HK1071378A1 - Immunoglobulin frameworks which demonstrate enhanced stability in the intracellular environment and methods of identifying same - Google Patents

Immunoglobulin frameworks which demonstrate enhanced stability in the intracellular environment and methods of identifying same

Info

Publication number
HK1071378A1
HK1071378A1 HK05104060.2A HK05104060A HK1071378A1 HK 1071378 A1 HK1071378 A1 HK 1071378A1 HK 05104060 A HK05104060 A HK 05104060A HK 1071378 A1 HK1071378 A1 HK 1071378A1
Authority
HK
Hong Kong
Prior art keywords
methods
enhanced stability
intracellular environment
demonstrate enhanced
immunoglobulin frameworks
Prior art date
Application number
HK05104060.2A
Other languages
English (en)
Inventor
Kathrin Tissot
Stefan Ewert
Der Maur Adrian Auf
Alcide Barberis
Dominik Escher
Original Assignee
Esbatech A Novartis Co Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esbatech A Novartis Co Llc filed Critical Esbatech A Novartis Co Llc
Publication of HK1071378A1 publication Critical patent/HK1071378A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G01N33/6857—Antibody fragments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/80—Immunoglobulins specific features remaining in the (producing) cell, i.e. intracellular antibodies or intrabodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/80—Immunoglobulins specific features remaining in the (producing) cell, i.e. intracellular antibodies or intrabodies
    • C07K2317/82—Immunoglobulins specific features remaining in the (producing) cell, i.e. intracellular antibodies or intrabodies functional in the cytoplasm, the inner aspect of the cell membrane, the nucleus or the mitochondria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
HK05104060.2A 2002-05-22 2005-05-13 Immunoglobulin frameworks which demonstrate enhanced stability in the intracellular environment and methods of identifying same HK1071378A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38264902P 2002-05-22 2002-05-22
US43825603P 2003-01-03 2003-01-03
PCT/EP2003/005324 WO2003097697A2 (en) 2002-05-22 2003-05-21 Immunoglobulin frameworks which demonstrate enhanced stability in the intracellular environment and methods of identifying same

Publications (1)

Publication Number Publication Date
HK1071378A1 true HK1071378A1 (en) 2005-07-15

Family

ID=29553590

Family Applications (3)

Application Number Title Priority Date Filing Date
HK05104060.2A HK1071378A1 (en) 2002-05-22 2005-05-13 Immunoglobulin frameworks which demonstrate enhanced stability in the intracellular environment and methods of identifying same
HK11106519.6A HK1152320A1 (en) 2002-05-22 2011-06-23 IMMUNOGLOBULIN FRAMEWORKS WHICH DEMONSTRATE ENHANCED STABILITY IN THE g INTRACELLULAR ENVIRONMENT AND METHODS OF IDENTIFYING SAME
HK16105597.8A HK1217712A1 (zh) 2002-05-22 2016-05-16 細胞內環境下表現增强的穩定性的免疫球蛋白框架區及其鑒定方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
HK11106519.6A HK1152320A1 (en) 2002-05-22 2011-06-23 IMMUNOGLOBULIN FRAMEWORKS WHICH DEMONSTRATE ENHANCED STABILITY IN THE g INTRACELLULAR ENVIRONMENT AND METHODS OF IDENTIFYING SAME
HK16105597.8A HK1217712A1 (zh) 2002-05-22 2016-05-16 細胞內環境下表現增强的穩定性的免疫球蛋白框架區及其鑒定方法

Country Status (15)

Country Link
US (5) US8853362B2 (xx)
EP (5) EP2332989B1 (xx)
JP (10) JP2006508638A (xx)
CN (4) CN103739706B (xx)
AU (2) AU2003238370B2 (xx)
CA (2) CA2483285C (xx)
CY (1) CY1114225T1 (xx)
DK (2) DK2332989T3 (xx)
ES (3) ES2656427T3 (xx)
HK (3) HK1071378A1 (xx)
HU (1) HUE048922T2 (xx)
NZ (1) NZ536412A (xx)
PT (2) PT2332989E (xx)
SI (2) SI2332989T1 (xx)
WO (1) WO2003097697A2 (xx)

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US9597379B1 (en) 2010-02-09 2017-03-21 David Gordon Bermudes Protease inhibitor combination with therapeutic proteins including antibodies
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Also Published As

Publication number Publication date
JP2012228272A (ja) 2012-11-22
US20170107272A1 (en) 2017-04-20
CN103739706A (zh) 2014-04-23
AU2010202634A1 (en) 2010-07-15
US20150057191A1 (en) 2015-02-26
CN1662556B (zh) 2013-05-01
EP3656787A1 (en) 2020-05-27
ES2656427T3 (es) 2018-02-27
JP6261136B2 (ja) 2018-01-17
WO2003097697A3 (en) 2004-12-09
JP2015227372A (ja) 2015-12-17
CN102093477B (zh) 2014-02-26
EP1506236B1 (en) 2013-01-23
HK1217712A1 (zh) 2017-01-20
JP2013078343A (ja) 2013-05-02
EP2314622B1 (en) 2017-10-18
EP2332989B1 (en) 2015-04-01
HK1152320A1 (en) 2012-02-24
EP2947095B1 (en) 2019-10-02
EP2332989A1 (en) 2011-06-15
CA2483285C (en) 2015-01-27
CN103739706B (zh) 2015-11-18
JP2020171286A (ja) 2020-10-22
WO2003097697A2 (en) 2003-11-27
HUE048922T2 (hu) 2020-09-28
ES2537104T3 (es) 2015-06-02
SI2332989T1 (sl) 2015-06-30
CN105175535A (zh) 2015-12-23
PT1506236E (pt) 2013-03-27
NZ536412A (en) 2008-10-31
CA2867542C (en) 2020-04-14
EP1506236A2 (en) 2005-02-16
CA2483285A1 (en) 2003-11-27
AU2010202634B2 (en) 2012-08-23
US20190119361A1 (en) 2019-04-25
PT2332989E (pt) 2015-08-05
JP6075836B2 (ja) 2017-02-08
CN1662556A (zh) 2005-08-31
CA2867542A1 (en) 2003-11-27
DK1506236T3 (da) 2013-03-04
JP6918033B2 (ja) 2021-08-11
US10570190B2 (en) 2020-02-25
JP6100544B2 (ja) 2017-03-22
US20060035320A1 (en) 2006-02-16
CY1114225T1 (el) 2016-08-31
AU2003238370B2 (en) 2010-04-29
JP2017201990A (ja) 2017-11-16
US20200165322A1 (en) 2020-05-28
CN102093477A (zh) 2011-06-15
US10125186B2 (en) 2018-11-13
DK2332989T3 (en) 2015-05-11
US8853362B2 (en) 2014-10-07
JP2010187678A (ja) 2010-09-02
JP2013256533A (ja) 2013-12-26
JP2006508638A (ja) 2006-03-16
JP2015214583A (ja) 2015-12-03
AU2003238370A1 (en) 2003-12-02
EP2947095A1 (en) 2015-11-25
ES2399617T3 (es) 2013-04-02
SI2947095T1 (sl) 2020-04-30
US9518108B2 (en) 2016-12-13
JP2019058191A (ja) 2019-04-18
EP2314622A1 (en) 2011-04-27

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Effective date: 20230520