HK1022907A1 - Substituted (1,3-bis(cyclohexylmethyl)-1,2,3,6-tetrahydro-2,6-dioxo-9H-purin-8-yl)phenyl derivatives, their preparation and their use in the treatmentof inflammatory conditions and immune disorders - Google Patents

Substituted (1,3-bis(cyclohexylmethyl)-1,2,3,6-tetrahydro-2,6-dioxo-9H-purin-8-yl)phenyl derivatives, their preparation and their use in the treatmentof inflammatory conditions and immune disorders

Info

Publication number
HK1022907A1
HK1022907A1 HK00101936A HK00101936A HK1022907A1 HK 1022907 A1 HK1022907 A1 HK 1022907A1 HK 00101936 A HK00101936 A HK 00101936A HK 00101936 A HK00101936 A HK 00101936A HK 1022907 A1 HK1022907 A1 HK 1022907A1
Authority
HK
Hong Kong
Prior art keywords
treatmentof
purin
cyclohexylmethyl
dioxo
tetrahydro
Prior art date
Application number
HK00101936A
Other languages
English (en)
Inventor
Susan Mary Daluge
Gerald Wolberg
Douglas Alan Livingston
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of HK1022907A1 publication Critical patent/HK1022907A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK00101936A 1997-02-14 2000-03-29 Substituted (1,3-bis(cyclohexylmethyl)-1,2,3,6-tetrahydro-2,6-dioxo-9H-purin-8-yl)phenyl derivatives, their preparation and their use in the treatmentof inflammatory conditions and immune disorders HK1022907A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9703044.9A GB9703044D0 (en) 1997-02-14 1997-02-14 Phenyl xanthine esters and amides
PCT/EP1998/000784 WO1998035966A1 (en) 1997-02-14 1998-02-12 Substituted (1,3-bis(cyclohexylmethyl)-1,2,3,6-tetrahydro-2,6-dioxo-9h-purin-8-yl)phenyl derivatives, their preparation and their use in the treatment of inflammatory conditions and immune disorders

Publications (1)

Publication Number Publication Date
HK1022907A1 true HK1022907A1 (en) 2000-08-25

Family

ID=10807635

Family Applications (1)

Application Number Title Priority Date Filing Date
HK00101936A HK1022907A1 (en) 1997-02-14 2000-03-29 Substituted (1,3-bis(cyclohexylmethyl)-1,2,3,6-tetrahydro-2,6-dioxo-9H-purin-8-yl)phenyl derivatives, their preparation and their use in the treatmentof inflammatory conditions and immune disorders

Country Status (38)

Country Link
US (3) US6355646B1 (de)
EP (1) EP0970081B1 (de)
JP (1) JP2001511792A (de)
KR (1) KR100522639B1 (de)
CN (1) CN1140527C (de)
AP (1) AP1000A (de)
AR (1) AR011441A1 (de)
AT (1) ATE304542T1 (de)
AU (1) AU754456B2 (de)
BG (1) BG103722A (de)
BR (1) BR9807682B1 (de)
CA (1) CA2280730C (de)
CO (1) CO4940444A1 (de)
CZ (1) CZ298764B6 (de)
DE (1) DE69831559T2 (de)
DK (1) DK0970081T3 (de)
EA (1) EA199900648A1 (de)
EE (1) EE9900348A (de)
ES (1) ES2249822T3 (de)
GB (1) GB9703044D0 (de)
HK (1) HK1022907A1 (de)
HR (1) HRP980077A2 (de)
HU (1) HU225962B1 (de)
ID (1) ID22770A (de)
IL (1) IL131179A (de)
IS (1) IS5144A (de)
MY (1) MY118545A (de)
NO (1) NO325685B1 (de)
NZ (1) NZ336923A (de)
PE (1) PE58899A1 (de)
PL (1) PL188018B1 (de)
SK (1) SK110399A3 (de)
TR (1) TR199901942T2 (de)
TW (1) TW520371B (de)
UA (1) UA57767C2 (de)
WO (1) WO1998035966A1 (de)
YU (1) YU38399A (de)
ZA (1) ZA981175B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9703044D0 (en) * 1997-02-14 1997-04-02 Glaxo Group Ltd Phenyl xanthine esters and amides
GB9817623D0 (en) 1998-08-13 1998-10-07 Glaxo Group Ltd Pharmaceutical compounds
US6545002B1 (en) * 1999-06-01 2003-04-08 University Of Virginia Patent Foundation Substituted 8-phenylxanthines useful as antagonists of A2B adenosine receptors
FR2804958B1 (fr) * 2000-02-15 2005-07-08 Hoechst Marion Roussel Inc Derives de xanthine, leur procede de preparation et les intermediaires de ce procede, leur application comme medicament et les compositions pharmaceutiques les renfermant
ES2262798T3 (es) * 2001-02-28 2006-12-01 Smithkline Beecham Corporation Derivados glicolicos de xantinas para tratar el sindrome del intestino irritable.
US20080318983A1 (en) * 2001-11-09 2008-12-25 Rao Kalla A2b adenosine receptor antagonists
US7125993B2 (en) * 2001-11-09 2006-10-24 Cv Therapeutics, Inc. A2B adenosine receptor antagonists
US20040072848A1 (en) * 2002-02-26 2004-04-15 Huber Brian E Methods of treating irritable bowel syndrome and functional dyspepsia
AU2012227249B2 (en) * 2003-12-16 2014-10-02 Nektar Therapeutics Chemically modified small molecules
PL1694363T3 (pl) * 2003-12-16 2014-07-31 Nektar Therapeutics Monodyspersyjne kompozycje PEGylowanego naloksolu
US20060182692A1 (en) 2003-12-16 2006-08-17 Fishburn C S Chemically modified small molecules
WO2005102976A1 (en) * 2004-04-21 2005-11-03 Smithkline Beecham Corporation Process for preparing nonaethylene glycol monomethyl ether
WO2006028810A2 (en) * 2004-09-01 2006-03-16 Cv Therapeutics, Inc. Method of wound healing using a2b adenosine receptor antagonists
US20070059740A1 (en) * 2005-08-26 2007-03-15 Linden Joel M Method of targeting a2b adenosine receptor antagonist therapy
US8193200B2 (en) * 2007-01-04 2012-06-05 University Of Virginia Patent Foundation Antagonists of A2B adenosine receptors for treatment of inflammatory bowel disease

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8510758D0 (en) 1985-04-27 1985-06-05 Wellcome Found Compounds
US4968672A (en) 1987-01-02 1990-11-06 The United States Of America As Represented By The Department Of Health And Human Services Adenosine receptor prodrugs
US5015647A (en) 1987-04-24 1991-05-14 Burroughs Wellcome Co. Method for treating viral infections
GB8826595D0 (en) 1988-11-14 1988-12-21 Beecham Wuelfing Gmbh & Co Kg Active compounds
GB8906792D0 (en) 1989-03-23 1989-05-10 Beecham Wuelfing Gmbh & Co Kg Treatment and compounds
NZ240644A (en) 1990-11-21 1994-08-26 Smithkline Beecham Corp Use of xanthine derivatives to inhibit the production of tumour necrosis factor (tnf)
GB9210839D0 (en) * 1992-05-21 1992-07-08 Smithkline Beecham Plc Novel compounds
TW252044B (de) * 1992-08-10 1995-07-21 Boehringer Ingelheim Kg
JP2613355B2 (ja) 1992-09-28 1997-05-28 協和醗酵工業株式会社 パーキンソン氏病治療剤
GB9415529D0 (en) 1994-08-01 1994-09-21 Wellcome Found Phenyl xanthine derivatives
DE19535504A1 (de) 1995-09-25 1997-03-27 Bayer Ag Substituierte Xanthine
SI0812844T1 (en) 1996-06-07 2003-02-28 Hoechst Aktiengesellschaft Use of theophyllin derivatives for the treatment and prophylaxis fo shock conditions, novel xanthine compounds and processes for the production thereof
GB9703044D0 (en) * 1997-02-14 1997-04-02 Glaxo Group Ltd Phenyl xanthine esters and amides
US6117878A (en) 1998-02-24 2000-09-12 University Of Virginia 8-phenyl- or 8-cycloalkyl xanthine antagonists of A2B human adenosine receptors
WO1999043673A1 (fr) 1998-02-26 1999-09-02 Zenyaku Kogyo Kabushiki Kaisha Derives de 1-aza-indolizine
GB9817623D0 (en) * 1998-08-13 1998-10-07 Glaxo Group Ltd Pharmaceutical compounds
NZ519781A (en) 1999-12-23 2004-04-30 Nitromed Inc Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
US6751206B1 (en) * 2000-06-29 2004-06-15 Qualcomm Incorporated Method and apparatus for beam switching in a wireless communication system

Also Published As

Publication number Publication date
CA2280730A1 (en) 1998-08-20
GB9703044D0 (en) 1997-04-02
JP2001511792A (ja) 2001-08-14
CN1140527C (zh) 2004-03-03
IL131179A0 (en) 2001-01-28
ID22770A (id) 1999-12-09
DE69831559D1 (de) 2005-10-20
PL188018B1 (pl) 2004-11-30
YU38399A (sh) 2002-06-19
ZA981175B (en) 1999-08-12
EP0970081A1 (de) 2000-01-12
US6437124B1 (en) 2002-08-20
PL335135A1 (en) 2000-04-10
AU6622198A (en) 1998-09-08
NO993915D0 (no) 1999-08-13
UA57767C2 (uk) 2003-07-15
BG103722A (en) 2000-06-30
KR100522639B1 (ko) 2005-10-19
TR199901942T2 (xx) 1999-12-21
EA199900648A1 (ru) 2000-04-24
US6355646B1 (en) 2002-03-12
ATE304542T1 (de) 2005-09-15
US20030181471A1 (en) 2003-09-25
IS5144A (is) 1999-07-30
NZ336923A (en) 2001-02-23
CO4940444A1 (es) 2000-07-24
DK0970081T3 (da) 2006-02-06
EP0970081B1 (de) 2005-09-14
CN1252071A (zh) 2000-05-03
TW520371B (en) 2003-02-11
AU754456B2 (en) 2002-11-14
SK110399A3 (en) 2000-06-12
BR9807682B1 (pt) 2009-01-13
DE69831559T2 (de) 2006-06-14
NO325685B1 (no) 2008-07-07
HUP0000894A2 (hu) 2001-05-28
KR20000071010A (ko) 2000-11-25
EE9900348A (et) 2000-02-15
HRP980077A2 (en) 1998-12-31
WO1998035966A1 (en) 1998-08-20
CA2280730C (en) 2006-10-10
US7002012B2 (en) 2006-02-21
PE58899A1 (es) 1999-06-17
BR9807682A (pt) 2000-02-15
HU225962B1 (en) 2008-01-28
HUP0000894A3 (en) 2002-04-29
IL131179A (en) 2004-05-12
AP9901622A0 (en) 1999-09-30
AP1000A (en) 2001-08-11
CZ298764B6 (cs) 2008-01-23
AR011441A1 (es) 2000-08-16
ES2249822T3 (es) 2006-04-01
NO993915L (no) 1999-10-13
CZ288799A3 (cs) 2000-04-12
MY118545A (en) 2004-12-31

Similar Documents

Publication Publication Date Title
DK0789562T3 (da) Caffeinformulering med vedvarende afgivelse
HK1022907A1 (en) Substituted (1,3-bis(cyclohexylmethyl)-1,2,3,6-tetrahydro-2,6-dioxo-9H-purin-8-yl)phenyl derivatives, their preparation and their use in the treatmentof inflammatory conditions and immune disorders
CS410991A3 (en) 2-substituted, 5-substituted 1,3-oxathiolate derivatives
HUP0100069A3 (en) 4(3)substituted-4(3)-aminomethyl-pyran, or -thiopyran-piperidine derivatives, their preparation and their use in the treatment of neurological disorders
GB2242144B (en) Anti-slip surfaces
NZ241385A (en) N-pyrimidinyl, -triazolyl and -triazinyl-n'-phenylsulphonyl urea and -thiourea derivatives; intermediates in the preparation thereof and herbicidal compositions
NZ222162A (en) 1,3-cyclohexanedione derivatives and herbicidal compositions
IL133997A (en) 2-[pyrazolyl- and triazolyl-3'-oxymethylene] phenylisoxazolones, -triazolones and -tetrazolones, their preparation and compositions comprising them
DE69307792D1 (de) Vulkanisierbare Organopolysiloxan-Zusammensetzung
EP0757891A3 (de) Feststoff-Formulierungen
NZ234369A (en) 6-(naphthalenylethyl)-4-hydroxy-pyran-2-one derivatives and the 3,5-dihydroxyheptanoates; pharmaceutical compositions
HUP0102832A3 (en) Herbicidal substituted 2,4-diamino-1,3,5-triazine derivatives, preparation and use thereof
ZA932576B (en) 1,2,4-benzothiadiazine-3-carboxylic acid derivatives, their preparation and their use
SI0970081T1 (sl) Substituirani (1,3-bis(cikloheksilmetil)-1,2,3,6-tetrahidro-2,6-diokso-9h-purin-8-il) fenilni derivati, njihova priprava in njihova uporaba pri zdravljenju vnetnih stanj in imunskih motenj
GB9319284D0 (en) Anti-slip surfaces
ZA918863B (en) Substituted amino acid derivatives their preparation and use
MX9206482A (es) 1,5-pentanodioles substituidos y procesos para la preparacion de los mismos
GB2324090B (en) 5,6-O-alkylidene glucono-1(4)-lactones and derivatives thereof,their preparation and use
NZ240236A (en) Pyrimidine derivatives, preparation and fungicidal compositions thereof
HUT57542A (en) Herbicidal composition comprising n-phenyl-3,4,5,6-tetrahydrophtalimide and phenoxyalkanecarboxylic acid derivatives
IE890121L (en) New galenic formulations with programmed release
GB9117865D0 (en) Dihydropyrimidine derivatives
ZA903802B (en) Anti inflammatory aminophenol derivatives
IT240214Y1 (it) Innovazione nelle cosiddette "forme" sia per dolci, budini, gelatineo sformati, pate' ed altre analoghe composizioni culinarie, sia se
IE901547L (en) Alloys and aromatic polyamides and poly-n-vinyl-pyrrolidones

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20100212