HK1090924A1 - Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof - Google Patents
Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereofInfo
- Publication number
- HK1090924A1 HK1090924A1 HK06112592.1A HK06112592A HK1090924A1 HK 1090924 A1 HK1090924 A1 HK 1090924A1 HK 06112592 A HK06112592 A HK 06112592A HK 1090924 A1 HK1090924 A1 HK 1090924A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- synthesis
- intermediates
- carbamate prodrugs
- acyloxy
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53364903P | 2003-12-30 | 2003-12-30 | |
US60663704P | 2004-08-13 | 2004-08-13 | |
PCT/US2004/043823 WO2005066122A2 (en) | 2003-12-30 | 2004-12-30 | Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1090924A1 true HK1090924A1 (en) | 2007-01-05 |
Family
ID=34753006
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK06112592.1A HK1090924A1 (en) | 2003-12-30 | 2006-11-16 | Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof |
Country Status (10)
Country | Link |
---|---|
US (5) | US7227028B2 (xx) |
EP (2) | EP1716115B1 (xx) |
JP (2) | JP4927563B2 (xx) |
CN (1) | CN102702065A (xx) |
CA (1) | CA2551859C (xx) |
DK (1) | DK1716115T3 (xx) |
ES (1) | ES2405329T3 (xx) |
HK (1) | HK1090924A1 (xx) |
IL (2) | IL176341A (xx) |
WO (1) | WO2005066122A2 (xx) |
Families Citing this family (62)
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EP1716115B1 (en) | 2003-12-30 | 2013-02-27 | XenoPort, Inc. | Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof |
AU2005299771A1 (en) * | 2004-10-21 | 2006-05-04 | High Point Pharmaceuticals, Llc | Bissulfonamide compounds as agonists of GalR1, compositions, and methods of use |
WO2006050472A2 (en) | 2004-11-03 | 2006-05-11 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphonous and -phosphinic acids |
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WO2010008886A2 (en) * | 2008-06-24 | 2010-01-21 | Teva Pharmaceutical Industries Ltd. | Processes for preparing prodrugs of gabapentin and intermediates thereof |
WO2010003046A2 (en) * | 2008-07-02 | 2010-01-07 | Teva Pharmaceutical Industries Ltd. | Gabapentin enacarbil salts and processes for their preparation |
US7989641B2 (en) | 2008-08-07 | 2011-08-02 | Xenoport, Inc. | Methods of synthesizing N-hydroxysuccinimidyl carbonates |
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CN105801489B (zh) | 2010-03-18 | 2019-12-10 | 第一三共株式会社 | 环烷基取代的咪唑衍生物 |
UA113165C2 (xx) | 2011-03-01 | 2016-12-26 | Застосування комбінації баклофену і акампросату для лікування неврологічних захворювань та композиція, яка містить баклофен і акампросат | |
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US9248111B2 (en) | 2011-03-01 | 2016-02-02 | Pharnext | Therapeutic approaches for treating parkinson's disease |
PL2560631T3 (pl) | 2011-03-01 | 2014-06-30 | Pharnext | Terapia zaburzeń neurologicznych oparta na baklofenie i akamprozacie |
WO2013023155A1 (en) | 2011-08-11 | 2013-02-14 | Xenoport, Inc. | Anhydrous and hemihydrate crystalline forms of an (r)-baclofen prodrug, methods of synthesis and methods of use |
WO2013026777A1 (en) * | 2011-08-24 | 2013-02-28 | Solvay Sa | Fluoroalkyl s-(fluoro)alkyl thiocarbonates, a method for the preparation of fluoroalkyl s-(fluoro)alkyl thiocarbonates, and their use |
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EP3206695A4 (en) * | 2014-10-17 | 2018-06-20 | The Board of Trustees of the University of Illionis | Scalable synthesis of reduced toxicity derivative of amphotericin b |
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DE3262698D1 (en) | 1981-11-17 | 1985-04-25 | Kabivitrum Ab | Antifibrinolytically active compounds |
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EA200200161A1 (ru) * | 1999-07-15 | 2002-06-27 | Эли Лилли Энд Компани | Пролекарства псевдомицина |
GB2365425A (en) * | 2000-08-01 | 2002-02-20 | Parke Davis & Co Ltd | Alkyl amino acid derivatives useful as pharmaceutical agents |
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US7265140B2 (en) * | 2003-09-23 | 2007-09-04 | Pfizer Inc | Acyloxymethylcarbamate prodrugs of oxazolidinones |
EP1716115B1 (en) | 2003-12-30 | 2013-02-27 | XenoPort, Inc. | Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof |
WO2006050471A2 (en) | 2004-11-03 | 2006-05-11 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs of sulfinic acids, methods of synthesis, and use |
WO2006050472A2 (en) | 2004-11-03 | 2006-05-11 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphonous and -phosphinic acids |
-
2004
- 2004-12-30 EP EP04815821A patent/EP1716115B1/en active Active
- 2004-12-30 JP JP2006547532A patent/JP4927563B2/ja active Active
- 2004-12-30 DK DK04815821.6T patent/DK1716115T3/da active
- 2004-12-30 WO PCT/US2004/043823 patent/WO2005066122A2/en active Application Filing
- 2004-12-30 ES ES04815821T patent/ES2405329T3/es active Active
- 2004-12-30 EP EP11001106A patent/EP2371815A1/en not_active Ceased
- 2004-12-30 CN CN2012101837531A patent/CN102702065A/zh active Pending
- 2004-12-30 CA CA2551859A patent/CA2551859C/en active Active
- 2004-12-30 US US11/026,491 patent/US7227028B2/en active Active
-
2006
- 2006-06-15 IL IL176341A patent/IL176341A/en active IP Right Grant
- 2006-11-16 HK HK06112592.1A patent/HK1090924A1/xx not_active IP Right Cessation
-
2007
- 2007-05-25 US US11/754,232 patent/US7511158B2/en active Active
-
2009
- 2009-02-20 US US12/390,000 patent/US8003809B2/en active Active
- 2009-09-08 IL IL200821A patent/IL200821A/en active IP Right Grant
-
2011
- 2011-08-11 US US13/208,176 patent/US8378137B2/en active Active
- 2011-08-11 JP JP2011175796A patent/JP5670842B2/ja not_active Expired - Fee Related
-
2013
- 2013-01-15 US US13/742,134 patent/US9353057B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CA2551859A1 (en) | 2005-07-21 |
WO2005066122A3 (en) | 2005-10-13 |
US20070037988A9 (en) | 2007-02-15 |
US20130131355A1 (en) | 2013-05-23 |
US7227028B2 (en) | 2007-06-05 |
US7511158B2 (en) | 2009-03-31 |
US8378137B2 (en) | 2013-02-19 |
EP1716115B1 (en) | 2013-02-27 |
US20070244331A1 (en) | 2007-10-18 |
IL176341A0 (en) | 2008-02-09 |
DK1716115T3 (da) | 2013-05-27 |
CA2551859C (en) | 2011-10-04 |
CN102702065A (zh) | 2012-10-03 |
WO2005066122A2 (en) | 2005-07-21 |
US20050222431A1 (en) | 2005-10-06 |
ES2405329T3 (es) | 2013-05-30 |
EP1716115A2 (en) | 2006-11-02 |
US9353057B2 (en) | 2016-05-31 |
IL200821A (en) | 2013-03-24 |
JP4927563B2 (ja) | 2012-05-09 |
US8003809B2 (en) | 2011-08-23 |
EP2371815A1 (en) | 2011-10-05 |
IL176341A (en) | 2013-03-24 |
US20090216037A1 (en) | 2009-08-27 |
US20120010425A1 (en) | 2012-01-12 |
JP2007518723A (ja) | 2007-07-12 |
JP5670842B2 (ja) | 2015-02-18 |
JP2011236247A (ja) | 2011-11-24 |
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