EA200200161A1 - Пролекарства псевдомицина - Google Patents

Пролекарства псевдомицина

Info

Publication number
EA200200161A1
EA200200161A1 EA200200161A EA200200161A EA200200161A1 EA 200200161 A1 EA200200161 A1 EA 200200161A1 EA 200200161 A EA200200161 A EA 200200161A EA 200200161 A EA200200161 A EA 200200161A EA 200200161 A1 EA200200161 A1 EA 200200161A1
Authority
EA
Eurasian Patent Office
Prior art keywords
psevdomycin
procare
prodrug
acyloxyalkylcarbamate
bond
Prior art date
Application number
EA200200161A
Other languages
English (en)
Inventor
Шу Хьюи Чен
Майкл Джон Родригез
Ксиченг Сун
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA200200161A1 publication Critical patent/EA200200161A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Описано пролекарство псевдомицина, представленное структурой (А), где Rпредставляет собой ацилоксиалкилкарбаматную связь. Указанное пролекарство демонстрирует противогрибковую активность при меньшем количестве неблагоприятных побочных эффектов.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200200161A 1999-07-15 2000-06-08 Пролекарства псевдомицина EA200200161A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14384099P 1999-07-15 1999-07-15
PCT/US2000/015016 WO2001005813A1 (en) 1999-07-15 2000-06-08 Pseudomycin prodrugs

Publications (1)

Publication Number Publication Date
EA200200161A1 true EA200200161A1 (ru) 2002-06-27

Family

ID=22505903

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200200161A EA200200161A1 (ru) 1999-07-15 2000-06-08 Пролекарства псевдомицина

Country Status (11)

Country Link
EP (1) EP1198470A1 (ru)
JP (1) JP2003505396A (ru)
CN (1) CN1373770A (ru)
AU (1) AU5310500A (ru)
BR (1) BR0013153A (ru)
CA (1) CA2379058A1 (ru)
EA (1) EA200200161A1 (ru)
HU (1) HUP0202223A3 (ru)
MX (1) MXPA02000315A (ru)
NO (1) NO20020192L (ru)
WO (1) WO2001005813A1 (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
KR101140559B1 (ko) 2003-08-20 2012-07-05 제노포트 인코포레이티드 아실옥시알킬 카르바메이트 프로드러그, 합성 및 사용 방법
CN1902175B (zh) * 2003-12-30 2012-08-22 什诺波特有限公司 酰氧基烃基氨基甲酸酯前药及其中间体的合成
CA2551859C (en) * 2003-12-30 2011-10-04 Xenoport, Inc. Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
JP4938771B2 (ja) 2005-06-20 2012-05-23 ゼノポート，インコーポレーテッド トラネキサム酸のカルバミン酸アシルオキシアルキルプロドラッグ、合成法、および使用
US7531572B2 (en) 2006-07-28 2009-05-12 Xenoport, Inc. Acyloxyalkyl carbamate prodrugs of α-amino acids, methods of synthesis and use
US7989641B2 (en) 2008-08-07 2011-08-02 Xenoport, Inc. Methods of synthesizing N-hydroxysuccinimidyl carbonates

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5576298A (en) * 1992-11-30 1996-11-19 Research And Development Institute, Inc. At Montana State University Peptides from pseudomonas syringae possessing broad-spectrum antibiotic activity

Also Published As

Publication number Publication date
CA2379058A1 (en) 2001-01-25
CN1373770A (zh) 2002-10-09
JP2003505396A (ja) 2003-02-12
HUP0202223A3 (en) 2002-11-28
HUP0202223A2 (en) 2002-10-28
MXPA02000315A (es) 2002-06-21
NO20020192L (no) 2002-03-14
WO2001005813A1 (en) 2001-01-25
NO20020192D0 (no) 2002-01-14
EP1198470A1 (en) 2002-04-24
BR0013153A (pt) 2002-04-02
AU5310500A (en) 2001-02-05

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