HK1046288A1 - 人erab/hadh2的肽突變體、其x射線晶體結構、以及用於鍳定其抑制劑的材料和方法 - Google Patents

人erab/hadh2的肽突變體、其x射線晶體結構、以及用於鍳定其抑制劑的材料和方法

Info

Publication number
HK1046288A1
HK1046288A1 HK02107461.3A HK02107461A HK1046288A1 HK 1046288 A1 HK1046288 A1 HK 1046288A1 HK 02107461 A HK02107461 A HK 02107461A HK 1046288 A1 HK1046288 A1 HK 1046288A1
Authority
HK
Hong Kong
Prior art keywords
hadh2
inhibitors
identification
materials
crystal structure
Prior art date
Application number
HK02107461.3A
Other languages
English (en)
Chinese (zh)
Inventor
A Abreo Melwyn
S Agree Charles
A Pelletier Laura
M Aust Robert
Abraham Rejto Paul
Arthur Thomson James
J Meng Jerry
Louis Vanderpool Darin
R Kissinger Charles
Margosiak Stephen
Edward Showalter Richard
Ernesto Villafranca Jesus
Tempczyk-Russel Anna
Original Assignee
Agouron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agouron Pharma filed Critical Agouron Pharma
Publication of HK1046288A1 publication Critical patent/HK1046288A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK02107461.3A 2000-08-18 2002-10-15 人erab/hadh2的肽突變體、其x射線晶體結構、以及用於鍳定其抑制劑的材料和方法 HK1046288A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22612300P 2000-08-18 2000-08-18

Publications (1)

Publication Number Publication Date
HK1046288A1 true HK1046288A1 (zh) 2003-01-03

Family

ID=22847647

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02107461.3A HK1046288A1 (zh) 2000-08-18 2002-10-15 人erab/hadh2的肽突變體、其x射線晶體結構、以及用於鍳定其抑制劑的材料和方法

Country Status (14)

Country Link
US (2) US6964957B2 (ja)
EP (2) EP1311511A1 (ja)
JP (2) JP2004506737A (ja)
AR (1) AR035486A1 (ja)
AU (1) AU2001296854A1 (ja)
BR (1) BR0113461A (ja)
CA (2) CA2415182A1 (ja)
GT (1) GT200100169A (ja)
HK (1) HK1046288A1 (ja)
MX (1) MXPA03001455A (ja)
PA (1) PA8525801A1 (ja)
PE (1) PE20020394A1 (ja)
UY (1) UY26895A1 (ja)
WO (1) WO2002016365A1 (ja)

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DE10221052A1 (de) * 2002-05-10 2003-12-04 Transmit Technologietransfer Wirkstoffe zu Therapie, Diagnostik und Prophylaxe von Erkrankungen, bei denen abnorme Proteinstrukturen auftreten
WO2004102151A2 (en) * 2003-05-06 2004-11-25 New Century Pharmaceuticals Albumin binding sites for evaluating drug interactions and methods of evaluating or designing drugs based on therir albumin binding properties
US20070043509A1 (en) * 2003-11-03 2007-02-22 Carter Daniel C Albumin binding sites for evaluating drug interactions and methods of evaluating or designing drugs based on their albumin binding properties
US20080274975A1 (en) * 2004-04-12 2008-11-06 The Trustees Of Columbia University In The City Of New Yourk Methods and Compositions for Inhibiting Abad/Abeta Protein Interaction
US9132135B2 (en) * 2004-09-24 2015-09-15 University Of Maryland, Baltimore Method of treating organophosphorous poisoning
ES2519690T3 (es) * 2004-09-24 2014-11-07 University Of Maryland, Baltimore Método de tratamiento de envenenamiento por organosfósforo
WO2010118367A2 (en) * 2009-04-10 2010-10-14 Progenics Pharmaceuticals, Inc. Antiviral pyrimidines
MA41291A (fr) 2014-12-30 2017-11-07 Forma Therapeutics Inc Dérivés de la pyrrolotriazinone et de l'imidazotriazinone en tant qu'inhibiteurs de la protéase spécifique de l'ubiquitine n° 7 (usp7) pour le traitement d'un cancer
AR103297A1 (es) 2014-12-30 2017-05-03 Forma Therapeutics Inc Pirrolo y pirazolopirimidinas como inhibidores de la proteasa 7 específica de ubiquitina
US9938300B2 (en) 2015-02-05 2018-04-10 Forma Therapeutics, Inc. Isothiazolopyrimidinones, pyrazolopyrimidinones, and pyrrolopyrimidinones as ubiquitin-specific protease 7 inhibitors
WO2016126926A1 (en) 2015-02-05 2016-08-11 Forma Therapeutics, Inc. Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors
JP2018504431A (ja) 2015-02-05 2018-02-15 フォーマ セラピューティクス，インコーポレイテッド ユビキチン特異的プロテアーゼ７阻害物質としてのチエノピリミジノン
WO2023146880A1 (en) * 2022-01-25 2023-08-03 Board Of Regents Of The University Of Nebraska Functionalized allopurinol derivatives for treatment of alzheimer's disease

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DE68908786T2 (de) 1988-06-16 1994-03-17 Smith Kline French Lab Condensierte Pyrimidinderivate, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen.
US5109119A (en) * 1989-06-06 1992-04-28 Schering Corporation Crystalline r-h-gm-csf and method
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US5294612A (en) 1992-03-30 1994-03-15 Sterling Winthrop Inc. 6-heterocyclyl pyrazolo [3,4-d]pyrimidin-4-ones and compositions and method of use thereof
US5322933A (en) * 1992-05-07 1994-06-21 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Crystal structure of TGF-β-2
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US5294611A (en) 1993-04-23 1994-03-15 American Cyanamid Company Angiotensin II receptor blocking 2,3,6 substituted quinazolinones
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US5872011A (en) * 1997-06-13 1999-02-16 The Rockefeller University Crystal of a protein-ligand complex containing an N-terminal truncated eIF4E, and methods of use thereof
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JP2003502320A (ja) 1999-06-10 2003-01-21 ワーナー−ランバート・カンパニー アミロイドタンパク質凝集を阻害し、アミロイド沈着物を画像化する方法に使用するためのローダニン誘導体
DE60012742T2 (de) 1999-06-10 2005-01-13 Warner-Lambert Co. Llc Inhibition von amyloid protein aggregation und bilderzeugung von amyloidniederschlägen mit isoindolderivate
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JP2003507013A (ja) 1999-08-13 2003-02-25 ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク βシートフィブリルのＲＡＧＥへの結合を阻害する方法及びその結果

Also Published As

Publication number Publication date
JP2004506737A (ja) 2004-03-04
AU2001296854A1 (en) 2002-03-04
MXPA03001455A (es) 2004-05-04
PE20020394A1 (es) 2002-06-21
EP1223176A2 (en) 2002-07-17
WO2002016365A1 (en) 2002-02-28
JP2002360269A (ja) 2002-12-17
US20020132319A1 (en) 2002-09-19
BR0113461A (pt) 2003-07-01
PA8525801A1 (es) 2002-08-29
UY26895A1 (es) 2002-04-26
CA2354653A1 (en) 2002-02-18
AR035486A1 (es) 2004-06-02
US20020065292A1 (en) 2002-05-30
US6964957B2 (en) 2005-11-15
GT200100169A (es) 2002-05-16
EP1223176A3 (en) 2002-10-23
CA2415182A1 (en) 2002-02-28
EP1311511A1 (en) 2003-05-21

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