HK1054552B - 以曼里期(mannich)為本的3-(吡咯-2-甲烯)-2-吲哚酮衍生物作為藥物及作為蛋白激酶調節物的用途 - Google Patents

以曼里期(mannich)為本的3-(吡咯-2-甲烯)-2-吲哚酮衍生物作為藥物及作為蛋白激酶調節物的用途

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Publication number
HK1054552B
HK1054552B HK03106800.4A HK03106800A HK1054552B HK 1054552 B HK1054552 B HK 1054552B HK 03106800 A HK03106800 A HK 03106800A HK 1054552 B HK1054552 B HK 1054552B
Authority
HK
Hong Kong
Prior art keywords
ylmethylidene
pyrrol
modulators
protein kinases
mannich base
Prior art date
Application number
HK03106800.4A
Other languages
English (en)
Other versions
HK1054552A1 (en
Inventor
Malcolm Wilson Moon
Walter Morozowich
Ping Gao
Peng Cho Tang
Original Assignee
Sugen Inc
Pharmacia & Upjohn Co Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sugen Inc, Pharmacia & Upjohn Co Llc filed Critical Sugen Inc
Publication of HK1054552A1 publication Critical patent/HK1054552A1/xx
Publication of HK1054552B publication Critical patent/HK1054552B/zh

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    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
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    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

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HK03106800.4A 2000-05-24 2003-09-22 以曼里期(mannich)為本的3-(吡咯-2-甲烯)-2-吲哚酮衍生物作為藥物及作為蛋白激酶調節物的用途 HK1054552B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20700000P 2000-05-24 2000-05-24
US22504500P 2000-08-11 2000-08-11
PCT/US2001/016757 WO2001090068A2 (en) 2000-05-24 2001-05-24 Mannich base prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives and their use a modulators of protein kinases

Publications (2)

Publication Number Publication Date
HK1054552A1 HK1054552A1 (en) 2003-12-05
HK1054552B true HK1054552B (zh) 2006-12-08

Family

ID=26901875

Family Applications (2)

Application Number Title Priority Date Filing Date
HK03106800.4A HK1054552B (zh) 2000-05-24 2003-09-22 以曼里期(mannich)為本的3-(吡咯-2-甲烯)-2-吲哚酮衍生物作為藥物及作為蛋白激酶調節物的用途
HK03106876A HK1054741A1 (en) 2000-05-24 2003-09-24 1-(Pyrrolidin-1-ylmethyl)-3(pyrrol-2-ylmethylidene)-2-indolinone derivatives and their use as modulators of protein kinases

Family Applications After (1)

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HK03106876A HK1054741A1 (en) 2000-05-24 2003-09-24 1-(Pyrrolidin-1-ylmethyl)-3(pyrrol-2-ylmethylidene)-2-indolinone derivatives and their use as modulators of protein kinases

Country Status (13)

Country Link
US (8) US6710067B2 (zh)
EP (3) EP1283835A2 (zh)
JP (3) JP2003534342A (zh)
AR (3) AR033977A1 (zh)
AT (2) ATE333453T1 (zh)
AU (3) AU2001264877A1 (zh)
CA (3) CA2408709A1 (zh)
DE (2) DE60116487T2 (zh)
ES (2) ES2253385T3 (zh)
HK (2) HK1054552B (zh)
MY (2) MY128449A (zh)
TW (1) TWI270545B (zh)
WO (3) WO2001090104A2 (zh)

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