HK1047437B - 釋放促性腺激素的激素受體拮抗劑及其有關方法 - Google Patents

釋放促性腺激素的激素受體拮抗劑及其有關方法

Info

Publication number
HK1047437B
HK1047437B HK02109095.3A HK02109095A HK1047437B HK 1047437 B HK1047437 B HK 1047437B HK 02109095 A HK02109095 A HK 02109095A HK 1047437 B HK1047437 B HK 1047437B
Authority
HK
Hong Kong
Prior art keywords
receptor antagonists
releasing hormone
related methods
hormone receptor
gonadotropin releasing
Prior art date
Application number
HK02109095.3A
Other languages
English (en)
Other versions
HK1047437A1 (en
Inventor
Zhu Yun-Fei
D Gross Timothy
Gao Yinghong
J Connors Patrick Jr
Guo Zhiqiang
Chen Chen
Original Assignee
Neurocrine Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurocrine Biosciences Inc filed Critical Neurocrine Biosciences Inc
Publication of HK1047437A1 publication Critical patent/HK1047437A1/xx
Publication of HK1047437B publication Critical patent/HK1047437B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK02109095.3A 1999-10-15 2002-12-16 釋放促性腺激素的激素受體拮抗劑及其有關方法 HK1047437B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41876899A 1999-10-15 1999-10-15
PCT/US2000/028677 WO2001029044A1 (en) 1999-10-15 2000-10-16 Gonadotropin-releasing hormone receptor antagonists and methods relating thereto

Publications (2)

Publication Number Publication Date
HK1047437A1 HK1047437A1 (en) 2003-02-21
HK1047437B true HK1047437B (zh) 2005-12-16

Family

ID=23659500

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02109095.3A HK1047437B (zh) 1999-10-15 2002-12-16 釋放促性腺激素的激素受體拮抗劑及其有關方法

Country Status (11)

Country Link
EP (1) EP1220857B1 (zh)
JP (1) JP2003512379A (zh)
KR (1) KR20020045609A (zh)
AT (1) ATE305008T1 (zh)
AU (1) AU769855B2 (zh)
CA (1) CA2386942A1 (zh)
DE (1) DE60022769T2 (zh)
ES (1) ES2249302T3 (zh)
HK (1) HK1047437B (zh)
MX (1) MXPA02003614A (zh)
WO (1) WO2001029044A1 (zh)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1255738E (pt) 2000-01-25 2012-06-19 Neurocrine Biosciences Inc Antagonistas do receptor da hormona de libertação da gonadotrofina e métodos relacionados com os mesmos
WO2002102401A1 (en) 2001-04-30 2002-12-27 Zentaris Gmbh Treatment of dementia and neurodegenerative diseases with intermediate doses of lhrh antagonists
US6740656B2 (en) 2001-08-02 2004-05-25 Neurocrine Biosciences, Inc. Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
WO2003011293A2 (en) 2001-08-02 2003-02-13 Neurocrine Biosciences, Inc. Pyridinone and pyridazinone derivatives as gonadotropin-releasing hormone receptor antagonists
WO2003011841A1 (en) 2001-08-02 2003-02-13 Neurocrine Biosciences, Inc. 1,2,4-triazin-3,5-diones as gonadotropin-releasing hormone receptor (gnrh) antagonists
MXPA04000985A (es) * 2001-08-02 2005-02-17 Neurocrine Biosciences Inc Piridin-4-onas sustituidas y su uso como antagonistas del receptor de hormona de liberacion de gonadotropina.
AU2002324586B2 (en) 2001-08-02 2008-04-24 Neurocrine Biosciences, Inc. 1,3,5-triazine-2,4,6-triones, preparation and use as gonadotropin-releasing hormone receptor antagonists
WO2003068769A1 (en) 2002-02-12 2003-08-21 Pfizer Inc. Non-peptide compounds affecting the action of gonadotropin-releasing hormone (gnrh)
WO2003106446A1 (en) 2002-06-13 2003-12-24 Pfizer Inc. Non-peptide gnrh agents, pharmaceutical compositions and methods for their use
WO2005007633A1 (en) 2003-07-07 2005-01-27 Neurocrine Biosciences, Inc. Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
KR20060052790A (ko) 2003-07-07 2006-05-19 뉴로크린 바이오사이언시즈 인코퍼레이티드 고나도트로핀-방출 호르몬 수용체 길항제로서의피리미딘-2,4-디온 유도체
SI1646389T1 (sl) 2003-07-07 2009-02-28 Neurocrine Biosciences Inc Derivati pirimidin-2,4-diona kot antagonisti receptorja gonadotropin sproĺ äśajoäśega hormona
CL2008000986A1 (es) 2007-04-06 2008-10-17 Neurocrine Biosciences Inc COMPUESTO DERIVADO DE HETEROCICLOS DE NITROGENO, AGONISTAS DEL RECEPTOR GnRH; COMPOSICION FARMACEUTICA QUE COMPRENDE A DICHO COMPUESTO; Y USO PARA TRATAR UNA AFECCION RELACIONADA CON LAS HORMONAS SEXUALES, ENDOMETRIOSIS, DISMENORREA, ENFERMEDAD DE OV
CN101678007B (zh) 2007-04-06 2013-07-03 纽罗克里生物科学有限公司 促性腺激素释放激素受体拮抗剂及其制药用途
EP2231671B1 (en) 2007-12-13 2013-04-24 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
CN101987865B (zh) * 2009-07-29 2014-07-30 中国人民解放军军事医学科学院毒物药物研究所 含有乙内酰脲结构的促黄体生成素释放激素拮抗剂
TW201130854A (en) 2009-12-22 2011-09-16 Bayer Schering Pharma Ag Pyridinone derivatives and pharmaceutical compositions thereof
WO2012175514A1 (en) 2011-06-21 2012-12-27 Bayer Intellectual Property Gmbh Pyridinone derivatives and pharmaceutical compositions thereof
BR112014021331B1 (pt) * 2012-02-28 2020-12-15 Tiumbio Co., Ltd Antagonistas do receptor do hormônio liberador de gonadotropina, composição farmacêutica compreendendo os mesmos e uso desses
JPWO2014133112A1 (ja) * 2013-03-01 2017-02-02 国立大学法人 東京大学 オートタキシン阻害活性を有する８−置換イミダゾピリミジノン誘導体
KR101973074B1 (ko) * 2018-11-30 2019-04-26 주식회사 티움바이오 퓨로피리미딘 화합물의 염 및 결정형, 및 이를 포함하는 약학적 조성물
CR20220308A (es) 2019-11-25 2022-08-04 Amgen Inc Compuestos heterocíclicos como inhibidores de delta-5 desaturasa y métodos de uso

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1277612A (zh) * 1997-12-26 2000-12-20 武田药品工业株式会社 含氮杂环化合物及其制备方法和用途
US6081508A (en) * 1998-02-25 2000-06-27 Indus River Networks, Inc. Remote computer communication
EP1067930A4 (en) * 1998-04-02 2002-09-18 Merck & Co Inc GONADOLIBER'S ANTAGONISTS

Also Published As

Publication number Publication date
KR20020045609A (ko) 2002-06-19
MXPA02003614A (es) 2002-10-23
DE60022769D1 (de) 2006-02-02
DE60022769T2 (de) 2006-07-06
EP1220857B1 (en) 2005-09-21
AU769855B2 (en) 2004-02-05
ES2249302T3 (es) 2006-04-01
AU1208901A (en) 2001-04-30
CA2386942A1 (en) 2001-04-26
JP2003512379A (ja) 2003-04-02
WO2001029044A1 (en) 2001-04-26
HK1047437A1 (en) 2003-02-21
ATE305008T1 (de) 2005-10-15
EP1220857A1 (en) 2002-07-10

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20091016