HK1062170A1 - Process for the preparation of 1,3-substituted in denes and aryl-fused azapolycyclic compounds - Google Patents

Process for the preparation of 1,3-substituted in denes and aryl-fused azapolycyclic compounds

Info

Publication number
HK1062170A1
HK1062170A1 HK04105132A HK04105132A HK1062170A1 HK 1062170 A1 HK1062170 A1 HK 1062170A1 HK 04105132 A HK04105132 A HK 04105132A HK 04105132 A HK04105132 A HK 04105132A HK 1062170 A1 HK1062170 A1 HK 1062170A1
Authority
HK
Hong Kong
Prior art keywords
denes
aryl
substituted
preparation
fused azapolycyclic
Prior art date
Application number
HK04105132A
Other languages
English (en)
Inventor
Robert Alan Singer
Jason Daniel Mckinley
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of HK1062170A1 publication Critical patent/HK1062170A1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00Sulfones; Sulfoxides
    • C07C317/44Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34Tobacco-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36Opioid-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00Preparation of carboxylic acid nitriles
    • C07C253/30Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • C07C255/45Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C255/47Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of rings being part of condensed ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HK04105132A 2001-04-20 2004-07-14 Process for the preparation of 1,3-substituted in denes and aryl-fused azapolycyclic compounds HK1062170A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28513101P 2001-04-20 2001-04-20
PCT/IB2002/000660 WO2002085843A2 (en) 2001-04-20 2002-03-04 Process for the preparation of 1,3-substituted indenes and aryl-fused azapolycyclic compounds

Publications (1)

Publication Number Publication Date
HK1062170A1 true HK1062170A1 (en) 2004-10-21

Family

ID=23092860

Family Applications (1)

Application Number Title Priority Date Filing Date
HK04105132A HK1062170A1 (en) 2001-04-20 2004-07-14 Process for the preparation of 1,3-substituted in denes and aryl-fused azapolycyclic compounds

Country Status (25)

Country Link
US (2) US7091372B2 (de)
EP (1) EP1383733B1 (de)
JP (1) JP2004527545A (de)
KR (1) KR100551183B1 (de)
CN (1) CN1321107C (de)
AR (2) AR035957A1 (de)
AT (1) ATE388135T1 (de)
AU (1) AU2002234836B2 (de)
BR (1) BR0208992A (de)
CA (1) CA2443946A1 (de)
CZ (1) CZ20032814A3 (de)
DE (1) DE60225433T2 (de)
DK (1) DK1383733T3 (de)
ES (1) ES2300430T3 (de)
HK (1) HK1062170A1 (de)
HU (1) HUP0303811A3 (de)
IL (1) IL157881A0 (de)
MX (1) MXPA03009527A (de)
PL (1) PL366657A1 (de)
PT (1) PT1383733E (de)
RU (1) RU2282619C9 (de)
TW (1) TWI244472B (de)
WO (1) WO2002085843A2 (de)
YU (1) YU78303A (de)
ZA (1) ZA200307205B (de)

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PL377292A1 (pl) * 2002-11-25 2006-01-23 Pfizer Products Inc. Ulepszony sposób wytwarzania 1,3-podstawionych indenów
RS20050513A (en) * 2003-01-15 2007-11-15 Pfizer Products Inc., Process for the preparation of aryl fused polycyclic lactams
JP2006526607A (ja) * 2003-06-04 2006-11-24 ファイザー・プロダクツ・インク 2,3−ジヒドロキシ−1,4−ヂオキサンを用いたジアニリンからの置換キノキサリンの製造方法
BRPI0412880A (pt) * 2003-07-21 2006-10-03 Pfizer Prod Inc compostos azapolicìclicos fundidos a arila
ES2343141T3 (es) * 2005-11-16 2010-07-23 F. Hoffmann-La Roche Ag Nuevo procedimiento para la preparacion de thoc.
DE102006024903A1 (de) * 2006-05-24 2007-11-29 Basf Ag Verfahren zur Vermeidung von Fumarsäureablagerungen bei der Herstellung von Maleinsäureanhydrid
MY154498A (en) 2007-05-16 2015-06-30 Takeda Gmbh Pyrazolone derivatives as pde4 inhibitors
EP2019107A1 (de) 2007-07-26 2009-01-28 Dynamit Nobel GmbH Explosivstoff- und Systemtechnik Verwendung von Phosphonium-Salzen in Kupplungsreaktionen und Verfahren zu ihrer Herstellung
WO2009065872A2 (en) * 2007-11-20 2009-05-28 Medichem, S.A. Improved processes for the synthesis of varenicline l-tartrate
EP2260037A2 (de) * 2008-02-15 2010-12-15 Medichem, S.A. Polymorphe form eines pyrazino[2,3-h][3]benzazepinderivats
CA2709774C (en) 2008-05-22 2012-10-02 Teva Pharmaceutical Industries Ltd. Varenicline tosylate, an intermediate in the preparation process of varenicline l-tartrate
US20090318695A1 (en) * 2008-06-19 2009-12-24 Vinod Kumar Kansal Processes for the preparation of varenicline and intermediates thereof
WO2010005643A1 (en) * 2008-07-10 2010-01-14 Teva Pharmaceutical Industries Ltd. Processes for purifying varenicline l-tartrate salt and preparing crystalline forms of varenicline l-tartrate salt
EP2438054A1 (de) 2009-06-22 2012-04-11 Teva Pharmaceutical Industries Ltd. Festkörperformen von vareniclinsalzen und herstellungsverfahren dafür
US20120004239A1 (en) 2010-06-11 2012-01-05 Medichem, S.A. Process for Preparing Quinoxaline Derivatives
KR101603427B1 (ko) * 2014-08-14 2016-03-15 영남대학교 산학협력단 케스케이드 반응을 통한 인덴 유도체의 효율적 합성방법
CN104478803A (zh) * 2014-12-19 2015-04-01 连云港恒运医药科技有限公司 伐尼克兰中间体及其硝基还原杂质的制备方法
AU2016309967B2 (en) * 2015-08-14 2021-07-01 Boulos & Cooper Pharmaceuticals Pty Ltd Synthesis of aryl compounds
MX2019000175A (es) 2016-07-07 2020-01-20 Hughes Howard Med Inst Canales iónicos activados por ligando modificados y métodos de uso.
CN111556751B (zh) * 2017-11-10 2024-07-12 霍华休斯医学研究院 经修饰的配体门控的离子通道及使用方法
CN111995519B (zh) * 2020-09-26 2022-08-26 安徽金禾实业股份有限公司 一种3-甲氧基丙烯酸甲酯的制备方法
CN115322105A (zh) * 2021-05-11 2022-11-11 江苏润安制药有限公司 一种合成艾拉莫德关键中间体的方法

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Also Published As

Publication number Publication date
CA2443946A1 (en) 2002-10-31
HUP0303811A3 (en) 2008-05-28
KR100551183B1 (ko) 2006-02-13
ES2300430T3 (es) 2008-06-16
MXPA03009527A (es) 2004-02-12
DE60225433T2 (de) 2008-06-12
WO2002085843A3 (en) 2003-06-05
US7186870B2 (en) 2007-03-06
ATE388135T1 (de) 2008-03-15
US20060079707A1 (en) 2006-04-13
AU2002234836B2 (en) 2007-08-23
CN1503781A (zh) 2004-06-09
AR043636A2 (es) 2005-08-03
JP2004527545A (ja) 2004-09-09
KR20030092087A (ko) 2003-12-03
EP1383733A2 (de) 2004-01-28
BR0208992A (pt) 2004-04-27
IL157881A0 (en) 2004-03-28
RU2282619C2 (ru) 2006-08-27
RU2003130751A (ru) 2005-03-27
DE60225433D1 (de) 2008-04-17
PL366657A1 (en) 2005-02-07
US20030060624A1 (en) 2003-03-27
DK1383733T3 (da) 2008-06-09
CZ20032814A3 (cs) 2004-08-18
EP1383733B1 (de) 2008-03-05
HUP0303811A2 (hu) 2004-03-01
ZA200307205B (en) 2004-09-15
US7091372B2 (en) 2006-08-15
PT1383733E (pt) 2008-04-15
TWI244472B (en) 2005-12-01
RU2282619C9 (ru) 2006-12-20
WO2002085843A2 (en) 2002-10-31
YU78303A (sh) 2006-05-25
CN1321107C (zh) 2007-06-13
AR035957A1 (es) 2004-07-28

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Effective date: 20110304