HK1023599A1 - Cells for preventing graft rejection in transplantation and their uses. - Google Patents
Cells for preventing graft rejection in transplantation and their uses.Info
- Publication number
- HK1023599A1 HK1023599A1 HK00102732A HK00102732A HK1023599A1 HK 1023599 A1 HK1023599 A1 HK 1023599A1 HK 00102732 A HK00102732 A HK 00102732A HK 00102732 A HK00102732 A HK 00102732A HK 1023599 A1 HK1023599 A1 HK 1023599A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- graft rejection
- cells
- lag
- host
- transplantation
- Prior art date
Links
- 206010052779 Transplant rejections Diseases 0.000 title abstract 3
- 238000002054 transplantation Methods 0.000 title 1
- 102000017578 LAG3 Human genes 0.000 abstract 3
- 101150030213 Lag3 gene Proteins 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 210000000987 immune system Anatomy 0.000 abstract 2
- 210000000056 organ Anatomy 0.000 abstract 2
- 206010062016 Immunosuppression Diseases 0.000 abstract 1
- 230000000735 allogeneic effect Effects 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 238000001415 gene therapy Methods 0.000 abstract 1
- 230000001506 immunosuppresive effect Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2066—IL-10
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Transplantation (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP1996/005280 WO1998023748A1 (en) | 1996-11-29 | 1996-11-29 | Methods for preventing graft rejection in transplantation and for producing a universal gene therapy host cell using lymphocyte activation (lag-3) |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1023599A1 true HK1023599A1 (en) | 2000-09-15 |
Family
ID=8166413
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK00102732A HK1023599A1 (en) | 1996-11-29 | 2000-05-05 | Cells for preventing graft rejection in transplantation and their uses. |
Country Status (20)
Country | Link |
---|---|
US (1) | US6500422B2 (da) |
EP (1) | EP0941329B1 (da) |
JP (1) | JP3920928B2 (da) |
KR (1) | KR100481230B1 (da) |
AR (1) | AR018489A1 (da) |
AT (1) | ATE271607T1 (da) |
AU (1) | AU733825B2 (da) |
BR (1) | BR9612821A (da) |
CA (1) | CA2272130C (da) |
DE (1) | DE69632967T2 (da) |
DK (1) | DK0941329T3 (da) |
EA (1) | EA003772B1 (da) |
ES (1) | ES2225901T3 (da) |
HK (1) | HK1023599A1 (da) |
IL (1) | IL130168A (da) |
NO (1) | NO324378B1 (da) |
PT (1) | PT941329E (da) |
UA (1) | UA73270C2 (da) |
WO (1) | WO1998023748A1 (da) |
ZA (1) | ZA9710737B (da) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL130168A (en) * | 1996-11-29 | 2006-09-05 | Serono Lab | Genetically engineered cells containing LAG-3-expressing DNA and their use |
AU2004217526B2 (en) * | 2003-02-28 | 2010-02-04 | St. Jude Children's Research Hospital Inc. | T cell regulation |
KR20050082389A (ko) * | 2004-02-18 | 2005-08-23 | 메덱스젠 주식회사 | 직렬 연쇄체를 갖는 면역접합체를 포함하는 장기이식합병증 치료용 약제학적 조성물 |
EP2044949A1 (en) * | 2007-10-05 | 2009-04-08 | Immutep | Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response |
AR072999A1 (es) * | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
UY34887A (es) | 2012-07-02 | 2013-12-31 | Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware | Optimización de anticuerpos que se fijan al gen de activación de linfocitos 3 (lag-3) y sus usos |
RS64268B1 (sr) | 2013-09-20 | 2023-07-31 | Bristol Myers Squibb Co | Kombinacija anti-lag-3 antitela i anti-pd-1 antitela za lečenje tumora |
GB201322626D0 (en) | 2013-12-19 | 2014-02-05 | Immutep S A | Combined preparations for the treatment of cancer |
JO3663B1 (ar) | 2014-08-19 | 2020-08-27 | Merck Sharp & Dohme | الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين |
GB201500374D0 (en) | 2015-01-09 | 2015-02-25 | Immutep S A | Combined preparations for the treatment of cancer |
SI3356411T1 (sl) | 2015-10-02 | 2021-09-30 | F. Hoffmann-La Roche Ag | Bispecifična protitelesa, specifična za PD1 in TIM3 |
CN109069570A (zh) | 2015-12-16 | 2018-12-21 | 默沙东公司 | 抗lag3抗体和抗原结合片段 |
AU2018247765B2 (en) | 2017-04-03 | 2023-11-23 | F. Hoffmann-La Roche Ag | Immunoconjugates of an Anti-PD-1 antibody with a mutant IL-2 or with IL-15 |
IL268527B2 (en) | 2017-04-05 | 2024-03-01 | Hoffmann La Roche | Bispecific antibodies bind to PD1 and LAG3 specifically |
MX2019012076A (es) | 2017-05-30 | 2019-12-09 | Bristol Myers Squibb Co | Composiciones que comprenden un anticuerpo anti gen-3 de activacion del linfocito (lag-3) o un anticuerpo anti-lag-3 y un anticuerpo anti muerte celular programada 1 (pd-1) o anti ligando 1 de muerte celular programada (pd-l1). |
EP4306542A3 (en) | 2017-05-30 | 2024-04-17 | Bristol-Myers Squibb Company | Treatment of lag-3 positive tumors |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2656800B1 (fr) | 1990-01-08 | 1992-05-15 | Roussy Inst Gustave | Nouvelles proteines produits par les lymphocytes humains, sequence d'adn codant pour ces proteines et applications pharmaceutiques et biologiques. |
US5876708A (en) * | 1992-02-19 | 1999-03-02 | The General Hospital Corporation | Allogeneic and xenogeneic transplantation |
JP3700859B2 (ja) | 1994-05-06 | 2005-09-28 | アンスティテュ ギュスタブ ルシ | Lag−3タンパク質の可溶性ポリペプチドフラクション;製造方法、治療用製剤、抗イディオタイプ抗体 |
IL130168A (en) * | 1996-11-29 | 2006-09-05 | Serono Lab | Genetically engineered cells containing LAG-3-expressing DNA and their use |
-
1996
- 1996-11-29 IL IL130168A patent/IL130168A/en not_active IP Right Cessation
- 1996-11-29 JP JP52611398A patent/JP3920928B2/ja not_active Expired - Fee Related
- 1996-11-29 KR KR10-1999-7004274A patent/KR100481230B1/ko not_active IP Right Cessation
- 1996-11-29 ES ES96940658T patent/ES2225901T3/es not_active Expired - Lifetime
- 1996-11-29 AU AU10667/97A patent/AU733825B2/en not_active Ceased
- 1996-11-29 US US09/319,147 patent/US6500422B2/en not_active Expired - Fee Related
- 1996-11-29 EP EP96940658A patent/EP0941329B1/en not_active Expired - Lifetime
- 1996-11-29 CA CA002272130A patent/CA2272130C/en not_active Expired - Fee Related
- 1996-11-29 DK DK96940658T patent/DK0941329T3/da active
- 1996-11-29 UA UA99063590A patent/UA73270C2/uk unknown
- 1996-11-29 AT AT96940658T patent/ATE271607T1/de not_active IP Right Cessation
- 1996-11-29 EA EA199900507A patent/EA003772B1/ru not_active IP Right Cessation
- 1996-11-29 BR BR9612821-6A patent/BR9612821A/pt not_active Application Discontinuation
- 1996-11-29 WO PCT/EP1996/005280 patent/WO1998023748A1/en active IP Right Grant
- 1996-11-29 DE DE69632967T patent/DE69632967T2/de not_active Expired - Fee Related
- 1996-11-29 PT PT96940658T patent/PT941329E/pt unknown
-
1997
- 1997-11-28 ZA ZA9710737A patent/ZA9710737B/xx unknown
- 1997-11-28 AR ARP970105619A patent/AR018489A1/es not_active Application Discontinuation
-
1999
- 1999-05-27 NO NO19992569A patent/NO324378B1/no not_active IP Right Cessation
-
2000
- 2000-05-05 HK HK00102732A patent/HK1023599A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2272130A1 (en) | 1998-06-04 |
JP2001505770A (ja) | 2001-05-08 |
IL130168A0 (en) | 2000-06-01 |
AR018489A1 (es) | 2001-11-28 |
KR100481230B1 (ko) | 2005-04-07 |
DK0941329T3 (da) | 2004-11-29 |
NO992569D0 (no) | 1999-05-27 |
CA2272130C (en) | 2007-10-23 |
EA199900507A1 (ru) | 2000-02-28 |
WO1998023748A1 (en) | 1998-06-04 |
EP0941329A1 (en) | 1999-09-15 |
NO324378B1 (no) | 2007-10-01 |
AU1066797A (en) | 1998-06-22 |
IL130168A (en) | 2006-09-05 |
ZA9710737B (en) | 1998-07-30 |
DE69632967T2 (de) | 2005-08-11 |
US6500422B2 (en) | 2002-12-31 |
KR20000053291A (ko) | 2000-08-25 |
US20020081282A1 (en) | 2002-06-27 |
EP0941329B1 (en) | 2004-07-21 |
DE69632967D1 (de) | 2004-08-26 |
UA73270C2 (en) | 2005-07-15 |
JP3920928B2 (ja) | 2007-05-30 |
BR9612821A (pt) | 2000-04-11 |
EA003772B1 (ru) | 2003-08-28 |
AU733825B2 (en) | 2001-05-24 |
PT941329E (pt) | 2004-11-30 |
ATE271607T1 (de) | 2004-08-15 |
NO992569L (no) | 1999-05-27 |
ES2225901T3 (es) | 2005-03-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
CHPA | Change of a particular in the register (except of change of ownership) | ||
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20091129 |