HK1086281A1 - Novel method for synthesising perindopril and the pharmaceutically acceptable salt thereof - Google Patents

Novel method for synthesising perindopril and the pharmaceutically acceptable salt thereof

Info

Publication number
HK1086281A1
HK1086281A1 HK06106195A HK06106195A HK1086281A1 HK 1086281 A1 HK1086281 A1 HK 1086281A1 HK 06106195 A HK06106195 A HK 06106195A HK 06106195 A HK06106195 A HK 06106195A HK 1086281 A1 HK1086281 A1 HK 1086281A1
Authority
HK
Hong Kong
Prior art keywords
perindopril
synthesising
pharmaceutically acceptable
acceptable salt
novel method
Prior art date
Application number
HK06106195A
Other languages
English (en)
Inventor
Thierry Dubuffet
Pascal Langlois
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of HK1086281A1 publication Critical patent/HK1086281A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
HK06106195A 2003-02-28 2006-05-29 Novel method for synthesising perindopril and the pharmaceutically acceptable salt thereof HK1086281A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03290485A EP1403275B1 (fr) 2003-02-28 2003-02-28 Nouveau procédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables
PCT/FR2004/000446 WO2004078107A2 (fr) 2003-02-28 2004-02-27 Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables

Publications (1)

Publication Number Publication Date
HK1086281A1 true HK1086281A1 (en) 2006-09-15

Family

ID=31970533

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06106195A HK1086281A1 (en) 2003-02-28 2006-05-29 Novel method for synthesising perindopril and the pharmaceutically acceptable salt thereof

Country Status (18)

Country Link
US (1) US7166633B2 (xx)
EP (1) EP1403275B1 (xx)
JP (1) JP4563372B2 (xx)
CN (1) CN1326871C (xx)
AR (1) AR043409A1 (xx)
AT (1) ATE307139T1 (xx)
AU (1) AU2004217599B2 (xx)
DE (1) DE60301930T2 (xx)
DK (1) DK1403275T3 (xx)
EA (1) EA009066B1 (xx)
ES (1) ES2250846T3 (xx)
HK (1) HK1086281A1 (xx)
MY (1) MY136989A (xx)
NZ (1) NZ541424A (xx)
PL (1) PL215131B1 (xx)
SI (1) SI1403275T1 (xx)
WO (1) WO2004078107A2 (xx)
ZA (1) ZA200505781B (xx)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1403275T3 (da) * 2003-02-28 2005-12-05 Servier Lab Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
EP1833789B1 (en) * 2004-12-28 2011-07-06 DSM IP Assets B.V. Process for the preparation of enantiomerically enriched indoline-2-carboxylic acid
CN105828892B (zh) 2013-12-27 2018-05-15 株式会社宝登 球
FR3050380B1 (fr) 2016-04-20 2020-07-10 Les Laboratoires Servier Composition pharmaceutique comprenant un betabloquant, un inhibiteur de l'enzyme de conversion et un antihypertenseur ou un ains.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR78413B (xx) * 1981-12-29 1984-09-27 Hoechst Ag
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
FR2807431B1 (fr) * 2000-04-06 2002-07-19 Adir Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
FR2827860B1 (fr) * 2001-07-24 2004-12-10 Servier Lab Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril
EP1472094B1 (en) * 2002-02-07 2011-09-14 Ricoh Company, Ltd. Pressure adjustment mechanism and inkjet printing apparatus
DK1403275T3 (da) * 2003-02-28 2005-12-05 Servier Lab Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf

Also Published As

Publication number Publication date
DK1403275T3 (da) 2005-12-05
PL215131B1 (pl) 2013-10-31
WO2004078107A2 (fr) 2004-09-16
US7166633B2 (en) 2007-01-23
ATE307139T1 (de) 2005-11-15
AR043409A1 (es) 2005-07-27
JP2006519177A (ja) 2006-08-24
JP4563372B2 (ja) 2010-10-13
MY136989A (en) 2008-12-31
EP1403275A1 (fr) 2004-03-31
ZA200505781B (en) 2006-11-29
AU2004217599B2 (en) 2009-07-30
ES2250846T3 (es) 2006-04-16
AU2004217599A1 (en) 2004-09-16
WO2004078107A3 (fr) 2004-10-21
EP1403275B1 (fr) 2005-10-19
DE60301930D1 (de) 2006-03-02
SI1403275T1 (sl) 2006-02-28
EA009066B1 (ru) 2007-10-26
CN1326871C (zh) 2007-07-18
DE60301930T2 (de) 2006-07-27
US20060149081A1 (en) 2006-07-06
CN1753906A (zh) 2006-03-29
EA200501258A1 (ru) 2006-04-28
NZ541424A (en) 2008-03-28
PL377238A1 (pl) 2006-01-23

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20190225