WO2006122162A3 - Procede et composition pour traiter la mucosite - Google Patents

Procede et composition pour traiter la mucosite Download PDF

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Publication number
WO2006122162A3
WO2006122162A3 PCT/US2006/018014 US2006018014W WO2006122162A3 WO 2006122162 A3 WO2006122162 A3 WO 2006122162A3 US 2006018014 W US2006018014 W US 2006018014W WO 2006122162 A3 WO2006122162 A3 WO 2006122162A3
Authority
WO
WIPO (PCT)
Prior art keywords
mucositis
treatment
growth factor
peptides derived
derived
Prior art date
Application number
PCT/US2006/018014
Other languages
English (en)
Other versions
WO2006122162A2 (fr
Inventor
F Gary Toback
Original Assignee
Univ Chicago
F Gary Toback
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP05010217A external-priority patent/EP1595547A3/fr
Application filed by Univ Chicago, F Gary Toback filed Critical Univ Chicago
Priority to US11/913,928 priority Critical patent/US8017576B2/en
Priority to EP06770157A priority patent/EP1885390B1/fr
Priority to CA2643736A priority patent/CA2643736C/fr
Priority to AU2006244080A priority patent/AU2006244080C1/en
Priority to JP2008511298A priority patent/JP5058980B2/ja
Priority to MX2007013982A priority patent/MX2007013982A/es
Priority to AT06770157T priority patent/ATE526983T1/de
Publication of WO2006122162A2 publication Critical patent/WO2006122162A2/fr
Publication of WO2006122162A3 publication Critical patent/WO2006122162A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne des procédés et des compositions à base de peptides dérivés d'AMP-18, qui font la preuve de façon validante que les compositions à base de peptides dérivés d'AMP-18 atténuent de façon surprenante la mucosite chez les mammifères. L'invention concerne notamment des procédés et des compositions qui traitent la mucosite, qui retardent la survenue ou la durée de la mucosite, y-compris les mucosites induites par les thérapies anticancéreuses. Les peptides AMP 77-97 dérivés de la protéine AMP-18 humaine atténuent les mucosites induites par les thérapies anticancéreuses.
PCT/US2006/018014 2005-05-10 2006-05-09 Procede et composition pour traiter la mucosite WO2006122162A2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
US11/913,928 US8017576B2 (en) 2005-05-10 2006-05-09 Methods and compositions to treat mucositis
EP06770157A EP1885390B1 (fr) 2005-05-10 2006-05-09 Utilisation des derivees du facteur de croissance amp-18 pour le traitement de la stomatitis
CA2643736A CA2643736C (fr) 2005-05-10 2006-05-09 Procede et composition pour traiter la mucosite
AU2006244080A AU2006244080C1 (en) 2005-05-10 2006-05-09 Use of peptides derived from the growth factor AMP-18 for the treatment of mucositis
JP2008511298A JP5058980B2 (ja) 2005-05-10 2006-05-09 粘膜炎を処置するための増殖因子ａｍｐ−１８に由来するペプチドの使用
MX2007013982A MX2007013982A (es) 2005-05-10 2006-05-09 Uso de peptidos derivados del factor de crecimiento amp-18 para el tratamiento de la mucositis.
AT06770157T ATE526983T1 (de) 2005-05-10 2006-05-09 Verwendung von peptiden aus dem wachstumsfaktors amp-18 zur behandlung von stomatitis

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP05010217.7 2005-05-10
EP05010217A EP1595547A3 (fr) 2004-05-11 2005-05-10 Utilisation du facteur de croissance AMP pour le traitement des lésions gastrointestinales et de la insuffisance renale aigue
US79017706P 2006-04-07 2006-04-07
US60/790,177 2006-04-07

Publications (2)

Publication Number Publication Date
WO2006122162A2 WO2006122162A2 (fr) 2006-11-16
WO2006122162A3 true WO2006122162A3 (fr) 2007-08-30

Family

ID=37081600

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/018014 WO2006122162A2 (fr) 2005-05-10 2006-05-09 Procede et composition pour traiter la mucosite

Country Status (2)

Country Link
AU (1) AU2006244080C1 (fr)
WO (1) WO2006122162A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090092574A1 (en) 2006-12-29 2009-04-09 Scott Richard W Ophthalmic And Otic Compositions Of Facially Amphiphilic Polymers And Oligomers And Uses Thereof
EP2259844A4 (fr) * 2008-03-05 2012-02-01 Vicus Therapeutics Llc Compositions et procédés pour des thérapies de la mucosite et d oncologie
US8802683B2 (en) 2011-05-16 2014-08-12 Cellceutix Corporation Compounds for use in treatment of mucositis
FR2979241B1 (fr) 2011-08-30 2014-05-09 Nutrialys Medical Nutrition Sa Utilisation de compositions a faible teneur en polyamines dans la prevention ou le traitement des effets indesirables lies a un traitement anti-cancereux
US9889120B2 (en) 2016-01-14 2018-02-13 Vicus Therapeutics, Llc Combination drug therapies for cancer and methods of making and using them
SG11201908629WA (en) * 2017-04-19 2019-10-30 Otsuka Pharma Factory Inc Anti-inflammatory agent
WO2021248008A1 (fr) 2020-06-05 2021-12-09 Innovation Pharmaceuticals Inc. Composés arylamides pour le traitement et la prévention d'infections virales

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002078640A2 (fr) * 2001-03-29 2002-10-10 University Of Chicago Regulation de la croissance et de la reparation de tissus gastro-intestinaux par des gastrokines et des inhibiteurs
US20050031582A1 (en) * 2001-03-29 2005-02-10 Toback F. Gary Control of growth and repair of gastro-intestinal tissues by gastrokines and inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002078640A2 (fr) * 2001-03-29 2002-10-10 University Of Chicago Regulation de la croissance et de la reparation de tissus gastro-intestinaux par des gastrokines et des inhibiteurs
US20050031582A1 (en) * 2001-03-29 2005-02-10 Toback F. Gary Control of growth and repair of gastro-intestinal tissues by gastrokines and inhibitors

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE BIOSIS 2003, WALSH-REITZ, M.M. ET AL.: "Accumulation of specific tight and adherens junction proteins is stimulated by antrum mucosal protein-18 in colonic epithelial cells in culture and mouse in vivo", XP002354652, Database accession no. PREV200300571862 *
MARTIN, T.E. ET AL.: "A novel mitogenic protein that is highly expressed in cells of the gastric antrum mucosa", AMERICAN JOURNAL OF PHYSIOLOGY: GASTROINTESTINAL AND LIVER PHYSIOLOGY, vol. 285, no. 2, August 2003 (2003-08-01), pages G332 - G343, XP002355078 *
TOBACK, F.G. ET AL.: "Peptide fragments of AMP-18, a novel secreted gastric antrum mucosal protein, are mitogenic and motogenic", AMERICAN JOURNAL OF PHYSIOLOGY: GASTROINTESTINAL AND LIVER PHYSIOLOGY, vol. 285, no. 2, August 2003 (2003-08-01), pages G344 - G353, XP002355079 *

Also Published As

Publication number Publication date
AU2006244080A1 (en) 2006-11-16
WO2006122162A2 (fr) 2006-11-16
AU2006244080C1 (en) 2012-02-02
AU2006244080B2 (en) 2011-09-08

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