PT828736E - Heterociclicos sulfonilfenilicos como inibidores de ciclooxigenase-2 e de 5-lipoxigenase - Google Patents
Heterociclicos sulfonilfenilicos como inibidores de ciclooxigenase-2 e de 5-lipoxigenaseInfo
- Publication number
- PT828736E PT828736E PT96917888T PT96917888T PT828736E PT 828736 E PT828736 E PT 828736E PT 96917888 T PT96917888 T PT 96917888T PT 96917888 T PT96917888 T PT 96917888T PT 828736 E PT828736 E PT 828736E
- Authority
- PT
- Portugal
- Prior art keywords
- sulfonylphenylic
- ciclooxigenase
- heterocyclics
- lipoxygenase inhibitors
- lipoxygenase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/460,324 US5643933A (en) | 1995-06-02 | 1995-06-02 | Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
PT828736E true PT828736E (pt) | 2003-12-31 |
Family
ID=23828245
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT00100201T PT995747E (pt) | 1995-06-02 | 1996-05-31 | Heterociclos de sulfonilfenilo substituidos como inibidores de cicloxigenase-2 e 5-lipoxigenase |
PT96917888T PT828736E (pt) | 1995-06-02 | 1996-05-31 | Heterociclicos sulfonilfenilicos como inibidores de ciclooxigenase-2 e de 5-lipoxigenase |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT00100201T PT995747E (pt) | 1995-06-02 | 1996-05-31 | Heterociclos de sulfonilfenilo substituidos como inibidores de cicloxigenase-2 e 5-lipoxigenase |
Country Status (11)
Country | Link |
---|---|
US (1) | US5643933A (pt) |
EP (2) | EP0995747B1 (pt) |
AT (2) | ATE246188T1 (pt) |
AU (1) | AU6027996A (pt) |
CA (1) | CA2223091A1 (pt) |
DE (2) | DE69629290T2 (pt) |
DK (2) | DK0828736T3 (pt) |
ES (2) | ES2205035T3 (pt) |
HK (1) | HK1027802A1 (pt) |
PT (2) | PT995747E (pt) |
WO (1) | WO1996038442A1 (pt) |
Families Citing this family (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5633272A (en) * | 1995-02-13 | 1997-05-27 | Talley; John J. | Substituted isoxazoles for the treatment of inflammation |
US6512121B2 (en) | 1998-09-14 | 2003-01-28 | G.D. Searle & Co. | Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
EP0828718A1 (en) | 1995-06-02 | 1998-03-18 | G.D. SEARLE & CO. | Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
DE69709069T2 (de) | 1996-02-13 | 2002-07-04 | Searle & Co | Zusammensetzungen mit immunosuppressiven wirkungen, welche 5-lipoxygenase-inhibitoren und cyclooxygenase-2-inhibitoren enthalten |
US5908858A (en) | 1996-04-05 | 1999-06-01 | Sankyo Company, Limited | 1,2-diphenylpyrrole derivatives, their preparation and their therapeutic uses |
US6677364B2 (en) * | 1998-04-20 | 2004-01-13 | G.D. Searle & Co. | Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
EE04237B1 (et) * | 1996-08-14 | 2004-02-16 | G.D. Searle & Co. | 4-(5-metüül-3-fenüülisoksasool-4-üül)benseensulfoonamiidi kristalliline vorm, selle kasutamine ja valmistamise meetod |
FR2753449B1 (fr) * | 1996-09-13 | 1998-12-04 | Union Pharma Scient Appl | Nouveaux derives 3,4-diaryloxazolone, leurs procedes de preparation, et leurs utilisations en therapeutique |
EP0971714B1 (en) * | 1997-04-03 | 2002-10-09 | G.D. Searle & Co. | Method of using cyclooxygenase-2 inhibitors in the treatment and prevention of dementia |
US6127545A (en) * | 1997-04-18 | 2000-10-03 | Merck & Co., Inc. | Process for making 2-aryl-3-aryl-5-halo pyridines useful as COX-2 inhibitors |
US6130334A (en) * | 1998-04-15 | 2000-10-10 | Merck & Co., Inc. | Process for making 2-aryl-3-aryl-5-halo pyridines useful as COX-2 inhibitors |
TW492959B (en) * | 1997-04-18 | 2002-07-01 | Merck & Co Inc | Process for making 2-aryl-3-aryl-5-halo pyridines useful as cox-2 inhibitors |
IL132163A0 (en) * | 1997-04-18 | 2001-03-19 | Searle & Co | Method of using cyclooxygenase-2 inhibitors in the prevention of cardiovascular disorders |
FR2769311B1 (fr) * | 1997-10-07 | 1999-12-24 | Union Pharma Scient Appl | Nouveaux derives 3,4-diarylthiazolin-2-one ou -2-thione, leurs procedes de preparation et leurs utilisations en therapeutique |
US7041694B1 (en) | 1997-12-17 | 2006-05-09 | Cornell Research Foundation, Inc. | Cyclooxygenase-2 inhibition |
AU4428899A (en) | 1998-06-08 | 1999-12-30 | Advanced Medicine, Inc. | Multibinding inhibitors of cyclooxygenase-2 |
TW477789B (en) * | 1998-09-03 | 2002-03-01 | Japan Tobacco Inc | Production method of oxazole compound |
SA99191255B1 (ar) | 1998-11-30 | 2006-11-25 | جي دي سيرل اند كو | مركبات سيليكوكسيب celecoxib |
ES2159479B1 (es) * | 1999-10-25 | 2002-05-01 | Menarini Lab | Nuevos indazoles como inhibidores de la ciclooxigenasa-ii |
KR100793668B1 (ko) * | 1999-12-08 | 2008-01-10 | 파마시아 코포레이션 | 강화된 생체이용률을 지닌 고체상 형태의 셀레콕시브 |
PE20020146A1 (es) * | 2000-07-13 | 2002-03-31 | Upjohn Co | Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2) |
US7115565B2 (en) * | 2001-01-18 | 2006-10-03 | Pharmacia & Upjohn Company | Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability |
US7695736B2 (en) | 2001-04-03 | 2010-04-13 | Pfizer Inc. | Reconstitutable parenteral composition |
UA80682C2 (en) * | 2001-08-06 | 2007-10-25 | Pharmacia Corp | Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition |
US20050101563A1 (en) * | 2001-08-14 | 2005-05-12 | Pharmacia Corporation | Method and compositions for the treatment and prevention of pain and inflammation |
US20030114416A1 (en) * | 2001-08-14 | 2003-06-19 | Pharmacia Corporation | Method and compositions for the treatment and prevention of pain and inflammation with a cyclooxygenase-2 selective inhibitor and chondroitin sulfate |
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US20030212138A1 (en) * | 2002-01-14 | 2003-11-13 | Pharmacia Corporation | Combinations of peroxisome proliferator-activated receptor-alpha agonists and cyclooxygenase-2 selective inhibitors and therapeutic uses therefor |
US20030220374A1 (en) * | 2002-01-14 | 2003-11-27 | Pharmacia Corporation | Compositions and methods of treatment involving peroxisome proliferator-activated receptor-gamma agonists and cyclooxygenase-2 selective inhibitors |
US20040034083A1 (en) * | 2002-04-18 | 2004-02-19 | Stephenson Diane T. | Combination therapy for the treatment of Parkinson's disease with cyclooxygenase-2 (COX2) inhibitor(s) |
CA2482510A1 (en) * | 2002-04-18 | 2003-10-30 | Pharmacia Corporation | Monotherapy for the treatment of parkinson`s disease with cyclooxygenase-2 (cox 2) inhibitor(s) |
ES2375181T3 (es) | 2002-05-09 | 2012-02-27 | The Brigham And Women's Hospital, Inc. | 1l 1rl-1 como un marcador de enfermedades cardiovasculares. |
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US20040147581A1 (en) * | 2002-11-18 | 2004-07-29 | Pharmacia Corporation | Method of using a Cox-2 inhibitor and a 5-HT1A receptor modulator as a combination therapy |
CA2509605C (en) | 2002-12-13 | 2010-10-05 | Warner-Lambert Company Llc | Alpha-2-delta ligand to treat lower urinary tract symptoms |
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US20040204411A1 (en) * | 2002-12-17 | 2004-10-14 | Pharmacia Corporation | Method for the treatment, prevention, or inhibition of a CNS disorder and/or pain and inflammation using a combination of reboxetine and a cyclooxygenase-2 selective inhibitor and compositions thereof |
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EP3081214A3 (en) | 2003-08-29 | 2016-11-16 | The Brigham And Women's Hospital, Inc. | Inhibitors of cellular necrosis |
ATE546734T1 (de) | 2003-12-05 | 2012-03-15 | Cleveland Clinic Foundation | Risikomarker für eine herzkreislaufkrankheit |
EP1708718A1 (en) | 2004-01-22 | 2006-10-11 | Pfizer Limited | Triazole derivatives which inhibit vasopressin antagonistic activity |
WO2006042192A2 (en) | 2004-10-06 | 2006-04-20 | The Brigham And Womens's Hospital, Inc. | Relevance of achieved levels of markers of systemic inflammation following treatment |
US8119358B2 (en) * | 2005-10-11 | 2012-02-21 | Tethys Bioscience, Inc. | Diabetes-related biomarkers and methods of use thereof |
CA2626446A1 (en) * | 2005-11-07 | 2007-05-18 | Irm Llc | Compounds and compositions as ppar modulators |
HUE056086T2 (hu) | 2006-03-15 | 2022-01-28 | Brigham & Womens Hospital Inc | Gelszolin alkalmazása gyulladásos betegségek diagnosztizálására és kezelésére |
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US8128460B2 (en) * | 2006-09-14 | 2012-03-06 | The Material Works, Ltd. | Method of producing rust inhibitive sheet metal through scale removal with a slurry blasting descaling cell |
EA017171B1 (ru) | 2006-12-22 | 2012-10-30 | Рекордати Айерленд Лимитед | КОМБИНИРОВАННАЯ ТЕРАПИЯ ЗАБОЛЕВАНИЙ НИЖНИХ МОЧЕВЫВОДЯЩИХ ПУТЕЙ С ИСПОЛЬЗОВАНИЕМ ЛИГАНДОВ αδ И НЕСТЕРОИДНЫХ ПРОТИВОВОСПАЛИТЕЛЬНЫХ ПРЕПАРАТОВ (НПВП) |
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ES2434215T3 (es) | 2007-04-18 | 2013-12-16 | Tethys Bioscience, Inc. | Biomarcadores relacionados con la diabetes y métodos de uso de los mismos |
BRPI0814542A2 (pt) | 2007-07-12 | 2014-09-30 | Tragara Pharmaceuticals Inc | Métodos e composições para o tratamento de câncer, tumores e desordens relacionadas a tumores |
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US9725452B2 (en) | 2013-03-15 | 2017-08-08 | Presidents And Fellows Of Harvard College | Substituted indoles and pyrroles as RIP kinase inhibitors |
US9453002B2 (en) | 2013-08-16 | 2016-09-27 | Janssen Pharmaceutica Nv | Substituted imidazoles as N-type calcium channel blockers |
TWI690521B (zh) | 2014-04-07 | 2020-04-11 | 美商同步製藥公司 | 作為隱花色素調節劑之含有咔唑之醯胺類、胺基甲酸酯類及脲類 |
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CA3209491A1 (en) | 2021-03-15 | 2022-09-22 | Saul Yedgar | Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory disease |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5242940A (en) * | 1987-05-29 | 1993-09-07 | Ortho Pharmaceutical Corporation | Pharmacologically active N-1 and C-5 heterocyclic pyrazoles and method for synthesizing the same |
US5234950A (en) * | 1988-12-23 | 1993-08-10 | Imperial Chemical Industries Plc | Tetrahydrofuran derivatives |
GB8927287D0 (en) * | 1988-12-23 | 1990-01-31 | Ici Plc | Cyclic ether derivatives |
US5196419A (en) * | 1989-02-28 | 1993-03-23 | Imperial Chemical Industries Plc | Heterocyclic cyclic ethers |
US5234939A (en) * | 1990-03-27 | 1993-08-10 | Warner-Lambert Company | 3,5-di-tertiary-butyl-4-hydroxyphenyl imidazolyl methanones and related compounds as antiinflammatory agents |
AU637500B2 (en) * | 1990-06-21 | 1993-05-27 | Zeneca Limited | Bicyclic heterocyclic compounds |
ATE134630T1 (de) * | 1990-06-21 | 1996-03-15 | Zeneca Ltd | Bizyklische pyran-derivate und ihre verwendung als 5-lipoxygenasehemmer |
GB9113137D0 (en) * | 1990-07-13 | 1991-08-07 | Ici Plc | Thioxo heterocycles |
IE913655A1 (en) * | 1990-11-06 | 1992-05-22 | Zeneca Ltd | Synergistic agents |
CA2099868C (en) * | 1991-01-31 | 2002-04-02 | Thomas Richard Belliotti | Substituted 4,6-di-tertiary-butyl-5-hydroxy-pyrimidines |
US5308852A (en) * | 1992-06-29 | 1994-05-03 | Merck Frosst Canada, Inc. | Heteroarylnaphthalenes as inhibitors of leukotriene biosynthesis |
US5354865A (en) * | 1992-09-10 | 1994-10-11 | Abbott Laboratories | Phenylmethyl derivatives having lipoxygenase inhibitory activity |
US5604260A (en) * | 1992-12-11 | 1997-02-18 | Merck Frosst Canada Inc. | 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2 |
ATE160345T1 (de) * | 1993-01-15 | 1997-12-15 | Searle & Co | 3,4-diarylthiophene und analoga davon, sowie deren verwendung als entzündungshemmende mittel |
US5409944A (en) * | 1993-03-12 | 1995-04-25 | Merck Frosst Canada, Inc. | Alkanesulfonamido-1-indanone derivatives as inhibitors of cyclooxygenase |
AU6718494A (en) * | 1993-05-13 | 1994-12-12 | Merck Frosst Canada Inc. | 2-substituted-3,4-diarylthiophene derivatives as inhibitors of cyclooxygenase |
US5380738A (en) * | 1993-05-21 | 1995-01-10 | Monsanto Company | 2-substituted oxazoles further substituted by 4-fluorophenyl and 4-methylsulfonylphenyl as antiinflammatory agents |
US5474995A (en) * | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
US5298521A (en) * | 1993-08-30 | 1994-03-29 | Ortho Pharmaceutical Corporation | 1,5-diphenyl-3-pyrazolylalkyl-N-hydroxydithiocaramates, compositions and use |
US5344991A (en) * | 1993-10-29 | 1994-09-06 | G.D. Searle & Co. | 1,2 diarylcyclopentenyl compounds for the treatment of inflammation |
US5401765A (en) * | 1993-11-30 | 1995-03-28 | G. D. Searle | 1,4,5-triphenyl pyrazolyl compounds for the treatment of inflammation and inflammation-related disorders |
US5393790A (en) * | 1994-02-10 | 1995-02-28 | G.D. Searle & Co. | Substituted spiro compounds for the treatment of inflammation |
WO1995030669A1 (en) * | 1994-05-06 | 1995-11-16 | Zeneca Limited | Ether derivatives and pharmaceutical compositions containing them |
-
1995
- 1995-06-02 US US08/460,324 patent/US5643933A/en not_active Expired - Fee Related
-
1996
- 1996-05-31 AU AU60279/96A patent/AU6027996A/en not_active Abandoned
- 1996-05-31 PT PT00100201T patent/PT995747E/pt unknown
- 1996-05-31 CA CA002223091A patent/CA2223091A1/en not_active Abandoned
- 1996-05-31 PT PT96917888T patent/PT828736E/pt unknown
- 1996-05-31 DE DE69629290T patent/DE69629290T2/de not_active Expired - Fee Related
- 1996-05-31 DE DE69622894T patent/DE69622894T2/de not_active Expired - Fee Related
- 1996-05-31 DK DK96917888T patent/DK0828736T3/da active
- 1996-05-31 DK DK00100201T patent/DK0995747T3/da active
- 1996-05-31 ES ES96917888T patent/ES2205035T3/es not_active Expired - Lifetime
- 1996-05-31 AT AT96917888T patent/ATE246188T1/de not_active IP Right Cessation
- 1996-05-31 EP EP00100201A patent/EP0995747B1/en not_active Expired - Lifetime
- 1996-05-31 EP EP96917888A patent/EP0828736B1/en not_active Expired - Lifetime
- 1996-05-31 WO PCT/US1996/008183 patent/WO1996038442A1/en active IP Right Grant
- 1996-05-31 ES ES00100201T patent/ES2181614T3/es not_active Expired - Lifetime
- 1996-05-31 AT AT00100201T patent/ATE221885T1/de not_active IP Right Cessation
-
2000
- 2000-08-21 HK HK00105257A patent/HK1027802A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DK0828736T3 (da) | 2003-11-24 |
DK0995747T3 (da) | 2002-11-25 |
AU6027996A (en) | 1996-12-18 |
ES2205035T3 (es) | 2004-05-01 |
EP0995747B1 (en) | 2002-08-07 |
DE69622894D1 (de) | 2002-09-12 |
EP0828736A1 (en) | 1998-03-18 |
EP0828736B1 (en) | 2003-07-30 |
DE69629290T2 (de) | 2004-04-22 |
EP0995747A1 (en) | 2000-04-26 |
DE69622894T2 (de) | 2003-04-30 |
HK1027802A1 (en) | 2001-01-23 |
CA2223091A1 (en) | 1996-12-05 |
US5643933A (en) | 1997-07-01 |
WO1996038442A1 (en) | 1996-12-05 |
ATE221885T1 (de) | 2002-08-15 |
ES2181614T3 (es) | 2003-03-01 |
DE69629290D1 (en) | 2003-09-04 |
PT995747E (pt) | 2002-12-31 |
ATE246188T1 (de) | 2003-08-15 |
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