ES8606281A1 - Procedimiento para preparar nuevos derivados de benzo (g) quinolina - Google Patents

Procedimiento para preparar nuevos derivados de benzo (g) quinolina

Info

Publication number
ES8606281A1
ES8606281A1 ES526493A ES526493A ES8606281A1 ES 8606281 A1 ES8606281 A1 ES 8606281A1 ES 526493 A ES526493 A ES 526493A ES 526493 A ES526493 A ES 526493A ES 8606281 A1 ES8606281 A1 ES 8606281A1
Authority
ES
Spain
Prior art keywords
group
octahydrobenzo
pharmaceutically active
quinoline derivatives
novel pharmaceutically
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES526493A
Other languages
English (en)
Other versions
ES526493A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES8606281A1 publication Critical patent/ES8606281A1/es
Publication of ES526493A0 publication Critical patent/ES526493A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/08—Aza-anthracenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE BENZO G-QUINOLINA, EN PARTICULAR PARA LA PREPARACION DE UNA 6- O 7-OXI-TRANS-1,2,3,4,4A,5,10,10A-OCTAHIDRO-BENZO G-QUINOLINA, EN LA QUE LA POSICION 3 ESTA SUSTITUIDA POR UN GRUPO CARBOXI OPCIONALMENTE AMIDADO, UN GRUPO HIDROXIMETILO OPCIONALMENTE ETERIFICADO O UN GRUPO CIANOMETILO, Y SUS SALES DE ADICION FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR LA CORRESPONDIENTE 6- O 7-METOXI-TRANS-1,2,3,4,4A,5,10,10A-OCTAHIDRO-BENZO G-QUINOLINA, DE FORMULA ESTRUCTURAL (I), EN LA QUE LOS ANILLOS A Y B ESTAN TRANS-FUSIONADOS, CON UN ACIDO AMINOSULFONICO O AMINOCARBOXILICO O CON UN DERIVADO REACTIVO DE LOS MISMOS, TAL COMO UN COMPUESTO DE FORMULA GENERAL (II) O DE FORMULA GENERAL (III). DE APLICACION EN LA PREPARACION DE COMPOSICIONES FARMACEUTICAS.
ES526493A 1981-10-16 1983-10-14 Procedimiento para preparar nuevos derivados de benzo (g) quinolina Expired ES8606281A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH663181 1981-10-16
CH392782 1982-06-25

Publications (2)

Publication Number Publication Date
ES8606281A1 true ES8606281A1 (es) 1986-04-16
ES526493A0 ES526493A0 (es) 1986-04-16

Family

ID=25694193

Family Applications (3)

Application Number Title Priority Date Filing Date
ES516551A Expired ES8405373A1 (es) 1981-10-16 1982-10-15 Procedimiento para preparar nuevos derivados del benzo g 7-quinolina.
ES526492A Expired ES8706120A1 (es) 1981-10-16 1983-10-14 Procedimiento para preparar nuevos derivados de benzo (g) quinolina
ES526493A Expired ES8606281A1 (es) 1981-10-16 1983-10-14 Procedimiento para preparar nuevos derivados de benzo (g) quinolina

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES516551A Expired ES8405373A1 (es) 1981-10-16 1982-10-15 Procedimiento para preparar nuevos derivados del benzo g 7-quinolina.
ES526492A Expired ES8706120A1 (es) 1981-10-16 1983-10-14 Procedimiento para preparar nuevos derivados de benzo (g) quinolina

Country Status (19)

Country Link
US (1) US4565818A (es)
EP (1) EP0077754B1 (es)
JP (1) JPH02138262A (es)
AT (1) ATE56958T1 (es)
AU (1) AU558375B2 (es)
CA (1) CA1200241A (es)
CY (1) CY1736A (es)
DE (2) DE19575006I2 (es)
DK (1) DK160820C (es)
ES (3) ES8405373A1 (es)
FI (1) FI78908C (es)
HK (1) HK107794A (es)
HU (1) HU190703B (es)
IE (1) IE56836B1 (es)
IL (1) IL66987A (es)
LU (1) LU88619I2 (es)
NZ (1) NZ202169A (es)
PH (1) PH22774A (es)
PT (1) PT75679A (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2540112B1 (fr) * 1983-02-01 1986-08-29 Sandoz Sa Nouveaux derives de la benzo(g)quinoleine, leur preparation et leur utilisation comme medicaments
AT393997B (de) * 1983-06-22 1992-01-10 Heidelberger Druckmasch Ag Vorrichtung zur entnahme von bedruckten bogen fuer deren begutachtung
NL8702680A (nl) * 1986-11-21 1988-06-16 Sandoz Ag Nieuwe benzogchinolinen en werkwijzen voor het bereiden en toepassen van deze verbindingen.
WO1990000896A1 (en) * 1988-07-22 1990-02-08 Sandoz Ag USE OF BENZO(g)QUINOLINES IN TREATMENT OF NICOTINE ADDICTION
GB8829330D0 (en) * 1988-12-16 1989-02-01 Sandoz Ltd Improvements in or relating to organic compounds
US5262422A (en) * 1991-05-02 1993-11-16 Sandoz Ltd. Octahydrobenzo[g]quinoline
DE4114325A1 (de) * 1991-05-02 1992-11-05 Sandoz Ag Octahydrobenzo(g)chinolin, seine herstellung und verwendung
US5264577A (en) * 1992-04-22 1993-11-23 Warner-Lambert Company Cyclic amino acids and derivatives thereof
GB9326010D0 (en) * 1993-12-21 1994-02-23 Sandoz Ltd Improvements in or relating to organic compounds
TW357143B (en) * 1995-07-07 1999-05-01 Novartis Ag Benzo[g]quinoline derivatives
TW378209B (en) * 1996-07-08 2000-01-01 Novartis Ag Benzo[g]quinoline derivatives, their preparation and the pharmaceutical composition containing them
US6187808B1 (en) 1998-07-28 2001-02-13 Warner-Lambert Company Hexahydro-naphthalenone oximes and hydrazones
US6380217B1 (en) * 1999-03-31 2002-04-30 Millennium Pharmaceuticals, Inc. Methods for controlling GGT-positive bacteria
SE0001438D0 (sv) * 2000-04-18 2000-04-18 Axon Chemicals Bv New chemical compounds and their use in therapy
EP1874313B8 (en) 2005-04-29 2010-09-01 Ferring International Center S.A. Treatment or prevention of ovarian hyperstimulation syndrome (ohss) using a dopamine agonist
US8067410B2 (en) 2008-06-27 2011-11-29 H. Lundbeck A/S Phenolic and catecholic amines and prodrugs thereof
CN102131790A (zh) * 2008-06-27 2011-07-20 H.隆德贝克有限公司 新型苯酚型和儿茶酚型胺及其前药
AU2018371193B2 (en) 2017-11-24 2022-12-22 H. Lundbeck A/S New catecholamine prodrugs for use in the treatment of Parkinson's disease
US11104697B2 (en) 2019-05-20 2021-08-31 H. Lundbeck A/S Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4AR,10AR)-7-hydroxy-1- propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11130775B2 (en) 2019-05-20 2021-09-28 H. Lundbeck A/S Solid forms of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4A,5,10,10A-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11111263B2 (en) 2019-05-20 2021-09-07 H. Lundbeck A/S Process for the manufacture of (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
US11168056B2 (en) 2019-05-20 2021-11-09 H. Lundbeck A/S Process for the manufacturing of (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-G]quinoline and (4aR,10aR)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[G]quinoline-6,7-diol

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3839338A (en) * 1968-05-09 1974-10-01 W Michne 1,2,3,4,4A,5,10,10A-OCTAHYDROBENZO{8 g{9 QUINOLINES
US4100164A (en) * 1974-05-20 1978-07-11 Sterling Drug Inc. 2,6-Methano-3-benzazocines
US4169893A (en) * 1978-03-13 1979-10-02 Sandoz, Inc. 4-hydroxy-naphthpyridine-2(1h)-one-3-carboxylic acids and esters
US4235909A (en) * 1979-04-19 1980-11-25 Eli Lilly And Company Octahydro-2H-pyrrolo[3,4-g]quinolines
DE3063420D1 (en) * 1979-03-26 1983-07-07 Takeda Chemical Industries Ltd Tetrahydroisoquinolines, their production and the compounds and pharmaceutical compositions containing them for use in the prevention or treatment of hypertension

Also Published As

Publication number Publication date
DK160820B (da) 1991-04-22
FI823436L (fi) 1983-04-17
FI78908B (fi) 1989-06-30
DE19575006I2 (de) 2003-01-09
FI78908C (fi) 1989-10-10
ES526492A0 (es) 1987-06-01
EP0077754A3 (en) 1985-05-22
IE822500L (en) 1983-04-16
JPH02138262A (ja) 1990-05-28
ES516551A0 (es) 1984-06-01
ES8706120A1 (es) 1987-06-01
ES526493A0 (es) 1986-04-16
ATE56958T1 (de) 1990-10-15
IL66987A (en) 1986-11-30
FI823436A0 (fi) 1982-10-08
LU88619I2 (fr) 1995-07-10
IE56836B1 (en) 1992-01-01
CY1736A (en) 1994-06-03
AU8936782A (en) 1983-04-21
JPH059430B2 (es) 1993-02-04
HK107794A (en) 1994-10-14
CA1200241A (en) 1986-02-04
ES8405373A1 (es) 1984-06-01
EP0077754A2 (en) 1983-04-27
AU558375B2 (en) 1987-01-29
PH22774A (en) 1988-12-12
NZ202169A (en) 1985-07-31
DK160820C (da) 1991-10-07
HU190703B (en) 1986-10-28
IL66987A0 (en) 1983-02-23
DE3280252D1 (de) 1990-10-31
US4565818A (en) 1986-01-21
PT75679A (en) 1982-11-01
DK457182A (da) 1983-04-17
EP0077754B1 (en) 1990-09-26

Similar Documents

Publication Publication Date Title
ES8706120A1 (es) Procedimiento para preparar nuevos derivados de benzo (g) quinolina
ES2000368A6 (es) Un procedimiento para preparar di-t-butilfenoles sustituidos
ES8800950A1 (es) Un metodo para preparar nuevos derivados de cefem
IE56653B1 (en) Novel pharmaceutically active 1,2,3,4,4a,5,10,10a-octahydrobenzo(g)quinoline derivatives,their production and use
RO84457B (ro) Procedeu pentru prepararea unor derivati de acid 7-beta-aminooxazolilacetilamino-3-cefem-4-carboxilic
ES2000369A6 (es) Un procedimiento para preparar di-t-butilfenoles sustituidos
GR77230B (es)
ES8301933A1 (es) "procedimiento para la preparacion de derivados de 4-(5)-alcohil-mercaptoimidazoles".
ES8604157A1 (es) Un procedimiento para la preparacion de un derivado trici- clico de quinolina
MY102089A (en) Antibacterial compounds.
ES8304925A1 (es) Un procedimiento para la preparacion de nuevos derivados del acido &-glutamil-diaminopimelilo.
PH21970A (en) Octahydropyrimido (4,5-g) quinoline derivatives as dopamine d-1 agonists

Legal Events

Date Code Title Description
PC1A Transfer granted
FD1A Patent lapsed

Effective date: 20051231