HK1051042A1 - Gonadotropin-releasing hormone receptor antagonists and methods relating thereto - Google Patents

Gonadotropin-releasing hormone receptor antagonists and methods relating thereto

Info

Publication number
HK1051042A1
HK1051042A1 HK03103248.1A HK03103248A HK1051042A1 HK 1051042 A1 HK1051042 A1 HK 1051042A1 HK 03103248 A HK03103248 A HK 03103248A HK 1051042 A1 HK1051042 A1 HK 1051042A1
Authority
HK
Hong Kong
Prior art keywords
receptor antagonists
gonadotropin
releasing hormone
methods relating
hormone receptor
Prior art date
Application number
HK03103248.1A
Other languages
English (en)
Inventor
Yun-Fei Zhu
Chen Chen
Fabio C Tucci
Zhiqiang Guo
Timothy D Gross
Martin Rowbottom
R Scott Struthers
Original Assignee
Neurocrine Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurocrine Biosciences Inc filed Critical Neurocrine Biosciences Inc
Publication of HK1051042A1 publication Critical patent/HK1051042A1/xx

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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
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HK03103248.1A 2000-01-25 2003-05-07 Gonadotropin-releasing hormone receptor antagonists and methods relating thereto HK1051042A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17793300P 2000-01-25 2000-01-25
US23968300P 2000-10-11 2000-10-11
PCT/US2001/002740 WO2001055119A2 (en) 2000-01-25 2001-01-25 Gonadotropin-releasing hormone receptor antagonists and methods relating thereto

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US (4) US6608197B2 (xx)
EP (1) EP1255738B1 (xx)
JP (1) JP4931314B2 (xx)
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