HK1050144A1 - Uses and compositions of nitrate esters for providing sedation. - Google Patents

Uses and compositions of nitrate esters for providing sedation.

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Publication number
HK1050144A1
HK1050144A1 HK03102415A HK03102415A HK1050144A1 HK 1050144 A1 HK1050144 A1 HK 1050144A1 HK 03102415 A HK03102415 A HK 03102415A HK 03102415 A HK03102415 A HK 03102415A HK 1050144 A1 HK1050144 A1 HK 1050144A1
Authority
HK
Hong Kong
Prior art keywords
compositions
nitrate esters
providing sedation
providing
sedation
Prior art date
Application number
HK03102415A
Other languages
English (en)
Inventor
Gregory R J Thatcher
Brian M Bennett
James N Reynolds
Khem Jhamandas
Original Assignee
Univ Kingston
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Filing date
Publication date
Application filed by Univ Kingston filed Critical Univ Kingston
Publication of HK1050144A1 publication Critical patent/HK1050144A1/xx

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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/04—Nitro compounds
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/275—Nitriles; Isonitriles
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    • A61K31/425—Thiazoles
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    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
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    • C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group

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HK03102415A 1999-12-29 2003-04-03 Uses and compositions of nitrate esters for providing sedation. HK1050144A1 (en)

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US09/473,713 US7115661B1 (en) 1999-12-29 1999-12-29 Methods and compositions for mitigating pain
PCT/CA2000/001523 WO2001049275A2 (en) 1999-12-29 2000-12-27 Methods and compositions for mitigating pain using nitrate esters

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US7163958B2 (en) * 2002-07-03 2007-01-16 Nitromed Inc. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
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JP2005089457A (ja) * 2003-09-03 2005-04-07 Yung Shin Pharmaceutical Industry Co Ltd 骨成長を促進するまたは骨吸収を阻害するための薬剤組成物
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US8134010B2 (en) 2004-05-05 2012-03-13 Renopharm Ltd. Thiazole-based nitric oxide donors having aryl substituent(s) and uses thereof
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US7189750B2 (en) * 2004-05-05 2007-03-13 Renopharm Ltd. Thiazole-based nitric oxide donors having at least two thiazole moieties and uses thereof
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CN101820978B (zh) * 2007-10-05 2013-01-09 国立大学法人九州工业大学 介电电泳装置及方法
US20100035929A1 (en) * 2008-06-09 2010-02-11 Lindsley Craig W Unnatural dispyrin analogues, preparation and uses thereof
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AU782489C (en) 2006-04-27
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IL150487A0 (en) 2002-12-01
WO2001049275A2 (en) 2001-07-12
AU2335101A (en) 2001-07-16
DE60016460T2 (de) 2005-12-22
WO2001049275A3 (en) 2001-12-13
ES2233489T3 (es) 2005-06-16
US7115661B1 (en) 2006-10-03
DK1246625T3 (da) 2005-02-14
EP1518553A2 (en) 2005-03-30
JP2003519176A (ja) 2003-06-17
US20070066575A1 (en) 2007-03-22
CA2394184A1 (en) 2001-07-12
EP1246625B1 (en) 2004-12-01
AU782489B2 (en) 2005-08-04
PT1246625E (pt) 2005-03-31
DE60016460D1 (de) 2005-01-05

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