HK1071066A1 - Synergistic association of (-)- gossypol with docetaxel or paclitaxel for cancer treatment - Google Patents

Synergistic association of (-)- gossypol with docetaxel or paclitaxel for cancer treatment

Info

Publication number
HK1071066A1
HK1071066A1 HK05103834.9A HK05103834A HK1071066A1 HK 1071066 A1 HK1071066 A1 HK 1071066A1 HK 05103834 A HK05103834 A HK 05103834A HK 1071066 A1 HK1071066 A1 HK 1071066A1
Authority
HK
Hong Kong
Prior art keywords
bcl
gossypol
docetaxel
paclitaxel
cancer treatment
Prior art date
Application number
HK05103834.9A
Other languages
English (en)
Inventor
Shaomeng Wang
Dajun Yang
Original Assignee
Univ Michigan
Univ Georgetown
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Michigan, Univ Georgetown filed Critical Univ Michigan
Publication of HK1071066A1 publication Critical patent/HK1071066A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/11—Aldehydes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
HK05103834.9A 2001-05-30 2005-05-06 Synergistic association of (-)- gossypol with docetaxel or paclitaxel for cancer treatment HK1071066A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29398301P 2001-05-30 2001-05-30
PCT/US2002/017206 WO2002097053A2 (fr) 2001-05-30 2002-05-30 Petits antagonistes moleculaires de proteines de la famille bcl2

Publications (1)

Publication Number Publication Date
HK1071066A1 true HK1071066A1 (en) 2005-07-08

Family

ID=31495521

Family Applications (1)

Application Number Title Priority Date Filing Date
HK05103834.9A HK1071066A1 (en) 2001-05-30 2005-05-06 Synergistic association of (-)- gossypol with docetaxel or paclitaxel for cancer treatment

Country Status (18)

Country Link
US (1) US20030008924A1 (fr)
EP (1) EP1474121B1 (fr)
JP (1) JP2005515158A (fr)
KR (1) KR20040108528A (fr)
CN (1) CN1589135A (fr)
AT (1) ATE474568T1 (fr)
AU (1) AU2002305769B2 (fr)
CA (1) CA2449245A1 (fr)
DE (1) DE60237115D1 (fr)
ES (1) ES2349349T3 (fr)
HK (1) HK1071066A1 (fr)
IL (1) IL159110A0 (fr)
MX (1) MXPA03010977A (fr)
NO (1) NO20035301D0 (fr)
NZ (1) NZ529792A (fr)
SG (1) SG157952A1 (fr)
WO (1) WO2002097053A2 (fr)
ZA (1) ZA200309306B (fr)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO20023357D0 (no) * 2002-04-19 2002-07-11 Amersham Health As Blanding
US20070060615A1 (en) * 2003-02-18 2007-03-15 University Of South Florida Method of Modulating Apoptosis Through Modulation of E2F1
ATE478663T1 (de) * 2003-06-25 2010-09-15 Burnham Inst Analoga von apogossypol zur verwendung in der behandlung von krebs
ZA200607956B (en) * 2004-03-25 2008-02-27 Univ Michigan Gossypol co-crystals and the use thereof
US7842815B2 (en) 2004-06-17 2010-11-30 Infinity Pharmaceuticals, Inc. Compounds and methods for inhibiting the interaction of BCL proteins with binding partners
CN101006065B (zh) 2004-06-17 2012-07-11 英菲尼蒂发现公司 抑制bcl蛋白与结合伴侣的相互作用的化合物和方法
US20060144723A1 (en) * 2004-11-02 2006-07-06 Mary Fuller Device for securing valuables
CA2600797A1 (fr) * 2005-03-11 2006-09-21 The Regents Of The University Of Michigan Inhibiteurs de chromen-4-one des elements anti-apoptotiques de la famille bcl-2 et utilisations
TWI403320B (zh) 2005-12-16 2013-08-01 Infinity Discovery Inc 用於抑制ｂｃｌ蛋白和結合夥伴間之交互作用的化合物及方法
JP2009532354A (ja) * 2006-03-30 2009-09-10 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン ゴシポール共結晶の生産方法
CA2650520A1 (fr) 2006-04-24 2008-01-31 Gloucester Pharmaceuticals Traitement de tumeurs exprimant ras
US8957027B2 (en) 2006-06-08 2015-02-17 Celgene Corporation Deacetylase inhibitor therapy
TWI389895B (zh) 2006-08-21 2013-03-21 Infinity Discovery Inc 抑制ｂｃｌ蛋白質與結合夥伴間之交互作用的化合物及方法
US7857804B2 (en) 2006-09-01 2010-12-28 Mccaffrey Timothy A Use of Bcl inhibitors for the prevention of fibroproliferative reclosure of dilated blood vessels and other iatrogenic fibroproliferative disorders
US20090030088A1 (en) * 2007-04-20 2009-01-29 Clemson University Therapeutic benefits of gossypol, 6-methoxy gossypol, and 6,6'-dimothxy gossypol
WO2009036035A1 (fr) * 2007-09-10 2009-03-19 Curis, Inc. Inhibiteurs de bcl-2
EP2205088B1 (fr) * 2007-10-19 2018-02-21 Burnham Institute for Medical Research Inhibiteurs à base de naphtalène de protéines anti-apoptotiques
EP2323648A4 (fr) * 2008-08-14 2012-10-03 Uab Research Foundation Agents anti-arythmie, procédés pour leur utilisation, procédés pour leur identification et kits pertinents
NZ593343A (en) * 2008-12-11 2013-04-26 Abraxis Bioscience Llc Combination cancer treatment conprising Abraxane and an inflamatory inhibitor
US8937193B2 (en) * 2009-10-08 2015-01-20 Sanford-Burnham Medical Research Institute Apogossypolone derivatives as anticancer agents
AU2011279303B2 (en) 2010-07-12 2015-07-16 Celgene Corporation Romidepsin solid forms and uses thereof
US8859502B2 (en) 2010-09-13 2014-10-14 Celgene Corporation Therapy for MLL-rearranged leukemia
US8945627B2 (en) 2011-05-05 2015-02-03 Wisconsin Alumni Research Foundation Micelles for the solubilization of gossypol
US8940737B2 (en) * 2011-10-14 2015-01-27 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
EP2794592A1 (fr) 2011-12-23 2014-10-29 Novartis AG Composés inhibiteurs de l'interaction entre bcl2 et des partenaires de liaison
CA2859869A1 (fr) 2011-12-23 2013-06-27 Novartis Ag Composes inhibiteurs de l'interaction entre bcl2 et des partenaires de liaison
WO2013096049A1 (fr) 2011-12-23 2013-06-27 Novartis Ag Composés permettant d'inhiber l'interaction de bcl-2 avec des partenaires de liaison
JP2015503516A (ja) 2011-12-23 2015-02-02 ノバルティス アーゲー Ｂｃｌ２と結合相手の相互作用を阻害するための化合物
MX2014007732A (es) 2011-12-23 2015-01-12 Novartis Ag Compuestos para inhibir la interaccion de bcl2 con los mismos componentes de enlace.
AU2013202506B2 (en) 2012-09-07 2015-06-18 Celgene Corporation Resistance biomarkers for hdac inhibitors
AU2013202507B9 (en) 2012-11-14 2015-08-13 Celgene Corporation Inhibition of drug resistant cancer cells
NZ630311A (en) 2013-12-27 2016-03-31 Celgene Corp Romidepsin formulations and uses thereof
WO2015123617A1 (fr) * 2014-02-14 2015-08-20 Arizona Board Of Regents For The University Of Arizona Procédé pour réduire l'expression du gène bcl2
EP3708170A1 (fr) 2014-05-05 2020-09-16 BioVentures, LLC Compositions et procédés d'inhibition de protéines antiapoptotiques bcl-2 comme agents anti-âge
CA2955972A1 (fr) 2014-07-22 2016-01-28 Bioventures, Llc. Compositions et procedes de depletion selective de cellules senescentes
CN105884634B (zh) * 2015-01-05 2019-06-04 南开大学 棉酚衍生物和它们的制备,在农药上的应用及抗癌活性
WO2017027845A1 (fr) 2015-08-12 2017-02-16 Memorial Sloan-Kettering Cancer Center Dérivés phénylsulfonamido-benzofurane et leur utilisation dans le traitement de maladies prolifératives
WO2017087810A1 (fr) * 2015-11-20 2017-05-26 Memorial Sloan-Kettering Cancer Center Procédé de criblage d'inhibiteurs ciblant des voies de survie anti-apoptotiques
CN108697667A (zh) 2016-02-18 2018-10-23 延世大学校产学协力团 用于治疗癌症、含有多酚化合物作为活性成分的药物组合物
WO2017142348A1 (fr) * 2016-02-18 2017-08-24 연세대학교 산학협력단 Composition pharmaceutique pour le traitement d'un cancer, contenant un composé polyphénol utilisé comme principe actif
CN109152933B (zh) 2016-04-21 2022-12-02 生物风险投资有限责任公司 诱导抗细胞凋亡bcl-2家族蛋白的降解的化合物及其用途
CN109718377B (zh) * 2017-10-31 2021-03-26 中国科学院脑科学与智能技术卓越创新中心 KPNB1抑制剂和Bcl-xL抑制剂在制备抗肿瘤药物中的应用
CN112105360B (zh) 2018-01-22 2024-01-30 生物风险投资有限责任公司 用于癌症治疗的bcl-2蛋白降解剂
WO2019221755A1 (fr) 2018-05-18 2019-11-21 Bioventures, Llc Analogues de piperlongumine et leurs utilisations
CN109876145A (zh) * 2019-04-25 2019-06-14 中国科学院化学研究所 醋酸棉酚和化疗药的联合用药物
AU2020293230A1 (en) 2019-06-12 2022-01-27 Juno Therapeutics, Inc. Combination therapy of a cell-mediated cytotoxic therapy and an inhibitor of a prosurvival BCL2 family protein
WO2022133030A1 (fr) 2020-12-16 2022-06-23 Juno Therapeutics, Inc. Polythérapie de thérapie cellulaire et d'inhibiteur de bcl2
AU2022405016A1 (en) 2021-12-09 2024-06-06 University Of Florida Research Foundation, Incorporated Bcl-xl/bcl-2 dual degraders for treatment of cancers
WO2023220655A1 (fr) 2022-05-11 2023-11-16 Celgene Corporation Méthodes pour surmonter la résistance aux médicaments par ré-sensibilisation de cellules cancéreuses à un traitement avec une thérapie antérieure par l'intermédiaire d'un traitement avec une thérapie par lymphocytes t

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4806568A (en) * 1985-09-12 1989-02-21 Research Corporation Gossypol derivatives
US5026726A (en) * 1989-12-11 1991-06-25 The University Of New Mexico Gossylic iminolactones and gossylic lactones and their anti-viral activities
US5385936A (en) * 1990-07-12 1995-01-31 The United States Of America As Represented By The Secretary Of The Department Of The Health And Human Services Gossypol acetic acid for the treatment of cancer
US9002545B2 (en) 2011-01-07 2015-04-07 Wabtec Holding Corp. Data improvement system and method

Also Published As

Publication number Publication date
WO2002097053A2 (fr) 2002-12-05
US20030008924A1 (en) 2003-01-09
JP2005515158A (ja) 2005-05-26
NO20035301D0 (no) 2003-11-28
NZ529792A (en) 2007-04-27
ATE474568T1 (de) 2010-08-15
KR20040108528A (ko) 2004-12-24
EP1474121A4 (fr) 2006-05-03
IL159110A0 (en) 2004-06-01
DE60237115D1 (de) 2010-09-02
ZA200309306B (fr) 2006-07-26
MXPA03010977A (es) 2005-04-08
WO2002097053A3 (fr) 2004-09-10
EP1474121B1 (fr) 2010-07-21
AU2002305769B2 (en) 2007-07-19
CA2449245A1 (fr) 2002-12-05
ES2349349T3 (es) 2010-12-30
EP1474121A2 (fr) 2004-11-10
SG157952A1 (en) 2010-01-29
CN1589135A (zh) 2005-03-02

Similar Documents

Publication Publication Date Title
HK1071066A1 (en) Synergistic association of (-)- gossypol with docetaxel or paclitaxel for cancer treatment
BR0201714A (pt) Uso de hidroxiflavanonas para encobrir o sabor amargo
EP2476461A3 (fr) Formulations pour le traitement du cancer
WO2004030627A3 (fr) Methodes et compositions synergetiques pour le traitement du cancer
HK1109638A1 (en) Dr5 antibodies and uses thereof dr5
NO20060978L (no) Farmasoytiske blandingr for behandling av prematur ejakulasjon ved pulmonal inhalering
EP2497478A3 (fr) Composition d'oligosaccarides et leur utilisation dans le traitement d'infection
EP1181013A4 (fr) Procede et composition pour le traitement du cancer
IL169897A0 (en) Sustituted heterocycles
IL190796A0 (en) Compositions and their uses for gene therapy of bone conditions
MY143795A (en) Tetrahydropyridoindole derivatives
WO2007002836A3 (fr) Procedes et compositions pour la prevention et le traitement de maladie renale
PL1654253T3 (pl) Podstawione pochodne 3-pirolidynoindolu
HUP0400231A3 (en) Methods and pharmaceutical compositions for immune deception, particularly useful in the treatment of cancer
NO20085147L (no) Sammensetning for behandling av motstandsdyktige kreftformer omfattende oridonin
MX2007012623A (es) Inulina de cadena larga.
TW200716088A (en) Formulations and methods for treating amyloidosis
HK1083296A1 (en) Enteral composition for the prevention and/or treatment of sepsis
DE602004017871D1 (de) Zubereitungen zur behandlung von arthritischen erscheinungen
EP1773363A4 (fr) Compositions de ngna et procédés d'utilisation de celles-ci
WO2006122162A3 (fr) Procede et composition pour traiter la mucosite
SI1951738T1 (sl) Nadaljnje kristalinične oblike rostafuroksina
PL1677818T3 (pl) Stabilne kompozycje wodne zawierające G-CSF
DE602005015329D1 (de) Rutheniumkomplexe zur krebsbehandlung
BRPI0410967A (pt) compostos, composições e seus usos para o tratamento de infecções por vìrus da famìlia flaviviridae

Legal Events

Date Code Title Description
PE Patent expired

Effective date: 20220529