HK1047889B - 極細的左旋肉鹼及其製備方法、含左旋肉鹼的組合物及其使用方法 - Google Patents

極細的左旋肉鹼及其製備方法、含左旋肉鹼的組合物及其使用方法

Info

Publication number
HK1047889B
HK1047889B HK02109100.6A HK02109100A HK1047889B HK 1047889 B HK1047889 B HK 1047889B HK 02109100 A HK02109100 A HK 02109100A HK 1047889 B HK1047889 B HK 1047889B
Authority
HK
Hong Kong
Prior art keywords
same
methods
carnitine
ultrafine
preparing
Prior art date
Application number
HK02109100.6A
Other languages
English (en)
Other versions
HK1047889A1 (en
Inventor
Ken Hassen
Original Assignee
Sigma-Tau Ind Farmaceutiche Riunite Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26849378&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1047889(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sigma-Tau Ind Farmaceutiche Riunite Spa filed Critical Sigma-Tau Ind Farmaceutiche Riunite Spa
Publication of HK1047889A1 publication Critical patent/HK1047889A1/xx
Publication of HK1047889B publication Critical patent/HK1047889B/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nutrition Science (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
HK02109100.6A 1999-09-03 2002-12-16 極細的左旋肉鹼及其製備方法、含左旋肉鹼的組合物及其使用方法 HK1047889B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15224099P 1999-09-03 1999-09-03
US15824599P 1999-10-08 1999-10-08
PCT/US2000/024279 WO2001017525A1 (en) 1999-09-03 2000-09-05 Ultrafine l-carnitine, methods of preparing the same, compositions containing the same, and methods of using the same

Publications (2)

Publication Number Publication Date
HK1047889A1 HK1047889A1 (en) 2003-03-14
HK1047889B true HK1047889B (zh) 2009-04-09

Family

ID=26849378

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02109100.6A HK1047889B (zh) 1999-09-03 2002-12-16 極細的左旋肉鹼及其製備方法、含左旋肉鹼的組合物及其使用方法

Country Status (17)

Country Link
US (2) US20020111383A1 (zh)
EP (1) EP1218001B1 (zh)
JP (3) JP2003508488A (zh)
KR (1) KR100827900B1 (zh)
CN (1) CN1399549A (zh)
AT (1) ATE418978T1 (zh)
AU (1) AU770563B2 (zh)
CA (1) CA2383814C (zh)
CY (1) CY1110223T1 (zh)
DE (1) DE60041269D1 (zh)
DK (1) DK1218001T3 (zh)
ES (1) ES2322328T3 (zh)
HK (1) HK1047889B (zh)
MX (1) MXPA02002327A (zh)
NZ (1) NZ517597A (zh)
PT (1) PT1218001E (zh)
WO (1) WO2001017525A1 (zh)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7169770B2 (en) 2001-04-24 2007-01-30 Lonza Ltd. Method of enhancing reproductive performance in sows
WO2002085134A1 (en) * 2001-04-24 2002-10-31 Lonza Ltd. Method of enhancing reproductive performance in sows
DE10129502A1 (de) * 2001-06-19 2003-01-09 Beiersdorf Ag Verwendung von Carnitin und/oder einem oder mehreren Acyl-Carnitinen zur Herstellung von kosmetischen oder dermatologischen Zubereitungen zur Steigerung der Ceramidbiosynthese
US7977049B2 (en) * 2002-08-09 2011-07-12 President And Fellows Of Harvard College Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms
DE10350140A1 (de) * 2003-03-28 2004-10-14 Martin Schymura Fruchtgummizusammensetzung
EP2236131A3 (en) * 2003-07-01 2011-03-02 President and Fellows of Harvard College Sirt1 modulators for manipulating cell/organism lifespan/stress response
EP1708689A2 (en) 2003-12-29 2006-10-11 The President and Fellows of Harvard College Compositions for treating or preventing obesity and insulin resistance disorders
US8017634B2 (en) 2003-12-29 2011-09-13 President And Fellows Of Harvard College Compositions for treating obesity and insulin resistance disorders
JP4539096B2 (ja) * 2004-01-16 2010-09-08 日油株式会社 油性成分被覆ｌ−カルニチン塩粉末およびその用途
WO2006007411A2 (en) * 2004-06-16 2006-01-19 President And Fellows Of Harvard College Methods and compositions for modulating bax-mediated apoptosis
US20060014705A1 (en) * 2004-06-30 2006-01-19 Howitz Konrad T Compositions and methods for selectively activating human sirtuins
WO2006138418A2 (en) 2005-06-14 2006-12-28 President And Fellows Of Harvard College Improvement of cognitive performance with sirtuin activators
AU2006265280B2 (en) * 2005-07-05 2011-07-14 Lonza Ag Spray-drying process for producing a dry carnitine powder or granulate
DE102007009649A1 (de) 2007-02-26 2008-08-28 Beiersdorf Ag Nahrungsergänzungsmittel zur Pflege und/oder Verschönerung der Haut
DE102007009650A1 (de) 2007-02-26 2008-08-28 Beiersdorf Ag Kosmetisches Kombinationsprodukt zur Verbesserung des äußeren Erscheinungsbildes
CN101224202A (zh) * 2007-12-26 2008-07-23 广州康采恩医药有限公司 减肥组合物
AU2015283905B2 (en) 2014-07-03 2020-10-22 NAN Global, LLC Methods and compositions for treating obesity, preventing weight gain, promoting weight loss, promoting slimming, or treating or preventing the development of diabetes
WO2017105090A1 (ko) * 2015-12-14 2017-06-22 제이투에이치바이오텍 (주) 오로트산 l-카르니틴의 결정질 다형체, 이의 제조방법 또는 용도
WO2020092243A1 (en) * 2018-10-29 2020-05-07 Lonza Inc. Method and composition for increasing the bioavailability of carnitine
CN112250588B (zh) * 2020-11-06 2023-03-31 哈尔滨工业大学（深圳） 一种左旋肉碱离子液体及其制备方法、应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1156852B (it) * 1978-07-10 1987-02-04 Sigma Tau Ind Farmaceuti Procedimento industriale per la preparazione del d'canforato della l carnitinammide e del d canforato della d carnitinammide e sue applicazioni
IT1172394B (it) * 1983-12-28 1987-06-18 Sigma Tau Ind Farmaceuti Sali della l-carnitina e di alcuni alcanoil derivati della l-carnitina e procedimento per la loro preparazione
EP0150688B1 (en) * 1983-12-28 1987-04-22 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Salts of l-carnitine and alkanoyl l-carnitines and process for preparing same
US5057597A (en) * 1990-07-03 1991-10-15 Koskan Larry P Process for the manufacture of anhydro polyamino acids and polyamino acids
IT1256705B (it) * 1992-12-21 1995-12-12 Sigma Tau Ind Farmaceuti Procedimento per la preparazione di l-(-)-carnitina a partire da un prodotto di scarto avente opposta configurazione.
JPH08259445A (ja) * 1995-01-27 1996-10-08 Takeda Chem Ind Ltd 胃排出能改善性医薬組成物
KR100201352B1 (ko) * 1995-03-16 1999-06-15 성재갑 단일주사 백신 제형
AU718308B2 (en) * 1996-05-31 2000-04-13 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Stable, non-hygroscopic salts of L(-)carnitine and alkanoyl L(-)carnitines, a process for their preparation and solid, orally administrable compositions containing such salts
IT1289974B1 (it) * 1997-02-25 1998-10-19 Aldo Fassi Procedimento per la produzione di sali stabili e non igroscopici di l(-)carnitina e di alcanoli l(-)-carnitine
US6488961B1 (en) * 1996-09-20 2002-12-03 Ethypharm, Inc. Effervescent granules and methods for their preparation
US6242487B1 (en) * 1996-12-03 2001-06-05 Lonza, Inc. Carnitine supplemented diets for gestating and lactating swine
IT1291113B1 (it) * 1997-03-20 1998-12-29 Sigma Tau Ind Farmaceuti Composizione nutritiva terapeutica per soggetti affetti da diabete mellito
US6149939A (en) * 1997-05-09 2000-11-21 Strumor; Mathew A. Healthful dissolvable oral tablets, and mini-bars
US6090848A (en) * 1997-12-01 2000-07-18 Sigma-Tau Healthscience S.P.A. Compositions and methods for increasing the concentration and/or motility of spermatozoa in humans
US6090849A (en) * 1999-03-23 2000-07-18 The Board Of Regents For Oklahoma State University Carnitine supplemented diet to prevent sudden death syndrome in breeder type poultry
IT1305308B1 (it) * 1999-03-26 2001-05-04 Biosint S P A Granulato ad alto contenuto di l-carnitina o alcanoil-l-carnitina,particolarmente adatto alla produzione di compresse per compressione
US6476010B2 (en) * 2000-03-10 2002-11-05 Hill's Pet Nutrition Method for increasing intestinal absorption of fat soluble vitamins in post-menopausal women and lower animals

Also Published As

Publication number Publication date
JP2009067809A (ja) 2009-04-02
US20050124558A1 (en) 2005-06-09
DE60041269D1 (de) 2009-02-12
JP2003508488A (ja) 2003-03-04
DK1218001T3 (da) 2009-04-14
EP1218001A4 (en) 2005-05-18
KR20020066322A (ko) 2002-08-14
US7303765B2 (en) 2007-12-04
ES2322328T3 (es) 2009-06-19
CN1399549A (zh) 2003-02-26
CY1110223T1 (el) 2015-01-14
KR100827900B1 (ko) 2008-05-07
AU7347000A (en) 2001-04-10
AU770563B2 (en) 2004-02-26
CA2383814A1 (en) 2001-03-15
EP1218001A1 (en) 2002-07-03
MXPA02002327A (es) 2004-07-16
HK1047889A1 (en) 2003-03-14
CA2383814C (en) 2010-08-17
ATE418978T1 (de) 2009-01-15
US20020111383A1 (en) 2002-08-15
WO2001017525A1 (en) 2001-03-15
JP2013136635A (ja) 2013-07-11
NZ517597A (en) 2003-11-28
EP1218001B1 (en) 2008-12-31
PT1218001E (pt) 2009-03-31

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20170905