HK1042844A1 - Enhanced vaccines based on chimeric immunoglobuline peptides - Google Patents
Enhanced vaccines based on chimeric immunoglobuline peptidesInfo
- Publication number
- HK1042844A1 HK1042844A1 HK02102312A HK02102312A HK1042844A1 HK 1042844 A1 HK1042844 A1 HK 1042844A1 HK 02102312 A HK02102312 A HK 02102312A HK 02102312 A HK02102312 A HK 02102312A HK 1042844 A1 HK1042844 A1 HK 1042844A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- immunogenic polypeptides
- methods
- mammal
- ige
- nucleic acid
- Prior art date
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 6
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 6
- 229960005486 vaccine Drugs 0.000 title abstract 4
- 230000002163 immunogen Effects 0.000 abstract 5
- 229920001184 polypeptide Polymers 0.000 abstract 5
- 241000124008 Mammalia Species 0.000 abstract 4
- 239000000463 material Substances 0.000 abstract 3
- 102000039446 nucleic acids Human genes 0.000 abstract 3
- 108020004707 nucleic acids Proteins 0.000 abstract 3
- 150000007523 nucleic acids Chemical class 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
- C07K16/4291—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Virology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10665298P | 1998-11-02 | 1998-11-02 | |
US09/401,636 US6913749B2 (en) | 1998-11-02 | 1999-09-22 | Immunogenic polypeptides for inducing anti-self IgE responses |
PCT/SE1999/001896 WO2000025722A2 (en) | 1998-11-02 | 1999-10-21 | ENHANCED VACCINES COMPRISING SELF AND NON-SELF IgE PORTIONS OR DIMERIC ANTIGENS |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1042844A1 true HK1042844A1 (en) | 2002-08-30 |
Family
ID=26803871
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK02102312A HK1042844A1 (en) | 1998-11-02 | 2002-03-26 | Enhanced vaccines based on chimeric immunoglobuline peptides |
Country Status (18)
Country | Link |
---|---|
US (3) | US6913749B2 (de) |
EP (1) | EP1135158B1 (de) |
JP (2) | JP4205861B2 (de) |
KR (1) | KR100559918B1 (de) |
AT (1) | ATE314087T1 (de) |
AU (1) | AU771889B2 (de) |
CA (1) | CA2348756A1 (de) |
DE (1) | DE69929240T2 (de) |
DK (1) | DK1135158T3 (de) |
ES (1) | ES2255325T3 (de) |
HK (1) | HK1042844A1 (de) |
HU (1) | HUP0105392A3 (de) |
IL (1) | IL142582A0 (de) |
NO (1) | NO20012135L (de) |
NZ (1) | NZ511079A (de) |
PL (1) | PL348611A1 (de) |
PT (1) | PT1135158E (de) |
WO (1) | WO2000025722A2 (de) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU7658101A (en) * | 2000-07-28 | 2002-02-13 | Cytos Biotechnology Ag | Compositions for inducing self-specific anti-ige antibodies and uses thereof |
EP2361635A3 (de) * | 2000-08-30 | 2011-09-14 | Pfizer Products Inc. | Anti-IgE Vakzine |
IL154219A0 (en) * | 2000-09-06 | 2003-07-31 | Pharmexa As | Method for down-regulating ige |
US20040071671A1 (en) | 2001-02-20 | 2004-04-15 | Leturcq Didier J. | Cell therapy method for the treatment of tumors |
DE60226853D1 (de) | 2001-02-20 | 2008-07-10 | Ortho Mcneil Pharm Inc | Zelltherapieverfahren für die behandlung von tumoren |
EP2687593A1 (de) * | 2001-05-15 | 2014-01-22 | Ortho-McNeil Pharmaceutical, Inc. | Ex-vivo-Priming zur Erzeugung zytotoxischer T-Lymphozyten, die für Nicht-Tumorantigene spezifisch sind, zur Behandlung von Autoimmunerkrankung und Allergie |
JP2003047482A (ja) * | 2001-05-22 | 2003-02-18 | Pfizer Prod Inc | 非アナフィラキシー誘発性IgEワクチン |
EP1504102A2 (de) * | 2002-05-21 | 2005-02-09 | Resistentia Pharmaceuticals AB | Chimäre ige-polypeptide und wirtszellen |
JP2006510588A (ja) * | 2002-09-05 | 2006-03-30 | レジステンシア ファーマシューティカルズ アーベー | アレルギーワクチン |
US20080118524A1 (en) * | 2006-10-20 | 2008-05-22 | Stefan Persson | Anti-IgE Vaccines |
WO2008153761A1 (en) * | 2007-05-23 | 2008-12-18 | Mastcell Pharmaceuticals, Inc. | Methods |
WO2009142772A2 (en) * | 2008-05-23 | 2009-11-26 | Mastcell Pharmaceuticals, Inc. | Methods and treatment for allergies and inflammation associated with gastrointestinal diseases |
EP2376108B1 (de) | 2008-12-09 | 2017-02-22 | Pfizer Vaccines LLC | Ige ch3 peptidimpstoff |
CA2800774A1 (en) | 2010-06-07 | 2011-12-15 | Pfizer Vaccines Llc | Ige ch3 peptide vaccine |
US9187553B2 (en) * | 2012-01-25 | 2015-11-17 | Swey-Shen Chen | Displaying native human IgE neutralizing FcepsilonRIa-contacting IgE B-cell epitopes by constraining super beta(b)-strands and cystine knots on thermostable protein scaffold |
WO2013156054A1 (en) * | 2012-04-16 | 2013-10-24 | Universität Stuttgart | The igm and ige heavy chain domain 2 as covalently linked homodimerization modules for the generation of fusion proteins with dual specificity |
JP5918851B2 (ja) * | 2012-06-18 | 2016-05-18 | 日本全薬工業株式会社 | IgEペプチドワクチン |
AU2017221425A1 (en) | 2016-02-16 | 2018-08-23 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a mutant kynureninase gene |
Family Cites Families (59)
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US5698201A (en) | 1973-05-07 | 1997-12-16 | The Ohio State University | Method for treatment of antigenically modified polypeptides |
US4767842A (en) | 1973-05-07 | 1988-08-30 | The Ohio State University | Antigenic modification of polypeptides |
US4873191A (en) | 1981-06-12 | 1989-10-10 | Ohio University | Genetic transformation of zygotes |
US4483793A (en) | 1982-10-04 | 1984-11-20 | The Regents Of The University Of California | Dimeric oligopeptides as heptenic epitopic sites for hepatitis |
US4703004A (en) | 1984-01-24 | 1987-10-27 | Immunex Corporation | Synthesis of protein with an identification peptide |
US4782137A (en) | 1984-01-24 | 1988-11-01 | Immunex Corporation | Synthesis of protein with an identification peptide, and hybrid polypeptide incorporating same |
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US5175385A (en) | 1987-09-03 | 1992-12-29 | Ohio University/Edison Animal Biotechnolgy Center | Virus-resistant transgenic mice |
GB8727045D0 (en) | 1987-11-19 | 1987-12-23 | Research Corp Ltd | Immunoglobulin e competitor |
EP0407392B2 (de) | 1987-12-31 | 1998-10-28 | Tanox Biosystems, Inc. | Antigene epitope, die sich ausschliesslich auf ige-tragenden b-lymphocyten befinden |
US5254671A (en) * | 1990-04-27 | 1993-10-19 | Tanox Biosystems, Inc. | Extracellular segments of human e immunoglobulin anchoring peptides and antibodies specific therefor |
JP3095168B2 (ja) | 1988-02-05 | 2000-10-03 | エル. モリソン,シェリー | ドメイン‐変性不変部を有する抗体 |
US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
GB8910263D0 (en) | 1989-05-04 | 1989-06-21 | Ciba Geigy Ag | Monoclonal antibodies specific for an immunoglobulin isotype |
GB8913737D0 (en) | 1989-06-15 | 1989-08-02 | Univ Birmingham | A novel anti-allergy treatment |
US5955076A (en) * | 1989-06-15 | 1999-09-21 | Peptide Therapeutics Limited | Immunoactive peptides and antibodies and their use in anti-allergy treatment |
JPH04506662A (ja) | 1989-07-14 | 1992-11-19 | アメリカン・サイアナミド・カンパニー | 接合体ワクチンのためのサイトカイニンおよびホルモンのキヤリヤー |
US5733553A (en) | 1989-09-29 | 1998-03-31 | Talwar; Gursaran Prasad | Recombinant birth control vaccine |
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US5196197A (en) | 1990-08-29 | 1993-03-23 | National Institute Of Immunology | Reversible fertility control for prevention of pregnancy in females |
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SE9102808L (sv) * | 1991-09-26 | 1993-03-27 | Lars T Hellman Inst F Immunolo | Vaccin, foer humant bruk, vars avsedda effekt aer att lindra symptomen eller foerhindra uppkomsten av ige-medierade allergiska reaktioner |
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US6099846A (en) | 1992-10-14 | 2000-08-08 | The Board Of Trustees Of The Leland Stanford Junior University | Enhancement of B cell lymphoma and tumor resistance using idiotype/cytokine conjugates |
US5762931A (en) | 1992-12-31 | 1998-06-09 | National Institute Of Immunology | Anti-cancer utility of HCG vaccines |
US5532142A (en) * | 1993-02-12 | 1996-07-02 | Board Of Regents, The University Of Texas System | Method of isolation and purification of fusion polypeptides |
US5552537A (en) * | 1993-03-24 | 1996-09-03 | The Regents Of The University Of California | IgE isoforms and methods of use |
US5501855A (en) | 1993-09-02 | 1996-03-26 | Talwar; Gursaran P. | Neem oil as a male contraceptive |
DK96493D0 (da) | 1993-08-26 | 1993-08-26 | Mouritsen Og Elsner Aps | Fremgangsmaade til at inducere antistofresponser mod selvproteiner og autovaccine fremstillet ved fremgangsmaaden |
US5874085A (en) * | 1993-11-10 | 1999-02-23 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Vaccine for enhanced production of IgA antibodies |
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CN1167491A (zh) | 1994-10-25 | 1997-12-10 | 美国联合生物医学公司 | 用于治疗变态反应的合成IgE膜锚肽免疫原 |
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US6949244B1 (en) | 1995-12-20 | 2005-09-27 | The Board Of Trustees Of The University Of Kentucky | Murine monoclonal anti-idiotype antibody 11D10 and methods of use thereof |
JPH08333390A (ja) | 1995-04-07 | 1996-12-17 | Hoechst Japan Ltd | ペプチド及びそれからなる自己免疫疾患治療剤 |
AU716716B2 (en) * | 1995-07-17 | 2000-03-02 | Medivir Uk Ltd | Cysteine protease inhibitors for use in treatment of IgE mediated allergic diseases |
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US5723125A (en) * | 1995-12-28 | 1998-03-03 | Tanox Biosystems, Inc. | Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide |
KR100498198B1 (ko) | 1996-03-01 | 2005-09-09 | 노파르티스 아게 | 알레르기에 대한 백신접종 및 치료를 위한 펩티드 임뮤노겐 |
WO1998005684A2 (en) | 1996-08-05 | 1998-02-12 | President And Fellows Of Havard College | Mhc binding peptide oligomers and methods of use |
BR9811462A (pt) | 1997-04-15 | 2000-09-12 | Ferring Farma Lab | Moléculas de tnfalfa modificadas, dna que codifica tais moléculas de tnfalfa modificadas e vacinas que compreendem tais tnfalfa modificadas e dna. |
US6165476A (en) * | 1997-07-10 | 2000-12-26 | Beth Israel Deaconess Medical Center | Fusion proteins with an immunoglobulin hinge region linker |
US5891432A (en) * | 1997-07-29 | 1999-04-06 | The Immune Response Corporation | Membrane-bound cytokine compositions comprising GM=CSF and methods of modulating an immune response using same |
DE69815692T2 (de) | 1997-09-05 | 2004-04-29 | Glaxosmithkline Biologicals S.A. | Öl in wasser emulsionen mit saponinen |
EP1053343A2 (de) | 1998-02-11 | 2000-11-22 | Maxygen, Inc. | Targeting von genetischen impfstoffvektoren |
US6299875B1 (en) | 1998-06-04 | 2001-10-09 | Panacea Pharmaceuticals, Llc | Methods to block IGE binding to cell surface receptors of mast cells |
TWI227241B (en) | 1998-06-20 | 2005-02-01 | United Biomedical Inc | IgE-CH3 domain antigen peptide, peptide conjugate containing the same, and pharmaceutical composition for treating allergies containing the peptide conjugate |
JP2002526419A (ja) | 1998-10-05 | 2002-08-20 | ファーメクサ エイ/エス | 治療上のワクチン注射のための新規な方法 |
CN100534529C (zh) | 1998-11-30 | 2009-09-02 | 希托斯生物技术股份公司 | 抗原的有序分子呈递,制备及使用的方法 |
GB9908533D0 (en) | 1999-04-14 | 1999-06-09 | Novartis Ag | Organic compounds |
TR200103046T2 (tr) | 1999-04-23 | 2002-06-21 | Pharmexa A/S | IL5 aktivitesini düşürmek için yöntem. |
AU7658101A (en) | 2000-07-28 | 2002-02-13 | Cytos Biotechnology Ag | Compositions for inducing self-specific anti-ige antibodies and uses thereof |
IL154219A0 (en) | 2000-09-06 | 2003-07-31 | Pharmexa As | Method for down-regulating ige |
CA2455387A1 (en) | 2001-06-15 | 2002-12-27 | Tanox, Inc. | Fce fusion proteins for treatment of allergy and asthma |
-
1999
- 1999-09-22 US US09/401,636 patent/US6913749B2/en not_active Expired - Fee Related
- 1999-10-21 HU HU0105392A patent/HUP0105392A3/hu not_active Application Discontinuation
- 1999-10-21 AU AU20081/00A patent/AU771889B2/en not_active Ceased
- 1999-10-21 DK DK99963705T patent/DK1135158T3/da active
- 1999-10-21 NZ NZ511079A patent/NZ511079A/en not_active IP Right Cessation
- 1999-10-21 KR KR1020017005276A patent/KR100559918B1/ko not_active IP Right Cessation
- 1999-10-21 WO PCT/SE1999/001896 patent/WO2000025722A2/en active IP Right Grant
- 1999-10-21 DE DE69929240T patent/DE69929240T2/de not_active Expired - Lifetime
- 1999-10-21 PL PL99348611A patent/PL348611A1/xx not_active Application Discontinuation
- 1999-10-21 AT AT99963705T patent/ATE314087T1/de not_active IP Right Cessation
- 1999-10-21 EP EP99963705A patent/EP1135158B1/de not_active Expired - Lifetime
- 1999-10-21 JP JP2000579167A patent/JP4205861B2/ja not_active Expired - Fee Related
- 1999-10-21 CA CA002348756A patent/CA2348756A1/en not_active Abandoned
- 1999-10-21 ES ES99963705T patent/ES2255325T3/es not_active Expired - Lifetime
- 1999-10-21 PT PT99963705T patent/PT1135158E/pt unknown
- 1999-10-21 IL IL14258299A patent/IL142582A0/xx not_active IP Right Cessation
-
2001
- 2001-04-30 NO NO20012135A patent/NO20012135L/no unknown
-
2002
- 2002-03-26 HK HK02102312A patent/HK1042844A1/xx not_active IP Right Cessation
- 2002-06-19 US US10/176,664 patent/US7459158B2/en not_active Expired - Fee Related
-
2003
- 2003-09-29 US US10/673,594 patent/US20040076625A1/en not_active Abandoned
-
2005
- 2005-09-07 JP JP2005258648A patent/JP4188353B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1135158A2 (de) | 2001-09-26 |
US20010038843A1 (en) | 2001-11-08 |
US6913749B2 (en) | 2005-07-05 |
WO2000025722A3 (en) | 2000-10-12 |
EP1135158B1 (de) | 2005-12-28 |
WO2000025722A2 (en) | 2000-05-11 |
HUP0105392A2 (hu) | 2002-04-29 |
DK1135158T3 (da) | 2006-05-15 |
KR20010089364A (ko) | 2001-10-06 |
NO20012135L (no) | 2001-06-25 |
ATE314087T1 (de) | 2006-01-15 |
NO20012135D0 (no) | 2001-04-30 |
JP4205861B2 (ja) | 2009-01-07 |
AU771889B2 (en) | 2004-04-08 |
JP2002531064A (ja) | 2002-09-24 |
JP2006068015A (ja) | 2006-03-16 |
PL348611A1 (en) | 2002-06-03 |
JP4188353B2 (ja) | 2008-11-26 |
DE69929240T2 (de) | 2006-08-31 |
PT1135158E (pt) | 2006-05-31 |
HUP0105392A3 (en) | 2008-04-28 |
CA2348756A1 (en) | 2000-05-11 |
US20030031663A1 (en) | 2003-02-13 |
KR100559918B1 (ko) | 2006-03-13 |
IL142582A0 (en) | 2002-03-10 |
US7459158B2 (en) | 2008-12-02 |
DE69929240D1 (de) | 2006-02-02 |
US20040076625A1 (en) | 2004-04-22 |
ES2255325T3 (es) | 2006-06-16 |
AU2008100A (en) | 2000-05-22 |
NZ511079A (en) | 2003-08-29 |
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