HK1027802A1 - Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors - Google Patents
Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitorsInfo
- Publication number
- HK1027802A1 HK1027802A1 HK00105257A HK00105257A HK1027802A1 HK 1027802 A1 HK1027802 A1 HK 1027802A1 HK 00105257 A HK00105257 A HK 00105257A HK 00105257 A HK00105257 A HK 00105257A HK 1027802 A1 HK1027802 A1 HK 1027802A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- cyclooxygenase
- lipoxygenase inhibitors
- substituted sulfonylphenylheterocycles
- sulfonylphenylheterocycles
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Pain & Pain Management (AREA)
- Animal Behavior & Ethology (AREA)
- Rheumatology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/460,324 US5643933A (en) | 1995-06-02 | 1995-06-02 | Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1027802A1 true HK1027802A1 (en) | 2001-01-23 |
Family
ID=23828245
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK00105257A HK1027802A1 (en) | 1995-06-02 | 2000-08-21 | Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
Country Status (11)
Country | Link |
---|---|
US (1) | US5643933A (de) |
EP (2) | EP0828736B1 (de) |
AT (2) | ATE246188T1 (de) |
AU (1) | AU6027996A (de) |
CA (1) | CA2223091A1 (de) |
DE (2) | DE69622894T2 (de) |
DK (2) | DK0995747T3 (de) |
ES (2) | ES2205035T3 (de) |
HK (1) | HK1027802A1 (de) |
PT (2) | PT995747E (de) |
WO (1) | WO1996038442A1 (de) |
Families Citing this family (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5633272A (en) * | 1995-02-13 | 1997-05-27 | Talley; John J. | Substituted isoxazoles for the treatment of inflammation |
EP0828718A1 (de) | 1995-06-02 | 1998-03-18 | G.D. SEARLE & CO. | Heterocyclo-substituierte hydroxaminsäurederivate als cyclooxygenase-2 und 5-lipoxygenase inhibitoren |
US6512121B2 (en) | 1998-09-14 | 2003-01-28 | G.D. Searle & Co. | Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
ATE210461T1 (de) | 1996-02-13 | 2001-12-15 | Searle & Co | Zusammensetzungen mit immunosuppressiven wirkungen, welche 5-lipoxygenase-inhibitoren und cyclooxygenase-2-inhibitoren enthalten |
US5908858A (en) | 1996-04-05 | 1999-06-01 | Sankyo Company, Limited | 1,2-diphenylpyrrole derivatives, their preparation and their therapeutic uses |
US6677364B2 (en) * | 1998-04-20 | 2004-01-13 | G.D. Searle & Co. | Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
ATE228117T1 (de) * | 1996-08-14 | 2002-12-15 | Searle & Co | Kristalline form von 4-(5-methyl-3-phenylisoxazol-4-yl)benzolsulfona id |
FR2753449B1 (fr) * | 1996-09-13 | 1998-12-04 | Union Pharma Scient Appl | Nouveaux derives 3,4-diaryloxazolone, leurs procedes de preparation, et leurs utilisations en therapeutique |
EP0971714B1 (de) * | 1997-04-03 | 2002-10-09 | G.D. Searle & Co. | Verfahren zur verwendung von cyclooxygenase-2 hemmern zur behandlung und vorbeugung der demenz |
US6130334A (en) * | 1998-04-15 | 2000-10-10 | Merck & Co., Inc. | Process for making 2-aryl-3-aryl-5-halo pyridines useful as COX-2 inhibitors |
US6127545A (en) * | 1997-04-18 | 2000-10-03 | Merck & Co., Inc. | Process for making 2-aryl-3-aryl-5-halo pyridines useful as COX-2 inhibitors |
TR199902545T2 (xx) * | 1997-04-18 | 2000-01-21 | G.D. Searle & Co. | Kalp damar hastal�klar�n�n �nlenmesinde siklooksijenaz-2 inhibit�rlerini kullanma y�ntemi |
TW492959B (en) * | 1997-04-18 | 2002-07-01 | Merck & Co Inc | Process for making 2-aryl-3-aryl-5-halo pyridines useful as cox-2 inhibitors |
FR2769311B1 (fr) * | 1997-10-07 | 1999-12-24 | Union Pharma Scient Appl | Nouveaux derives 3,4-diarylthiazolin-2-one ou -2-thione, leurs procedes de preparation et leurs utilisations en therapeutique |
US7041694B1 (en) | 1997-12-17 | 2006-05-09 | Cornell Research Foundation, Inc. | Cyclooxygenase-2 inhibition |
US6395724B1 (en) | 1998-06-08 | 2002-05-28 | Advanced Medicine, Inc. | Multibinding inhibitors of cyclooxygenase-2 |
TW477789B (en) * | 1998-09-03 | 2002-03-01 | Japan Tobacco Inc | Production method of oxazole compound |
SA99191255B1 (ar) | 1998-11-30 | 2006-11-25 | جي دي سيرل اند كو | مركبات سيليكوكسيب celecoxib |
ES2159479B1 (es) * | 1999-10-25 | 2002-05-01 | Menarini Lab | Nuevos indazoles como inhibidores de la ciclooxigenasa-ii |
CO5261556A1 (es) * | 1999-12-08 | 2003-03-31 | Pharmacia Corp | Composiciones inhibidoras de ciclooxigenasa-2 que tiene rapido acceso de efecto terapeutico |
PE20020146A1 (es) * | 2000-07-13 | 2002-03-31 | Upjohn Co | Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2) |
US7115565B2 (en) * | 2001-01-18 | 2006-10-03 | Pharmacia & Upjohn Company | Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability |
US7695736B2 (en) | 2001-04-03 | 2010-04-13 | Pfizer Inc. | Reconstitutable parenteral composition |
UA80682C2 (en) * | 2001-08-06 | 2007-10-25 | Pharmacia Corp | Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition |
US20030114416A1 (en) * | 2001-08-14 | 2003-06-19 | Pharmacia Corporation | Method and compositions for the treatment and prevention of pain and inflammation with a cyclooxygenase-2 selective inhibitor and chondroitin sulfate |
US20050101563A1 (en) * | 2001-08-14 | 2005-05-12 | Pharmacia Corporation | Method and compositions for the treatment and prevention of pain and inflammation |
AR038957A1 (es) | 2001-08-15 | 2005-02-02 | Pharmacia Corp | Terapia de combinacion para el tratamiento del cancer |
US20030220374A1 (en) * | 2002-01-14 | 2003-11-27 | Pharmacia Corporation | Compositions and methods of treatment involving peroxisome proliferator-activated receptor-gamma agonists and cyclooxygenase-2 selective inhibitors |
US20030212138A1 (en) * | 2002-01-14 | 2003-11-13 | Pharmacia Corporation | Combinations of peroxisome proliferator-activated receptor-alpha agonists and cyclooxygenase-2 selective inhibitors and therapeutic uses therefor |
MXPA04010186A (es) * | 2002-04-18 | 2005-02-03 | Pharmacia Corp | Monoterapia para el tratamiento de la enfermedad de parkinson con inhibidor (es) de la ciclooxigenasa-2 (cox 2). |
MXPA04009352A (es) * | 2002-04-18 | 2005-01-25 | Pharmacia Corp | Terapia de combinacion para el tratamiento de la enfermedad de parkinson con inhibidores de ciclooxigenasa-2 (cox2). |
HUE027779T2 (en) | 2002-05-09 | 2016-11-28 | Brigham & Womens Hospital Inc | 1L1RL-1 is a marker of cardiovascular disease |
CN100348586C (zh) * | 2002-05-24 | 2007-11-14 | 法玛西雅公司 | 二芳基吡唑的合成方法 |
US20040147581A1 (en) * | 2002-11-18 | 2004-07-29 | Pharmacia Corporation | Method of using a Cox-2 inhibitor and a 5-HT1A receptor modulator as a combination therapy |
ES2341240T3 (es) | 2002-12-13 | 2010-06-17 | Warner-Lambert Company Llc | Ligando alfa-2-delta para tratar los sintomas del tracto urinario inferior. |
US20040204411A1 (en) * | 2002-12-17 | 2004-10-14 | Pharmacia Corporation | Method for the treatment, prevention, or inhibition of a CNS disorder and/or pain and inflammation using a combination of reboxetine and a cyclooxygenase-2 selective inhibitor and compositions thereof |
US20040235925A1 (en) * | 2002-12-17 | 2004-11-25 | Pharmacia Corporation | Method for the treatment, prevention, or inhibition of a CNS disorder and/or pain and inflammation using a combination of duloxetine, venlafaxine or atomoxetine and a cyclooxygenase-2 selective inhibitor and compositions thereof |
SI2266584T1 (sl) * | 2003-05-07 | 2012-12-31 | Osteologix A/S, Symbion | Sestavek s stroncijem in vitaminom D za profilakso in/ali zdravljenje patologij hrustanca in/ali kosti |
PT1534305E (pt) * | 2003-05-07 | 2007-02-28 | Osteologix As | Tratamento de afecções cartilagineas / osseas com sais de estroncio hidrosoluveis |
HUE027546T2 (en) | 2003-08-29 | 2016-10-28 | Brigham & Womens Hospital Inc | Hydantoin derivatives as cell necrosis inhibitors |
AU2004296829A1 (en) | 2003-12-05 | 2005-06-23 | The Cleveland Clinic Foundation | Risk markers for cardiovascular disease |
BRPI0506994A (pt) | 2004-01-22 | 2007-07-03 | Pfizer | derivados de triazol que inibem a atividade antagonista da vasopressina |
CA2624601C (en) | 2004-10-06 | 2018-07-03 | The Brigham And Women's Hospital, Inc. | Relevance of achieved levels of markers of systemic inflammation following treatment |
US8119358B2 (en) | 2005-10-11 | 2012-02-21 | Tethys Bioscience, Inc. | Diabetes-related biomarkers and methods of use thereof |
US20080292608A1 (en) * | 2005-11-07 | 2008-11-27 | Irm Llc | Compounds and Compositions as Ppar Modulators |
WO2007109056A2 (en) | 2006-03-15 | 2007-09-27 | The Brigham And Women's Hospital, Inc. | Use of gelsolin to diagnose and treat inflammatory diseases |
US20080057590A1 (en) | 2006-06-07 | 2008-03-06 | Mickey Urdea | Markers associated with arteriovascular events and methods of use thereof |
US8128460B2 (en) * | 2006-09-14 | 2012-03-06 | The Material Works, Ltd. | Method of producing rust inhibitive sheet metal through scale removal with a slurry blasting descaling cell |
MX2009006575A (es) | 2006-12-22 | 2009-07-02 | Recordati Ireland Ltd | Terapia de combinacion de trastornos del tracto urinario inferior con ligandos a2d y farmacos anti-inflamatorios no esteroidales (nsaids). |
CA2676413A1 (en) * | 2007-01-19 | 2008-07-31 | Mallinckrodt Inc. | Diagnostic and therapeutic cyclooxygenase-2 binding ligands |
TW200849035A (en) | 2007-04-18 | 2008-12-16 | Tethys Bioscience Inc | Diabetes-related biomarkers and methods of use thereof |
CN101801188A (zh) | 2007-07-12 | 2010-08-11 | 特拉加拉医药品公司 | 治疗癌症、肿瘤和肿瘤相关性疾病的方法和组合物 |
GB2460915B (en) | 2008-06-16 | 2011-05-25 | Biovascular Inc | Controlled release compositions of agents that reduce circulating levels of platelets and methods therefor |
JP2013518618A (ja) | 2010-02-01 | 2013-05-23 | ザ・ホスピタル・フォー・シック・チルドレン | 再狭窄を治療および予防するための遠隔虚血コンディショニング |
SG10201502031XA (en) | 2010-03-31 | 2015-05-28 | Hospital For Sick Children | Use of remote ischemic conditioning to improve outcome after myocardial infarction |
DK2705365T3 (en) * | 2011-01-14 | 2016-10-24 | Hal Allergy Holding B V | Immunoassay for the direct determination of the antigen content in the products containing the adjuvant-linked antigen particles |
JP6377054B2 (ja) | 2012-05-11 | 2018-08-22 | リセット セラピューティークス, インコーポレイテッド | クリプトクロム調節薬としてのカルバゾール含有スルホンアミド |
CN102839200B (zh) * | 2012-05-25 | 2015-03-18 | 杭州师范大学 | 酶催化合成2,4,5-三取代的咪唑环类衍生物的方法 |
MX2015002036A (es) * | 2012-08-16 | 2016-01-22 | Janssen Pharmaceutica Nv | Pirazoles sustituidos como bloqueadores del canal de calcio tipo n. |
AU2013305884B2 (en) | 2012-08-21 | 2017-10-05 | Saladax Biomedical Inc. | Antibodies to risperidone haptens and use thereof |
CA2882490A1 (en) | 2012-08-21 | 2014-02-27 | Ortho-Clinical Diagnostics, Inc. | Antibodies to paliperidone and use thereof |
CA2897585C (en) | 2013-02-20 | 2021-03-23 | Basf Se | Anthranilamide compounds, their mixtures and the use thereof as pesticides |
WO2014145022A1 (en) | 2013-03-15 | 2014-09-18 | President And Fellows Of Harvard College | Hybrid necroptosis inhibitors |
US9453002B2 (en) | 2013-08-16 | 2016-09-27 | Janssen Pharmaceutica Nv | Substituted imidazoles as N-type calcium channel blockers |
TWI690521B (zh) | 2014-04-07 | 2020-04-11 | 美商同步製藥公司 | 作為隱花色素調節劑之含有咔唑之醯胺類、胺基甲酸酯類及脲類 |
MA53652A (fr) | 2018-09-19 | 2021-07-28 | Modernatx Inc | Lipides peg de haute pureté et leurs utilisations |
MA53650A (fr) | 2018-09-19 | 2021-07-28 | Modernatx Inc | Lipides peg et leurs utilisations |
CA3209491A1 (en) | 2021-03-15 | 2022-09-22 | Saul Yedgar | Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory disease |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5242940A (en) * | 1987-05-29 | 1993-09-07 | Ortho Pharmaceutical Corporation | Pharmacologically active N-1 and C-5 heterocyclic pyrazoles and method for synthesizing the same |
GB8927287D0 (en) * | 1988-12-23 | 1990-01-31 | Ici Plc | Cyclic ether derivatives |
US5234950A (en) * | 1988-12-23 | 1993-08-10 | Imperial Chemical Industries Plc | Tetrahydrofuran derivatives |
US5196419A (en) * | 1989-02-28 | 1993-03-23 | Imperial Chemical Industries Plc | Heterocyclic cyclic ethers |
US5234939A (en) * | 1990-03-27 | 1993-08-10 | Warner-Lambert Company | 3,5-di-tertiary-butyl-4-hydroxyphenyl imidazolyl methanones and related compounds as antiinflammatory agents |
ES2083526T3 (es) * | 1990-06-21 | 1996-04-16 | Zeneca Ltd | Derivados piranicos biciclicos y su uso como inhibidores de 5-lipoxigenasa. |
AU637500B2 (en) * | 1990-06-21 | 1993-05-27 | Zeneca Limited | Bicyclic heterocyclic compounds |
GB9113137D0 (en) * | 1990-07-13 | 1991-08-07 | Ici Plc | Thioxo heterocycles |
IE913655A1 (en) * | 1990-11-06 | 1992-05-22 | Zeneca Ltd | Synergistic agents |
CA2099868C (en) * | 1991-01-31 | 2002-04-02 | Thomas Richard Belliotti | Substituted 4,6-di-tertiary-butyl-5-hydroxy-pyrimidines |
US5308852A (en) * | 1992-06-29 | 1994-05-03 | Merck Frosst Canada, Inc. | Heteroarylnaphthalenes as inhibitors of leukotriene biosynthesis |
US5354865A (en) * | 1992-09-10 | 1994-10-11 | Abbott Laboratories | Phenylmethyl derivatives having lipoxygenase inhibitory activity |
US5604260A (en) * | 1992-12-11 | 1997-02-18 | Merck Frosst Canada Inc. | 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2 |
DE9422447U1 (de) * | 1993-01-15 | 2002-10-17 | G D Searle Llc Chicago | 3,4-Diarylthiophene und Analoga davon, sowie deren Verwendung als entzündungshemmende Mittel |
US5409944A (en) * | 1993-03-12 | 1995-04-25 | Merck Frosst Canada, Inc. | Alkanesulfonamido-1-indanone derivatives as inhibitors of cyclooxygenase |
CA2161789A1 (en) * | 1993-05-13 | 1994-11-24 | Jacques Yves Gauthier | 2-substituted-3,4-diarylthiophene derivatives as inhibitors of cyclooxygenase |
US5380738A (en) * | 1993-05-21 | 1995-01-10 | Monsanto Company | 2-substituted oxazoles further substituted by 4-fluorophenyl and 4-methylsulfonylphenyl as antiinflammatory agents |
US5474995A (en) * | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
US5298521A (en) * | 1993-08-30 | 1994-03-29 | Ortho Pharmaceutical Corporation | 1,5-diphenyl-3-pyrazolylalkyl-N-hydroxydithiocaramates, compositions and use |
US5344991A (en) * | 1993-10-29 | 1994-09-06 | G.D. Searle & Co. | 1,2 diarylcyclopentenyl compounds for the treatment of inflammation |
US5401765A (en) * | 1993-11-30 | 1995-03-28 | G. D. Searle | 1,4,5-triphenyl pyrazolyl compounds for the treatment of inflammation and inflammation-related disorders |
US5393790A (en) * | 1994-02-10 | 1995-02-28 | G.D. Searle & Co. | Substituted spiro compounds for the treatment of inflammation |
WO1995030669A1 (en) * | 1994-05-06 | 1995-11-16 | Zeneca Limited | Ether derivatives and pharmaceutical compositions containing them |
-
1995
- 1995-06-02 US US08/460,324 patent/US5643933A/en not_active Expired - Fee Related
-
1996
- 1996-05-31 AT AT96917888T patent/ATE246188T1/de not_active IP Right Cessation
- 1996-05-31 EP EP96917888A patent/EP0828736B1/de not_active Expired - Lifetime
- 1996-05-31 PT PT00100201T patent/PT995747E/pt unknown
- 1996-05-31 AT AT00100201T patent/ATE221885T1/de not_active IP Right Cessation
- 1996-05-31 DK DK00100201T patent/DK0995747T3/da active
- 1996-05-31 DE DE69622894T patent/DE69622894T2/de not_active Expired - Fee Related
- 1996-05-31 WO PCT/US1996/008183 patent/WO1996038442A1/en active IP Right Grant
- 1996-05-31 CA CA002223091A patent/CA2223091A1/en not_active Abandoned
- 1996-05-31 ES ES96917888T patent/ES2205035T3/es not_active Expired - Lifetime
- 1996-05-31 PT PT96917888T patent/PT828736E/pt unknown
- 1996-05-31 DK DK96917888T patent/DK0828736T3/da active
- 1996-05-31 DE DE69629290T patent/DE69629290T2/de not_active Expired - Fee Related
- 1996-05-31 AU AU60279/96A patent/AU6027996A/en not_active Abandoned
- 1996-05-31 EP EP00100201A patent/EP0995747B1/de not_active Expired - Lifetime
- 1996-05-31 ES ES00100201T patent/ES2181614T3/es not_active Expired - Lifetime
-
2000
- 2000-08-21 HK HK00105257A patent/HK1027802A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
PT995747E (pt) | 2002-12-31 |
DE69629290D1 (en) | 2003-09-04 |
DE69622894D1 (de) | 2002-09-12 |
AU6027996A (en) | 1996-12-18 |
ATE246188T1 (de) | 2003-08-15 |
DK0828736T3 (da) | 2003-11-24 |
ES2205035T3 (es) | 2004-05-01 |
WO1996038442A1 (en) | 1996-12-05 |
EP0828736B1 (de) | 2003-07-30 |
EP0995747B1 (de) | 2002-08-07 |
CA2223091A1 (en) | 1996-12-05 |
EP0995747A1 (de) | 2000-04-26 |
ATE221885T1 (de) | 2002-08-15 |
US5643933A (en) | 1997-07-01 |
DE69629290T2 (de) | 2004-04-22 |
PT828736E (pt) | 2003-12-31 |
EP0828736A1 (de) | 1998-03-18 |
DE69622894T2 (de) | 2003-04-30 |
ES2181614T3 (es) | 2003-03-01 |
DK0995747T3 (da) | 2002-11-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1027802A1 (en) | Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors | |
PL326203A1 (en) | (methylsulphonyl)phenyl-2-(5)-furanones as cox-2 inhibitors | |
IL132797A0 (en) | Compounds and methods for the inhibition of the expression of vcam-1 | |
IL123002A0 (en) | 1-Phenyl-2- phenylacetoxy- ethanone derivatives | |
MY129189A (en) | Prostaglandin agonists and their use to treat bone disorders | |
PL337758A1 (en) | Derivatives of piperazine and their application as anti-inflammatory agents | |
ES2171723T3 (es) | 3,4-diaril-2-hidroxi-2,5-dihidrofuranos como profarmacos de inhibidores de cox-2. | |
PL328225A1 (en) | Diphenylstilbenes as pro-medications used to produce cox-2-inhibitors | |
MX9704739A (es) | Monomeros de 3,3-(disustituido)ciclohexan-1-ona y compuestos relacionados. | |
MX9704733A (es) | Monomeros de ciclohesan-1-ona 4,4-disubstituidos y compuestos relacionados. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PF | Patent in force | ||
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20060531 |