HK1056576A1 - Pseudotype retroviral vectors containing membrane proteins having hemagglutinin activity - Google Patents
Pseudotype retroviral vectors containing membrane proteins having hemagglutinin activityInfo
- Publication number
- HK1056576A1 HK1056576A1 HK03108959.9A HK03108959A HK1056576A1 HK 1056576 A1 HK1056576 A1 HK 1056576A1 HK 03108959 A HK03108959 A HK 03108959A HK 1056576 A1 HK1056576 A1 HK 1056576A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- vectors containing
- membrane proteins
- retroviral vectors
- containing membrane
- hemagglutinin activity
- Prior art date
Links
- 101710154606 Hemagglutinin Proteins 0.000 title 1
- 108010052285 Membrane Proteins Proteins 0.000 title 1
- 101710093908 Outer capsid protein VP4 Proteins 0.000 title 1
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 title 1
- 101710176177 Protein A56 Proteins 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- 239000000185 hemagglutinin Substances 0.000 title 1
- 230000001177 retroviral effect Effects 0.000 title 1
- 239000013598 vector Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- C12N15/867—Retroviral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15041—Use of virus, viral particle or viral elements as a vector
- C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15041—Use of virus, viral particle or viral elements as a vector
- C12N2740/15045—Special targeting system for viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15051—Methods of production or purification of viral material
- C12N2740/15052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
- C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000169090 | 2000-06-01 | ||
PCT/JP2001/004659 WO2001092508A1 (fr) | 2000-06-01 | 2001-06-01 | Vecteur de retrovirus de pseudo-type contenant une proteine de membrane possedant une activite d'hemagglutinine |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1056576A1 true HK1056576A1 (en) | 2004-02-20 |
Family
ID=18672001
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK03108959.9A HK1056576A1 (en) | 2000-06-01 | 2003-12-10 | Pseudotype retroviral vectors containing membrane proteins having hemagglutinin activity |
Country Status (10)
Country | Link |
---|---|
US (1) | US7510706B2 (zh) |
EP (1) | EP1291419B1 (zh) |
JP (1) | JP4700888B2 (zh) |
KR (1) | KR100807016B1 (zh) |
CN (1) | CN100531802C (zh) |
AU (1) | AU2001262684A1 (zh) |
CA (1) | CA2413995C (zh) |
ES (1) | ES2430991T3 (zh) |
HK (1) | HK1056576A1 (zh) |
WO (1) | WO2001092508A1 (zh) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6490775B1 (en) * | 1999-04-23 | 2002-12-10 | Veri-Tek Inc. | Press operation verification system |
US7226786B2 (en) * | 1999-05-18 | 2007-06-05 | Dnavec Research Inc. | Envelope gene-deficient Paramyxovirus vector |
US20030166252A1 (en) * | 1999-05-18 | 2003-09-04 | Kaio Kitazato | Paramyxovirus-derived RNP |
ES2288866T3 (es) * | 1999-09-06 | 2008-02-01 | Dnavec Research, Inc. | Paramixovirus que contienen una secuencia de inicio de la transcripcion modificada. |
US7314614B1 (en) | 1999-11-02 | 2008-01-01 | Dnavec Research, Inc. | Recombinant sendai virus vector for introducing exogenous genes to airway epithelia |
CN1418252A (zh) * | 2000-01-19 | 2003-05-14 | 株式会社载体研究所 | 副粘病毒属载体在血管内基因转移中的用途 |
JPWO2001072340A1 (ja) | 2000-03-30 | 2004-01-08 | 株式会社ディナベック研究所 | センダイウイルスベクターを用いたaidsウイルスワクチン |
CA2414077A1 (en) * | 2000-06-27 | 2002-01-03 | Dnavec Research Inc. | Virus vector for introducing gene into renal cells |
WO2002031138A1 (fr) * | 2000-10-06 | 2002-04-18 | Dnavec Research Inc. | Vecteur de paramyxovirus permettant de transferer un gene etranger dans le muscle squelettique |
JP2002142770A (ja) * | 2000-11-08 | 2002-05-21 | Dnavec Research Inc | 循環系への遺伝子送達用パラミクソウイルスベクター |
AU2002224113A1 (en) | 2000-11-27 | 2002-06-03 | Dnavec Research Inc. | Paramyxovirus vector encoding angiogenesis gene and utilization thereof |
GB0202569D0 (en) * | 2002-02-04 | 2002-03-20 | Oxford Biomedica Ltd | Delivery means |
JPWO2003092738A1 (ja) * | 2002-04-30 | 2005-09-08 | 株式会社ディナベック研究所 | ヘマグルチニン活性を低下させた薬剤または遺伝子運搬組成物 |
AU2003261931A1 (en) * | 2002-09-04 | 2004-03-29 | Dnavec Research Inc. | Process for producing virus vector containing membrane protein having sialic acid-binding activitiy in envelope with the use of gram-positive bacterium-origin neuraminidase |
EP1398041A1 (en) * | 2002-09-13 | 2004-03-17 | Université de Nantes | Recombinant lentiviral vector pseudotyped with the hemagglutinin protein for gene transfer into the retina |
JPWO2004038029A1 (ja) * | 2002-10-24 | 2006-02-23 | 株式会社ディナベック研究所 | T細胞に遺伝子を導入する方法 |
EP1454988A1 (en) * | 2003-03-03 | 2004-09-08 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Infectious flavivirus pseudo-particles containing functional prM-E envelope proteins |
US8158420B2 (en) * | 2003-04-04 | 2012-04-17 | The Trustees Of Columbia University In The City Of New York | Methods for inhibiting the differentation of proliferative telencephalic cells in vitro by addition of ATF5 |
US20050164384A1 (en) * | 2003-04-04 | 2005-07-28 | Greene Lloyd A. | Methods for regulating differentiation of neural cells and uses thereof |
KR20060028432A (ko) * | 2003-06-30 | 2006-03-29 | 가부시키가이샤 디나벡크 겐큐쇼 | 고변이영역이 개변된 유전자를 탑재하는 마이너스가닥 rna 바이러스 벡터 |
JPWO2005071085A1 (ja) * | 2004-01-22 | 2007-09-06 | 株式会社ディナベック研究所 | ウイルスベクターの製造方法 |
WO2005087936A1 (ja) * | 2004-03-16 | 2005-09-22 | Dnavec Research Inc. | 胚性幹細胞に遺伝子を導入する方法 |
EP1859813A1 (en) * | 2005-02-23 | 2007-11-28 | DNAVEC Research, Inc. | Remedy for disease associated with apoptotic degeneration in ocular cell tissue with the use of siv-pedf vector |
SI1950307T1 (sl) | 2005-10-28 | 2016-02-29 | Id Pharma Co., Ltd. | Transfer gena v epitelijsko matično celico dihalnih poti z uporabo lentivirusnega vektorja, psevdotipiziranega z RNA virusnim spike proteinom |
CA2541872A1 (en) * | 2006-04-26 | 2007-10-26 | Institut Pasteur | H5 pseudotyped viruses and uses thereof |
EP1975239A1 (en) | 2006-09-27 | 2008-10-01 | Bundesrepublik Deutschland, letztvertreten durch den Präsidenten des Paul-Ehrlich-Instituts Prof. Dr. Johannes Löwer | Pseudotyping of retroviral vectors, methods for production and use thereof for targeted gene transfer and high-throughput screening |
CN108114276A (zh) | 2007-08-03 | 2018-06-05 | 巴斯德研究院 | 慢病毒基因转移载体及其医学应用 |
WO2011085247A2 (en) * | 2010-01-08 | 2011-07-14 | Immusoft Corporation | Vectors and methods for transducing b cells |
US20160160234A1 (en) * | 2013-07-12 | 2016-06-09 | Ishihara Sangyo Kaisha, Ltd. | Composition for transferring gene to cell |
GB2526339A (en) * | 2014-05-21 | 2015-11-25 | Imp Innovations Ltd | Lentiviral vectors |
KR20200074204A (ko) * | 2017-10-30 | 2020-06-24 | 밀테니 비오텍 비.브이. & 씨오. 케이지 | 표적 세포의 선택적 형질도입을 위한 어댑터-기반 레트로바이러스 벡터 시스템 |
GB202105276D0 (en) * | 2021-04-13 | 2021-05-26 | Imperial College Innovations Ltd | Delivery of gene therapy vectors |
GB202105278D0 (en) * | 2021-04-13 | 2021-05-26 | Imperial College Innovations Ltd | Cell therapy |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1325960A3 (en) * | 1995-10-31 | 2004-09-15 | Dnavec Research Inc. | Negative strand RNA virus vector having autonomously replicating activity |
AU7335296A (en) * | 1995-11-01 | 1997-05-22 | Dnavec Research Inc. | Recombinant sendai virus |
US6743620B1 (en) * | 1996-12-16 | 2004-06-01 | Eisai Co., Ltd. | Method for preparing retrovirus vector for gene therapy |
US6207455B1 (en) * | 1997-05-01 | 2001-03-27 | Lung-Ji Chang | Lentiviral vectors |
WO1999013905A1 (en) * | 1997-09-18 | 1999-03-25 | The Trustees Of The University Of Pennsylvania | Receptor-binding pocket mutants of influenza a virus hemagglutinin for use in targeted gene delivery |
US6828138B1 (en) * | 1998-08-11 | 2004-12-07 | Dnavec Research Inc. | Recombinant sendai virus vector including a gene encoding a chemokine |
US20030166252A1 (en) * | 1999-05-18 | 2003-09-04 | Kaio Kitazato | Paramyxovirus-derived RNP |
US7226786B2 (en) * | 1999-05-18 | 2007-06-05 | Dnavec Research Inc. | Envelope gene-deficient Paramyxovirus vector |
ES2288866T3 (es) * | 1999-09-06 | 2008-02-01 | Dnavec Research, Inc. | Paramixovirus que contienen una secuencia de inicio de la transcripcion modificada. |
US7314614B1 (en) * | 1999-11-02 | 2008-01-01 | Dnavec Research, Inc. | Recombinant sendai virus vector for introducing exogenous genes to airway epithelia |
CN1418252A (zh) * | 2000-01-19 | 2003-05-14 | 株式会社载体研究所 | 副粘病毒属载体在血管内基因转移中的用途 |
JPWO2001072340A1 (ja) * | 2000-03-30 | 2004-01-08 | 株式会社ディナベック研究所 | センダイウイルスベクターを用いたaidsウイルスワクチン |
CA2322057A1 (en) * | 2000-05-18 | 2001-11-18 | Dnavec Research Inc. | Paramyxovirus vectors used for transfer of foreign genes |
CA2414077A1 (en) * | 2000-06-27 | 2002-01-03 | Dnavec Research Inc. | Virus vector for introducing gene into renal cells |
WO2002031138A1 (fr) * | 2000-10-06 | 2002-04-18 | Dnavec Research Inc. | Vecteur de paramyxovirus permettant de transferer un gene etranger dans le muscle squelettique |
JP2002142770A (ja) * | 2000-11-08 | 2002-05-21 | Dnavec Research Inc | 循環系への遺伝子送達用パラミクソウイルスベクター |
AU2002224113A1 (en) * | 2000-11-27 | 2002-06-03 | Dnavec Research Inc. | Paramyxovirus vector encoding angiogenesis gene and utilization thereof |
GB0202569D0 (en) | 2002-02-04 | 2002-03-20 | Oxford Biomedica Ltd | Delivery means |
AU2003261931A1 (en) | 2002-09-04 | 2004-03-29 | Dnavec Research Inc. | Process for producing virus vector containing membrane protein having sialic acid-binding activitiy in envelope with the use of gram-positive bacterium-origin neuraminidase |
-
2001
- 2001-06-01 KR KR1020027016131A patent/KR100807016B1/ko active IP Right Grant
- 2001-06-01 CN CNB018135854A patent/CN100531802C/zh not_active Expired - Lifetime
- 2001-06-01 JP JP2002500700A patent/JP4700888B2/ja not_active Expired - Lifetime
- 2001-06-01 EP EP01936834.9A patent/EP1291419B1/en not_active Expired - Lifetime
- 2001-06-01 AU AU2001262684A patent/AU2001262684A1/en not_active Abandoned
- 2001-06-01 CA CA2413995A patent/CA2413995C/en not_active Expired - Lifetime
- 2001-06-01 ES ES01936834T patent/ES2430991T3/es not_active Expired - Lifetime
- 2001-06-01 WO PCT/JP2001/004659 patent/WO2001092508A1/ja active Application Filing
-
2002
- 2002-11-29 US US10/306,949 patent/US7510706B2/en not_active Expired - Lifetime
-
2003
- 2003-12-10 HK HK03108959.9A patent/HK1056576A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR100807016B1 (ko) | 2008-02-25 |
CN100531802C (zh) | 2009-08-26 |
CN1444650A (zh) | 2003-09-24 |
US20030203489A1 (en) | 2003-10-30 |
EP1291419A1 (en) | 2003-03-12 |
EP1291419B1 (en) | 2013-09-18 |
ES2430991T3 (es) | 2013-11-22 |
CA2413995C (en) | 2013-08-13 |
WO2001092508A1 (fr) | 2001-12-06 |
EP1291419A4 (en) | 2004-09-08 |
CA2413995A1 (en) | 2002-12-02 |
KR20030074115A (ko) | 2003-09-19 |
JP4700888B2 (ja) | 2011-06-15 |
US7510706B2 (en) | 2009-03-31 |
AU2001262684A1 (en) | 2001-12-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1056576A1 (en) | Pseudotype retroviral vectors containing membrane proteins having hemagglutinin activity | |
AU4012100A (en) | Pseudotyped lentiviral vectors and uses thereof | |
ATA159397A (de) | Fibrinschwamm | |
IL150756A0 (en) | Novel use of hiv proteins | |
NO20002320L (no) | Dipeptid-nitriler | |
AU2001276692A1 (en) | Modified hollow-fiber membrane | |
HK1054746A1 (en) | Hexahydrofuro'2,3-B!furan-3-yl-N- Ä3'(1,3-benzodioxol -5- ylsulfonyl) (isobutyl) amino! -1-benzyl-2-hydroxypropylÜ carbamate as retroviral protease inhibitor. | |
DE59800452D1 (de) | Lagerstabile, permanent wasserbenetzbare, vulkanisate ergebende polysiloxanmasse | |
AU8260701A (en) | Solution preparations stabilized over long time | |
DK0940712T3 (da) | Projektionsskræm | |
SG78413A1 (en) | Solvent-resistant microporous polybenzimidazole membranes | |
DE69715152T2 (de) | Kapseln, enthaltend Molkeprotein | |
AU2001232219A8 (en) | Protein monitoring the activity of small gtp-binding protein | |
DE69829006D1 (de) | Triphendioxazinverbindungen | |
DE59806062D1 (de) | Wässrige schellacklösung oder -dispersion | |
AU2002358756A8 (en) | Sequencing on perforated membranes | |
DE29801953U1 (de) | Bahnförmige Membran | |
EP0970192A4 (en) | NUCLEIC ACID ENCODING AN ALGU $ i PROTEIN (M. TUBERCULOSIS) | |
GB0030309D0 (en) | Antibodies,Peptides,Analogs and uses thereof | |
AU2001265190A1 (en) | Siv derived lentiviral vector systems | |
EP1283870A4 (en) | NOVEL CELL SYSTEMS HAVING SPECIFICALLY INTERACTED PEPTIDE BINDING PAIRS | |
DE69710620D1 (de) | Düse für druckbehälter | |
AU2003267971A8 (en) | Improved alphavirus vectors having attenuated virion structural proteins | |
DE59903807D1 (de) | Wirkstoffkonzentrat | |
GB0202889D0 (en) | Peptides (assay) |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20130601 |