharmaceutical compositions containing them
US5684018A (en) * 1994-12-13 1997-11-04 Merck & Co., Inc. Acyloxyisopropyl carbamates as prodrugs for amine drugs
JPH10148903A (ja) * 1996-11-20 1998-06-02 Konica Corp 耐圧性の改良されたハロゲン化銀写真感光材料
JP3526243B2 (ja) 1999-07-09 2004-05-10 松下電器産業株式会社 基地局装置及び回線品質劣化防止方法
CN1373770A (zh) * 1999-07-15 2002-10-09 伊莱利利公司 假单胞菌素前药
GB2365425A (en) * 2000-08-01 2002-02-20 Parke Davis & Co Ltd Alkyl amino acid derivatives useful as pharmaceutical agents
IL159299A0 (en) * 2001-06-11 2004-06-01 Xenoport Inc Orally administered dosage forms of gaba analog prodrugs having reduced toxicity
AU2004267100B2 (en) 2003-08-20 2010-10-07 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
US7265140B2 (en) * 2003-09-23 2007-09-04 Pfizer Inc Acyloxymethylcarbamate prodrugs of oxazolidinones
ES2405329T3 (es) 2003-12-30 2013-05-30 Xenoport, Inc. Síntesis de profármacos de carbarnato de aciloxialquilo y productos intermedios de los mismos
WO2006050471A2 (en) 2004-11-03 2006-05-11 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of sulfinic acids, methods of synthesis, and use
WO2006050472A2 (en) 2004-11-03 2006-05-11 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphonous and -phosphinic acids

Also Published As

Publication number Publication date
US20070037988A9 (en) 2007-02-15
US9353057B2 (en) 2016-05-31
EP1716115A2 (en) 2006-11-02
US8378137B2 (en) 2013-02-19
EP2371815A1 (en) 2011-10-05
CN102702065A (zh) 2012-10-03
DK1716115T3 (da) 2013-05-27
US20070244331A1 (en) 2007-10-18
WO2005066122A2 (en) 2005-07-21
US8003809B2 (en) 2011-08-23
US7511158B2 (en) 2009-03-31
JP4927563B2 (ja) 2012-05-09
US7227028B2 (en) 2007-06-05
CA2551859C (en) 2011-10-04
IL176341A0 (en) 2008-02-09
WO2005066122A3 (en) 2005-10-13
IL176341A (en) 2013-03-24
US20050222431A1 (en) 2005-10-06
CA2551859A1 (en) 2005-07-21
US20120010425A1 (en) 2012-01-12
JP2011236247A (ja) 2011-11-24
JP5670842B2 (ja) 2015-02-18
IL200821A (en) 2013-03-24
ES2405329T3 (es) 2013-05-30
EP1716115B1 (en) 2013-02-27
JP2007518723A (ja) 2007-07-12
US20130131355A1 (en) 2013-05-23
US20090216037A1 (en) 2009-08-27

Similar Documents

Publication Publication Date Title
HK1090924A1 (en) Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
PT1660440E (pt) Pró-fármacos de aciloxialquilcarbamato, métodos de síntese e utilização
IL185494A0 (en) Purification of cinacalcet
WO2005087724A3 (en) Sulphonylpyrroles as hdac inhibitors
IN2014DN05011A (ja)
HK1108157A1 (en) Intermediates for the preparation of dioxane-2-alkyl carbamates
DK1718677T3 (da) Monovalente antistoffragmenter egnede som terapeutiske midler
WO2006124713A3 (en) 4-biarylyl-1-phenylazetidin-2-ones
WO2005047898A3 (en) Methods and compositions for identifying therapeutic compounds
WO2006138503A8 (en) New regimens for oral monophasic contraceptives
TW200722897A (en) Projection partitioning and aligning
TW200744567A (en) Phenylethylamine analogs and their use for treating glaucoma
NL1019993A1 (nl) Aandrijfinrichting voor verwijderbare schijf.
EA200602017A1 (ru) КОМПОЗИЦИЯ ДЛЯ АЭРОЗОЛЬНОЙ ИНГАЛЯЦИИ β-АГОНИСТОВ
AU2003299227A1 (en) Synthesis of amines and intermediates for the synthesis thereof
WO2003026632A3 (en) Substituted phenol compounds useful for anesthesia and sedation
WO2004047751A3 (en) Calcilytic compounds
WO2005021733A3 (en) Methods and compositions for sirna expression
SG145759A1 (en) Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
ITMI20041229A1 (it) Procedimento per la preparazione di carbammati di poliammine primarie e secondarie
GB2458395B (en) Identification of the channel frequency response using stepped frequencies
EP1406605A4 (en) 2-HETEROCYCLIC 1,2-ETHANEDIOL CARBAMATES
WO2006010077A3 (en) Prodrugs of lonidamine and lonidamine analogs
WO2007057703A3 (en) Intermediate compounds for the preparation of statins
AU2002353814A1 (en) Process for the preparation of polyethylene glycol bis amine

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20161230