HK1090912A1 - Acyloxyalkyl carbamate prodrugs, methods of synthesis and use - Google Patents

Acyloxyalkyl carbamate prodrugs, methods of synthesis and use

Info

Publication number
HK1090912A1
HK1090912A1 HK06112680.4A HK06112680A HK1090912A1 HK 1090912 A1 HK1090912 A1 HK 1090912A1 HK 06112680 A HK06112680 A HK 06112680A HK 1090912 A1 HK1090912 A1 HK 1090912A1
Authority
HK
Hong Kong
Prior art keywords
synthesis
methods
acyloxyalkyl carbamate
carbamate prodrugs
group
Prior art date
Application number
HK06112680.4A
Other languages
English (en)
Inventor
Mark A Gallop
Fenmei Yao
Thu Phan
Ge Peng
Maria J Ludwikow
Original Assignee
Xenoport Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2004/027330 external-priority patent/WO2005019163A2/en
Application filed by Xenoport Inc filed Critical Xenoport Inc
Publication of HK1090912A1 publication Critical patent/HK1090912A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrrole Compounds (AREA)
  • Medicinal Preparation (AREA)
HK06112680.4A 2003-08-20 2006-11-17 Acyloxyalkyl carbamate prodrugs, methods of synthesis and use HK1090912A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49693803P 2003-08-20 2003-08-20
US60663704P 2004-08-13 2004-08-13
PCT/US2004/027330 WO2005019163A2 (en) 2003-08-20 2004-08-20 Acyloxyalkyl carbamate prodrugs, methods of synthesis and use

Publications (1)

Publication Number Publication Date
HK1090912A1 true HK1090912A1 (en) 2007-01-05

Family

ID=36762986

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06112680.4A HK1090912A1 (en) 2003-08-20 2006-11-17 Acyloxyalkyl carbamate prodrugs, methods of synthesis and use

Country Status (14)

Country Link
EP (1) EP1660440B1 (ja)
JP (3) JP5148874B2 (ja)
CN (2) CN101914040A (ja)
AT (1) ATE546427T1 (ja)
CA (1) CA2536257C (ja)
CY (1) CY1112827T1 (ja)
ES (1) ES2382000T3 (ja)
HK (1) HK1090912A1 (ja)
IL (1) IL173826A (ja)
NO (1) NO335606B1 (ja)
NZ (1) NZ545719A (ja)
PL (1) PL1660440T3 (ja)
RU (2) RU2423347C2 (ja)
SG (1) SG145759A1 (ja)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG145759A1 (en) * 2003-08-20 2008-09-29 Xenoport Inc Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
CA2706575C (en) * 2008-01-25 2015-07-14 Xenoport, Inc. Enantiomerically resolving acyloxyalkyl thiocarbonates used in synthesizing acyloxyalkyl carbamate prodrugs
JP6925080B2 (ja) * 2017-08-25 2021-08-25 ▲広▼州市恒▲諾▼康医▲薬▼科技有限公司Ｇｕａｎｇｚｈｏｕ Ｈｅｎｏｖｃｏｍ Ｂｉｏｓｃｉｅｎｃｅ Ｃｏ．， Ｌｔｄ 長時間作用型ラサギリンプロドラッグ、その製造方法および用途
CN107805202A (zh) * 2017-12-01 2018-03-16 内蒙古圣氏化学股份有限公司 一种氯甲基异丙基碳酸酯连续化反应装置及方法
CN117623989A (zh) * 2022-08-29 2024-03-01 广州市恒诺康医药科技有限公司 一种mao-b抑制剂前药的多晶型及其制备方法和用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3475065D1 (en) * 1983-06-23 1988-12-15 Merck & Co Inc (acyloxyalkoxy) carbonyl derivatives as bioreversible prodrug moieties for primary and secondary amine functions in drugs, their preparation and pharmaceutical compositions containing said derivatives
GB2365425A (en) * 2000-08-01 2002-02-20 Parke Davis & Co Ltd Alkyl amino acid derivatives useful as pharmaceutical agents
AU2002345664C1 (en) * 2001-06-11 2008-03-06 Xenoport, Inc. Prodrugs of gaba analogs, compositions and uses thereof
SG145759A1 (en) * 2003-08-20 2008-09-29 Xenoport Inc Acyloxyalkyl carbamate prodrugs, methods of synthesis and use

Also Published As

Publication number Publication date
EP1660440A2 (en) 2006-05-31
CA2536257A1 (en) 2005-03-03
CY1112827T1 (el) 2016-02-10
SG145759A1 (en) 2008-09-29
IL173826A (en) 2014-07-31
RU2423347C2 (ru) 2011-07-10
JP2011256182A (ja) 2011-12-22
CN1860101A (zh) 2006-11-08
ATE546427T1 (de) 2012-03-15
EP1660440B1 (en) 2012-02-22
NO20061268L (no) 2006-05-22
CA2536257C (en) 2012-01-03
JP2013006842A (ja) 2013-01-10
CN1860101B (zh) 2010-10-27
JP2007521318A (ja) 2007-08-02
CN101914040A (zh) 2010-12-15
RU2010147826A (ru) 2012-05-27
RU2006108541A (ru) 2007-09-27
ES2382000T3 (es) 2012-06-04
NO335606B1 (no) 2015-01-12
PL1660440T3 (pl) 2012-07-31
NZ545719A (en) 2010-03-26
IL173826A0 (en) 2006-07-05
JP5148874B2 (ja) 2013-02-20

Similar Documents

Publication Publication Date Title
HK1090912A1 (en) Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
TW200602043A (en) Use of indazolecarboxamide derivatives for preparing a medicinal product intended for the treatment and prevention of malaria
MX2009008439A (es) Nuevos inhibidores de la replicacion del virus de hepatitis c.
EA200802223A1 (ru) 1,5-дифенилпиразолы ii в качестве ингибиторов hsp90
TW200609227A (en) Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
WO2008106128A3 (en) CYCLIC UREA AND CARBAMATE INHIBITORS OF 11β -HYDROXYSTEROID DEHYDROGENASE 1
ATE485258T1 (de) Glycyrrhetinsäurederivate und ihre verwendung zur herstellung eines medikaments zur hemmung der 11- beta-hydroxysteroid dehydrogenase
NO20060847L (no) Substituert 2-aminotetralin til behandling av depresjon
EA201000098A1 (ru) Производные хиназолинамида
WO2007144394A3 (en) Pharmaceutical use of substituted piperidine carboxamides
WO2009026176A3 (en) Antiinfective flavononol compounds and methods of use thereof
TN2009000481A1 (en) Novel peptide inhibitors of hepatitis c virus replication
NZ601483A (en) Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
DK1758860T3 (da) Mættede og umættede 3-pyridylbenzocykloalkylmethylaminer til behandling af smerter, depressioner og angsttilstande
WO2009066041A3 (fr) Derives de 1,2,4,5-tetrahydro-3h-benzazepines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU2009258040A8 (en) Compounds and method for reducing uric acid
WO2009134616A8 (en) Novel inhibitors of hepatitis c virus replication
ATE500752T1 (de) Verwendung von sphingolipiden bei der behandlung und vorbeugung von typ-2-diabetes mellitus, insulinresistenz und metabolismussyndrom
WO2009148961A3 (en) Drugs to prevent hpv infection
WO2009015485A8 (en) Cyclic inhibitors of carnitine palmitoyltransferase and treating cancer
EP4327886A3 (en) Pyrimido- pyridazinone compounds and use thereof
ATE451922T1 (de) Verwendung von thiazolidinon-derivaten zur behandlung von festen tumoren
SE0301232D0 (sv) Novel use
JP2010520242A5 (ja)
WO2009022687A1 (ja) フェニル酢酸化合物

Legal Events

Date Code Title Description
AM Amended specification (according sect 146 of patent law)

Free format text: CORRECTION OF THE PRIORITY APPLICATION NO. FROM 10/932,374 TO 606637 UNDER SECTION 146

Effective date: 20120809

PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20170820