HK107794A - Novel pharmaceutically active 1,2,3,4,4a,5,10,10a-octahydrobenzo(g)quinoline derivatives - Google Patents
Novel pharmaceutically active 1,2,3,4,4a,5,10,10a-octahydrobenzo(g)quinoline derivatives Download PDFInfo
- Publication number
- HK107794A HK107794A HK107794A HK107794A HK107794A HK 107794 A HK107794 A HK 107794A HK 107794 A HK107794 A HK 107794A HK 107794 A HK107794 A HK 107794A HK 107794 A HK107794 A HK 107794A
- Authority
- HK
- Hong Kong
- Prior art keywords
- formula
- benzo
- methoxy
- quinoline
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/08—Aza-anthracenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Luminescent Compositions (AREA)
- Photoreceptors In Electrophotography (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH663181 | 1981-10-16 | ||
| CH392782 | 1982-06-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK107794A true HK107794A (en) | 1994-10-14 |
Family
ID=25694193
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK107794A HK107794A (en) | 1981-10-16 | 1994-10-06 | Novel pharmaceutically active 1,2,3,4,4a,5,10,10a-octahydrobenzo(g)quinoline derivatives |
Country Status (19)
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH22782A (en) * | 1983-02-01 | 1988-12-12 | Sandoz Ltd | Novel pharmaceutical active 1,2,3,4,4a,5,10,10a octahydrobenzo(g)quinoline derivatives |
| AT393997B (de) * | 1983-06-22 | 1992-01-10 | Heidelberger Druckmasch Ag | Vorrichtung zur entnahme von bedruckten bogen fuer deren begutachtung |
| NL8702680A (nl) * | 1986-11-21 | 1988-06-16 | Sandoz Ag | Nieuwe benzogchinolinen en werkwijzen voor het bereiden en toepassen van deze verbindingen. |
| AU3879789A (en) * | 1988-07-22 | 1990-02-19 | Sandoz Ag | Use of benzo(g)quinolines in treatment of nicotine addiction |
| GB8829330D0 (en) * | 1988-12-16 | 1989-02-01 | Sandoz Ltd | Improvements in or relating to organic compounds |
| US5262422A (en) * | 1991-05-02 | 1993-11-16 | Sandoz Ltd. | Octahydrobenzo[g]quinoline |
| DE4114325A1 (de) * | 1991-05-02 | 1992-11-05 | Sandoz Ag | Octahydrobenzo(g)chinolin, seine herstellung und verwendung |
| US5264577A (en) * | 1992-04-22 | 1993-11-23 | Warner-Lambert Company | Cyclic amino acids and derivatives thereof |
| GB9326010D0 (en) * | 1993-12-21 | 1994-02-23 | Sandoz Ltd | Improvements in or relating to organic compounds |
| TW357143B (en) * | 1995-07-07 | 1999-05-01 | Novartis Ag | Benzo[g]quinoline derivatives |
| TW378209B (en) * | 1996-07-08 | 2000-01-01 | Novartis Ag | Benzo[g]quinoline derivatives, their preparation and the pharmaceutical composition containing them |
| AU4413999A (en) | 1998-07-28 | 2000-02-21 | Warner-Lambert Company | Hexahydro-naphthalenone oximes and hydrazones |
| US6380217B1 (en) * | 1999-03-31 | 2002-04-30 | Millennium Pharmaceuticals, Inc. | Methods for controlling GGT-positive bacteria |
| SE0001438D0 (sv) | 2000-04-18 | 2000-04-18 | Axon Chemicals Bv | New chemical compounds and their use in therapy |
| PT1874313E (pt) | 2005-04-29 | 2010-10-21 | Ferring Int Ct Sa | Tratamento ou prevenção do síndroma de hiperestimulação ovárica (ohss) através de um agonista da dopamina |
| US8067410B2 (en) | 2008-06-27 | 2011-11-29 | H. Lundbeck A/S | Phenolic and catecholic amines and prodrugs thereof |
| JP2011525893A (ja) * | 2008-06-27 | 2011-09-29 | ハー・ルンドベック・アクチエゼルスカベット | 新規のフェノールアミン類およびカテコールアミン類ならびにそのプロドラッグ |
| JOP20200114A1 (ar) | 2017-11-24 | 2020-05-17 | H Lundbeck As | عقاقير أولية جديدة من الكاتيكولامين للاستخدام في علاج مرض باركنسون |
| US11130775B2 (en) | 2019-05-20 | 2021-09-28 | H. Lundbeck A/S | Solid forms of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
| US11111263B2 (en) | 2019-05-20 | 2021-09-07 | H. Lundbeck A/S | Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
| US11104697B2 (en) | 2019-05-20 | 2021-08-31 | H. Lundbeck A/S | Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4AR,10AR)-7-hydroxy-1- propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid |
| US11168056B2 (en) | 2019-05-20 | 2021-11-09 | H. Lundbeck A/S | Process for the manufacturing of (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-G]quinoline and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[G]quinoline-6,7-diol |
| US12398106B2 (en) | 2019-05-21 | 2025-08-26 | H. Lundbeck A/S | Catecholamine carbamate prodrugs for use in the treatment of parkinson's disease |
| EP3972970A1 (en) | 2019-05-21 | 2022-03-30 | H. Lundbeck A/S | New catecholamine prodrugs for use in the treatment of parkinson's disease |
| US12319710B2 (en) | 2019-05-21 | 2025-06-03 | H. Lundbeck A/S | Catecholamine prodrugs for use in the treatment of Parkinson's diseases |
| CN119707810A (zh) | 2019-05-21 | 2025-03-28 | H.隆德贝克有限公司 | 用于治疗帕金森病的新儿茶酚胺前药 |
| WO2024153752A1 (en) * | 2023-01-20 | 2024-07-25 | Ferring B.V. | Stereoselective synthesis of intermediates and synthesis of quinagolids |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3839338A (en) * | 1968-05-09 | 1974-10-01 | W Michne | 1,2,3,4,4A,5,10,10A-OCTAHYDROBENZO{8 g{9 QUINOLINES |
| US4100164A (en) * | 1974-05-20 | 1978-07-11 | Sterling Drug Inc. | 2,6-Methano-3-benzazocines |
| US4169893A (en) * | 1978-03-13 | 1979-10-02 | Sandoz, Inc. | 4-hydroxy-naphthpyridine-2(1h)-one-3-carboxylic acids and esters |
| US4235909A (en) * | 1979-04-19 | 1980-11-25 | Eli Lilly And Company | Octahydro-2H-pyrrolo[3,4-g]quinolines |
| DE3063420D1 (en) * | 1979-03-26 | 1983-07-07 | Takeda Chemical Industries Ltd | Tetrahydroisoquinolines, their production and the compounds and pharmaceutical compositions containing them for use in the prevention or treatment of hypertension |
-
1982
- 1982-10-06 EP EP82810413A patent/EP0077754B1/en not_active Expired - Lifetime
- 1982-10-06 LU LU88619C patent/LU88619I2/fr unknown
- 1982-10-06 AT AT82810413T patent/ATE56958T1/de active
- 1982-10-06 DE DE1995175006 patent/DE19575006I2/de active Active
- 1982-10-06 DE DE8282810413T patent/DE3280252D1/de not_active Expired - Lifetime
- 1982-10-08 FI FI823436A patent/FI78908C/fi not_active IP Right Cessation
- 1982-10-14 IL IL66987A patent/IL66987A/xx not_active IP Right Cessation
- 1982-10-14 US US06/434,202 patent/US4565818A/en not_active Expired - Lifetime
- 1982-10-14 NZ NZ202169A patent/NZ202169A/en unknown
- 1982-10-14 CA CA000413440A patent/CA1200241A/en not_active Expired
- 1982-10-14 DK DK457182A patent/DK160820C/da active Protection Beyond IP Right Term
- 1982-10-14 AU AU89367/82A patent/AU558375B2/en not_active Expired
- 1982-10-15 PT PT75679A patent/PT75679A/pt unknown
- 1982-10-15 HU HU823285A patent/HU190703B/hu unknown
- 1982-10-15 IE IE2500/82A patent/IE56836B1/en not_active IP Right Cessation
- 1982-10-15 ES ES516551A patent/ES516551A0/es active Granted
- 1982-10-18 PH PH27998A patent/PH22774A/en unknown
-
1983
- 1983-10-14 ES ES526492A patent/ES8706120A1/es not_active Expired
- 1983-10-14 ES ES526493A patent/ES8606281A1/es not_active Expired
-
1989
- 1989-10-13 JP JP1267924A patent/JPH02138262A/ja active Granted
-
1994
- 1994-06-03 CY CY173694A patent/CY1736A/xx unknown
- 1994-10-06 HK HK107794A patent/HK107794A/en not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PE | Patent expired |