HK1068807A1 - Expression vectors encoding epitopes of antigens and methods for their design - Google Patents
Expression vectors encoding epitopes of antigens and methods for their designInfo
- Publication number
- HK1068807A1 HK1068807A1 HK05101449A HK05101449A HK1068807A1 HK 1068807 A1 HK1068807 A1 HK 1068807A1 HK 05101449 A HK05101449 A HK 05101449A HK 05101449 A HK05101449 A HK 05101449A HK 1068807 A1 HK1068807 A1 HK 1068807A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- epitope
- substrate polypeptide
- methods
- proteasome
- liberation
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000000427 antigen Substances 0.000 title abstract 2
- 102000036639 antigens Human genes 0.000 title abstract 2
- 108091007433 antigens Proteins 0.000 title abstract 2
- 239000013604 expression vector Substances 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 6
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 6
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 6
- 239000000758 substrate Substances 0.000 abstract 5
- 102000004245 Proteasome Endopeptidase Complex Human genes 0.000 abstract 3
- 108090000708 Proteasome Endopeptidase Complex Proteins 0.000 abstract 3
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 2
- 230000003213 activating effect Effects 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001184—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464484—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
- A61K39/464488—NY-ESO
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6075—Viral proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Oncology (AREA)
- Wood Science & Technology (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Spectroscopy & Molecular Physics (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33696801P | 2001-11-07 | 2001-11-07 | |
PCT/US2002/036098 WO2003063770A2 (fr) | 2001-11-07 | 2002-11-07 | Epitopes codant pour des vecteurs d'expression d'antigenes associes a des cibles et procedes permettant leur conception |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1068807A1 true HK1068807A1 (en) | 2005-05-06 |
Family
ID=27662934
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK05101449A HK1068807A1 (en) | 2001-11-07 | 2005-02-22 | Expression vectors encoding epitopes of antigens and methods for their design |
HK05109682A HK1075473A1 (en) | 2001-11-07 | 2005-10-31 | Expression vectors encoding epitopes of target-associated antigens and methods for their design |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK05109682A HK1075473A1 (en) | 2001-11-07 | 2005-10-31 | Expression vectors encoding epitopes of target-associated antigens and methods for their design |
Country Status (12)
Country | Link |
---|---|
US (3) | US8637305B2 (fr) |
EP (2) | EP2314712B1 (fr) |
CN (2) | CN1313617C (fr) |
AT (1) | ATE494387T1 (fr) |
AU (1) | AU2008229722B2 (fr) |
CA (1) | CA2469738A1 (fr) |
DE (1) | DE60238864D1 (fr) |
DK (1) | DK1453471T3 (fr) |
ES (1) | ES2358642T3 (fr) |
HK (2) | HK1068807A1 (fr) |
MX (1) | MXPA04005382A (fr) |
WO (1) | WO2003063770A2 (fr) |
Families Citing this family (76)
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US6136311A (en) | 1996-05-06 | 2000-10-24 | Cornell Research Foundation, Inc. | Treatment and diagnosis of cancer |
US6977074B2 (en) | 1997-07-10 | 2005-12-20 | Mannkind Corporation | Method of inducing a CTL response |
US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
EP1964573B1 (fr) | 1999-10-22 | 2014-11-26 | Aventis Pasteur Limited | Procédé d'induction et/ou amélioration d'une réponse immune vers des antigènes de tumeurs |
US20030215425A1 (en) * | 2001-12-07 | 2003-11-20 | Simard John J. L. | Epitope synchronization in antigen presenting cells |
WO2003008537A2 (fr) * | 2001-04-06 | 2003-01-30 | Mannkind Corporation | Sequences d'epitope |
CN1313617C (zh) * | 2001-11-07 | 2007-05-02 | 曼康公司 | 编码靶相关抗原表位的表达载体及其设计方法 |
DE60318938T2 (de) | 2002-03-20 | 2009-01-22 | Mannkind Corp., Valencia | Inhalationsgerät |
US7178491B2 (en) * | 2003-06-05 | 2007-02-20 | Caterpillar Inc | Control system and method for engine valve actuator |
WO2004112825A2 (fr) | 2003-06-17 | 2004-12-29 | Mannkind Corporation | Combinaisons d'antigenes associes a des tumeurs dans des compositions pour divers types de cancers |
MXPA05013973A (es) * | 2003-06-17 | 2006-03-02 | Mannkind Corp | Metodos para producir, mejorar y sustentar respuestas inmunes contra epitopes restringidos mhc clase i, para propositos profilacticos o terapeuticos. |
US20070014807A1 (en) * | 2003-09-03 | 2007-01-18 | Maida Anthony E Iii | Multiplex vaccine |
AU2005265182B2 (en) * | 2004-06-17 | 2012-06-21 | Mannkind Corporation | Epitope analogs |
US20060008468A1 (en) * | 2004-06-17 | 2006-01-12 | Chih-Sheng Chiang | Combinations of tumor-associated antigens in diagnostics for various types of cancers |
US20060159689A1 (en) * | 2004-06-17 | 2006-07-20 | Chih-Sheng Chiang | Combinations of tumor-associated antigens in diagnostics for various types of cancers |
JP2008503494A (ja) * | 2004-06-17 | 2008-02-07 | マンカインド コーポレイション | 診断方法を治療方法と統合することによる免疫療法の効力改善 |
EP1786784B1 (fr) | 2004-08-20 | 2010-10-27 | MannKind Corporation | Catalyse de la synthese de dicetopiperazine |
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AU2005325715B2 (en) * | 2004-12-16 | 2011-10-06 | Wake Forest University Health Sciences | Use of flagellin in tumor immunotherapy |
EP1835932A2 (fr) * | 2004-12-29 | 2007-09-26 | Mannkind Corporation | Methodes de declenchement, d'accentuation et de maintien de reponses immunitaires contre des epitopes restreints du cmh de classe i a des fins prophylactiques ou therapeutiques |
US20060159694A1 (en) * | 2004-12-29 | 2006-07-20 | Chih-Sheng Chiang | Combinations of tumor-associated antigens in compositions for various types of cancers |
WO2006071990A2 (fr) * | 2004-12-29 | 2006-07-06 | Mannkind Corporation | Methodes de declenchement d'une reponse immunitaire sans implication de cellules cd+4 |
WO2006071934A2 (fr) | 2004-12-29 | 2006-07-06 | Mannkind Corporation | Procedes permettant de declencher, maintenir et manipuler des modificateurs de reponse biologique a l'interieur d'organes lympoides |
EP2385060A3 (fr) | 2005-06-17 | 2012-02-15 | Mannkind Corporation | Procédés et communications pour susciter des réponses immunes polyvalentes contre des épitopes dominants et sous-dominants exprimés sur des cellules cancéreuses et le stroma tumoral |
EP2371851A3 (fr) * | 2005-06-17 | 2012-08-01 | Mannkind Corporation | Analogues d'épitopes |
WO2006138568A2 (fr) * | 2005-06-17 | 2006-12-28 | Mannkind Corporation | Immunotherapie multivalente a effet de declenchement et d'amplification, destinee au traitement d'une tumeur cancereuse |
US7803404B2 (en) | 2005-09-14 | 2010-09-28 | Mannkind Corporation | Method of drug formulation based on increasing the affinity of active agents for crystalline microparticle surfaces |
BRPI0707991B8 (pt) | 2006-02-22 | 2021-05-25 | Mannkind Corp | métodos de preparação de um medicamento em pó seco com uma propriedade farmacêutica melhorada, dito pó seco e uso de uma quantidade efetiva do pó seco |
US8940871B2 (en) | 2006-03-20 | 2015-01-27 | The Regents Of The University Of California | Engineered anti-prostate stem cell antigen (PSCA) antibodies for cancer targeting |
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EP2152890A1 (fr) * | 2007-05-23 | 2010-02-17 | MannKind Corporation | Vecteurs multicistroniques et procédés pour leur conception |
JP6126773B2 (ja) | 2007-09-04 | 2017-05-10 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 癌のターゲッティングおよび検出のための高親和性抗前立腺幹細胞抗原(psca)抗体 |
CA2721366C (fr) | 2008-04-17 | 2017-06-06 | Elizabeth Ann Vasievich | Stimulation de reponse immunitaire par des enantiomeres de lipides cationiques |
US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
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TWI614024B (zh) | 2008-08-11 | 2018-02-11 | 曼凱公司 | 超快起作用胰島素之用途 |
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ES2712732T3 (es) | 2009-02-17 | 2019-05-14 | Cornell Res Foundation Inc | Métodos y kits para el diagnóstico de cáncer y la predicción de valor terapéutico |
PL2405963T3 (pl) | 2009-03-11 | 2014-04-30 | Mannkind Corp | Urządzenie, układ i sposób pomiaru oporu inhalatora |
KR20180079458A (ko) | 2009-06-12 | 2018-07-10 | 맨카인드 코포레이션 | 한정된 비표면적을 갖는 디케토피페라진 마이크로입자 |
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US8673847B2 (en) * | 2009-10-05 | 2014-03-18 | The Medical College Of Wisconsin, Inc. | Peptide based peroxidase inhibitors and methods of using same |
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EP2496295A1 (fr) | 2009-11-03 | 2012-09-12 | MannKind Corporation | Appareil et méthode de simulation d'efforts d'inhalation |
EP2506876B1 (fr) | 2009-12-02 | 2016-10-12 | Imaginab, Inc. | Minobodies j591 et cys-diabodies pour le ciblage de l'antigène membranaire spécifique de la prostate humaine (psma), et procédés d'utilisation |
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CA2812153C (fr) * | 2010-09-20 | 2020-06-30 | Biontech Ag | Recepteur des cellules t specifiques des antigenes et epitopes des cellules t |
CN105667994B (zh) | 2011-04-01 | 2018-04-06 | 曼金德公司 | 用于药物药盒的泡罩包装 |
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AU2012328885B2 (en) | 2011-10-24 | 2017-08-31 | Mannkind Corporation | Methods and compositions for treating pain |
CN108057154B (zh) | 2012-07-12 | 2021-04-16 | 曼金德公司 | 干粉药物输送系统和方法 |
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US10159644B2 (en) | 2012-10-26 | 2018-12-25 | Mannkind Corporation | Inhalable vaccine compositions and methods |
EP2968607B1 (fr) * | 2013-03-15 | 2019-07-24 | The Trustees Of The University Of Pennsylvania | Vaccins anticancéreux et méthodes de traitement les utilisant |
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CN104761644A (zh) * | 2014-01-03 | 2015-07-08 | 百奇生物科技(苏州)有限公司 | 大肠杆菌表达的融合蛋白mbp-mart-1及其制备和应用 |
US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
WO2015153969A1 (fr) | 2014-04-04 | 2015-10-08 | The Board Of Trustees Of The Leland Stanford Junior University | Découverte de ligands pour les récepteurs de cellule t |
WO2015199617A1 (fr) * | 2014-06-24 | 2015-12-30 | National University Of Singapore | Anticorps monoclonal à spécificité du type récepteur des cellules t qui cible des cellules tumorales humaines infectées par le virus d'epstein-barr sur la base de leur expression d'ebna1 |
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- 2002-11-07 WO PCT/US2002/036098 patent/WO2003063770A2/fr not_active Application Discontinuation
- 2002-11-07 EP EP20100180603 patent/EP2314712B1/fr not_active Expired - Lifetime
- 2002-11-07 EP EP20020806695 patent/EP1453471B1/fr not_active Expired - Lifetime
- 2002-11-07 DK DK02806695T patent/DK1453471T3/da active
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- 2002-11-07 CA CA 2469738 patent/CA2469738A1/fr not_active Abandoned
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US20030228634A1 (en) | 2003-12-11 |
CN1612935A (zh) | 2005-05-04 |
HK1075473A1 (en) | 2005-12-16 |
DE60238864D1 (de) | 2011-02-17 |
WO2003063770A9 (fr) | 2004-06-17 |
EP2314712B1 (fr) | 2014-01-08 |
WO2003063770A3 (fr) | 2004-04-01 |
CA2469738A1 (fr) | 2003-08-07 |
EP2314712A1 (fr) | 2011-04-27 |
ATE494387T1 (de) | 2011-01-15 |
US8252916B2 (en) | 2012-08-28 |
CN1313617C (zh) | 2007-05-02 |
EP1453471A4 (fr) | 2006-11-29 |
AU2008229722A1 (en) | 2008-10-30 |
ES2358642T3 (es) | 2011-05-12 |
AU2008229722B2 (en) | 2012-09-06 |
MXPA04005382A (es) | 2005-02-24 |
US7232682B2 (en) | 2007-06-19 |
DK1453471T3 (da) | 2011-03-28 |
US20040132088A1 (en) | 2004-07-08 |
EP1453471A2 (fr) | 2004-09-08 |
US8637305B2 (en) | 2014-01-28 |
WO2003063770A2 (fr) | 2003-08-07 |
EP1453471B1 (fr) | 2011-01-05 |
US20040203051A1 (en) | 2004-10-14 |
CN101024842A (zh) | 2007-08-29 |
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