HK1047432A1 - Hemisynthetic method and new compounds - Google Patents

Hemisynthetic method and new compounds Download PDF

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Publication number
HK1047432A1
HK1047432A1 HK02108867A HK02108867A HK1047432A1 HK 1047432 A1 HK1047432 A1 HK 1047432A1 HK 02108867 A HK02108867 A HK 02108867A HK 02108867 A HK02108867 A HK 02108867A HK 1047432 A1 HK1047432 A1 HK 1047432A1
Authority
HK
Hong Kong
Prior art keywords
group
formula
compound
ring
process according
Prior art date
Application number
HK02108867A
Other languages
English (en)
Chinese (zh)
Other versions
HK1047432B (en
Inventor
C‧库瓦斯
M‧佩兹
A‧弗兰策斯奇
C‧弗兰德兹
J‧L‧奇查罗
P‧加勒戈
M‧扎祖洛
F‧德拉卡勒
I‧曼扎纳雷斯
Original Assignee
法马马有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9911345.8A external-priority patent/GB9911345D0/en
Priority claimed from GBGB9918178.6A external-priority patent/GB9918178D0/en
Priority claimed from GBGB9923632.5A external-priority patent/GB9923632D0/en
Priority claimed from GB0001063A external-priority patent/GB0001063D0/en
Application filed by 法马马有限公司 filed Critical 法马马有限公司
Publication of HK1047432A1 publication Critical patent/HK1047432A1/xx
Publication of HK1047432B publication Critical patent/HK1047432B/xx

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18Bridged systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D515/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
HK02108867.1A 1999-05-14 2000-05-15 Hemisynthetic method and new compounds HK1047432B (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
GB9911345.8 1999-05-14
GBGB9911345.8A GB9911345D0 (cs) 1999-05-14 1999-05-14
GB9918178.6 1999-08-02
GBGB9918178.6A GB9918178D0 (en) 2000-05-15 1999-08-02 Synthetic methods
GBGB9923632.5A GB9923632D0 (en) 1999-10-06 1999-10-06 Hemisynthetic process towards ecteinascidin and phtalscidin compounds
GB9923632.5 1999-10-06
GB0001063.7 2000-01-17
GB0001063A GB0001063D0 (en) 2000-01-17 2000-01-17 Hemisynthetic process towards ecteinascidin and phtalascidin
PCT/GB2000/001852 WO2000069862A2 (en) 1999-05-14 2000-05-15 Hemisynthetic method and intermediates thereof

Publications (2)

Publication Number Publication Date
HK1047432A1 true HK1047432A1 (en) 2003-02-21
HK1047432B HK1047432B (en) 2006-07-14

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Also Published As

Publication number Publication date
CZ20014102A3 (cs) 2002-06-12
DE60016209D1 (de) 2004-12-30
MXPA01011631A (es) 2002-07-30
AU5649601A (en) 2001-11-26
BRPI0110801B8 (pt) 2021-05-25
PT1185536E (pt) 2005-04-29
NO20025186L (no) 2003-01-14
CZ20023746A3 (cs) 2003-04-16
SI1185536T1 (en) 2005-06-30
BG65896B1 (bg) 2010-04-30
CN1440414A (zh) 2003-09-03
ES2231486T3 (es) 2005-05-16
CN1229382C (zh) 2005-11-30
CN1441805A (zh) 2003-09-10
BRPI0110801B1 (pt) 2018-02-27
US7241892B1 (en) 2007-07-10
WO2001087894A1 (en) 2001-11-22
JP2002544280A (ja) 2002-12-24
BR0110443A (pt) 2003-04-08
CZ304966B6 (cs) 2015-02-18
DK1185536T3 (da) 2005-04-04
UA75333C2 (uk) 2006-04-17
US20040002602A1 (en) 2004-01-01
RU2237063C2 (ru) 2004-09-27
US20080045713A1 (en) 2008-02-21
BRPI0110443B8 (pt) 2021-05-25
MY130271A (en) 2007-06-29
BR0110801A (pt) 2003-02-11
BR0010559A (pt) 2002-07-02
CZ304973B6 (cs) 2015-02-25
HU230646B1 (hu) 2017-05-29
NO20025186D0 (no) 2002-10-29
HUP0201188A2 (en) 2002-07-29
SK287835B6 (sk) 2011-12-05
CN100475822C (zh) 2009-04-08
DE60016209T2 (de) 2005-12-15
CA2372058C (en) 2010-10-26
NO20015547D0 (no) 2001-11-13
WO2000069862A3 (en) 2001-03-22
NO20015547L (no) 2002-01-14
KR20020021636A (ko) 2002-03-21
NZ515424A (en) 2004-06-25
US7524956B2 (en) 2009-04-28
RU2237063C9 (ru) 2008-10-10
JP4445136B2 (ja) 2010-04-07
AU775580B2 (en) 2004-08-05
ATE283273T1 (de) 2004-12-15
ES2233367T3 (es) 2005-06-16
CY1108095T1 (el) 2014-02-12
TR200103273T2 (tr) 2002-04-22
AR035842A1 (es) 2004-07-21
CN1211386C (zh) 2005-07-20
CA2406095C (en) 2010-02-16
EP1185536B1 (en) 2004-11-24
CZ20023751A3 (en) 2004-05-12
BG107301A (bg) 2003-07-31
SK16502001A3 (sk) 2002-06-04
CA2372058A1 (en) 2000-11-23
CN1360588A (zh) 2002-07-24
CZ303536B6 (cs) 2012-11-21
BRPI0110443B1 (pt) 2018-06-26
SK287879B6 (sk) 2012-02-03
NO328301B1 (no) 2010-01-25
BRPI0010559B8 (pt) 2021-05-25
EP1185536A2 (en) 2002-03-13
BRPI0010559B1 (pt) 2016-08-30
SI1287004T1 (sl) 2005-12-31
NO322016B1 (no) 2006-08-07
PL353002A1 (en) 2003-09-22
AU4597300A (en) 2000-12-05
WO2001087895A1 (en) 2001-11-22
PL226890B1 (pl) 2017-09-29
SK15272002A3 (sk) 2003-06-03
WO2000069862A2 (en) 2000-11-23
CA2406095A1 (en) 2001-11-22
KR100834601B1 (ko) 2008-06-02

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PE Patent expired

Effective date: 20200514